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Protein

Alpha-mannosidase

Gene

Man2b1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  • alpha-mannosidase activity Source: RGD
  • mannose binding Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-8853383. Lysosomal oligosaccharide catabolism.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:Man2b1Imported
ORF Names:rCG_51515Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3039. Man2b1.

Subcellular locationi

GO - Cellular componenti

  • lysosome Source: RGD
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4949Sequence analysisAdd
BLAST
Chaini50 – 1009960Alpha-mannosidaseSequence analysisPRO_5007925972Add
BLAST

Expressioni

Gene expression databases

BgeeiENSRNOG00000023910.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030766.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 46580Alpha-mann_midInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1959. Eukaryota.
ENOG410XQMZ. LUCA.
GeneTreeiENSGT00510000046304.
HOGENOMiHOG000007676.
HOVERGENiHBG052391.
KOiK12311.
OMAiNMEAYSA.
OrthoDBiEOG091G02IS.
TreeFamiTF313840.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR013780. Glyco_hydro_b.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGSLAPGV RAGGGNTGWL WMSSCNLGLP VLSISFLIWL LLAAPGAQAA
60 70 80 90 100
GYKTCPTTKP GMLNVHLLPH THDDVGWLKT VDQYYYGIMS DVQHASVQYI
110 120 130 140 150
LDSVIYSLLN DPTRRFIYVE MAFFSRWWKQ QTNVTQDAVR NLVRQGRLEF
160 170 180 190 200
VNGGWVMNDE AATHYGAIVD QMTLGLRFLQ DTFGSDGLPR VAWHIDPFGH
210 220 230 240 250
SREQASLFAQ MGFDGFFLGR IDYQDKFNRK RKLKMEELWR ASASLKPPAA
260 270 280 290 300
DLFTGVLPNN YNPPKDLCWD VLCTDPPVVD DPTSPEFNAN KLVDYFLNLA
310 320 330 340 350
SSQKKYYRTN HTVMTMGSDF QYENANMWFK NMDKLIRLVN EQQANGSKVH
360 370 380 390 400
VLYSTPSCYL WELNKANLTW TVKEDDFFPY ADGPHMFWTG YFSSRPALKR
410 420 430 440 450
YERLSYNFLQ VCNQLEALVG PEAKVGPYGS GDSAPLNEAM AVLQHHDAVT
460 470 480 490 500
GTARQNVVND YAKQLAAGWG PCEVLVSNAL ARLSLYKQNF SFCREINISI
510 520 530 540 550
CPASQTSEHF RVIIYNPVGR KVDLMVRLPV SEGIFLVKDP NDRRISSNVV
560 570 580 590 600
MVPSAYSKTY QWELLFPASV PALGFSIYSV NKMSGHNHQA HNLTARPKKS
610 620 630 640 650
KSRVLVIENK YIRATFDSDT GLLRKIENLE QNISLPVRQG FFWYNASAGD
660 670 680 690 700
EESPQASGAY IFRPSHRKPL PVSHWAQVTL VKTNLVQEVH QNFSAWCSQV
710 720 730 740 750
IRLYEGQRHL ELEWTVGPIP VKDDWGKEVI SRFNTPMRTR GQFFTDSNGR
760 770 780 790 800
EILKRRDDFR PTWTLNQTEP VAGNYYPVNT RIYITDGHMQ LTVLTDRSQG
810 820 830 840 850
GSSLLDGSLE LMVHRRLLVD DERGVAEPLL ETDTGDKVRG RHLVILSSVS
860 870 880 890 900
DAAARHRLLA EQEVLAPQVV LAHGGSSPYH SQAPKMQFSA LRRELPPQVH
910 920 930 940 950
LLTLARWGPK MLLLRLEHQF AVKEDSNRNL SSPVTLNLQN LFKTFTINYL
960 970 980 990 1000
QETTLAANQP LSRVSRLKWM TDTGPISYPA PSRLDPTSIT LQPMQIRTFL

ASVQWQRLI
Length:1,009
Mass (Da):114,327
Last modified:July 5, 2004 - v1
Checksum:i259BCEC19987A886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072634 Genomic DNA. No translation available.
BC061819 mRNA. Translation: AAH61819.1.
CH473972 Genomic DNA. Translation: EDL92152.1.
RefSeqiNP_955436.1. NM_199404.1.
UniGeneiRn.102840.

Genome annotation databases

EnsembliENSRNOT00000037699; ENSRNOP00000030766; ENSRNOG00000023910.
GeneIDi361378.
KEGGirno:361378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072634 Genomic DNA. No translation available.
BC061819 mRNA. Translation: AAH61819.1.
CH473972 Genomic DNA. Translation: EDL92152.1.
RefSeqiNP_955436.1. NM_199404.1.
UniGeneiRn.102840.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030766.

Chemistry

ChEMBLiCHEMBL3448.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037699; ENSRNOP00000030766; ENSRNOG00000023910.
GeneIDi361378.
KEGGirno:361378.

Organism-specific databases

CTDi4125.
RGDi3039. Man2b1.

Phylogenomic databases

eggNOGiKOG1959. Eukaryota.
ENOG410XQMZ. LUCA.
GeneTreeiENSGT00510000046304.
HOGENOMiHOG000007676.
HOVERGENiHBG052391.
KOiK12311.
OMAiNMEAYSA.
OrthoDBiEOG091G02IS.
TreeFamiTF313840.

Enzyme and pathway databases

ReactomeiR-RNO-8853383. Lysosomal oligosaccharide catabolism.

Gene expression databases

BgeeiENSRNOG00000023910.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR013780. Glyco_hydro_b.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P762_RAT
AccessioniPrimary (citable) accession number: Q6P762
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.