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Protein

Plasma protease C1 inhibitor

Gene

Serping1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei469 – 470Reactive bond for chymotrypsinBy similarity2
Sitei470 – 471Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma protease C1 inhibitor
Short name:
C1 Inh
Short name:
C1Inh
Alternative name(s):
C1 esterase inhibitor
C1-inhibiting factor
Serpin G1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi735225. Serping1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: Ensembl
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000024896623 – 504Plasma protease C1 inhibitorAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P734.
PRIDEiQ6P734.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007457.
GenevisibleiQ6P734. RN.

Interactioni

Subunit structurei

Interacts with MASP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009817.

Structurei

3D structure databases

ProteinModelPortaliQ6P734.
SMRiQ6P734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000231936.
HOVERGENiHBG104060.
InParanoidiQ6P734.
KOiK04001.
OMAiIYLSAKW.
OrthoDBiEOG091G03BW.
PhylomeDBiQ6P734.
TreeFamiTF317350.

Family and domain databases

InterProiView protein in InterPro
IPR015553. C1-inh.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF269. PTHR11461:SF269. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKLTPLTL LLLLLAGDRA FSDSEVTSHS SQDPLVVQEG SRDSVPERDG
60 70 80 90 100
SRSPIEHTGQ SSTWPTTSGS TKISNDTMDQ VANESFIQHV QPAAQLPEDS
110 120 130 140 150
PSQSPVNSSS PPSTASAPPT QAPTEPLCPE PLAWCSDSDR DSSEATLSEA
160 170 180 190 200
LTDFSVKLYH AFSATKKAET NMAFSPFSIA SLLTQVLLGA GDSTKSNLED
210 220 230 240 250
ILSYPKDFAC VHQTLKAFSS KGVTSVSQIF HSPDLAIRDT YVNASLSLYG
260 270 280 290 300
SSPRVLGPDG DANLKLINTW VAENTNHKIN ELLDSLPSDT RLVLLNAVYL
310 320 330 340 350
SAKWKKTFEQ KKMMASFLYK NSMIKVPMLS SKKYPLALFN DQTLKAKVGQ
360 370 380 390 400
LQLSHNLSFV IMVPQSPTHQ LEDMEKALNP TVFKAILKKL ELSKFQPTYV
410 420 430 440 450
MMPRIKVKSS QDMLSIMEKL EFFDFTYDLN LCGLTEDPDL QVSSMKHETV
460 470 480 490 500
LELTETGVEA AAASTISVAR NLLIFEVQQP FLFLLWDQRH KFPVFMGRVY

DPRA
Length:504
Mass (Da):55,611
Last modified:July 5, 2004 - v1
Checksum:i5EADC6331BEA730D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061860 mRNA. Translation: AAH61860.1.
RefSeqiNP_954524.1. NM_199093.1.
XP_006234509.1. XM_006234447.2.
UniGeneiRn.100285.

Genome annotation databases

EnsembliENSRNOT00000009817; ENSRNOP00000009817; ENSRNOG00000007457.
GeneIDi295703.
KEGGirno:295703.
UCSCiRGD:735225. rat.

Similar proteinsi

Entry informationi

Entry nameiIC1_RAT
AccessioniPrimary (citable) accession number: Q6P734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families