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Q6P6Q2

- K2C5_RAT

UniProt

Q6P6Q2 - K2C5_RAT

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Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei413 – 4131StutterSequence Analysis

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:Krt5By similarity
Synonyms:Krt2-5Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi727894. Krt5.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Keratin, type II cytoskeletal 5PRO_0000063729Add
BLAST

Proteomic databases

PRIDEiQ6P6Q2.

PTM databases

PhosphoSiteiQ6P6Q2.

Expressioni

Tissue specificityi

Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication

Gene expression databases

GenevestigatoriQ6P6Q2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity).By similarity

Protein-protein interaction databases

BioGridi266785. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6P6Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 163163HeadSequence AnalysisAdd
BLAST
Regioni164 – 473310RodSequence AnalysisAdd
BLAST
Regioni164 – 19936Coil 1ASequence AnalysisAdd
BLAST
Regioni200 – 21819Linker 1Sequence AnalysisAdd
BLAST
Regioni219 – 31193Coil 1BSequence AnalysisAdd
BLAST
Regioni312 – 33423Linker 12Sequence AnalysisAdd
BLAST
Regioni335 – 473139Coil 2Sequence AnalysisAdd
BLAST
Regioni474 – 576103TailSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 13597Gly-richSequence AnalysisAdd
BLAST
Compositional biasi532 – 57645Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiQ6P6Q2.
KOiK07605.
PhylomeDBiQ6P6Q2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA
60 70 80 90 100
YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG
110 120 130 140 150
FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN
160 170 180 190 200
LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ
210 220 230 240 250
EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY
260 270 280 290 300
KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK
310 320 330 340 350
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR
360 370 380 390 400
TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK
410 420 430 440 450
KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ
460 470 480 490 500
ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG
510 520 530 540 550
RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG
560 570
FSSGGGSSSS VKFVSTTSSS RRSFKS
Length:576
Mass (Da):61,826
Last modified:July 5, 2004 - v1
Checksum:i23A1C2C47405EE3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141G → R in AAQ20893. (PubMed:14551252)Curated
Sequence conflicti473 – 4731E → Q in AAQ20893. (PubMed:14551252)Curated
Sequence conflicti508 – 5081S → F in AAQ20893. (PubMed:14551252)Curated
Sequence conflicti528 – 5281R → L in AAQ20893. (PubMed:14551252)Curated
Sequence conflicti562 – 5621K → Q in AAQ20893. (PubMed:14551252)Curated
Sequence conflicti575 – 5751K → N in AAQ20893. (PubMed:14551252)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY342389 mRNA. Translation: AAQ20893.1.
BC062086 mRNA. Translation: AAH62086.1.
RefSeqiNP_899162.1. NM_183333.1.
UniGeneiRn.129725.
Rn.195318.

Genome annotation databases

GeneIDi369017.
KEGGirno:369017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY342389 mRNA. Translation: AAQ20893.1 .
BC062086 mRNA. Translation: AAH62086.1 .
RefSeqi NP_899162.1. NM_183333.1.
UniGenei Rn.129725.
Rn.195318.

3D structure databases

ProteinModelPortali Q6P6Q2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 266785. 1 interaction.

PTM databases

PhosphoSitei Q6P6Q2.

Proteomic databases

PRIDEi Q6P6Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 369017.
KEGGi rno:369017.

Organism-specific databases

CTDi 3852.
RGDi 727894. Krt5.

Phylogenomic databases

HOVERGENi HBG013015.
InParanoidi Q6P6Q2.
KOi K07605.
PhylomeDBi Q6P6Q2.

Miscellaneous databases

NextBioi 692068.

Gene expression databases

Genevestigatori Q6P6Q2.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head."
    Kierszenbaum A.L., Rivkin E., Tres L.L.
    Mol. Biol. Cell 14:4628-4640(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiK2C5_RAT
AccessioniPrimary (citable) accession number: Q6P6Q2
Secondary accession number(s): Q7TN97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3