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Q6P6R6

- Q6P6R6_RAT

UniProt

Q6P6R6 - Q6P6R6_RAT

Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

Tgm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 calcium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei277 – 2771UniRule annotation
    Active sitei335 – 3351UniRule annotation
    Active sitei358 – 3581UniRule annotation
    Metal bindingi398 – 3981Calcium
    Metal bindingi400 – 4001Calcium
    Metal bindingi447 – 4471Calcium
    Metal bindingi452 – 4521Calcium

    GO - Molecular functioni

    1. enzyme binding Source: RGD
    2. GTP binding Source: RGD
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: RGD
    5. protein domain specific binding Source: RGD
    6. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

    GO - Biological processi

    1. blood vessel remodeling Source: RGD
    2. isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: RGD
    3. positive regulation of apoptotic process Source: RGD
    4. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
    5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
    6. positive regulation of inflammatory response Source: RGD
    7. positive regulation of smooth muscle cell proliferation Source: RGD
    8. protein homooligomerization Source: RGD

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transglutaminase 2, C polypeptideImported
    Gene namesi
    Name:Tgm2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621081. Tgm2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: RGD
    2. plasma membrane Source: RGD

    PTM / Processingi

    Proteomic databases

    PaxDbiQ6P6R6.
    PRIDEiQ6P6R6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P6R6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6R6.
    SMRiQ6P6R6. Positions 15-686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiQ6P6R6.
    KOiK05625.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P6R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEELNLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY    50
    EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL 100
    SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL 150
    DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN 200
    PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS 250
    PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
    YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG 350
    YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD 400
    VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP 450
    EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS 500
    ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY 550
    SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 600
    KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR 650
    VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA 686
    Length:686
    Mass (Da):76,936
    Last modified:July 5, 2004 - v1
    Checksum:iB29FF3E396989EDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062062 mRNA. Translation: AAH62062.1.
    RefSeqiNP_062259.2. NM_019386.2.
    UniGeneiRn.10.

    Genome annotation databases

    GeneIDi56083.
    KEGGirno:56083.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062062 mRNA. Translation: AAH62062.1 .
    RefSeqi NP_062259.2. NM_019386.2.
    UniGenei Rn.10.

    3D structure databases

    ProteinModelPortali Q6P6R6.
    SMRi Q6P6R6. Positions 15-686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018328.

    Proteomic databases

    PaxDbi Q6P6R6.
    PRIDEi Q6P6R6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 56083.
    KEGGi rno:56083.

    Organism-specific databases

    CTDi 7052.
    RGDi 621081. Tgm2.

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi Q6P6R6.
    KOi K05625.

    Miscellaneous databases

    NextBioi 611102.

    Gene expression databases

    Genevestigatori Q6P6R6.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ProstateImported.

    Entry informationi

    Entry nameiQ6P6R6_RAT
    AccessioniPrimary (citable) accession number: Q6P6R6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)