Reviewed, UniProtKB/Swiss-Prot Q6P7A1 (LARG2_RAT)

Names and origin

Protein names

Recommended name:
    Glycosyltransferase-like protein LARGE2
    EC=2.4.-.-
Alternative name(s):
    Glycosyltransferase-like 1B

Gene names

Name:

Gyltl1b

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	690 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Glycosyltransferase which participates in glycosylation of alpha-dystroglycan. May carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. Has a higher activity toward alpha-dystroglycan than LARGE By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 8 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 690	690	Glycosyltransferase-like protein LARGE2		PRO_0000226813
Regions
	Topological domain	1 – 7	7	Cytoplasmic Potential
	Transmembrane	8 – 28	21	Signal-anchor for type II membrane protein Potential
	Topological domain	29 – 690	662	Lumenal Potential
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	201	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6P7A1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 79C609E33EDD33E3	FASTA	690	79,309
	10 20 30 40 50 60 MLPRGRPRAL GAALLLLLLL VVGFFLFGRD PEYGLGTTAT LDGDPYGSRN RSTSSLQLLL 70 80 90 100 110 120 PPKCEMLHVA IVCAGYNSSR EIITLMKSVL FYRKNPLHLH LITDAVARNI LETLFRTWMV 130 140 150 160 170 180 PAVVVSFYDA EELKPLVSWI PNKHYSGLYG LMKLVLPSVL PLSLARVIVL DTDVTFSSDI 190 200 210 220 230 240 MELWALFGHF SDKQVVGLVE NQSDWYLGNL WKNHRPWPAL GRGFNTGVIL LWLDRLQQIG 250 260 270 280 290 300 WEQMWKLTAK RELLTLTATS LADQDIFNAV IKEHPELVHP LPCVWNVQLS DHTLAERCYL 310 320 330 340 350 360 EAADLKVIHW NSPKKLRVKN KHAEFFRDLH LTFLGFDGKL LCRELFGCPN QFPPGVEQLQ 370 380 390 400 410 420 QALAQLDEEE PCFEFRQQQL TVHRVHITFL SHQPPPPRPH DVTLVAQLSM DRLQMLEALC 430 440 450 460 470 480 RHWRGPMSLA LYLTDAEAQQ FLRFVETSPV LSARKDVAYH VVYRDGPLYP VNQLRNVALA 490 500 510 520 530 540 QALTPYVFLS DIDFLPAYSL YDYLRASIEQ LALGRRQRKA ALVVPAFETL HYRFSFPNSK 550 560 570 580 590 600 AELLTLLDAG SLHTFRYHEW PQGHASTDYT RWREAQAPYR VQWSADYEPY VVVPRDCPRY 610 620 630 640 650 660 DPRFVGFGWN KVAHIIELDA QEYEFLVLPE AFSIHLPHAP SLDISRFRSS PTYRDCLQAL 670 680 690 KEEFHQDLSR RYGSAALKYL TALQQSRSRA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC061762 mRNA. Translation: AAH61762.1.
IPI	IPI00566888.
RefSeq	NP_954538.1.
UniGene	Rn.205174
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT49. Glycosyltransferase Family 49. GT8. Glycosyltransferase Family 8.
Genome annotation databases
Ensembl	ENSRNOT00000051258; ENSRNOP00000041797; ENSRNOG00000006353; Rattus norvegicus. [Genome view]
GeneID	311202.
KEGG	rno:311202.
UCSC	NM_199107. rat.
Organism-specific databases
CTD	311202.
RGD	735214. Gyltl1b.
Phylogenomic databases
HOVERGEN	Q6P7A1.
Gene expression databases
ArrayExpress	Q6P7A1.
Genevestigator	Q6P7A1.
GermOnline	ENSRNOG00000006353. Rattus norvegicus.
Family and domain databases
InterPro	IPR002495. Glyco_trans_8. [Graphical view]
Pfam	PF01501. Glyco_transf_8. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	663191.

Entry information

Entry name

LARG2_RAT

Accession

Primary (citable) accession number: Q6P7A1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	October 13, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)