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Protein

TATA box-binding protein-associated factor, RNA polymerase I, subunit C

Gene

Taf1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-5250924 B-WICH complex positively regulates rRNA expression
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-73772 RNA Polymerase I Promoter Escape
R-RNO-73777 RNA Polymerase I Chain Elongation
R-RNO-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor, RNA polymerase I, subunit C
Alternative name(s):
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:Taf1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305658 Taf1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188651 – 842TATA box-binding protein-associated factor, RNA polymerase I, subunit CAdd BLAST842

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei808PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P773
PRIDEiQ6P773

Expressioni

Gene expression databases

BgeeiENSRNOG00000015632
GenevisibleiQ6P773 RN

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020990

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X Eukaryota
ENOG41101B7 LUCA
GeneTreeiENSGT00390000010767
HOGENOMiHOG000154497
HOVERGENiHBG079499
InParanoidiQ6P773
KOiK15214
OMAiLKWNHGL
OrthoDBiEOG091G09D1
PhylomeDBiQ6P773
TreeFamiTF351959

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPSTLRPS LFMAGPLGMT DGPDLSFMCS WRDALTLPGA QPQNCRDQTS
60 70 80 90 100
SFAKNLLWEP STPGPLPLVP PGPDPWDPGL AAQDFLFRGG HYYQYQSRVV
110 120 130 140 150
LDVTEQLSRF LWDHGDIAFA PLGKLMLENF RLEGNRGYSK KVTIVSVKRL
160 170 180 190 200
LQDLGGHQPW GCPWASLSRR LRRFSILGGP VLSRSVSLLM GRLLHEELAT
210 220 230 240 250
RWEQLLMDEA FTGGALAWLP GRTARAGQLV YPSGGALDKL YFQEVSVNSG
260 270 280 290 300
GNPRVLEDPG HIQLRGPVRQ VVTSTVQGET LLAVRSDYHC AVWKIDKQEP
310 320 330 340 350
PAPLQVLQVE KGATGISLSP HLSGELAICS RSGTVCLWTP QDGLQTIYKD
360 370 380 390 400
PETLAFRDPS PWRWADFTAH PRVLTVGDRT GVKMVDIQGP PGCGLLLFCA
410 420 430 440 450
GAEAACQKGE RVLLAQYLGQ PGPASTSLHL ICTQFSIYLM DERLPLVPML
460 470 480 490 500
KWDHGLPSAP LLARLLPPAS PGYPRPLLLG GQGGQVQLLH IAGEGTSIPQ
510 520 530 540 550
LAGPPQSLPS ITDSLSAFPL LEPKRQQQLQ ERLEAPVIGL AAAPPCASAP
560 570 580 590 600
GLLLFQLSAA GDVFYQHLRI QQTSSLREPD HPAPERPASR AAAPPVDQGS
610 620 630 640 650
TPSWTSRASA RCSRWLEALM ELSPTNPVWA APTFSHRRFL GHMERQKSQE
660 670 680 690 700
TLAQKLQAAM AKGQLLRPGD LGTLPKAEPP PAPQCSQQDE LTERLTKAWE
710 720 730 740 750
GQAAAWWKRH QDQTSGSQRQ SKRPKRRTQL SSTFSSFTSY MDSPDASSAP
760 770 780 790 800
HSQDLSNSEA CPQPPRTPPS QELTQELWAQ GVQHERRQTL RDYMAKLPLQ
810 820 830 840
DNPGPVATPP SQTSSRQTRS FRQQTPVLSG SHPPRKKPRM GF
Length:842
Mass (Da):92,371
Last modified:July 5, 2004 - v1
Checksum:i4B8AF9F2BFA77097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061804 mRNA Translation: AAH61804.1
RefSeqiNP_001014177.1, NM_001014155.1
UniGeneiRn.146984

Genome annotation databases

EnsembliENSRNOT00000020990; ENSRNOP00000020990; ENSRNOG00000015632
GeneIDi361420
KEGGirno:361420
UCSCiRGD:1305658 rat

Similar proteinsi

Entry informationi

Entry nameiTAF1C_RAT
AccessioniPrimary (citable) accession number: Q6P773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health