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Protein

Poly [ADP-ribose] polymerase 6

Gene

Parp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 6 (EC:2.4.2.30)
Short name:
PARP-6
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name:
ARTD17
Gene namesi
Name:Parp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914537. Parp6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524311 – 630Poly [ADP-ribose] polymerase 6Add BLAST630

Proteomic databases

PaxDbiQ6P6P7.
PRIDEiQ6P6P7.

PTM databases

PhosphoSitePlusiQ6P6P7.

Expressioni

Gene expression databases

CleanExiMM_PARP6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026267.

Structurei

3D structure databases

ProteinModelPortaliQ6P6P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 620PARP catalyticPROSITE-ProRule annotationAdd BLAST227

Phylogenomic databases

eggNOGiENOG410IE5T. Eukaryota.
ENOG410ZI9J. LUCA.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ6P6P7.
KOiK15258.
PhylomeDBiQ6P6P7.

Family and domain databases

InterProiView protein in InterPro
IPR012317. Poly(ADP-ribose)pol_cat_dom.
PfamiView protein in Pfam
PF00644. PARP. 1 hit.
PROSITEiView protein in PROSITE
PS51059. PARP_CATALYTIC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P6P7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI
60 70 80 90 100
YSENSVSIRE YGTIDDVDLD LHINISFLDE EVSTAWKVLR TEPIVLRLRF
110 120 130 140 150
SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILCMFTSQ QWKHLSNDFL
160 170 180 190 200
KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV
210 220 230 240 250
PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS
260 270 280 290 300
PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLQVA MCRAALESPR
360 370 380 390 400
KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY
410 420 430 440 450
LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS
460 470 480 490 500
SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG
510 520 530 540 550
AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS
560 570 580 590 600
IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620 630
GQVGDANINT QDPKIQKEIM RVIGTQVYTN
Length:630
Mass (Da):71,176
Last modified:July 5, 2004 - v1
Checksum:i10DEFC627655063A
GO
Isoform 2 (identifier: Q6P6P7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-252: Missing.
     498-518: LHGAAYGKGIYLSPISSISFG → EWAKDSTGCLPRMSWSRDTTG
     519-630: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):56,496
Checksum:i88570D9CACBF6FB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338Q → L in BAC36299 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020967233 – 252Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_020968498 – 518LHGAA…SISFG → EWAKDSTGCLPRMSWSRDTT G in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_020969519 – 630Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076321 mRNA. Translation: BAC36299.1.
BC062096 mRNA. Translation: AAH62096.1.
CCDSiCCDS57680.1. [Q6P6P7-1]
RefSeqiNP_001192168.1. NM_001205239.1.
UniGeneiMm.439943.

Genome annotation databases

GeneIDi67287.
KEGGimmu:67287.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPARP6_MOUSE
AccessioniPrimary (citable) accession number: Q6P6P7
Secondary accession number(s): Q8BVW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot