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Q6P6R0

- LFG1_RAT

UniProt

Q6P6R0 - LFG1_RAT

Protein

Protein lifeguard 1

Gene

Grina

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Potential apoptotic regulator.By similarity

    GO - Molecular functioni

    1. cation channel activity Source: RGD

    GO - Biological processi

    1. cation transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 1
    Alternative name(s):
    Glutamate [NMDA] receptor-associated protein 1
    NMDA receptor glutamate-binding subunit
    Gene namesi
    Name:Grina
    Synonyms:Lfg1, Nmdara1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi628873. Grina.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Protein lifeguard 1PRO_0000314441Add
    BLAST

    Proteomic databases

    PRIDEiQ6P6R0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P6R0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000045014.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 117103Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    GeneTreeiENSGT00500000044791.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    KOiK06890.
    OMAiFQPSPYG.
    OrthoDBiEOG7VB2G8.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P6R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHEKSFLVS GDSYPPPNPG YPVGPQAPMP PYVQPPYPGA PYPQAAFQPS    50
    PYGQPGYPHG PGPYPQGGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPPPF 100
    QDPGSPQHGN YQEEGPPSYY DNQDFPSVNW DKSIRQAFIR KVFLVLTLQL 150
    SVTLSTVAIF TFVGEVKGFV RANVWTYYVS YAIFFISLIV LSCCGDFRRK 200
    HPWNLVALSI LTISLSYMVG MIASFYNTEA VIMAVGITTA VCFTVVIFSM 250
    QTRYDFTSCM GVLLVSVVVL FIFAILCIFI RNRILEIVYA SLGALLFTCF 300
    LAVDTQLLLG NKQLSLSPEE YVFAALNLYT DIINIFLYIL TIIGRAKE 348
    Length:348
    Mass (Da):38,594
    Last modified:July 5, 2004 - v1
    Checksum:iA780611FC30D2861
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062074 mRNA. Translation: AAH62074.1.
    RefSeqiNP_695220.4. NM_153308.4.
    XP_006241838.1. XM_006241776.1.
    UniGeneiRn.5898.

    Genome annotation databases

    EnsembliENSRNOT00000059599; ENSRNOP00000056356; ENSRNOG00000029941.
    GeneIDi266668.
    KEGGirno:266668.
    UCSCiRGD:628873. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062074 mRNA. Translation: AAH62074.1 .
    RefSeqi NP_695220.4. NM_153308.4.
    XP_006241838.1. XM_006241776.1.
    UniGenei Rn.5898.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000045014.

    Chemistry

    ChEMBLi CHEMBL4129.

    Proteomic databases

    PRIDEi Q6P6R0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000059599 ; ENSRNOP00000056356 ; ENSRNOG00000029941 .
    GeneIDi 266668.
    KEGGi rno:266668.
    UCSCi RGD:628873. rat.

    Organism-specific databases

    CTDi 2907.
    RGDi 628873. Grina.

    Phylogenomic databases

    eggNOGi COG0670.
    GeneTreei ENSGT00500000044791.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    KOi K06890.
    OMAi FQPSPYG.
    OrthoDBi EOG7VB2G8.

    Miscellaneous databases

    NextBioi 624460.
    PROi Q6P6R0.

    Gene expression databases

    Genevestigatori Q6P6R0.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiLFG1_RAT
    AccessioniPrimary (citable) accession number: Q6P6R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3