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Q6P6N5 (SPRE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sprouty-related, EVH1 domain-containing protein 3

Short name=Spred-3
Gene names
Name:Spred3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Subunit structure

Interacts with Ras By similarity.

Subcellular location

Membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Brain specific. Ref.1

Post-translational modification

Phosphorylated on tyrosine By similarity.

Sequence similarities

Contains 1 KBD domain.

Contains 1 SPR (sprouty) domain.

Contains 1 WH1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Sprouty-related, EVH1 domain-containing protein 3
PRO_0000076914

Regions

Domain1 – 113113WH1
Domain192 – 24251KBD
Domain294 – 405112SPR
Compositional bias121 – 13010Poly-Ser
Compositional bias146 – 1538Poly-Ser
Compositional bias225 – 2295Poly-Pro

Experimental info

Sequence conflict1771R → P in BAC80222. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P6N5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2EFCD3BAF01325B6

FASTA40842,794
        10         20         30         40         50         60 
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI HGERLRDQKT 

        70         80         90        100        110        120 
TLECTLRPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD EFQKSLLAAL AALSRGSLTP 

       130        140        150        160        170        180 
SSSSSSSSPS QDTAETPCPL TSHVDSDSSS SHSRQETPPT APIATVESAA AFPLATRPQR 

       190        200        210        220        230        240 
RRSSAQSYPP LLPFTGIPEP SESLAGAGSQ GWGSRGYEDY RRSGPPPPPL ALSTCVVRFA 

       250        260        270        280        290        300 
KTGALRGAAL GPPVSLPAPL TEAAPPAPPA RPPPGPGPTP APAKASPEAE EAARCVHCRA 

       310        320        330        340        350        360 
LFRRRADGRG GRCAEAPDPG RLLVRRLSCL WCAESLLYHC LSDAEGDFSD PCACEPGHPR 

       370        380        390        400 
PAARWAALAA LSLAVPCLCC YAPLRACHWV AARCGCAGCG GRHEEAAR 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation."
Kato R., Nonami A., Taketomi T., Wakioka T., Kuroiwa A., Matsuda Y., Yoshimura A.
Biochem. Biophys. Res. Commun. 302:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB115762 mRNA. Translation: BAC80222.1.
BC062119 mRNA. Translation: AAH62119.1.
CCDSCCDS21065.1.
RefSeqNP_891557.3. NM_182927.3.
XP_006539516.1. XM_006539453.1.
XP_006539517.1. XM_006539454.1.
XP_006539518.1. XM_006539455.1.
XP_006539519.1. XM_006539456.1.
UniGeneMm.377262.

3D structure databases

ProteinModelPortalQ6P6N5.
SMRQ6P6N5. Positions 3-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6P6N5. 1 interaction.
MINTMINT-4997475.
STRING10090.ENSMUSP00000046216.

PTM databases

PhosphoSiteQ6P6N5.

Proteomic databases

PaxDbQ6P6N5.
PRIDEQ6P6N5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048923; ENSMUSP00000046216; ENSMUSG00000037239.
GeneID101809.
KEGGmmu:101809.
UCSCuc009gax.1. mouse.

Organism-specific databases

CTD399473.
MGIMGI:2142186. Spred3.

Phylogenomic databases

eggNOGNOG297893.
GeneTreeENSGT00730000110272.
HOGENOMHOG000220886.
HOVERGENHBG057556.
InParanoidQ6P6N5.
KOK04703.
OrthoDBEOG7T7GV7.
PhylomeDBQ6P6N5.
TreeFamTF321411.

Gene expression databases

BgeeQ6P6N5.
CleanExMM_SPRED3.
GenevestigatorQ6P6N5.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio355128.
PROQ6P6N5.
SOURCESearch...

Entry information

Entry nameSPRE3_MOUSE
AccessionPrimary (citable) accession number: Q6P6N5
Secondary accession number(s): Q7TNJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot