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Q6P6V0

- G6PI_RAT

UniProt

Q6P6V0 - G6PI_RAT

Protein

Glucose-6-phosphate isomerase

Gene

Gpi

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei358 – 3581Proton donorBy similarity
    Active sitei389 – 3891By similarity
    Active sitei519 – 5191By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: RGD
    2. intramolecular transferase activity Source: RGD
    3. monosaccharide binding Source: RGD

    GO - Biological processi

    1. aldehyde catabolic process Source: RGD
    2. angiogenesis Source: UniProtKB-KW
    3. carbohydrate metabolic process Source: RGD
    4. gluconeogenesis Source: UniProtKB-KW
    5. glucose 6-phosphate metabolic process Source: RGD
    6. glycolytic process Source: UniProtKB-UniPathway
    7. learning or memory Source: RGD
    8. methylglyoxal biosynthetic process Source: RGD
    9. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    10. negative regulation of neuron apoptotic process Source: RGD

    Keywords - Molecular functioni

    Cytokine, Growth factor, Isomerase

    Keywords - Biological processi

    Angiogenesis, Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    ReactomeiREACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RKQ6P6V0.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseBy similarity (EC:5.3.1.9)
    Short name:
    GPIBy similarity
    Alternative name(s):
    Autocrine motility factor
    Short name:
    AMF
    NeuroleukinBy similarity
    Short name:
    NLKBy similarity
    Phosphoglucose isomeraseBy similarity
    Short name:
    PGIBy similarity
    Phosphohexose isomeraseBy similarity
    Short name:
    PHIBy similarity
    Gene namesi
    Name:GpiImported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2727. Gpi.

    Subcellular locationi

    Secreted By similarity. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytosol Source: RGD
    3. extracellular space Source: UniProtKB-KW
    4. neuron projection Source: RGD
    5. nucleus Source: Ensembl
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 558557Glucose-6-phosphate isomeraseBy similarityPRO_0000349123Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei12 – 121N6-acetyllysineBy similarity
    Modified residuei142 – 1421N6-acetyllysineBy similarity
    Modified residuei185 – 1851Phosphoserine; by CK2By similarity
    Modified residuei454 – 4541N6-malonyllysineBy similarity

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ6P6V0.
    PRIDEiQ6P6V0.

    2D gel databases

    World-2DPAGE0004:Q6P6V0.

    PTM databases

    PhosphoSiteiQ6P6V0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P6V0.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi253982. 1 interaction.
    IntActiQ6P6V0. 2 interactions.
    STRINGi10116.ENSRNOP00000029515.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6V0.
    SMRiQ6P6V0. Positions 1-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG0166.
    GeneTreeiENSGT00390000000707.
    HOGENOMiHOG000261370.
    HOVERGENiHBG002877.
    InParanoidiQ6P6V0.
    KOiK01810.
    OMAiCGNELDN.
    OrthoDBiEOG7FXZXV.
    PhylomeDBiQ6P6V0.
    TreeFamiTF300436.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P6V0-1 [UniParc]FASTAAdd to Basket

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    MAALTRNPEF QKLLEWHRAN SANLKLRELF EADPERFNHF SLNLNTNHGH    50
    ILLDYSKNLV NKEVLHMLVD LAKSRGVEAA RDNMFSGLKI NSTEDRAVLH 100
    VALRNRSNRS IMMDGKDVMP EVNKVLDKMK SFCQRVRSGD WKGYTGKAIT 150
    DIINIGIGGS DLGPLMVTEA LKPYSKGGPR VWFVSNIDGT HIAKTLANLN 200
    PESSLFIIAS KTFTTQETIT NAETAKEWFL QAAKDPSAVA KHFVALSTNT 250
    DKVKEFGIDP KNMFEFWDWV GGRYSLWSAI GLSIALHVGF DHFEQLLSGA 300
    HWMDQHFMKT PLDKNAPVLL ALLGIWYINF YGCETHAMLP YDQYMHRFAA 350
    YFQQGDMESN GKYITKSGAR VDYQTGPIVW GEPGTNGQHA FYQLIHQGTK 400
    MIPCDFLIPV QTQHPIRNGL HHKILLANFL AQTEALMKGK SPEEARKELQ 450
    AAGKSPEELE KLLPHKVFEG NRPTNSIVFT KLTPFILGAL IAMYEHKIFV 500
    QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSSAVTSHDS STNGLIGFIK 550
    LQRDTKID 558
    Length:558
    Mass (Da):62,827
    Last modified:July 5, 2004 - v1
    Checksum:i2550ACB874E0302C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062005 mRNA. Translation: AAH62005.1.
    RefSeqiNP_997475.1. NM_207592.1.
    UniGeneiRn.84435.

    Genome annotation databases

    EnsembliENSRNOT00000032613; ENSRNOP00000029515; ENSRNOG00000023150.
    GeneIDi292804.
    KEGGirno:292804.
    UCSCiRGD:2727. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062005 mRNA. Translation: AAH62005.1 .
    RefSeqi NP_997475.1. NM_207592.1.
    UniGenei Rn.84435.

    3D structure databases

    ProteinModelPortali Q6P6V0.
    SMRi Q6P6V0. Positions 1-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 253982. 1 interaction.
    IntActi Q6P6V0. 2 interactions.
    STRINGi 10116.ENSRNOP00000029515.

    PTM databases

    PhosphoSitei Q6P6V0.

    2D gel databases

    World-2DPAGE 0004:Q6P6V0.

    Proteomic databases

    PaxDbi Q6P6V0.
    PRIDEi Q6P6V0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000032613 ; ENSRNOP00000029515 ; ENSRNOG00000023150 .
    GeneIDi 292804.
    KEGGi rno:292804.
    UCSCi RGD:2727. rat.

    Organism-specific databases

    CTDi 2821.
    RGDi 2727. Gpi.

    Phylogenomic databases

    eggNOGi COG0166.
    GeneTreei ENSGT00390000000707.
    HOGENOMi HOG000261370.
    HOVERGENi HBG002877.
    InParanoidi Q6P6V0.
    KOi K01810.
    OMAi CGNELDN.
    OrthoDBi EOG7FXZXV.
    PhylomeDBi Q6P6V0.
    TreeFami TF300436.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    Reactomei REACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RK Q6P6V0.

    Miscellaneous databases

    NextBioi 634825.
    PROi Q6P6V0.

    Gene expression databases

    Genevestigatori Q6P6V0.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ProstateImported.
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiG6PI_RAT
    AccessioniPrimary (citable) accession number: Q6P6V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3