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Q6P7A9 (LYAG_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal alpha-glucosidase

EC=3.2.1.20
Alternative name(s):
Acid maltase
Gene names
Name:Gaa
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for the degradation of glygogen to glucose in lysosomes By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Subcellular location

Lysosome By similarity. Lysosome membrane By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 31 family.

Contains 1 P-type (trefoil) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 6942 By similarity
PRO_0000260442
Chain70 – 953884Lysosomal alpha-glucosidase
PRO_0000260443

Regions

Domain80 – 13152P-type

Sites

Active site5181Nucleophile By similarity
Active site5211 By similarity

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation6521N-linked (GlcNAc...) Potential
Glycosylation8831N-linked (GlcNAc...) Potential
Glycosylation9261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6P7A9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D99723779AD41E05

FASTA953106,207
        10         20         30         40         50         60 
MNIRKPLCSN SVVGACTLVS LTTAVILGHL MLRELMLLPQ DLHESSSGLW KTYRPHHQES 

        70         80         90        100        110        120 
YEPAPLHIQE HAEQLRAVPT QCDVTPNSRF DCAPDKGITQ EQCEARGCCW VPAGQVLNGP 

       130        140        150        160        170        180 
VMGQPWCFFP PSYPSYRLEN LSSTESGYTA TLTRTSPTFF PKDVLTLQLE VLMETDSRLH 

       190        200        210        220        230        240 
FMIKDPTSKR YEVPLETPRV LSQAPSPLYS VEFSEEPFGV IVRRKLGGRV LLNTTVAPLF 

       250        260        270        280        290        300 
FADQFLQLST SLPSQHIAGL GEHLSPLMLS TEWTRITLWN RDVAPSQGVN LYGSHPFYLA 

       310        320        330        340        350        360 
LEDGGLAHGV FLLNSNAMDV VLQPSPALTW RSTGGILDVY VFLGPEPKSV VQQYLDVVGY 

       370        380        390        400        410        420 
PFMPPYWGLG FHLCRWGYSS TAIVRQVVEN MTRTHFPLDV QWNDLDYMDA RRDFTFNQDG 

       430        440        450        460        470        480 
FADFPDMVHE LHQGGRRYMM IVDPAISSSG PAGSYRPYDE GLRRGVFITN ETGQPLIGKV 

       490        500        510        520        530        540 
WPGSTAFPDF TNPETLDWWQ DMVSEFHAQV PFDGMWIDMN EPSNFIRGSQ QGCPDNELEN 

       550        560        570        580        590        600 
PPYVPGVVGG ALQAATICAS SHQFLSTHYN LHNLYGLTEA IASSRALVKT RGTRPFVISR 

       610        620        630        640        650        660 
STFAGHGRYA GHWTGDVWSS WEHLAYSVPE ILQFNLLGVP LVGADICGFQ GNTTEELCVR 

       670        680        690        700        710        720 
WTQLGAFYPF MRNHNDLNSL PQEPYRFSET AQQAMRKAFT LRYALLPYLY TLFHGAHVKG 

       730        740        750        760        770        780 
DTVARPLFLE FPEDPSTWSV DRQLLWGPAL LITPVLEPGK TDVTGYFPKG MWYNLQMVPV 

       790        800        810        820        830        840 
ETLGSLPSSS PASSFRSIVH SKGQWLTLEA PLDTINVHLR AGYIIPLQGP SLTTTESRKQ 

       850        860        870        880        890        900 
PMALAVALTE SGEASGELFW DDGESLGVLE RGAYTLVTFS AKNNTIVNKL VHVTKEGGEL 

       910        920        930        940        950 
QLREVTILGV TTAPTQVLSN GISVSNFTYS PDDKSLSIPV SLLMGERFQI DWS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC061753 mRNA. Translation: AAH61753.1.
RefSeqNP_954549.1. NM_199118.1.
UniGeneRn.162368.

3D structure databases

ProteinModelPortalQ6P7A9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6P7A9. 1 interaction.

Chemistry

BindingDBQ6P7A9.
ChEMBLCHEMBL3513.

Protein family/group databases

CAZyGH31. Glycoside Hydrolase Family 31.

Proteomic databases

PRIDEQ6P7A9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID367562.
KEGGrno:367562.

Organism-specific databases

CTD2548.
RGD735227. Gaa.

Phylogenomic databases

HOVERGENHBG006297.
KOK12316.
PhylomeDBQ6P7A9.

Enzyme and pathway databases

SABIO-RKQ6P7A9.

Gene expression databases

GenevestigatorQ6P7A9.

Family and domain databases

Gene3D4.10.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
[Graphical view]
PfamPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
PF00088. Trefoil. 1 hit.
[Graphical view]
SMARTSM00018. PD. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio691355.
PROQ6P7A9.

Entry information

Entry nameLYAG_RAT
AccessionPrimary (citable) accession number: Q6P7A9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries