Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P7A9

- LYAG_RAT

UniProt

Q6P7A9 - LYAG_RAT

Protein

Lysosomal alpha-glucosidase

Gene

Gaa

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential for the degradation of glygogen to glucose in lysosomes.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei518 – 5181NucleophilePROSITE-ProRule annotation
    Active sitei521 – 5211By similarity

    GO - Molecular functioni

    1. alpha-1,4-glucosidase activity Source: RGD
    2. carbohydrate binding Source: RGD
    3. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycogen catabolic process Source: RGD

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    SABIO-RKQ6P7A9.

    Protein family/group databases

    CAZyiGH31. Glycoside Hydrolase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal alpha-glucosidase (EC:3.2.1.20)
    Alternative name(s):
    Acid maltase
    Gene namesi
    Name:Gaa
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi735227. Gaa.

    Subcellular locationi

    Lysosome By similarity. Lysosome membrane By similarity

    GO - Cellular componenti

    1. lysosomal membrane Source: UniProtKB-SubCell
    2. lysosome Source: RGD

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 6942By similarityPRO_0000260442Add
    BLAST
    Chaini70 – 953884Lysosomal alpha-glucosidasePRO_0000260443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi883 – 8831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi926 – 9261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6P7A9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P7A9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6P7A9. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P7A9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 13152P-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 31 family.Curated
    Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006297.
    KOiK12316.
    PhylomeDBiQ6P7A9.

    Family and domain databases

    Gene3Di4.10.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    [Graphical view]
    PfamiPF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    PF00088. Trefoil. 1 hit.
    [Graphical view]
    SMARTiSM00018. PD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
    PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P7A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIRKPLCSN SVVGACTLVS LTTAVILGHL MLRELMLLPQ DLHESSSGLW    50
    KTYRPHHQES YEPAPLHIQE HAEQLRAVPT QCDVTPNSRF DCAPDKGITQ 100
    EQCEARGCCW VPAGQVLNGP VMGQPWCFFP PSYPSYRLEN LSSTESGYTA 150
    TLTRTSPTFF PKDVLTLQLE VLMETDSRLH FMIKDPTSKR YEVPLETPRV 200
    LSQAPSPLYS VEFSEEPFGV IVRRKLGGRV LLNTTVAPLF FADQFLQLST 250
    SLPSQHIAGL GEHLSPLMLS TEWTRITLWN RDVAPSQGVN LYGSHPFYLA 300
    LEDGGLAHGV FLLNSNAMDV VLQPSPALTW RSTGGILDVY VFLGPEPKSV 350
    VQQYLDVVGY PFMPPYWGLG FHLCRWGYSS TAIVRQVVEN MTRTHFPLDV 400
    QWNDLDYMDA RRDFTFNQDG FADFPDMVHE LHQGGRRYMM IVDPAISSSG 450
    PAGSYRPYDE GLRRGVFITN ETGQPLIGKV WPGSTAFPDF TNPETLDWWQ 500
    DMVSEFHAQV PFDGMWIDMN EPSNFIRGSQ QGCPDNELEN PPYVPGVVGG 550
    ALQAATICAS SHQFLSTHYN LHNLYGLTEA IASSRALVKT RGTRPFVISR 600
    STFAGHGRYA GHWTGDVWSS WEHLAYSVPE ILQFNLLGVP LVGADICGFQ 650
    GNTTEELCVR WTQLGAFYPF MRNHNDLNSL PQEPYRFSET AQQAMRKAFT 700
    LRYALLPYLY TLFHGAHVKG DTVARPLFLE FPEDPSTWSV DRQLLWGPAL 750
    LITPVLEPGK TDVTGYFPKG MWYNLQMVPV ETLGSLPSSS PASSFRSIVH 800
    SKGQWLTLEA PLDTINVHLR AGYIIPLQGP SLTTTESRKQ PMALAVALTE 850
    SGEASGELFW DDGESLGVLE RGAYTLVTFS AKNNTIVNKL VHVTKEGGEL 900
    QLREVTILGV TTAPTQVLSN GISVSNFTYS PDDKSLSIPV SLLMGERFQI 950
    DWS 953
    Length:953
    Mass (Da):106,207
    Last modified:July 5, 2004 - v1
    Checksum:iD99723779AD41E05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061753 mRNA. Translation: AAH61753.1.
    RefSeqiNP_954549.1. NM_199118.1.
    UniGeneiRn.162368.

    Genome annotation databases

    GeneIDi367562.
    KEGGirno:367562.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061753 mRNA. Translation: AAH61753.1 .
    RefSeqi NP_954549.1. NM_199118.1.
    UniGenei Rn.162368.

    3D structure databases

    ProteinModelPortali Q6P7A9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P7A9. 1 interaction.

    Chemistry

    BindingDBi Q6P7A9.
    ChEMBLi CHEMBL3513.

    Protein family/group databases

    CAZyi GH31. Glycoside Hydrolase Family 31.

    Proteomic databases

    PRIDEi Q6P7A9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 367562.
    KEGGi rno:367562.

    Organism-specific databases

    CTDi 2548.
    RGDi 735227. Gaa.

    Phylogenomic databases

    HOVERGENi HBG006297.
    KOi K12316.
    PhylomeDBi Q6P7A9.

    Enzyme and pathway databases

    SABIO-RK Q6P7A9.

    Miscellaneous databases

    NextBioi 691355.
    PROi Q6P7A9.

    Gene expression databases

    Genevestigatori Q6P7A9.

    Family and domain databases

    Gene3Di 4.10.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    [Graphical view ]
    Pfami PF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    PF00088. Trefoil. 1 hit.
    [Graphical view ]
    SMARTi SM00018. PD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
    PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiLYAG_RAT
    AccessioniPrimary (citable) accession number: Q6P7A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3