Reviewed, UniProtKB/Swiss-Prot Q6P6W3 (HDAC3_RAT)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 3
      Short name=HD3
    EC=3.5.1.98

Gene names

Name:

Hdac3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required to repress transcription of the POU1F1 transcription factor By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Interacts with HDAC7. Forms a heterologous complex at least with YY1. Interacts with HDAC10, DAXX, DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with GLIS2. Interacts with CBFA2T3 By similarity. Interacts with BTBD14B. Ref.3
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	histone deacetylation Inferred from electronic annotation. Source: InterPro regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW response to drug Inferred from expression pattern. Source: RGD transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromatin Inferred from direct assay. Source: RGD cytoplasm Inferred from direct assay. Source: RGD nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Histone deacetylase 3		PRO_0000281030
Regions
	Region	3 – 316	314	Histone deacetylase
Sites
	Active site	135	1	By similarity
Amino acid modifications
	Modified residue	424	1	Phosphoserine By similarity
	Cross-link	44		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P6W3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1CB84DE250C3BB2C	FASTA	428	48,821
	10 20 30 40 50 60 MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 70 80 90 100 110 120 FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 130 140 150 160 170 180 KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 190 200 210 220 230 240 FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 250 260 270 280 290 300 SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 310 320 330 340 350 360 RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 370 380 390 400 410 420 TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN DKESDVEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression pattern of rat histone deacetylases." Wilquet V., Chavez M., Korbers R., Geerts A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	"The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures." Korutla L., Wang P.J., Mackler S.A. J. Neurochem. 94:786-793(2005) [PubMed: 16033423] [Abstract] Cited for: INTERACTION WITH BTBD14B.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF321131 mRNA. Translation: AAK11184.1. BC061988 mRNA. Translation: AAH61988.1.
IPI	IPI00421548.
RefSeq	NP_445900.1.
UniGene	Rn.17284
3D structure databases
HSSP	HSSP built from PDB template 1T67 based on UniProtKB Q9BY41.
SMR	Q6P6W3. Positions 6-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P6W3.
PTM databases
PhosphoSite	Q6P6W3.
Genome annotation databases
Ensembl	ENSRNOT00000067516; ENSRNOP00000060357; ENSRNOG00000019618; Rattus norvegicus. [Genome view]
GeneID	84578.
KEGG	rno:84578.
Organism-specific databases
CTD	84578.
RGD	619977. Hdac3.
Phylogenomic databases
eggNOG	maNOG13829.
HOVERGEN	Q6P6W3.
InParanoid	Q6P6W3.
PhylomeDB	Q6P6W3.
Gene expression databases
ArrayExpress	Q6P6W3.
Genevestigator	Q6P6W3.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...
Other Resources
NextBio	617139.

Entry information

Entry name

HDAC3_RAT

Accession

Primary (citable) accession number: Q6P6W3
Secondary accession number(s): Q99PA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)