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Protein

Protein lifeguard 1

Gene

Grina

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.By similarity

GO - Molecular functioni

  1. cation channel activity Source: RGD

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. cation transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene namesi
Name:Grina
Synonyms:Lfg1, Nmdara1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi628873. Grina.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Protein lifeguard 1PRO_0000314441Add
BLAST

Proteomic databases

PRIDEiQ6P6R0.

Expressioni

Gene expression databases

GenevestigatoriQ6P6R0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045014.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 117103Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ6P6R0.
KOiK06890.
OMAiFQPSPYG.
OrthoDBiEOG7VB2G8.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6R0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDSYPPPNPG YPVGPQAPMP PYVQPPYPGA PYPQAAFQPS
60 70 80 90 100
PYGQPGYPHG PGPYPQGGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPPPF
110 120 130 140 150
QDPGSPQHGN YQEEGPPSYY DNQDFPSVNW DKSIRQAFIR KVFLVLTLQL
160 170 180 190 200
SVTLSTVAIF TFVGEVKGFV RANVWTYYVS YAIFFISLIV LSCCGDFRRK
210 220 230 240 250
HPWNLVALSI LTISLSYMVG MIASFYNTEA VIMAVGITTA VCFTVVIFSM
260 270 280 290 300
QTRYDFTSCM GVLLVSVVVL FIFAILCIFI RNRILEIVYA SLGALLFTCF
310 320 330 340
LAVDTQLLLG NKQLSLSPEE YVFAALNLYT DIINIFLYIL TIIGRAKE
Length:348
Mass (Da):38,594
Last modified:July 5, 2004 - v1
Checksum:iA780611FC30D2861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062074 mRNA. Translation: AAH62074.1.
RefSeqiNP_695220.4. NM_153308.4.
UniGeneiRn.5898.

Genome annotation databases

EnsembliENSRNOT00000059599; ENSRNOP00000056356; ENSRNOG00000029941.
GeneIDi266668.
KEGGirno:266668.
UCSCiRGD:628873. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062074 mRNA. Translation: AAH62074.1.
RefSeqiNP_695220.4. NM_153308.4.
UniGeneiRn.5898.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045014.

Chemistry

ChEMBLiCHEMBL4129.

Proteomic databases

PRIDEiQ6P6R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059599; ENSRNOP00000056356; ENSRNOG00000029941.
GeneIDi266668.
KEGGirno:266668.
UCSCiRGD:628873. rat.

Organism-specific databases

CTDi2907.
RGDi628873. Grina.

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ6P6R0.
KOiK06890.
OMAiFQPSPYG.
OrthoDBiEOG7VB2G8.

Miscellaneous databases

NextBioi624460.
PROiQ6P6R0.

Gene expression databases

GenevestigatoriQ6P6R0.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiLFG1_RAT
AccessioniPrimary (citable) accession number: Q6P6R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.