Reviewed, UniProtKB/Swiss-Prot Q6P6Z8 (ODO1_XENLA)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    2-oxoglutarate dehydrogenase complex component E1
      Short name=OGDC-E1

Gene names

Name:

ogdh

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	1021 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Enzyme regulation	Catabolite repressed By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
PTM	Isopeptide bond Ubl conjugation
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Mitochondrion Potential
	Chain	41 – 1021	981	2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000310982
Amino acid modifications
	Cross-link	533		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Experimental info
	Sequence conflict	115	1	S → A in AAH73298. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6P6Z8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1ED25C4DD47277DB	FASTA	1,021	115,633
	10 20 30 40 50 60 MFNLRTCASK LRPLTASQTI RSLKHNRPAA PRTFQQFRCL STPVAAEPFL SGTNSNYVEE 70 80 90 100 110 120 MYYAWLENPK SVHKSWDIFF RNANAGASPG AAYQSPPSLG SSLSTLTQAQ SLLHSQPNVD 130 140 150 160 170 180 KLVEDHLAVQ SLIRAYQIRG HHVAQLDPLG ILDADLDSCV PADIVTSSDK LGFYGLQESD 190 200 210 220 230 240 LDKVFHLPTT TFIGGNEMAL PLREIIRRLE NAYCQHIGVE FMFINDLEQC QWIRQKFEAP 250 260 270 280 290 300 GIMQFNNEEK RTLLARLVRS TRFEEFLHRK WSSEKRFGLE GCEVLIPALK TIIDKSSGNG 310 320 330 340 350 360 VDYVIMGMPH RGRLNVLANV IRKELEQIFC QFDSKLEATD EGSGDVKYHL GMYHRRINRV 370 380 390 400 410 420 TDRNITLSLV ANPSHLEAAD PVVQGKTKAE QFYCGDTEGK KVMAILLHGD AAFAGQGIVY 430 440 450 460 470 480 ETFHLSDLPS HTTHGTVHVV VNNQIGFTTD PRMARSSPYP TDVARVVNAP IFHVNADDPE 490 500 510 520 530 540 AVMYVCNVAA EWRSTFHKDV VVDLVCYRRN GHNEMDEPMF TQPLMYKQIR KQKAVLQKYA 550 560 570 580 590 600 ETLISQGVVN QLEYEEEISK YDKICEEAFA RSKDEKILHI KHWLDSPWPG FFTLDGQPRS 610 620 630 640 650 660 MTCPSTGLTE EDLTHIGNVA SSVPVEDFMI HGGLSRILKG RGEMVKNRTV DWALAEYMAL 670 680 690 700 710 720 GSLLKEGIHI RLSGQDVERG TFSHRHHVLH DQNVDKRTCI PMNHLWPNQA PYTVCNSSLS 730 740 750 760 770 780 EYGVLGFELG FAMASPNALV LWEAQFGDFH NTAQCIIDQF VCPGQAKWVR QNGIVLLLPH 790 800 810 820 830 840 GMEGMGPEHS SARPERFLQM CNDDPDVWPK ASEDFAVGQL YDCNWIVVNC STPANFFHVI 850 860 870 880 890 900 RRQILLPFRK PLIVFTPKSL LRHPEARSSF DDMLPSTHFQ RIIPEAGPAS QNPEGVKRLI 910 920 930 940 950 960 FCTGKVYYEL TKERSGRDME GDVAIARVEQ LSPFPFDLVE KEVQKYPNAD LVWCQEEHKN 970 980 990 1000 1010 1020 QGYYDYVKPR LRTTIHRTKP VWYAGRDPAA APATGNKKTH LTELRRFLDT AFNLDAFKGH F

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC061938 mRNA. Translation: AAH61938.1. BC073298 mRNA. Translation: AAH73298.1.
RefSeq	NP_001083614.1.
UniGene	Xl.5294
3D structure databases
SMR	Q6P6Z8. Positions 125-1015.
ModBase	Search...
Genome annotation databases
GeneID	399021.
KEGG	xla:399021.
Organism-specific databases
CTD	399021.
Xenbase	XB-FEAT-1010760. ogdh.
Phylogenomic databases
HOVERGEN	Q6P6Z8.
Enzyme and pathway databases
BRENDA	1.2.4.2. 648.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_XENLA

Accession

Primary (citable) accession number: Q6P6Z8
Secondary accession number(s): Q6GP46

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project