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Q6P6Z8

- ODO1_XENLA

UniProt

Q6P6Z8 - ODO1_XENLA

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Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
ogdh
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Enzyme regulationi

Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531Calcium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi153 – 1575 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Calcium, Metal-binding, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1010765. ogdh.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Mitochondrion Reviewed prediction
Add
BLAST
Chaini41 – 10219812-oxoglutarate dehydrogenase, mitochondrial
PRO_0000310982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki533 – 533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ6P6Z8.

Structurei

3D structure databases

ProteinModelPortaliQ6P6Z8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P6Z8-1 [UniParc]FASTAAdd to Basket

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MFNLRTCASK LRPLTASQTI RSLKHNRPAA PRTFQQFRCL STPVAAEPFL     50
SGTNSNYVEE MYYAWLENPK SVHKSWDIFF RNANAGASPG AAYQSPPSLG 100
SSLSTLTQAQ SLLHSQPNVD KLVEDHLAVQ SLIRAYQIRG HHVAQLDPLG 150
ILDADLDSCV PADIVTSSDK LGFYGLQESD LDKVFHLPTT TFIGGNEMAL 200
PLREIIRRLE NAYCQHIGVE FMFINDLEQC QWIRQKFEAP GIMQFNNEEK 250
RTLLARLVRS TRFEEFLHRK WSSEKRFGLE GCEVLIPALK TIIDKSSGNG 300
VDYVIMGMPH RGRLNVLANV IRKELEQIFC QFDSKLEATD EGSGDVKYHL 350
GMYHRRINRV TDRNITLSLV ANPSHLEAAD PVVQGKTKAE QFYCGDTEGK 400
KVMAILLHGD AAFAGQGIVY ETFHLSDLPS HTTHGTVHVV VNNQIGFTTD 450
PRMARSSPYP TDVARVVNAP IFHVNADDPE AVMYVCNVAA EWRSTFHKDV 500
VVDLVCYRRN GHNEMDEPMF TQPLMYKQIR KQKAVLQKYA ETLISQGVVN 550
QLEYEEEISK YDKICEEAFA RSKDEKILHI KHWLDSPWPG FFTLDGQPRS 600
MTCPSTGLTE EDLTHIGNVA SSVPVEDFMI HGGLSRILKG RGEMVKNRTV 650
DWALAEYMAL GSLLKEGIHI RLSGQDVERG TFSHRHHVLH DQNVDKRTCI 700
PMNHLWPNQA PYTVCNSSLS EYGVLGFELG FAMASPNALV LWEAQFGDFH 750
NTAQCIIDQF VCPGQAKWVR QNGIVLLLPH GMEGMGPEHS SARPERFLQM 800
CNDDPDVWPK ASEDFAVGQL YDCNWIVVNC STPANFFHVI RRQILLPFRK 850
PLIVFTPKSL LRHPEARSSF DDMLPSTHFQ RIIPEAGPAS QNPEGVKRLI 900
FCTGKVYYEL TKERSGRDME GDVAIARVEQ LSPFPFDLVE KEVQKYPNAD 950
LVWCQEEHKN QGYYDYVKPR LRTTIHRTKP VWYAGRDPAA APATGNKKTH 1000
LTELRRFLDT AFNLDAFKGH F 1021
Length:1,021
Mass (Da):115,633
Last modified:July 5, 2004 - v1
Checksum:i1ED25C4DD47277DB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151S → A in AAH73298. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061938 mRNA. Translation: AAH61938.1.
BC073298 mRNA. Translation: AAH73298.1.
RefSeqiNP_001083614.1. NM_001090145.1.
UniGeneiXl.5294.

Genome annotation databases

GeneIDi399021.
KEGGixla:399021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061938 mRNA. Translation: AAH61938.1 .
BC073298 mRNA. Translation: AAH73298.1 .
RefSeqi NP_001083614.1. NM_001090145.1.
UniGenei Xl.5294.

3D structure databases

ProteinModelPortali Q6P6Z8.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6P6Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399021.
KEGGi xla:399021.

Organism-specific databases

CTDi 4967.
Xenbasei XB-GENE-1010765. ogdh.

Phylogenomic databases

HOVERGENi HBG001892.
KOi K00164.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Spleen.

Entry informationi

Entry nameiODO1_XENLA
AccessioniPrimary (citable) accession number: Q6P6Z8
Secondary accession number(s): Q6GP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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