Reviewed,
UniProtKB/Swiss-Prot Q6P768 (B4GT3_RAT)
Last modified
February 9, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-1,4-galactosyltransferase 3 Short name=Beta-1,4-GalTase 3 Short name=Beta4Gal-T3 Short name=b4Gal-T3 EC=2.4.1.- Alternative name(s): UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3 UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3 Including the following 3 domains: 1- Recommended name: N-acetyllactosamine synthase EC=2.4.1.90 Alternative name(s): Nal synthetase 2- Recommended name: Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase EC=2.4.1.38 3- Recommended name: Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase EC=2.4.1.- | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 395 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids By similarity. |
| Catalytic activity | UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. |
| Cofactor | Manganese By similarity. |
| Pathway | |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Trans cisternae of Golgi stack By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 7 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane |
| Ligand | Manganese Metal-binding |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | N-acetyllactosamine synthase activity Inferred from electronic annotation. Source: EC beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activityInferred from electronic annotation. Source: EC manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 395 | 395 | Beta-1,4-galactosyltransferase 3 | PRO_0000080540 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 10 | 10 | Cytoplasmic Potential | ||||||||
| Transmembrane | 11 – 31 | 21 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 32 – 395 | 364 | Lumenal Potential | ||||||||
Sites | |||||||||||
| Metal binding | 199 | 1 | Manganese By similarity | ||||||||
| Metal binding | 293 | 1 | Manganese By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 57 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 168 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 339 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 387 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 79 ↔ 121 | By similarity | |||||||||
| Disulfide bond | 192 ↔ 211 | By similarity | |||||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC061812 mRNA. Translation: AAH61812.1. |
| IPI | IPI00421551. |
| RefSeq | NP_001009539.1. |
| UniGene | Rn.91751 |
3D structure databases | |
| SMR | Q6P768. Positions 76-346. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6P768. |
Protein family/group databases | |
| CAZy | GT7. Glycosyltransferase Family 7. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000004735; ENSRNOP00000004735; ENSRNOG00000003551; Rattus norvegicus. [Genome view] |
| GeneID | 494342. |
| KEGG | rno:494342. |
Organism-specific databases | |
| CTD | 494342. |
| RGD | 1359221. B4galt3. |
Phylogenomic databases | |
| eggNOG | roNOG07738. |
| HOVERGEN | Q6P768. |
| InParanoid | Q6P768. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.38. 248. 2.4.1.90. 248. |
Gene expression databases | |
| ArrayExpress | Q6P768. |
| Genevestigator | Q6P768. |
| GermOnline | ENSRNOG00000003551. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR003859. Galactosyl_T_2. [Graphical view] |
| PANTHER | PTHR19300. Galactosyl_T_2. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 697612. |
Entry information
| Entry name | B4GT3_RAT | ||||||||
| Accession | Primary (citable) accession number: Q6P768 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


