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Protein

TATA box-binding protein-associated factor, RNA polymerase I, subunit C

Gene

Taf1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor, RNA polymerase I, subunit C
Alternative name(s):
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:Taf1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305658. Taf1c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842TATA box-binding protein-associated factor, RNA polymerase I, subunit CPRO_0000118865Add
BLAST

Proteomic databases

PaxDbiQ6P773.
PRIDEiQ6P773.

Expressioni

Gene expression databases

GenevisibleiQ6P773. RN.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020990.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOGENOMiHOG000154497.
HOVERGENiHBG079499.
InParanoidiQ6P773.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ6P773.
TreeFamiTF351959.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPSTLRPS LFMAGPLGMT DGPDLSFMCS WRDALTLPGA QPQNCRDQTS
60 70 80 90 100
SFAKNLLWEP STPGPLPLVP PGPDPWDPGL AAQDFLFRGG HYYQYQSRVV
110 120 130 140 150
LDVTEQLSRF LWDHGDIAFA PLGKLMLENF RLEGNRGYSK KVTIVSVKRL
160 170 180 190 200
LQDLGGHQPW GCPWASLSRR LRRFSILGGP VLSRSVSLLM GRLLHEELAT
210 220 230 240 250
RWEQLLMDEA FTGGALAWLP GRTARAGQLV YPSGGALDKL YFQEVSVNSG
260 270 280 290 300
GNPRVLEDPG HIQLRGPVRQ VVTSTVQGET LLAVRSDYHC AVWKIDKQEP
310 320 330 340 350
PAPLQVLQVE KGATGISLSP HLSGELAICS RSGTVCLWTP QDGLQTIYKD
360 370 380 390 400
PETLAFRDPS PWRWADFTAH PRVLTVGDRT GVKMVDIQGP PGCGLLLFCA
410 420 430 440 450
GAEAACQKGE RVLLAQYLGQ PGPASTSLHL ICTQFSIYLM DERLPLVPML
460 470 480 490 500
KWDHGLPSAP LLARLLPPAS PGYPRPLLLG GQGGQVQLLH IAGEGTSIPQ
510 520 530 540 550
LAGPPQSLPS ITDSLSAFPL LEPKRQQQLQ ERLEAPVIGL AAAPPCASAP
560 570 580 590 600
GLLLFQLSAA GDVFYQHLRI QQTSSLREPD HPAPERPASR AAAPPVDQGS
610 620 630 640 650
TPSWTSRASA RCSRWLEALM ELSPTNPVWA APTFSHRRFL GHMERQKSQE
660 670 680 690 700
TLAQKLQAAM AKGQLLRPGD LGTLPKAEPP PAPQCSQQDE LTERLTKAWE
710 720 730 740 750
GQAAAWWKRH QDQTSGSQRQ SKRPKRRTQL SSTFSSFTSY MDSPDASSAP
760 770 780 790 800
HSQDLSNSEA CPQPPRTPPS QELTQELWAQ GVQHERRQTL RDYMAKLPLQ
810 820 830 840
DNPGPVATPP SQTSSRQTRS FRQQTPVLSG SHPPRKKPRM GF
Length:842
Mass (Da):92,371
Last modified:July 5, 2004 - v1
Checksum:i4B8AF9F2BFA77097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061804 mRNA. Translation: AAH61804.1.
RefSeqiNP_001014177.1. NM_001014155.1.
UniGeneiRn.146984.

Genome annotation databases

EnsembliENSRNOT00000020990; ENSRNOP00000020990; ENSRNOG00000015632.
GeneIDi361420.
KEGGirno:361420.
UCSCiRGD:1305658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061804 mRNA. Translation: AAH61804.1.
RefSeqiNP_001014177.1. NM_001014155.1.
UniGeneiRn.146984.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020990.

Proteomic databases

PaxDbiQ6P773.
PRIDEiQ6P773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020990; ENSRNOP00000020990; ENSRNOG00000015632.
GeneIDi361420.
KEGGirno:361420.
UCSCiRGD:1305658. rat.

Organism-specific databases

CTDi9013.
RGDi1305658. Taf1c.

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOGENOMiHOG000154497.
HOVERGENiHBG079499.
InParanoidiQ6P773.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ6P773.
TreeFamiTF351959.

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73863. RNA Polymerase I Transcription Termination.

Miscellaneous databases

PROiQ6P773.

Gene expression databases

GenevisibleiQ6P773. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiTAF1C_RAT
AccessioniPrimary (citable) accession number: Q6P773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.