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Q6P6V1

- GLT11_RAT

UniProt

Q6P6V1 - GLT11_RAT

Protein

Polypeptide N-acetylgalactosaminyltransferase 11

Gene

Galnt11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) By similarity.By similarity

    Catalytic activityi

    UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei222 – 2221SubstrateBy similarity
    Metal bindingi245 – 2451ManganeseBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Metal bindingi247 – 2471ManganeseBy similarity
    Binding sitei350 – 3501SubstrateBy similarity
    Metal bindingi378 – 3781ManganeseBy similarity
    Binding sitei381 – 3811SubstrateBy similarity
    Binding sitei386 – 3861SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. Notch binding Source: UniProtKB
    3. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cilium morphogenesis Source: UniProtKB
    2. determination of left/right symmetry Source: UniProtKB
    3. Notch receptor processing Source: UniProtKB
    4. Notch signaling involved in heart development Source: UniProtKB
    5. protein O-linked glycosylation via threonine Source: UniProtKB
    6. regulation of Notch signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Notch signaling pathway

    Keywords - Ligandi

    Lectin, Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196259. O-linked glycosylation of mucins.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiCBM13. Carbohydrate-Binding Module Family 13.
    GT27. Glycosyltransferase Family 27.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 11 (EC:2.4.1.41)
    Alternative name(s):
    Polypeptide GalNAc transferase 11
    Short name:
    GalNAc-T11
    Short name:
    pp-GaNTase 11
    Protein-UDP acetylgalactosaminyltransferase 11
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
    Gene namesi
    Name:Galnt11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi735097. Galnt11.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Polypeptide N-acetylgalactosaminyltransferase 11PRO_0000059127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi141 ↔ 373PROSITE-ProRule annotation
    Disulfide bondi364 ↔ 441PROSITE-ProRule annotation
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi493 ↔ 512PROSITE-ProRule annotation
    Disulfide bondi536 ↔ 553PROSITE-ProRule annotation
    Disulfide bondi578 ↔ 596PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6P6V1.

    PTM databases

    PhosphoSiteiQ6P6V1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P6V1.

    Interactioni

    Subunit structurei

    Interacts with NOTCH1.By similarity

    Protein-protein interaction databases

    MINTiMINT-4576490.
    STRINGi10116.ENSRNOP00000011815.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6V1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini30 – 608579LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini476 – 607132Ricin B-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 261112Catalytic subdomain AAdd
    BLAST
    Regioni319 – 38163Catalytic subdomain BAdd
    BLAST

    Domaini

    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity

    Sequence similaritiesi

    Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239675.
    GeneTreeiENSGT00740000115054.
    HOGENOMiHOG000038227.
    HOVERGENiHBG051699.
    InParanoidiQ6P6V1.
    KOiK00710.
    OMAiMIFNERD.
    OrthoDBiEOG7J9VP2.
    PhylomeDBiQ6P6V1.
    TreeFamiTF313267.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR027791. Galactosyl_T_C.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF02709. Glyco_transf_7C. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 2 hits.
    SSF53448. SSF53448. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P6V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSVTIRYFC YGCLFTSATW TVLLFIYFNF SEVTQPLRNV PIKGSGPHGP    50
    FPKKFYPRFT RGPGRVLEPQ FKANRMDDLM NNNIEDPDKG LSKSSSELGM 100
    IFNERDQELR DLGYQKHAFN MLISNRLGYH RDVPDTRNAE CRGKSYPTDL 150
    PTASVVICFY NEAFSALLRT VHSVVDRTPA HLLHEIILVD DSSDFDDLKG 200
    ELDEYIQRYL PAKVKVIRNM KREGLIRGRM IGAAHATGEV LVFLDSHCEV 250
    NVMWLQPLLA IILEDPHTVV CPVIDIISAD TLAYSSSPVV RGGFNWGLHF 300
    KWDLVPVSDL GGADSATAPI RSPTMAGGLF AMNRQYFNDL GQYDSGMDIW 350
    GGENLEISFR IWMCGGKLFI IPCSRVGHIF RKRRPYGSPE GQDTMTHNSL 400
    RLAHVWLDEY KEQYFSLRPD LKTKSFGNIS ERVELRKKLG CQSFKWYLDN 450
    VYPEMQVSGP KARLQQPVFI NRGPKRPRVL LRGRLYHLQT NKCLVAQGRS 500
    SQKGGLVLLK ACDYGDPTQV WIYNEEHELI LNNLLCLDMS ETRSSDPPRL 550
    MKCHGSGGSQ QWTFGKNNRL YQVSVGQCLR VVDQMDQKGY VGMAICDGSS 600
    SQQWRLEG 608
    Length:608
    Mass (Da):69,039
    Last modified:July 5, 2004 - v1
    Checksum:iED1295AC1EB35751
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062004 mRNA. Translation: AAH62004.1.
    RefSeqiNP_001258248.1. NM_001271319.1.
    NP_955425.2. NM_199393.2.
    XP_006235984.1. XM_006235922.1.
    XP_006235985.1. XM_006235923.1.
    UniGeneiRn.211885.

    Genome annotation databases

    EnsembliENSRNOT00000011814; ENSRNOP00000011815; ENSRNOG00000008117.
    GeneIDi311952.
    KEGGirno:311952.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062004 mRNA. Translation: AAH62004.1 .
    RefSeqi NP_001258248.1. NM_001271319.1.
    NP_955425.2. NM_199393.2.
    XP_006235984.1. XM_006235922.1.
    XP_006235985.1. XM_006235923.1.
    UniGenei Rn.211885.

    3D structure databases

    ProteinModelPortali Q6P6V1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4576490.
    STRINGi 10116.ENSRNOP00000011815.

    Protein family/group databases

    CAZyi CBM13. Carbohydrate-Binding Module Family 13.
    GT27. Glycosyltransferase Family 27.

    PTM databases

    PhosphoSitei Q6P6V1.

    Proteomic databases

    PRIDEi Q6P6V1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011814 ; ENSRNOP00000011815 ; ENSRNOG00000008117 .
    GeneIDi 311952.
    KEGGi rno:311952.

    Organism-specific databases

    CTDi 63917.
    RGDi 735097. Galnt11.

    Phylogenomic databases

    eggNOGi NOG239675.
    GeneTreei ENSGT00740000115054.
    HOGENOMi HOG000038227.
    HOVERGENi HBG051699.
    InParanoidi Q6P6V1.
    KOi K00710.
    OMAi MIFNERD.
    OrthoDBi EOG7J9VP2.
    PhylomeDBi Q6P6V1.
    TreeFami TF313267.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_196259. O-linked glycosylation of mucins.

    Miscellaneous databases

    NextBioi 664505.
    PROi Q6P6V1.

    Gene expression databases

    Genevestigatori Q6P6V1.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR027791. Galactosyl_T_C.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF02709. Glyco_transf_7C. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 2 hits.
    SSF53448. SSF53448. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiGLT11_RAT
    AccessioniPrimary (citable) accession number: Q6P6V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3