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Q6P6Q2 (K2C5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name=CK-5
Keratin-5
Short name=K5
Type-II keratin Kb5
Gene names
Name:Krt5
Synonyms:Krt2-5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP By similarity. UniProtKB P13647

Tissue specificity

Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes). Ref.1

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from direct assay Ref.1. Source: RGD

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Keratin, type II cytoskeletal 5
PRO_0000063729

Regions

Region1 – 163163Head
Region164 – 473310Rod
Region164 – 19936Coil 1A
Region200 – 21819Linker 1
Region219 – 31193Coil 1B
Region312 – 33423Linker 12
Region335 – 473139Coil 2
Region474 – 576103Tail
Compositional bias39 – 13597Gly-rich
Compositional bias532 – 57645Ser-rich

Sites

Site4131Stutter

Experimental info

Sequence conflict1141G → R in AAQ20893. Ref.1
Sequence conflict4731E → Q in AAQ20893. Ref.1
Sequence conflict5081S → F in AAQ20893. Ref.1
Sequence conflict5281R → L in AAQ20893. Ref.1
Sequence conflict5621K → Q in AAQ20893. Ref.1
Sequence conflict5751K → N in AAQ20893. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P6Q2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 23A1C2C47405EE3B

FASTA57661,826
        10         20         30         40         50         60 
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA YGAGGYGSRS 

        70         80         90        100        110        120 
LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG FGFGGGAGSG FGFGGGAGFG 

       130        140        150        160        170        180 
GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN LQIDPTIQRV RTEEREQIKT LNNKFASFID 

       190        200        210        220        230        240 
KVRFLEQQNK VLDTKWTLLQ EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL 

       250        260        270        280        290        300 
RNMQDLVEDY KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK 

       310        320        330        340        350        360 
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR TEAESWYQTK 

       370        380        390        400        410        420 
YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK KQCANLQNAI AEAEQRGELA 

       430        440        450        460        470        480 
LKDARNKLTE LEEALQKAKQ DMARLLREYQ ELMNTKLALD VEIATYRKLL EGEECRLSGE 

       490        500        510        520        530        540 
GVGPVNISVV TNSLSSGYGG RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG 

       550        560        570 
FSASSGQGGG FSSGGGSSSS VKFVSTTSSS RRSFKS 

« Hide

References

« Hide 'large scale' references
[1]"Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head."
Kierszenbaum A.L., Rivkin E., Tres L.L.
Mol. Biol. Cell 14:4628-4640(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY342389 mRNA. Translation: AAQ20893.1.
BC062086 mRNA. Translation: AAH62086.1.
RefSeqNP_899162.1. NM_183333.1.
UniGeneRn.129725.
Rn.195318.

3D structure databases

ProteinModelPortalQ6P6Q2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid266785. 1 interaction.

PTM databases

PhosphoSiteQ6P6Q2.

Proteomic databases

PRIDEQ6P6Q2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID369017.
KEGGrno:369017.

Organism-specific databases

CTD3852.
RGD727894. Krt5.

Phylogenomic databases

HOVERGENHBG013015.
KOK07605.
PhylomeDBQ6P6Q2.

Gene expression databases

GenevestigatorQ6P6Q2.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio692068.

Entry information

Entry nameK2C5_RAT
AccessionPrimary (citable) accession number: Q6P6Q2
Secondary accession number(s): Q7TN97
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families