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Q6P6Q2

- K2C5_RAT

UniProt

Q6P6Q2 - K2C5_RAT

Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei413 – 4131StutterSequence Analysis

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 5
    Alternative name(s):
    Cytokeratin-5
    Short name:
    CK-5
    Keratin-5
    Short name:
    K5
    Type-II keratin Kb5
    Gene namesi
    Name:Krt5By similarity
    Synonyms:Krt2-5Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi727894. Krt5.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: RGD

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Keratin, type II cytoskeletal 5PRO_0000063729Add
    BLAST

    Proteomic databases

    PRIDEiQ6P6Q2.

    PTM databases

    PhosphoSiteiQ6P6Q2.

    Expressioni

    Tissue specificityi

    Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication

    Gene expression databases

    GenevestigatoriQ6P6Q2.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi266785. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 163163HeadSequence AnalysisAdd
    BLAST
    Regioni164 – 473310RodSequence AnalysisAdd
    BLAST
    Regioni164 – 19936Coil 1ASequence AnalysisAdd
    BLAST
    Regioni200 – 21819Linker 1Sequence AnalysisAdd
    BLAST
    Regioni219 – 31193Coil 1BSequence AnalysisAdd
    BLAST
    Regioni312 – 33423Linker 12Sequence AnalysisAdd
    BLAST
    Regioni335 – 473139Coil 2Sequence AnalysisAdd
    BLAST
    Regioni474 – 576103TailSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 13597Gly-richSequence AnalysisAdd
    BLAST
    Compositional biasi532 – 57645Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOVERGENiHBG013015.
    KOiK07605.
    PhylomeDBiQ6P6Q2.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P6Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA    50
    YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG 100
    FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN 150
    LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ 200
    EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY 250
    KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK 300
    MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR 350
    TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK 400
    KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ 450
    ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG 500
    RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG 550
    FSSGGGSSSS VKFVSTTSSS RRSFKS 576
    Length:576
    Mass (Da):61,826
    Last modified:July 5, 2004 - v1
    Checksum:i23A1C2C47405EE3B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141G → R in AAQ20893. (PubMed:14551252)Curated
    Sequence conflicti473 – 4731E → Q in AAQ20893. (PubMed:14551252)Curated
    Sequence conflicti508 – 5081S → F in AAQ20893. (PubMed:14551252)Curated
    Sequence conflicti528 – 5281R → L in AAQ20893. (PubMed:14551252)Curated
    Sequence conflicti562 – 5621K → Q in AAQ20893. (PubMed:14551252)Curated
    Sequence conflicti575 – 5751K → N in AAQ20893. (PubMed:14551252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY342389 mRNA. Translation: AAQ20893.1.
    BC062086 mRNA. Translation: AAH62086.1.
    RefSeqiNP_899162.1. NM_183333.1.
    UniGeneiRn.129725.
    Rn.195318.

    Genome annotation databases

    GeneIDi369017.
    KEGGirno:369017.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY342389 mRNA. Translation: AAQ20893.1 .
    BC062086 mRNA. Translation: AAH62086.1 .
    RefSeqi NP_899162.1. NM_183333.1.
    UniGenei Rn.129725.
    Rn.195318.

    3D structure databases

    ProteinModelPortali Q6P6Q2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 266785. 1 interaction.

    PTM databases

    PhosphoSitei Q6P6Q2.

    Proteomic databases

    PRIDEi Q6P6Q2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 369017.
    KEGGi rno:369017.

    Organism-specific databases

    CTDi 3852.
    RGDi 727894. Krt5.

    Phylogenomic databases

    HOVERGENi HBG013015.
    KOi K07605.
    PhylomeDBi Q6P6Q2.

    Miscellaneous databases

    NextBioi 692068.

    Gene expression databases

    Genevestigatori Q6P6Q2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head."
      Kierszenbaum A.L., Rivkin E., Tres L.L.
      Mol. Biol. Cell 14:4628-4640(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-DawleyImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiK2C5_RAT
    AccessioniPrimary (citable) accession number: Q6P6Q2
    Secondary accession number(s): Q7TN97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3