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Protein

B box and SPRY domain-containing protein

Gene

Bspry

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 111B box-typeAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Alternative name(s):
Zetin-1
Gene namesi
Name:Bspry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708400 Bspry

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442591 – 448B box and SPRY domain-containing proteinAdd BLAST448

Proteomic databases

PaxDbiQ6P6S3
PRIDEiQ6P6S3

PTM databases

iPTMnetiQ6P6S3
PhosphoSitePlusiQ6P6S3

Expressioni

Tissue specificityi

Predominantly expressed in testis. Expressed in brain at low levels.1 Publication

Gene expression databases

BgeeiENSRNOG00000015105
ExpressionAtlasiQ6P6S3 baseline and differential
GenevisibleiQ6P6S3 RN

Interactioni

Subunit structurei

Interacts with TRPV5 and TRPV6 (By similarity). Interacts with YWHAZ/14-3-3 protein zeta.By similarity1 Publication

Protein-protein interaction databases

MINTiQ6P6S3
STRINGi10116.ENSRNOP00000020366

Structurei

3D structure databases

ProteinModelPortaliQ6P6S3
SMRiQ6P6S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 448B30.2/SPRYPROSITE-ProRule annotationAdd BLAST192

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 74Pro-richAdd BLAST59

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 111B box-typeAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF8 Eukaryota
ENOG4111EI7 LUCA
GeneTreeiENSGT00840000129835
HOGENOMiHOG000057290
HOVERGENiHBG080574
InParanoidiQ6P6S3
OMAiWVFSRYD
OrthoDBiEOG091G0BWZ
PhylomeDBiQ6P6S3
TreeFamiTF351014

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P6S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDVSGTES GSESGPESVP EPVPEPGPEP ESEPGPGPAP GPGPGPAPGP
60 70 80 90 100
GPGLGREPGQ RYQPCQLCPE HGKPLSWFCL SERRPVCATC AGFGGRCHRH
110 120 130 140 150
RIRRAEEHAE ELRNKIVDHC EKLQLQSAGI TKYVAEVLQG KNQKAMIMAN
160 170 180 190 200
ATREVIIQRL SLVRCLCESE EQRLLEQVHS EEERAHQCIL TQRAHWDDKL
210 220 230 240 250
RKLDSLRTSM VDMLTHLNDL QLIQMEQEIL ERAEEAEGIL EPQESEKLSF
260 270 280 290 300
NEKCAWSPLL TQLWATSVLG SLSGMEDVLI DERTVGPLLN LSEDRKTLTF
310 320 330 340 350
NAKKSKVCSD DPERFDHWPN ALAVNAFQTG LHAWAVNVKH SCAYKVGVAS
360 370 380 390 400
AQLPRKGSGS DCRLGHNAFS WVFSRYDQEF CFSHNGNHEP LALLRCPTQL
410 420 430 440
GLLLDLQAGE LIFYEPASGT VLHIHRESFP HRLFPVFAVA DQVISIVC
Length:448
Mass (Da):49,704
Last modified:June 27, 2006 - v2
Checksum:i1971FA20FE4019A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310 – 313DDPE → VTQQ in AAF72164 (PubMed:12615066).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062051 mRNA Translation: AAH62051.1
BC095901 mRNA Translation: AAH95901.1
CK598656 mRNA No translation available.
AF245225 mRNA Translation: AAF72164.1
RefSeqiNP_071597.2, NM_022261.2
UniGeneiRn.53996

Genome annotation databases

EnsembliENSRNOT00000020366; ENSRNOP00000020366; ENSRNOG00000015105
GeneIDi64027
KEGGirno:64027

Similar proteinsi

Entry informationi

Entry nameiBSPRY_RAT
AccessioniPrimary (citable) accession number: Q6P6S3
Secondary accession number(s): Q4VBG7, Q9JKB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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