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Q6P6N5

- SPRE3_MOUSE

UniProt

Q6P6N5 - SPRE3_MOUSE

Protein

Sprouty-related, EVH1 domain-containing protein 3

Gene

Spred3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

    GO - Biological processi

    1. inactivation of MAPK activity Source: MGI
    2. multicellular organismal development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Short name:
    Spred-3
    Gene namesi
    Name:Spred3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2142186. Spred3.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Sprouty-related, EVH1 domain-containing protein 3PRO_0000076914Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6P6N5.
    PRIDEiQ6P6N5.

    PTM databases

    PhosphoSiteiQ6P6N5.

    Expressioni

    Tissue specificityi

    Brain specific.1 Publication

    Gene expression databases

    BgeeiQ6P6N5.
    CleanExiMM_SPRED3.
    GenevestigatoriQ6P6N5.

    Interactioni

    Subunit structurei

    Interacts with Ras.By similarity

    Protein-protein interaction databases

    IntActiQ6P6N5. 1 interaction.
    MINTiMINT-4997475.
    STRINGi10090.ENSMUSP00000046216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P6N5.
    SMRiQ6P6N5. Positions 3-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 24251KBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 405112SPRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi121 – 13010Poly-Ser
    Compositional biasi146 – 1538Poly-Ser
    Compositional biasi225 – 2295Poly-Pro

    Sequence similaritiesi

    Contains 1 KBD domain.PROSITE-ProRule annotation
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG297893.
    GeneTreeiENSGT00730000110272.
    HOGENOMiHOG000220886.
    HOVERGENiHBG057556.
    InParanoidiQ6P6N5.
    KOiK04703.
    OrthoDBiEOG7T7GV7.
    PhylomeDBiQ6P6N5.
    TreeFamiTF321411.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P6N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI    50
    HGERLRDQKT TLECTLRPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD 100
    EFQKSLLAAL AALSRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS 150
    SHSRQETPPT APIATVESAA AFPLATRPQR RRSSAQSYPP LLPFTGIPEP 200
    SESLAGAGSQ GWGSRGYEDY RRSGPPPPPL ALSTCVVRFA KTGALRGAAL 250
    GPPVSLPAPL TEAAPPAPPA RPPPGPGPTP APAKASPEAE EAARCVHCRA 300
    LFRRRADGRG GRCAEAPDPG RLLVRRLSCL WCAESLLYHC LSDAEGDFSD 350
    PCACEPGHPR PAARWAALAA LSLAVPCLCC YAPLRACHWV AARCGCAGCG 400
    GRHEEAAR 408
    Length:408
    Mass (Da):42,794
    Last modified:July 5, 2004 - v1
    Checksum:i2EFCD3BAF01325B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771R → P in BAC80222. (PubMed:12646235)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB115762 mRNA. Translation: BAC80222.1.
    BC062119 mRNA. Translation: AAH62119.1.
    CCDSiCCDS21065.1.
    RefSeqiNP_891557.3. NM_182927.3.
    XP_006539516.1. XM_006539453.1.
    XP_006539517.1. XM_006539454.1.
    XP_006539518.1. XM_006539455.1.
    XP_006539519.1. XM_006539456.1.
    UniGeneiMm.377262.

    Genome annotation databases

    EnsembliENSMUST00000048923; ENSMUSP00000046216; ENSMUSG00000037239.
    GeneIDi101809.
    KEGGimmu:101809.
    UCSCiuc009gax.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB115762 mRNA. Translation: BAC80222.1 .
    BC062119 mRNA. Translation: AAH62119.1 .
    CCDSi CCDS21065.1.
    RefSeqi NP_891557.3. NM_182927.3.
    XP_006539516.1. XM_006539453.1.
    XP_006539517.1. XM_006539454.1.
    XP_006539518.1. XM_006539455.1.
    XP_006539519.1. XM_006539456.1.
    UniGenei Mm.377262.

    3D structure databases

    ProteinModelPortali Q6P6N5.
    SMRi Q6P6N5. Positions 3-116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P6N5. 1 interaction.
    MINTi MINT-4997475.
    STRINGi 10090.ENSMUSP00000046216.

    PTM databases

    PhosphoSitei Q6P6N5.

    Proteomic databases

    PaxDbi Q6P6N5.
    PRIDEi Q6P6N5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048923 ; ENSMUSP00000046216 ; ENSMUSG00000037239 .
    GeneIDi 101809.
    KEGGi mmu:101809.
    UCSCi uc009gax.1. mouse.

    Organism-specific databases

    CTDi 399473.
    MGIi MGI:2142186. Spred3.

    Phylogenomic databases

    eggNOGi NOG297893.
    GeneTreei ENSGT00730000110272.
    HOGENOMi HOG000220886.
    HOVERGENi HBG057556.
    InParanoidi Q6P6N5.
    KOi K04703.
    OrthoDBi EOG7T7GV7.
    PhylomeDBi Q6P6N5.
    TreeFami TF321411.

    Miscellaneous databases

    NextBioi 355128.
    PROi Q6P6N5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P6N5.
    CleanExi MM_SPRED3.
    Genevestigatori Q6P6N5.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation."
      Kato R., Nonami A., Taketomi T., Wakioka T., Kuroiwa A., Matsuda Y., Yoshimura A.
      Biochem. Biophys. Res. Commun. 302:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiSPRE3_MOUSE
    AccessioniPrimary (citable) accession number: Q6P6N5
    Secondary accession number(s): Q7TNJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3