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Protein

Nucleotide exchange factor SIL1

Gene

Sil1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:Sil1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi735103. Sil1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000022335632 – 465Nucleotide exchange factor SIL1Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P6S4.
PRIDEiQ6P6S4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019826.
GenevisibleiQ6P6S4. RN.

Interactioni

Subunit structurei

Interacts with HSPA5.By similarity

Protein-protein interaction databases

IntActiQ6P6S4. 1 interactor.
STRINGi10116.ENSRNOP00000026895.

Structurei

3D structure databases

ProteinModelPortaliQ6P6S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 260Interaction with HSPA5 and localization to the endoplasmic reticulumBy similarityAdd BLAST260

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048102.
HOGENOMiHOG000154326.
HOVERGENiHBG093955.
InParanoidiQ6P6S4.
KOiK14001.
OMAiQEQGWCE.
OrthoDBiEOG091G0196.
PhylomeDBiQ6P6S4.
TreeFamiTF324307.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P6S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQHLPSTR MAPQGMLLGL LLASCLTFCL SCQNSNNFAL TNPEKSTHED
60 70 80 90 100
SDTKETRREE ELDAEVLEVL NPTQEWQALQ PGQAVPAGSH VRMNLQTGVN
110 120 130 140 150
EVKLQQEDKF QSNWKGFKRG RRLDINTNTY TSQDLKSALA KFKEGTEMEN
160 170 180 190 200
SKDELARQAT VKQLFRPIEE LKKEFDELNV VLETDMQIMV RLINKFNSSS
210 220 230 240 250
SSLEEKVAAL FDLEYYVHQM DNAQDLLSFG GLQVVINGLN STEPLVKEYA
260 270 280 290 300
AFVLGAAFSS NPKVQVEAIE GGALQKLLVI LATEQPLPAK KKVLFALCSL
310 320 330 340 350
LRHFPYAQQQ FLKLGGLQVL RSLVQEKSAK VLAVRVVTLL YDLVTEKMFA
360 370 380 390 400
EEEAELTQES SPEKLQQYRQ VQLLPGLREQ GWCEITAQLL ALPEHDAREK
410 420 430 440 450
VLQTLGALLA TCRDRYRQDL ELSRTLGSLQ AEYQALASLE LQEGEDDGYF
460
RELLASIDSL VKELR
Length:465
Mass (Da):52,350
Last modified:July 5, 2004 - v1
Checksum:i5645924C08F6A8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062050 mRNA. Translation: AAH62050.1.
RefSeqiNP_955408.1. NM_199376.1.
XP_008770247.1. XM_008772025.2.
XP_017456394.1. XM_017600905.1.
UniGeneiRn.103851.

Genome annotation databases

EnsembliENSRNOT00000026895; ENSRNOP00000026895; ENSRNOG00000019826.
GeneIDi291673.
KEGGirno:291673.
UCSCiRGD:735103. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062050 mRNA. Translation: AAH62050.1.
RefSeqiNP_955408.1. NM_199376.1.
XP_008770247.1. XM_008772025.2.
XP_017456394.1. XM_017600905.1.
UniGeneiRn.103851.

3D structure databases

ProteinModelPortaliQ6P6S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P6S4. 1 interactor.
STRINGi10116.ENSRNOP00000026895.

Proteomic databases

PaxDbiQ6P6S4.
PRIDEiQ6P6S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026895; ENSRNOP00000026895; ENSRNOG00000019826.
GeneIDi291673.
KEGGirno:291673.
UCSCiRGD:735103. rat.

Organism-specific databases

CTDi64374.
RGDi735103. Sil1.

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048102.
HOGENOMiHOG000154326.
HOVERGENiHBG093955.
InParanoidiQ6P6S4.
KOiK14001.
OMAiQEQGWCE.
OrthoDBiEOG091G0196.
PhylomeDBiQ6P6S4.
TreeFamiTF324307.

Miscellaneous databases

PROiQ6P6S4.

Gene expression databases

BgeeiENSRNOG00000019826.
GenevisibleiQ6P6S4. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIL1_RAT
AccessioniPrimary (citable) accession number: Q6P6S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.