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Q6P6Z8

- ODO1_XENLA

UniProt

Q6P6Z8 - ODO1_XENLA

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi153 – 1531CalciumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi153 – 1575By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Calcium, Metal-binding, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:ogdh
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1010765. ogdh.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
    BLAST
    Chaini41 – 10219812-oxoglutarate dehydrogenase, mitochondrialPRO_0000310982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki533 – 533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ6P6Z8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6Z8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG001892.
    KOiK00164.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P6Z8-1 [UniParc]FASTAAdd to Basket

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    MFNLRTCASK LRPLTASQTI RSLKHNRPAA PRTFQQFRCL STPVAAEPFL     50
    SGTNSNYVEE MYYAWLENPK SVHKSWDIFF RNANAGASPG AAYQSPPSLG 100
    SSLSTLTQAQ SLLHSQPNVD KLVEDHLAVQ SLIRAYQIRG HHVAQLDPLG 150
    ILDADLDSCV PADIVTSSDK LGFYGLQESD LDKVFHLPTT TFIGGNEMAL 200
    PLREIIRRLE NAYCQHIGVE FMFINDLEQC QWIRQKFEAP GIMQFNNEEK 250
    RTLLARLVRS TRFEEFLHRK WSSEKRFGLE GCEVLIPALK TIIDKSSGNG 300
    VDYVIMGMPH RGRLNVLANV IRKELEQIFC QFDSKLEATD EGSGDVKYHL 350
    GMYHRRINRV TDRNITLSLV ANPSHLEAAD PVVQGKTKAE QFYCGDTEGK 400
    KVMAILLHGD AAFAGQGIVY ETFHLSDLPS HTTHGTVHVV VNNQIGFTTD 450
    PRMARSSPYP TDVARVVNAP IFHVNADDPE AVMYVCNVAA EWRSTFHKDV 500
    VVDLVCYRRN GHNEMDEPMF TQPLMYKQIR KQKAVLQKYA ETLISQGVVN 550
    QLEYEEEISK YDKICEEAFA RSKDEKILHI KHWLDSPWPG FFTLDGQPRS 600
    MTCPSTGLTE EDLTHIGNVA SSVPVEDFMI HGGLSRILKG RGEMVKNRTV 650
    DWALAEYMAL GSLLKEGIHI RLSGQDVERG TFSHRHHVLH DQNVDKRTCI 700
    PMNHLWPNQA PYTVCNSSLS EYGVLGFELG FAMASPNALV LWEAQFGDFH 750
    NTAQCIIDQF VCPGQAKWVR QNGIVLLLPH GMEGMGPEHS SARPERFLQM 800
    CNDDPDVWPK ASEDFAVGQL YDCNWIVVNC STPANFFHVI RRQILLPFRK 850
    PLIVFTPKSL LRHPEARSSF DDMLPSTHFQ RIIPEAGPAS QNPEGVKRLI 900
    FCTGKVYYEL TKERSGRDME GDVAIARVEQ LSPFPFDLVE KEVQKYPNAD 950
    LVWCQEEHKN QGYYDYVKPR LRTTIHRTKP VWYAGRDPAA APATGNKKTH 1000
    LTELRRFLDT AFNLDAFKGH F 1021
    Length:1,021
    Mass (Da):115,633
    Last modified:July 5, 2004 - v1
    Checksum:i1ED25C4DD47277DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti115 – 1151S → A in AAH73298. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061938 mRNA. Translation: AAH61938.1.
    BC073298 mRNA. Translation: AAH73298.1.
    RefSeqiNP_001083614.1. NM_001090145.1.
    UniGeneiXl.5294.

    Genome annotation databases

    GeneIDi399021.
    KEGGixla:399021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061938 mRNA. Translation: AAH61938.1 .
    BC073298 mRNA. Translation: AAH73298.1 .
    RefSeqi NP_001083614.1. NM_001090145.1.
    UniGenei Xl.5294.

    3D structure databases

    ProteinModelPortali Q6P6Z8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6P6Z8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399021.
    KEGGi xla:399021.

    Organism-specific databases

    CTDi 4967.
    Xenbasei XB-GENE-1010765. ogdh.

    Phylogenomic databases

    HOVERGENi HBG001892.
    KOi K00164.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Spleen.

    Entry informationi

    Entry nameiODO1_XENLA
    AccessioniPrimary (citable) accession number: Q6P6Z8
    Secondary accession number(s): Q6GP46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3