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Protein

Protrudin

Gene

Zfyve27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri337 – 40367FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • neuron projection development Source: UniProtKB
  • neurotrophin TRK receptor signaling pathway Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protrudin
Alternative name(s):
Zinc finger FYVE domain-containing protein 27
Gene namesi
Name:Zfyve27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi735177. Zfyve27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8522HelicalSequence analysisAdd
BLAST
Topological domaini86 – 905ExtracellularSequence analysis
Transmembranei91 – 10919HelicalSequence analysisAdd
BLAST
Topological domaini110 – 18778CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 404196ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: UniProtKB
  • dendrite Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • growth cone membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404ProtrudinPRO_0000410350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P7B7.

Interactioni

Subunit structurei

Interacts with SPAST. Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain) (By similarity). Interacts with RAB11A (GDP-bound form); regulates RAB11A.By similarity1 Publication

Protein-protein interaction databases

IntActiQ6P7B7. 1 interaction.
STRINGi10116.ENSRNOP00000051399.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6414Necessary for interaction with RAB11A and function in neurite outgrowthBy similarityAdd
BLAST
Regioni286 – 2927Necessary for interaction with VAPABy similarity

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri337 – 40367FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJBT. Eukaryota.
ENOG4111KCR. LUCA.
GeneTreeiENSGT00390000013298.
HOGENOMiHOG000155785.
HOVERGENiHBG054907.
InParanoidiQ6P7B7.
KOiK19368.
OMAiTVCMLYL.
OrthoDBiEOG7VTDNG.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSDRDLSG PEASPSVMPE VLSECSPAPT KSTAFDLFNL VLSYKRLEIY
60 70 80 90 100
LEPLKDAGDG VRYLLRWQMP LCSLLTCLGL NILFLTLNEG AWYSVGALII
110 120 130 140 150
SVPALLGYLQ EVCRAQLPES ELMRRKYHSV RQEDLQRVRL SRPEAVAEVK
160 170 180 190 200
SFLIRLEAFL ARLCYTCESA YRVLHWENPV VSSQFYGALL GMVCMLYLLP
210 220 230 240 250
LCWVLALLNS TLFLGNGEFF RVVSEYRACL QRRMSPKQEE CVCEGSALQD
260 270 280 290 300
AGGRAVVLDS TPAPTPTEDL TPGSVEEAEE AEPDEEFKDA IEEDDEGTPC
310 320 330 340 350
PAEDELTMQD NGFLSKNEVL RSKVSKLTER LRKRYPTNNF GNCAGCAATF
360 370 380 390 400
SVLKKRRSCS NCGNSFCSRC CSFKVPKSSM GATAPEAQRE TVFVCASCNQ

TLSK
Length:404
Mass (Da):44,948
Last modified:June 28, 2011 - v2
Checksum:i6D63A2ECB90264FC
GO

Sequence cautioni

The sequence AAH61741.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061741 mRNA. Translation: AAH61741.1. Different initiation.
RefSeqiNP_954535.2. NM_199104.2.
UniGeneiRn.8961.

Genome annotation databases

EnsembliENSRNOT00000083287; ENSRNOP00000074613; ENSRNOG00000014903.
GeneIDi309376.
KEGGirno:309376.
UCSCiRGD:735177. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061741 mRNA. Translation: AAH61741.1. Different initiation.
RefSeqiNP_954535.2. NM_199104.2.
UniGeneiRn.8961.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P7B7. 1 interaction.
STRINGi10116.ENSRNOP00000051399.

Proteomic databases

PaxDbiQ6P7B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083287; ENSRNOP00000074613; ENSRNOG00000014903.
GeneIDi309376.
KEGGirno:309376.
UCSCiRGD:735177. rat.

Organism-specific databases

CTDi118813.
RGDi735177. Zfyve27.

Phylogenomic databases

eggNOGiENOG410IJBT. Eukaryota.
ENOG4111KCR. LUCA.
GeneTreeiENSGT00390000013298.
HOGENOMiHOG000155785.
HOVERGENiHBG054907.
InParanoidiQ6P7B7.
KOiK19368.
OMAiTVCMLYL.
OrthoDBiEOG7VTDNG.

Miscellaneous databases

PROiQ6P7B7.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Protrudin induces neurite formation by directional membrane trafficking."
    Shirane M., Nakayama K.I.
    Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB11.

Entry informationi

Entry nameiZFY27_RAT
AccessioniPrimary (citable) accession number: Q6P7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.