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Protein

B box and SPRY domain-containing protein

Gene

Bspry

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 11149B box-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Alternative name(s):
Zetin-1
Gene namesi
Name:Bspry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708400. Bspry.

Subcellular locationi

GO - Cellular componenti

  • cell leading edge Source: RGD
  • membrane Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448B box and SPRY domain-containing proteinPRO_0000244259Add
BLAST

Proteomic databases

PaxDbiQ6P6S3.
PRIDEiQ6P6S3.

PTM databases

iPTMnetiQ6P6S3.
PhosphoSiteiQ6P6S3.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Expressed in brain at low levels.1 Publication

Gene expression databases

BgeeiENSRNOG00000015105.
ExpressionAtlasiQ6P6S3. baseline and differential.
GenevisibleiQ6P6S3. RN.

Interactioni

Subunit structurei

Interacts with TRPV5 and TRPV6 (By similarity). Interacts with YWHAZ/14-3-3 protein zeta.By similarity1 Publication

Protein-protein interaction databases

MINTiMINT-260067.
STRINGi10116.ENSRNOP00000020366.

Structurei

3D structure databases

ProteinModelPortaliQ6P6S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini257 – 448192B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 7459Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 11149B box-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF8. Eukaryota.
ENOG4111EI7. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ6P6S3.
OMAiRLGHNAF.
OrthoDBiEOG091G0BWZ.
PhylomeDBiQ6P6S3.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDVSGTES GSESGPESVP EPVPEPGPEP ESEPGPGPAP GPGPGPAPGP
60 70 80 90 100
GPGLGREPGQ RYQPCQLCPE HGKPLSWFCL SERRPVCATC AGFGGRCHRH
110 120 130 140 150
RIRRAEEHAE ELRNKIVDHC EKLQLQSAGI TKYVAEVLQG KNQKAMIMAN
160 170 180 190 200
ATREVIIQRL SLVRCLCESE EQRLLEQVHS EEERAHQCIL TQRAHWDDKL
210 220 230 240 250
RKLDSLRTSM VDMLTHLNDL QLIQMEQEIL ERAEEAEGIL EPQESEKLSF
260 270 280 290 300
NEKCAWSPLL TQLWATSVLG SLSGMEDVLI DERTVGPLLN LSEDRKTLTF
310 320 330 340 350
NAKKSKVCSD DPERFDHWPN ALAVNAFQTG LHAWAVNVKH SCAYKVGVAS
360 370 380 390 400
AQLPRKGSGS DCRLGHNAFS WVFSRYDQEF CFSHNGNHEP LALLRCPTQL
410 420 430 440
GLLLDLQAGE LIFYEPASGT VLHIHRESFP HRLFPVFAVA DQVISIVC
Length:448
Mass (Da):49,704
Last modified:June 27, 2006 - v2
Checksum:i1971FA20FE4019A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3134DDPE → VTQQ in AAF72164 (PubMed:12615066).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062051 mRNA. Translation: AAH62051.1.
BC095901 mRNA. Translation: AAH95901.1.
CK598656 mRNA. No translation available.
AF245225 mRNA. Translation: AAF72164.1.
RefSeqiNP_071597.2. NM_022261.2.
UniGeneiRn.53996.

Genome annotation databases

EnsembliENSRNOT00000020366; ENSRNOP00000020366; ENSRNOG00000015105.
GeneIDi64027.
KEGGirno:64027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062051 mRNA. Translation: AAH62051.1.
BC095901 mRNA. Translation: AAH95901.1.
CK598656 mRNA. No translation available.
AF245225 mRNA. Translation: AAF72164.1.
RefSeqiNP_071597.2. NM_022261.2.
UniGeneiRn.53996.

3D structure databases

ProteinModelPortaliQ6P6S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-260067.
STRINGi10116.ENSRNOP00000020366.

PTM databases

iPTMnetiQ6P6S3.
PhosphoSiteiQ6P6S3.

Proteomic databases

PaxDbiQ6P6S3.
PRIDEiQ6P6S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020366; ENSRNOP00000020366; ENSRNOG00000015105.
GeneIDi64027.
KEGGirno:64027.

Organism-specific databases

CTDi54836.
RGDi708400. Bspry.

Phylogenomic databases

eggNOGiENOG410ITF8. Eukaryota.
ENOG4111EI7. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ6P6S3.
OMAiRLGHNAF.
OrthoDBiEOG091G0BWZ.
PhylomeDBiQ6P6S3.
TreeFamiTF351014.

Miscellaneous databases

PROiQ6P6S3.

Gene expression databases

BgeeiENSRNOG00000015105.
ExpressionAtlasiQ6P6S3. baseline and differential.
GenevisibleiQ6P6S3. RN.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSPRY_RAT
AccessioniPrimary (citable) accession number: Q6P6S3
Secondary accession number(s): Q4VBG7, Q9JKB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.