Q6P6P7 (PARP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 6
Short name=PARP-6
EC=2.4.2.30

Gene names

Name:

Parp6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 PARP catalytic domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P6P7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P6P7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     233-252: Missing.
     498-518: LHGAAYGKGIYLSPISSISFG → EWAKDSTGCLPRMSWSRDTTG
     519-630: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Poly [ADP-ribose] polymerase 6		PRO_0000252431
Regions
	Domain	394 – 620	227	PARP catalytic
Natural variations
	Alternative sequence	233 – 252	20	Missing in isoform 2.		VSP_020967
	Alternative sequence	498 – 518	21	LHGAA…SISFG → EWAKDSTGCLPRMSWSRDTT G in isoform 2.		VSP_020968
	Alternative sequence	519 – 630	112	Missing in isoform 2.		VSP_020969
Experimental info
	Sequence conflict	338	1	Q → L in BAC36299. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 10DEFC627655063A	FASTA	630	71,176
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDLD LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILCMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH 250 260 270 280 290 300 VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 310 320 330 340 350 360 LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLQVA MCRAALESPR KSIIFEPYPS 370 380 390 400 410 420 VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW 430 440 450 460 470 480 IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW 490 500 510 520 530 540 HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN 550 560 570 580 590 600 RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED 610 620 630 GQVGDANINT QDPKIQKEIM RVIGTQVYTN
	Isoform 2 [UniParc]. Checksum: 88570D9CACBF6FB5	FASTA	498	56,496
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDLD LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILCMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQVSGHCKNI 250 260 270 280 290 300 PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM LKPAVCTREL CVFSFYTLGV 310 320 330 340 350 360 MSGAAEEVAT GAEVVDLQVA MCRAALESPR KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE 370 380 390 400 410 420 RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM 430 440 450 460 470 480 HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQEWA 490 KDSTGCLPRM SWSRDTTG

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK076321 mRNA. Translation: BAC36299.1. BC062096 mRNA. Translation: AAH62096.1.
IPI	IPI00669185. IPI00671644.
RefSeq	NP_001192168.1. NM_001205239.1.
UniGene	Mm.439943.
3D structure databases
ProteinModelPortal	Q6P6P7.
SMR	Q6P6P7. Positions 452-524.
ModBase	Search...
Proteomic databases
PRIDE	Q6P6P7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050483; ENSMUSP00000063065; ENSMUSG00000025237.
GeneID	67287.
KEGG	mmu:67287.
UCSC	uc009pyb.1. mouse.
Organism-specific databases
CTD	56965.
MGI	MGI:1914537. Parp6.
Phylogenomic databases
GeneTree	ENSGT00390000017707.
HOGENOM	HBG445795.
HOVERGEN	HBG057572.
InParanoid	Q6P6P7.
OrthoDB	EOG4DBTD8.
Gene expression databases
ArrayExpress	Q6P6P7.
Bgee	Q6P6P7.
CleanEx	MM_PARP6.
Genevestigator	Q6P6P7.
GermOnline	ENSMUSG00000025237. Mus musculus.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
KO	K15258.
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PARP6_MOUSE

Accession

Primary (citable) accession number: Q6P6P7
Secondary accession number(s): Q8BVW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program