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Q6P6N5

- SPRE3_MOUSE

UniProt

Q6P6N5 - SPRE3_MOUSE

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Protein

Sprouty-related, EVH1 domain-containing protein 3

Gene

Spred3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

GO - Biological processi

  1. inactivation of MAPK activity Source: MGI
  2. multicellular organismal development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 3
Short name:
Spred-3
Gene namesi
Name:Spred3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2142186. Spred3.

Subcellular locationi

Membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Sprouty-related, EVH1 domain-containing protein 3PRO_0000076914Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P6N5.
PaxDbiQ6P6N5.
PRIDEiQ6P6N5.

PTM databases

PhosphoSiteiQ6P6N5.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiQ6P6N5.
CleanExiMM_SPRED3.
GenevestigatoriQ6P6N5.

Interactioni

Subunit structurei

Interacts with Ras.By similarity

Protein-protein interaction databases

IntActiQ6P6N5. 1 interaction.
MINTiMINT-4997475.
STRINGi10090.ENSMUSP00000046216.

Structurei

3D structure databases

ProteinModelPortaliQ6P6N5.
SMRiQ6P6N5. Positions 3-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 24251KBDPROSITE-ProRule annotationAdd
BLAST
Domaini294 – 405112SPRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi121 – 13010Poly-Ser
Compositional biasi146 – 1538Poly-Ser
Compositional biasi225 – 2295Poly-Pro

Sequence similaritiesi

Contains 1 KBD domain.PROSITE-ProRule annotation
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
Contains 1 WH1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG297893.
GeneTreeiENSGT00730000110272.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ6P6N5.
KOiK04703.
OrthoDBiEOG7T7GV7.
PhylomeDBiQ6P6N5.
TreeFamiTF321411.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P6N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI
60 70 80 90 100
HGERLRDQKT TLECTLRPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD
110 120 130 140 150
EFQKSLLAAL AALSRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS
160 170 180 190 200
SHSRQETPPT APIATVESAA AFPLATRPQR RRSSAQSYPP LLPFTGIPEP
210 220 230 240 250
SESLAGAGSQ GWGSRGYEDY RRSGPPPPPL ALSTCVVRFA KTGALRGAAL
260 270 280 290 300
GPPVSLPAPL TEAAPPAPPA RPPPGPGPTP APAKASPEAE EAARCVHCRA
310 320 330 340 350
LFRRRADGRG GRCAEAPDPG RLLVRRLSCL WCAESLLYHC LSDAEGDFSD
360 370 380 390 400
PCACEPGHPR PAARWAALAA LSLAVPCLCC YAPLRACHWV AARCGCAGCG

GRHEEAAR
Length:408
Mass (Da):42,794
Last modified:July 5, 2004 - v1
Checksum:i2EFCD3BAF01325B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771R → P in BAC80222. (PubMed:12646235)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115762 mRNA. Translation: BAC80222.1.
BC062119 mRNA. Translation: AAH62119.1.
CCDSiCCDS21065.1.
RefSeqiNP_891557.3. NM_182927.3.
XP_006539516.1. XM_006539453.1.
XP_006539517.1. XM_006539454.1.
XP_006539518.1. XM_006539455.1.
XP_006539519.1. XM_006539456.1.
UniGeneiMm.377262.

Genome annotation databases

EnsembliENSMUST00000048923; ENSMUSP00000046216; ENSMUSG00000037239.
GeneIDi101809.
KEGGimmu:101809.
UCSCiuc009gax.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115762 mRNA. Translation: BAC80222.1 .
BC062119 mRNA. Translation: AAH62119.1 .
CCDSi CCDS21065.1.
RefSeqi NP_891557.3. NM_182927.3.
XP_006539516.1. XM_006539453.1.
XP_006539517.1. XM_006539454.1.
XP_006539518.1. XM_006539455.1.
XP_006539519.1. XM_006539456.1.
UniGenei Mm.377262.

3D structure databases

ProteinModelPortali Q6P6N5.
SMRi Q6P6N5. Positions 3-116.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6P6N5. 1 interaction.
MINTi MINT-4997475.
STRINGi 10090.ENSMUSP00000046216.

PTM databases

PhosphoSitei Q6P6N5.

Proteomic databases

MaxQBi Q6P6N5.
PaxDbi Q6P6N5.
PRIDEi Q6P6N5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048923 ; ENSMUSP00000046216 ; ENSMUSG00000037239 .
GeneIDi 101809.
KEGGi mmu:101809.
UCSCi uc009gax.1. mouse.

Organism-specific databases

CTDi 399473.
MGIi MGI:2142186. Spred3.

Phylogenomic databases

eggNOGi NOG297893.
GeneTreei ENSGT00730000110272.
HOGENOMi HOG000220886.
HOVERGENi HBG057556.
InParanoidi Q6P6N5.
KOi K04703.
OrthoDBi EOG7T7GV7.
PhylomeDBi Q6P6N5.
TreeFami TF321411.

Miscellaneous databases

NextBioi 355128.
PROi Q6P6N5.
SOURCEi Search...

Gene expression databases

Bgeei Q6P6N5.
CleanExi MM_SPRED3.
Genevestigatori Q6P6N5.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view ]
PROSITEi PS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation."
    Kato R., Nonami A., Taketomi T., Wakioka T., Kuroiwa A., Matsuda Y., Yoshimura A.
    Biochem. Biophys. Res. Commun. 302:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiSPRE3_MOUSE
AccessioniPrimary (citable) accession number: Q6P6N5
Secondary accession number(s): Q7TNJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3