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Protein
Submitted name:

Ephrin B1, isoform CRA_a

Gene

Efnb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2682334. EPH-Ephrin signaling.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-3928664. Ephrin signaling.
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Ephrin B1, isoform CRA_aImported
Submitted name:
Ephrin-B1Imported
Gene namesi
Name:Efnb1Imported
ORF Names:rCG_36210Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2540. Efnb1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 262HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501084531425 – 345Sequence analysisAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 153PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000006877.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-464N.
IntActiQ6P7B6. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 164Ephrin RBDInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3858. Eukaryota.
ENOG4111FMJ. LUCA.
GeneTreeiENSGT00390000005839.
HOVERGENiHBG051448.
KOiK05463.
OMAiRPYEYYK.
OrthoDBiEOG091G0BPC.

Family and domain databases

CDDicd10426. Ephrin-B_Ectodomain. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR008972. Cupredoxin.
IPR031328. Ephrin.
IPR034255. Ephrin-B_Ecto.
IPR019765. Ephrin_CS.
IPR001799. Ephrin_RBD.
PANTHERiPTHR11304. PTHR11304. 1 hit.
PfamiView protein in Pfam
PF00812. Ephrin. 1 hit.
PRINTSiPR01347. EPHRIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533. Ephrin. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiView protein in PROSITE
PS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPGQRWLS KWLVAMVVLT LCRLATPLAK NLEPVSWSSL NPKFLSGKGL
60 70 80 90 100
VIYPKIGDKL DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT
110 120 130 140 150
CNKPQQEIRF TIKFQEFSPN YMGLEFKKYH DYYITSTSNG SLEGLENREG
160 170 180 190 200
GVCRTRTMKI VMKVGQDPNA VTPEQLTTSR PSKESDNTVK TATQAPGRGS
210 220 230 240 250
QGDSDGKHET VNQQEKSGPG AGGSGSGDTD SFFNSKVALF AAVGAGCVIF
260 270 280 290 300
LLIIIFLTVL LLKLRKRHRK HTQQRAAALS LSTLASPKGG SGTAGTEPSD
310 320 330 340
IIIPLRTTEN NYCPHYEKVS GDYGHPVYIV QEMPPQSPAN IYYKV
Length:345
Mass (Da):37,893
Last modified:July 5, 2004 - v1
Checksum:i783046C6C7358F7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07039133 Genomic DNA. No translation available.
BC061744 mRNA. Translation: AAH61744.1.
CH473966 Genomic DNA. Translation: EDL95949.1.
CH473966 Genomic DNA. Translation: EDL95950.1.
RefSeqiNP_058785.2. NM_017089.2.
UniGeneiRn.44398.

Genome annotation databases

EnsembliENSRNOT00000009635; ENSRNOP00000009635; ENSRNOG00000006877.
GeneIDi25186.
KEGGirno:25186.

Similar proteinsi

Entry informationi

Entry nameiQ6P7B6_RAT
AccessioniPrimary (citable) accession number: Q6P7B6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported