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Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei413StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:Krt5By similarity
Synonyms:Krt2-5Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727894. Krt5.

Subcellular locationi

GO - Cellular componenti

  • keratin filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637291 – 576Keratin, type II cytoskeletal 5Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Cross-linki272Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6P6Q2.
PRIDEiQ6P6Q2.

PTM databases

iPTMnetiQ6P6Q2.
PhosphoSitePlusiQ6P6Q2.

Expressioni

Tissue specificityi

Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity). Interacts with KEPPK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi266785. 1 interactor.
STRINGi10116.ENSRNOP00000011644.

Structurei

3D structure databases

ProteinModelPortaliQ6P6Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 163HeadSequence analysisAdd BLAST163
Regioni164 – 473RodSequence analysisAdd BLAST310
Regioni164 – 199Coil 1ASequence analysisAdd BLAST36
Regioni200 – 218Linker 1Sequence analysisAdd BLAST19
Regioni219 – 311Coil 1BSequence analysisAdd BLAST93
Regioni312 – 334Linker 12Sequence analysisAdd BLAST23
Regioni335 – 473Coil 2Sequence analysisAdd BLAST139
Regioni474 – 576TailSequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 135Gly-richSequence analysisAdd BLAST97
Compositional biasi532 – 576Ser-richSequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiQ6P6Q2.
KOiK07605.
PhylomeDBiQ6P6Q2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA
60 70 80 90 100
YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG
110 120 130 140 150
FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN
160 170 180 190 200
LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ
210 220 230 240 250
EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY
260 270 280 290 300
KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK
310 320 330 340 350
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR
360 370 380 390 400
TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK
410 420 430 440 450
KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ
460 470 480 490 500
ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG
510 520 530 540 550
RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG
560 570
FSSGGGSSSS VKFVSTTSSS RRSFKS
Length:576
Mass (Da):61,826
Last modified:July 5, 2004 - v1
Checksum:i23A1C2C47405EE3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114G → R in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti473E → Q in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti508S → F in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti528R → L in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti562K → Q in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti575K → N in AAQ20893 (PubMed:14551252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY342389 mRNA. Translation: AAQ20893.1.
BC062086 mRNA. Translation: AAH62086.1.
RefSeqiNP_899162.1. NM_183333.1.
UniGeneiRn.129725.
Rn.195318.

Genome annotation databases

GeneIDi369017.
KEGGirno:369017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY342389 mRNA. Translation: AAQ20893.1.
BC062086 mRNA. Translation: AAH62086.1.
RefSeqiNP_899162.1. NM_183333.1.
UniGeneiRn.129725.
Rn.195318.

3D structure databases

ProteinModelPortaliQ6P6Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi266785. 1 interactor.
STRINGi10116.ENSRNOP00000011644.

PTM databases

iPTMnetiQ6P6Q2.
PhosphoSitePlusiQ6P6Q2.

Proteomic databases

PaxDbiQ6P6Q2.
PRIDEiQ6P6Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi369017.
KEGGirno:369017.

Organism-specific databases

CTDi3852.
RGDi727894. Krt5.

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiQ6P6Q2.
KOiK07605.
PhylomeDBiQ6P6Q2.

Miscellaneous databases

PROiQ6P6Q2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C5_RAT
AccessioniPrimary (citable) accession number: Q6P6Q2
Secondary accession number(s): Q7TN97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.