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Q6P6W3

- HDAC3_RAT

UniProt

Q6P6W3 - HDAC3_RAT

Protein

Histone deacetylase 3

Gene

Hdac3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351By similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. protein binding Source: RGD
    7. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. histone H3 deacetylation Source: RGD
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. response to drug Source: RGD
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 3 (EC:3.5.1.98)
    Short name:
    HD3
    Gene namesi
    Name:Hdac3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619977. Hdac3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: RGD
    2. cytoplasm Source: RGD
    3. nucleoplasm Source: Reactome
    4. nucleus Source: RGD
    5. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histone deacetylase 3PRO_0000281030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki44 – 44Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei424 – 4241PhosphoserineBy similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    PTM databases

    PhosphoSiteiQ6P6W3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P6W3.

    Interactioni

    Subunit structurei

    Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with HDAC10, DAXX and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Interact with SMRT/NCOR2 and BCL6 on DNA enhancer elements. Interacts with INSM1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi250009. 2 interactions.
    STRINGi10116.ENSRNOP00000057161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6W3.
    SMRiQ6P6W3. Positions 2-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3 – 316314Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    HOVERGENiHBG057112.
    InParanoidiQ6P6W3.
    KOiK11404.
    PhylomeDBiQ6P6W3.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q6P6W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP    50
    YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL 100
    FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
    VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
    PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI SQVVDFYQPT 250
    CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
    RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
    SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP 400
    EENYSRPEAP NEFYDGDHDN DKESDVEI 428
    Length:428
    Mass (Da):48,821
    Last modified:July 5, 2004 - v1
    Checksum:i1CB84DE250C3BB2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321131 mRNA. Translation: AAK11184.1.
    BC061988 mRNA. Translation: AAH61988.1.
    RefSeqiNP_445900.1. NM_053448.1.
    UniGeneiRn.17284.

    Genome annotation databases

    GeneIDi84578.
    KEGGirno:84578.
    UCSCiRGD:619977. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321131 mRNA. Translation: AAK11184.1 .
    BC061988 mRNA. Translation: AAH61988.1 .
    RefSeqi NP_445900.1. NM_053448.1.
    UniGenei Rn.17284.

    3D structure databases

    ProteinModelPortali Q6P6W3.
    SMRi Q6P6W3. Positions 2-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250009. 2 interactions.
    STRINGi 10116.ENSRNOP00000057161.

    Chemistry

    BindingDBi Q6P6W3.
    ChEMBLi CHEMBL2095943.

    PTM databases

    PhosphoSitei Q6P6W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84578.
    KEGGi rno:84578.
    UCSCi RGD:619977. rat.

    Organism-specific databases

    CTDi 8841.
    RGDi 619977. Hdac3.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    HOVERGENi HBG057112.
    InParanoidi Q6P6W3.
    KOi K11404.
    PhylomeDBi Q6P6W3.

    Miscellaneous databases

    NextBioi 617139.
    PROi Q6P6W3.

    Gene expression databases

    Genevestigatori Q6P6W3.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of rat histone deacetylases."
      Wilquet V., Chavez M., Korbers R., Geerts A.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures."
      Korutla L., Wang P.J., Mackler S.A.
      J. Neurochem. 94:786-793(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BTBD14B.

    Entry informationi

    Entry nameiHDAC3_RAT
    AccessioniPrimary (citable) accession number: Q6P6W3
    Secondary accession number(s): Q99PA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3