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Protein

Ankyrin repeat domain-containing protein 16

Gene

ANKRD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 16
Gene namesi
Name:ANKRD16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000134461.15.
HGNCiHGNC:23471. ANKRD16.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134461.
PharmGKBiPA134916467.

Polymorphism and mutation databases

BioMutaiANKRD16.
DMDMi74749136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408311 – 361Ankyrin repeat domain-containing protein 16Add BLAST361

Proteomic databases

EPDiQ6P6B7.
MaxQBiQ6P6B7.
PaxDbiQ6P6B7.
PeptideAtlasiQ6P6B7.
PRIDEiQ6P6B7.

PTM databases

iPTMnetiQ6P6B7.
PhosphoSitePlusiQ6P6B7.

Expressioni

Gene expression databases

BgeeiENSG00000134461.
CleanExiHS_ANKRD16.
GenevisibleiQ6P6B7. HS.

Organism-specific databases

HPAiHPA037920.
HPA037921.

Interactioni

Protein-protein interaction databases

BioGridi120015. 2 interactors.
IntActiQ6P6B7. 2 interactors.
STRINGi9606.ENSP00000369434.

Structurei

3D structure databases

ProteinModelPortaliQ6P6B7.
SMRiQ6P6B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 66ANK 1Add BLAST31
Repeati70 – 99ANK 2Add BLAST30
Repeati103 – 132ANK 3Add BLAST30
Repeati136 – 165ANK 4Add BLAST30
Repeati170 – 200ANK 5Add BLAST31
Repeati204 – 234ANK 6Add BLAST31
Repeati238 – 268ANK 7Add BLAST31
Repeati273 – 302ANK 8Add BLAST30
Repeati306 – 335ANK 9Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00900000140877.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiQ6P6B7.
OMAiSCGVTPF.
OrthoDBiEOG091G0AGX.
PhylomeDBiQ6P6B7.
TreeFamiTF329520.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 4 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 9 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P6B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPGDPRRL CRLVQEGRLR ALKEELQAAG GCPGPAGDTL LHCAARHGHR
60 70 80 90 100
DVLAYLAEAW GMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAAVDCL
110 120 130 140 150
KKADWTPLMM ACTRKNLGVI QELVEHGANP LLKNKDGWNS FHIASREGDP
160 170 180 190 200
LILQYLLTVC PGAWKTESKI RRTPLHTAAM HGHLEAVKVL LKRCQYEPDY
210 220 230 240 250
RDNCGVTALM DAIQCGHIDV ARLLLDEHGA CLSAEDSLGA QALHRAAVTG
260 270 280 290 300
QDEAIRFLVS ELGVDVDVRA TSTHLTALHY AAKEGHTSTI QTLLSLGADI
310 320 330 340 350
NSKDEKNRSA LHLACAGQHL ACAKFLLQSG LKDSEDITGT LAQQLPRRAD
360
VLQGSGHSAM T
Length:361
Mass (Da):39,284
Last modified:July 5, 2004 - v1
Checksum:i825E2D6EC6225F06
GO
Isoform 2 (identifier: Q6P6B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-304: EGHTSTIQTLLSLGADINSKD → PCIWPVQVSTWPVPSFSCSRD
     305-361: Missing.

Note: Gene prediction based on EST data.
Show »
Length:304
Mass (Da):33,447
Checksum:iA9F81EA09B142130
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033503128A → G. Corresponds to variant dbSNP:rs2296136Ensembl.1
Natural variantiVAR_026832353Q → R1 PublicationCorresponds to variant dbSNP:rs1052420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047046284 – 304EGHTS…INSKD → PCIWPVQVSTWPVPSFSCSR D in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_047047305 – 361Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. No translation available.
AL596094 Genomic DNA. No translation available.
BC062346 mRNA. Translation: AAH62346.1.
AL137614 mRNA. Translation: CAB70843.1.
CCDSiCCDS31136.1. [Q6P6B7-1]
CCDS31137.1. [Q6P6B7-2]
PIRiT46316.
RefSeqiNP_001009941.1. NM_001009941.2. [Q6P6B7-1]
NP_001009943.1. NM_001009943.2. [Q6P6B7-2]
NP_061919.1. NM_019046.2. [Q6P6B7-1]
UniGeneiHs.289828.

Genome annotation databases

EnsembliENST00000191063; ENSP00000352361; ENSG00000134461. [Q6P6B7-2]
ENST00000380092; ENSP00000369434; ENSG00000134461. [Q6P6B7-1]
ENST00000380094; ENSP00000369436; ENSG00000134461. [Q6P6B7-1]
GeneIDi54522.
KEGGihsa:54522.
UCSCiuc001iiq.4. human. [Q6P6B7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANR16_HUMAN
AccessioniPrimary (citable) accession number: Q6P6B7
Secondary accession number(s): A6NEF0, F8WEI4, Q9NT01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations