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Q6P6R6 (Q6P6R6_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Tgm2 EMBL AAH62062.1 RGD 621081
OrganismRattus norvegicus (Rat) EMBL AAH62062.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 1 calcium ion per subunit By similarity. PIRSR PIRSR000459-2

Ontologies

Keywords
   LigandCalcium PIRSR PIRSR000459-2
Metal-binding PIRSR PIRSR000459-2
Gene Ontology (GO)
   Biological_processblood vessel remodeling

Inferred from mutant phenotype PubMed 15550691. Source: RGD

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

Inferred from direct assay PubMed 16341586. Source: RGD

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from mutant phenotype PubMed 15471861. Source: RGD

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 11073883. Source: RGD

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from mutant phenotype PubMed 12054611. Source: RGD

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 15471861. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 14970202. Source: RGD

protein homooligomerization

Inferred from direct assay PubMed 12469910PubMed 16341586. Source: RGD

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 16341586. Source: RGD

plasma membrane

Inferred from direct assay PubMed 14970202. Source: RGD

   Molecular_functionGTP binding

Inferred from direct assay PubMed 14970202. Source: RGD

enzyme binding

Inferred by curator PubMed 16341586. Source: RGD

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 16709602. Source: RGD

protein domain specific binding

Inferred from physical interaction PubMed 12054611. Source: RGD

protein-glutamine gamma-glutamyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2771 By similarity PIRSR PIRSR000459-1
Active site3351 By similarity PIRSR PIRSR000459-1
Active site3581 By similarity PIRSR PIRSR000459-1
Metal binding3981Calcium By similarity PIRSR PIRSR000459-2
Metal binding4001Calcium By similarity PIRSR PIRSR000459-2
Metal binding4471Calcium By similarity PIRSR PIRSR000459-2
Metal binding4521Calcium By similarity PIRSR PIRSR000459-2

Sequences

Sequence LengthMass (Da)Tools
Q6P6R6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B29FF3E396989EDE

FASTA68676,936
        10         20         30         40         50         60 
MAEELNLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY EASVDRLTFG 

        70         80         90        100        110        120 
AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL SLQLCTPANA PVGQYRLSLE 

       130        140        150        160        170        180 
TSTGYQGSSF MLGHFILLFN AWCPADDVYL DSEAERREYV LTQQGFIYQG SVKFIKSVPW 

       190        200        210        220        230        240 
NFGQFEDGIL DACLMLLDVN PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR 

       250        260        270        280        290        300 
WDNNYGDGIS PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 

       310        320        330        340        350        360 
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG YEGWQAIDPT 

       370        380        390        400        410        420 
PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD VVDWIRQSDG SVLKSINNSL 

       430        440        450        460        470        480 
VVGQKISTKS VGRDDREDIT YTYKYPEGSP EEREVFTRAN HLNKLAEKEE TGVAMRIRVG 

       490        500        510        520        530        540 
DGMSLGNDFD VFAHIGNDTS ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS 

       550        560        570        580        590        600 
IPLRILYEKY SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 

       610        620        630        640        650        660 
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR VDLFPTDIGL 

       670        680 
HKLVVNFQCD KLKSVKGYRN IIIGPA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate EMBL AAH62062.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC062062 mRNA. Translation: AAH62062.1.
RefSeqNP_062259.2. NM_019386.2.
UniGeneRn.10.

3D structure databases

ProteinModelPortalQ6P6R6.
SMRQ6P6R6. Positions 15-686.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018328.

Proteomic databases

PaxDbQ6P6R6.
PRIDEQ6P6R6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID56083.
KEGGrno:56083.

Organism-specific databases

CTD7052.
RGD621081. Tgm2.

Phylogenomic databases

eggNOGNOG80379.
HOGENOMHOG000231695.
HOVERGENHBG004342.
InParanoidQ6P6R6.
KOK05625.

Gene expression databases

GenevestigatorQ6P6R6.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611102.

Entry information

Entry nameQ6P6R6_RAT
AccessionPrimary (citable) accession number: Q6P6R6
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)