Reviewed, UniProtKB/Swiss-Prot Q6P6B7 (ANR16_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 16

Gene names

Name:

ANKRD16

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 9 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Ankyrin repeat domain-containing protein 16		PRO_0000240831
Regions
	Repeat	36 – 66	31	ANK 1
	Repeat	70 – 99	30	ANK 2
	Repeat	103 – 132	30	ANK 3
	Repeat	136 – 165	30	ANK 4
	Repeat	170 – 200	31	ANK 5
	Repeat	204 – 234	31	ANK 6
	Repeat	238 – 268	31	ANK 7
	Repeat	273 – 302	30	ANK 8
	Repeat	306 – 335	30	ANK 9
Natural variations
	Natural variant	128	1	A → G: dbSNP rs2296136.		VAR_033503
	Natural variant	353	1	Q → R: dbSNP rs1052420. Ref.3		VAR_026832

Sequences

	Sequence		Length	Mass (Da)
	Q6P6B7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 825E2D6EC6225F06	FASTA	361	39,284
	10 20 30 40 50 60 MAQPGDPRRL CRLVQEGRLR ALKEELQAAG GCPGPAGDTL LHCAARHGHR DVLAYLAEAW 70 80 90 100 110 120 GMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAAVDCL KKADWTPLMM ACTRKNLGVI 130 140 150 160 170 180 QELVEHGANP LLKNKDGWNS FHIASREGDP LILQYLLTVC PGAWKTESKI RRTPLHTAAM 190 200 210 220 230 240 HGHLEAVKVL LKRCQYEPDY RDNCGVTALM DAIQCGHIDV ARLLLDEHGA CLSAEDSLGA 250 260 270 280 290 300 QALHRAAVTG QDEAIRFLVS ELGVDVDVRA TSTHLTALHY AAKEGHTSTI QTLLSLGADI 310 320 330 340 350 360 NSKDEKNRSA LHLACAGQHL ACAKFLLQSG LKDSEDITGT LAQQLPRRAD VLQGSGHSAM T

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 202-361, VARIANT ARG-353. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL137186 Genomic DNA. Translation: CAI41072.1. BC062346 mRNA. Translation: AAH62346.1. AL137614 mRNA. Translation: CAB70843.1.
IPI	IPI00418468.
PIR	T46316.
RefSeq	NP_001009941.1. NP_001009943.1. NP_061919.1.
UniGene	Hs.289828
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6P6B7.
Proteomic databases
PRIDE	Q6P6B7.
Genome annotation databases
Ensembl	ENST00000380092; ENSP00000369434; ENSG00000134461; Homo sapiens. [Genome view] ENST00000380094; ENSP00000369436; ENSG00000134461; Homo sapiens. [Genome view]
GeneID	54522.
KEGG	hsa:54522.
UCSC	uc001iin.1. human.
Organism-specific databases
CTD	54522.
GeneCards	GC10M005942.
HGNC	HGNC:23471. ANKRD16.
PharmGKB	PA134916467.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG717879.
HOVERGEN	Q6P6B7.
InParanoid	Q6P6B7.
OMA	KEGHTST.
OrthoDB	EOG9J13VH.
Gene expression databases
ArrayExpress	Q6P6B7.
Bgee	Q6P6B7.
CleanEx	HS_ANKRD16.
Genevestigator	Q6P6B7.
GermOnline	ENSG00000134461. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 2 hits.
Pfam	PF00023. Ank. 9 hits. [Graphical view]
SMART	SM00248. ANK. 9 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	56924.

Entry information

Entry name

ANR16_HUMAN

Accession

Primary (citable) accession number: Q6P6B7
Secondary accession number(s): A6NEF0, Q9NT01

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2004
Last modified:	December 15, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.