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Q6P6R6

- Q6P6R6_RAT

UniProt

Q6P6R6 - Q6P6R6_RAT

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Protein
Submitted name: Transglutaminase 2, C polypeptide
Gene
Tgm2
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei277 – 2771 By similarityUniRule annotation
Active sitei335 – 3351 By similarityUniRule annotation
Active sitei358 – 3581 By similarityUniRule annotation
Metal bindingi398 – 3981Calcium By similarityUniRule annotation
Metal bindingi400 – 4001Calcium By similarityUniRule annotation
Metal bindingi447 – 4471Calcium By similarityUniRule annotation
Metal bindingi452 – 4521Calcium By similarityUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: RGD
  2. enzyme binding Source: RGD
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: RGD
  5. protein domain specific binding Source: RGD
  6. protein-glutamine gamma-glutamyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. blood vessel remodeling Source: RGD
  2. isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: RGD
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  4. positive regulation of apoptotic process Source: RGD
  5. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  6. positive regulation of inflammatory response Source: RGD
  7. positive regulation of smooth muscle cell proliferation Source: RGD
  8. protein homooligomerization Source: RGD
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:Tgm2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621081. Tgm2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: RGD
  2. plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6P6R6.
PRIDEiQ6P6R6.

Expressioni

Gene expression databases

GenevestigatoriQ6P6R6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018328.

Structurei

3D structure databases

ProteinModelPortaliQ6P6R6.
SMRiQ6P6R6. Positions 15-686.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ6P6R6.
KOiK05625.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6R6-1 [UniParc]FASTAAdd to Basket

« Hide

MAEELNLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY    50
EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL 100
SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL 150
DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN 200
PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS 250
PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG 350
YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD 400
VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP 450
EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS 500
ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY 550
SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 600
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR 650
VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA 686
Length:686
Mass (Da):76,936
Last modified:July 5, 2004 - v1
Checksum:iB29FF3E396989EDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062062 mRNA. Translation: AAH62062.1.
RefSeqiNP_062259.2. NM_019386.2.
UniGeneiRn.10.

Genome annotation databases

GeneIDi56083.
KEGGirno:56083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062062 mRNA. Translation: AAH62062.1 .
RefSeqi NP_062259.2. NM_019386.2.
UniGenei Rn.10.

3D structure databases

ProteinModelPortali Q6P6R6.
SMRi Q6P6R6. Positions 15-686.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018328.

Proteomic databases

PaxDbi Q6P6R6.
PRIDEi Q6P6R6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 56083.
KEGGi rno:56083.

Organism-specific databases

CTDi 7052.
RGDi 621081. Tgm2.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q6P6R6.
KOi K05625.

Miscellaneous databases

NextBioi 611102.

Gene expression databases

Genevestigatori Q6P6R6.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.

Entry informationi

Entry nameiQ6P6R6_RAT
AccessioniPrimary (citable) accession number: Q6P6R6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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