Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Poly [ADP-ribose] polymerase 6

Gene

Parp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 6 (EC:2.4.2.30)
Short name:
PARP-6
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name:
ARTD17
Gene namesi
Name:Parp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914537. Parp6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Poly [ADP-ribose] polymerase 6PRO_0000252431Add
BLAST

Proteomic databases

PaxDbiQ6P6P7.
PRIDEiQ6P6P7.

PTM databases

PhosphoSiteiQ6P6P7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025237.
CleanExiMM_PARP6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026267.

Structurei

3D structure databases

ProteinModelPortaliQ6P6P7.
SMRiQ6P6P7. Positions 321-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 620227PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE5T. Eukaryota.
ENOG410ZI9J. LUCA.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ6P6P7.
KOiK15258.
PhylomeDBiQ6P6P7.

Family and domain databases

Gene3Di3.90.228.10. 2 hits.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P6P7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI
60 70 80 90 100
YSENSVSIRE YGTIDDVDLD LHINISFLDE EVSTAWKVLR TEPIVLRLRF
110 120 130 140 150
SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILCMFTSQ QWKHLSNDFL
160 170 180 190 200
KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV
210 220 230 240 250
PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS
260 270 280 290 300
PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLQVA MCRAALESPR
360 370 380 390 400
KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY
410 420 430 440 450
LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS
460 470 480 490 500
SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG
510 520 530 540 550
AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS
560 570 580 590 600
IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620 630
GQVGDANINT QDPKIQKEIM RVIGTQVYTN
Length:630
Mass (Da):71,176
Last modified:July 5, 2004 - v1
Checksum:i10DEFC627655063A
GO
Isoform 2 (identifier: Q6P6P7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-252: Missing.
     498-518: LHGAAYGKGIYLSPISSISFG → EWAKDSTGCLPRMSWSRDTTG
     519-630: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):56,496
Checksum:i88570D9CACBF6FB5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381Q → L in BAC36299 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 25220Missing in isoform 2. 1 PublicationVSP_020967Add
BLAST
Alternative sequencei498 – 51821LHGAA…SISFG → EWAKDSTGCLPRMSWSRDTT G in isoform 2. 1 PublicationVSP_020968Add
BLAST
Alternative sequencei519 – 630112Missing in isoform 2. 1 PublicationVSP_020969Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076321 mRNA. Translation: BAC36299.1.
BC062096 mRNA. Translation: AAH62096.1.
CCDSiCCDS57680.1. [Q6P6P7-1]
RefSeqiNP_001192168.1. NM_001205239.1.
UniGeneiMm.439943.

Genome annotation databases

GeneIDi67287.
KEGGimmu:67287.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076321 mRNA. Translation: BAC36299.1.
BC062096 mRNA. Translation: AAH62096.1.
CCDSiCCDS57680.1. [Q6P6P7-1]
RefSeqiNP_001192168.1. NM_001205239.1.
UniGeneiMm.439943.

3D structure databases

ProteinModelPortaliQ6P6P7.
SMRiQ6P6P7. Positions 321-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026267.

PTM databases

PhosphoSiteiQ6P6P7.

Proteomic databases

PaxDbiQ6P6P7.
PRIDEiQ6P6P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67287.
KEGGimmu:67287.

Organism-specific databases

CTDi56965.
MGIiMGI:1914537. Parp6.

Phylogenomic databases

eggNOGiENOG410IE5T. Eukaryota.
ENOG410ZI9J. LUCA.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ6P6P7.
KOiK15258.
PhylomeDBiQ6P6P7.

Miscellaneous databases

ChiTaRSiParp6. mouse.
PROiQ6P6P7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025237.
CleanExiMM_PARP6.

Family and domain databases

Gene3Di3.90.228.10. 2 hits.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARP6_MOUSE
AccessioniPrimary (citable) accession number: Q6P6P7
Secondary accession number(s): Q8BVW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.