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Protein

Ankyrin repeat domain-containing protein 16

Gene

ANKRD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 16
Gene namesi
Name:ANKRD16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23471. ANKRD16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916467.

Polymorphism and mutation databases

BioMutaiANKRD16.
DMDMi74749136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Ankyrin repeat domain-containing protein 16PRO_0000240831Add
BLAST

Proteomic databases

EPDiQ6P6B7.
MaxQBiQ6P6B7.
PaxDbiQ6P6B7.
PeptideAtlasiQ6P6B7.
PRIDEiQ6P6B7.

PTM databases

iPTMnetiQ6P6B7.
PhosphoSiteiQ6P6B7.

Expressioni

Gene expression databases

BgeeiQ6P6B7.
CleanExiHS_ANKRD16.
GenevisibleiQ6P6B7. HS.

Organism-specific databases

HPAiHPA037920.
HPA037921.

Interactioni

Protein-protein interaction databases

BioGridi120015. 2 interactions.
IntActiQ6P6B7. 2 interactions.
STRINGi9606.ENSP00000369434.

Structurei

3D structure databases

ProteinModelPortaliQ6P6B7.
SMRiQ6P6B7. Positions 10-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6631ANK 1Add
BLAST
Repeati70 – 9930ANK 2Add
BLAST
Repeati103 – 13230ANK 3Add
BLAST
Repeati136 – 16530ANK 4Add
BLAST
Repeati170 – 20031ANK 5Add
BLAST
Repeati204 – 23431ANK 6Add
BLAST
Repeati238 – 26831ANK 7Add
BLAST
Repeati273 – 30230ANK 8Add
BLAST
Repeati306 – 33530ANK 9Add
BLAST

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiQ6P6B7.
OMAiHMACIGQ.
OrthoDBiEOG7N63NG.
PhylomeDBiQ6P6B7.
TreeFamiTF329520.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P6B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPGDPRRL CRLVQEGRLR ALKEELQAAG GCPGPAGDTL LHCAARHGHR
60 70 80 90 100
DVLAYLAEAW GMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAAVDCL
110 120 130 140 150
KKADWTPLMM ACTRKNLGVI QELVEHGANP LLKNKDGWNS FHIASREGDP
160 170 180 190 200
LILQYLLTVC PGAWKTESKI RRTPLHTAAM HGHLEAVKVL LKRCQYEPDY
210 220 230 240 250
RDNCGVTALM DAIQCGHIDV ARLLLDEHGA CLSAEDSLGA QALHRAAVTG
260 270 280 290 300
QDEAIRFLVS ELGVDVDVRA TSTHLTALHY AAKEGHTSTI QTLLSLGADI
310 320 330 340 350
NSKDEKNRSA LHLACAGQHL ACAKFLLQSG LKDSEDITGT LAQQLPRRAD
360
VLQGSGHSAM T
Length:361
Mass (Da):39,284
Last modified:July 5, 2004 - v1
Checksum:i825E2D6EC6225F06
GO
Isoform 2 (identifier: Q6P6B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-304: EGHTSTIQTLLSLGADINSKD → PCIWPVQVSTWPVPSFSCSRD
     305-361: Missing.

Note: Gene prediction based on EST data.
Show »
Length:304
Mass (Da):33,447
Checksum:iA9F81EA09B142130
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281A → G.
Corresponds to variant rs2296136 [ dbSNP | Ensembl ].
VAR_033503
Natural varianti353 – 3531Q → R.1 Publication
Corresponds to variant rs1052420 [ dbSNP | Ensembl ].
VAR_026832

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 30421EGHTS…INSKD → PCIWPVQVSTWPVPSFSCSR D in isoform 2. CuratedVSP_047046Add
BLAST
Alternative sequencei305 – 36157Missing in isoform 2. CuratedVSP_047047Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. Translation: CAI41072.1.
AL596094 Genomic DNA. No translation available.
BC062346 mRNA. Translation: AAH62346.1.
AL137614 mRNA. Translation: CAB70843.1.
CCDSiCCDS31136.1. [Q6P6B7-1]
CCDS31137.1. [Q6P6B7-2]
PIRiT46316.
RefSeqiNP_001009941.1. NM_001009941.2. [Q6P6B7-1]
NP_001009943.1. NM_001009943.2. [Q6P6B7-2]
NP_061919.1. NM_019046.2. [Q6P6B7-1]
UniGeneiHs.289828.

Genome annotation databases

EnsembliENST00000191063; ENSP00000352361; ENSG00000134461. [Q6P6B7-2]
ENST00000380092; ENSP00000369434; ENSG00000134461. [Q6P6B7-1]
ENST00000380094; ENSP00000369436; ENSG00000134461. [Q6P6B7-1]
GeneIDi54522.
KEGGihsa:54522.
UCSCiuc001iiq.4. human. [Q6P6B7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. Translation: CAI41072.1.
AL596094 Genomic DNA. No translation available.
BC062346 mRNA. Translation: AAH62346.1.
AL137614 mRNA. Translation: CAB70843.1.
CCDSiCCDS31136.1. [Q6P6B7-1]
CCDS31137.1. [Q6P6B7-2]
PIRiT46316.
RefSeqiNP_001009941.1. NM_001009941.2. [Q6P6B7-1]
NP_001009943.1. NM_001009943.2. [Q6P6B7-2]
NP_061919.1. NM_019046.2. [Q6P6B7-1]
UniGeneiHs.289828.

3D structure databases

ProteinModelPortaliQ6P6B7.
SMRiQ6P6B7. Positions 10-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120015. 2 interactions.
IntActiQ6P6B7. 2 interactions.
STRINGi9606.ENSP00000369434.

PTM databases

iPTMnetiQ6P6B7.
PhosphoSiteiQ6P6B7.

Polymorphism and mutation databases

BioMutaiANKRD16.
DMDMi74749136.

Proteomic databases

EPDiQ6P6B7.
MaxQBiQ6P6B7.
PaxDbiQ6P6B7.
PeptideAtlasiQ6P6B7.
PRIDEiQ6P6B7.

Protocols and materials databases

DNASUi54522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000191063; ENSP00000352361; ENSG00000134461. [Q6P6B7-2]
ENST00000380092; ENSP00000369434; ENSG00000134461. [Q6P6B7-1]
ENST00000380094; ENSP00000369436; ENSG00000134461. [Q6P6B7-1]
GeneIDi54522.
KEGGihsa:54522.
UCSCiuc001iiq.4. human. [Q6P6B7-1]

Organism-specific databases

CTDi54522.
GeneCardsiANKRD16.
HGNCiHGNC:23471. ANKRD16.
HPAiHPA037920.
HPA037921.
neXtProtiNX_Q6P6B7.
PharmGKBiPA134916467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiQ6P6B7.
OMAiHMACIGQ.
OrthoDBiEOG7N63NG.
PhylomeDBiQ6P6B7.
TreeFamiTF329520.

Miscellaneous databases

GenomeRNAii54522.
PROiQ6P6B7.

Gene expression databases

BgeeiQ6P6B7.
CleanExiHS_ANKRD16.
GenevisibleiQ6P6B7. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 202-361 (ISOFORM 1), VARIANT ARG-353.
    Tissue: Testis.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiANR16_HUMAN
AccessioniPrimary (citable) accession number: Q6P6B7
Secondary accession number(s): A6NEF0, F8WEI4, Q9NT01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.