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Q6P6R0 (LFG1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene names
Name:Grina
Synonyms:Lfg1, Nmdara1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential apoptotic regulator By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncation channel activity

Non-traceable author statement PubMed 1719427. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Protein lifeguard 1
PRO_0000314441

Regions

Transmembrane142 – 16221Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane260 – 28021Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane323 – 34321Helical; Potential
Compositional bias15 – 117103Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q6P6R0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A780611FC30D2861

FASTA34838,594
        10         20         30         40         50         60 
MSHEKSFLVS GDSYPPPNPG YPVGPQAPMP PYVQPPYPGA PYPQAAFQPS PYGQPGYPHG 

        70         80         90        100        110        120 
PGPYPQGGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPPPF QDPGSPQHGN YQEEGPPSYY 

       130        140        150        160        170        180 
DNQDFPSVNW DKSIRQAFIR KVFLVLTLQL SVTLSTVAIF TFVGEVKGFV RANVWTYYVS 

       190        200        210        220        230        240 
YAIFFISLIV LSCCGDFRRK HPWNLVALSI LTISLSYMVG MIASFYNTEA VIMAVGITTA 

       250        260        270        280        290        300 
VCFTVVIFSM QTRYDFTSCM GVLLVSVVVL FIFAILCIFI RNRILEIVYA SLGALLFTCF 

       310        320        330        340 
LAVDTQLLLG NKQLSLSPEE YVFAALNLYT DIINIFLYIL TIIGRAKE

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC062074 mRNA. Translation: AAH62074.1.
IPIIPI00421503.
RefSeqNP_695220.4. NM_153308.4.
UniGeneRn.5898.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000045014.

Proteomic databases

PRIDEQ6P6R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000059599; ENSRNOP00000056356; ENSRNOG00000029941.
GeneID266668.
KEGGrno:266668.
UCSCRGD:628873. rat.

Organism-specific databases

CTD2907.
RGD628873. Grina.

Phylogenomic databases

eggNOGCOG0670.
GeneTreeENSGT00500000044791.
HOGENOMHOG000060393.
HOVERGENHBG012084.
KOK06890.
OrthoDBEOG41G358.

Gene expression databases

ArrayExpressQ6P6R0.
GenevestigatorQ6P6R0.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
PROSITEPS01243. BI1. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL4129.
NextBio624460.

Entry information

Entry nameLFG1_RAT
AccessionPrimary (citable) accession number: Q6P6R0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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