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Q6P6Z8

- ODO1_XENLA

UniProt

Q6P6Z8 - ODO1_XENLA

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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

Enzyme regulationi

Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531CalciumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi153 – 1575By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Calcium, Metal-binding, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1010765. ogdh.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
BLAST
Chaini41 – 10219812-oxoglutarate dehydrogenase, mitochondrialPRO_0000310982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki533 – 533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ6P6Z8.

Structurei

3D structure databases

ProteinModelPortaliQ6P6Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P6Z8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNLRTCASK LRPLTASQTI RSLKHNRPAA PRTFQQFRCL STPVAAEPFL
60 70 80 90 100
SGTNSNYVEE MYYAWLENPK SVHKSWDIFF RNANAGASPG AAYQSPPSLG
110 120 130 140 150
SSLSTLTQAQ SLLHSQPNVD KLVEDHLAVQ SLIRAYQIRG HHVAQLDPLG
160 170 180 190 200
ILDADLDSCV PADIVTSSDK LGFYGLQESD LDKVFHLPTT TFIGGNEMAL
210 220 230 240 250
PLREIIRRLE NAYCQHIGVE FMFINDLEQC QWIRQKFEAP GIMQFNNEEK
260 270 280 290 300
RTLLARLVRS TRFEEFLHRK WSSEKRFGLE GCEVLIPALK TIIDKSSGNG
310 320 330 340 350
VDYVIMGMPH RGRLNVLANV IRKELEQIFC QFDSKLEATD EGSGDVKYHL
360 370 380 390 400
GMYHRRINRV TDRNITLSLV ANPSHLEAAD PVVQGKTKAE QFYCGDTEGK
410 420 430 440 450
KVMAILLHGD AAFAGQGIVY ETFHLSDLPS HTTHGTVHVV VNNQIGFTTD
460 470 480 490 500
PRMARSSPYP TDVARVVNAP IFHVNADDPE AVMYVCNVAA EWRSTFHKDV
510 520 530 540 550
VVDLVCYRRN GHNEMDEPMF TQPLMYKQIR KQKAVLQKYA ETLISQGVVN
560 570 580 590 600
QLEYEEEISK YDKICEEAFA RSKDEKILHI KHWLDSPWPG FFTLDGQPRS
610 620 630 640 650
MTCPSTGLTE EDLTHIGNVA SSVPVEDFMI HGGLSRILKG RGEMVKNRTV
660 670 680 690 700
DWALAEYMAL GSLLKEGIHI RLSGQDVERG TFSHRHHVLH DQNVDKRTCI
710 720 730 740 750
PMNHLWPNQA PYTVCNSSLS EYGVLGFELG FAMASPNALV LWEAQFGDFH
760 770 780 790 800
NTAQCIIDQF VCPGQAKWVR QNGIVLLLPH GMEGMGPEHS SARPERFLQM
810 820 830 840 850
CNDDPDVWPK ASEDFAVGQL YDCNWIVVNC STPANFFHVI RRQILLPFRK
860 870 880 890 900
PLIVFTPKSL LRHPEARSSF DDMLPSTHFQ RIIPEAGPAS QNPEGVKRLI
910 920 930 940 950
FCTGKVYYEL TKERSGRDME GDVAIARVEQ LSPFPFDLVE KEVQKYPNAD
960 970 980 990 1000
LVWCQEEHKN QGYYDYVKPR LRTTIHRTKP VWYAGRDPAA APATGNKKTH
1010 1020
LTELRRFLDT AFNLDAFKGH F
Length:1,021
Mass (Da):115,633
Last modified:July 5, 2004 - v1
Checksum:i1ED25C4DD47277DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151S → A in AAH73298. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061938 mRNA. Translation: AAH61938.1.
BC073298 mRNA. Translation: AAH73298.1.
RefSeqiNP_001083614.1. NM_001090145.1.
UniGeneiXl.5294.

Genome annotation databases

GeneIDi399021.
KEGGixla:399021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061938 mRNA. Translation: AAH61938.1 .
BC073298 mRNA. Translation: AAH73298.1 .
RefSeqi NP_001083614.1. NM_001090145.1.
UniGenei Xl.5294.

3D structure databases

ProteinModelPortali Q6P6Z8.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6P6Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399021.
KEGGi xla:399021.

Organism-specific databases

CTDi 4967.
Xenbasei XB-GENE-1010765. ogdh.

Phylogenomic databases

HOVERGENi HBG001892.
KOi K00164.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Spleen.

Entry informationi

Entry nameiODO1_XENLA
AccessioniPrimary (citable) accession number: Q6P6Z8
Secondary accession number(s): Q6GP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3