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Protein

Ankyrin repeat domain-containing protein 16

Gene

ANKRD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 16
Gene namesi
Name:ANKRD16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23471. ANKRD16.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134461.
PharmGKBiPA134916467.

Polymorphism and mutation databases

BioMutaiANKRD16.
DMDMi74749136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408311 – 361Ankyrin repeat domain-containing protein 16Add BLAST361

Proteomic databases

EPDiQ6P6B7.
MaxQBiQ6P6B7.
PaxDbiQ6P6B7.
PeptideAtlasiQ6P6B7.
PRIDEiQ6P6B7.

PTM databases

iPTMnetiQ6P6B7.
PhosphoSitePlusiQ6P6B7.

Expressioni

Gene expression databases

BgeeiENSG00000134461.
CleanExiHS_ANKRD16.
GenevisibleiQ6P6B7. HS.

Organism-specific databases

HPAiHPA037920.
HPA037921.

Interactioni

Protein-protein interaction databases

BioGridi120015. 2 interactors.
IntActiQ6P6B7. 2 interactors.
STRINGi9606.ENSP00000369434.

Structurei

3D structure databases

ProteinModelPortaliQ6P6B7.
SMRiQ6P6B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 66ANK 1Add BLAST31
Repeati70 – 99ANK 2Add BLAST30
Repeati103 – 132ANK 3Add BLAST30
Repeati136 – 165ANK 4Add BLAST30
Repeati170 – 200ANK 5Add BLAST31
Repeati204 – 234ANK 6Add BLAST31
Repeati238 – 268ANK 7Add BLAST31
Repeati273 – 302ANK 8Add BLAST30
Repeati306 – 335ANK 9Add BLAST30

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133884.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiQ6P6B7.
OMAiHMACIGQ.
OrthoDBiEOG091G0AGX.
PhylomeDBiQ6P6B7.
TreeFamiTF329520.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P6B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPGDPRRL CRLVQEGRLR ALKEELQAAG GCPGPAGDTL LHCAARHGHR
60 70 80 90 100
DVLAYLAEAW GMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAAVDCL
110 120 130 140 150
KKADWTPLMM ACTRKNLGVI QELVEHGANP LLKNKDGWNS FHIASREGDP
160 170 180 190 200
LILQYLLTVC PGAWKTESKI RRTPLHTAAM HGHLEAVKVL LKRCQYEPDY
210 220 230 240 250
RDNCGVTALM DAIQCGHIDV ARLLLDEHGA CLSAEDSLGA QALHRAAVTG
260 270 280 290 300
QDEAIRFLVS ELGVDVDVRA TSTHLTALHY AAKEGHTSTI QTLLSLGADI
310 320 330 340 350
NSKDEKNRSA LHLACAGQHL ACAKFLLQSG LKDSEDITGT LAQQLPRRAD
360
VLQGSGHSAM T
Length:361
Mass (Da):39,284
Last modified:July 5, 2004 - v1
Checksum:i825E2D6EC6225F06
GO
Isoform 2 (identifier: Q6P6B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-304: EGHTSTIQTLLSLGADINSKD → PCIWPVQVSTWPVPSFSCSRD
     305-361: Missing.

Note: Gene prediction based on EST data.
Show »
Length:304
Mass (Da):33,447
Checksum:iA9F81EA09B142130
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033503128A → G.Corresponds to variant rs2296136dbSNPEnsembl.1
Natural variantiVAR_026832353Q → R.1 PublicationCorresponds to variant rs1052420dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047046284 – 304EGHTS…INSKD → PCIWPVQVSTWPVPSFSCSR D in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_047047305 – 361Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. Translation: CAI41072.1.
AL596094 Genomic DNA. No translation available.
BC062346 mRNA. Translation: AAH62346.1.
AL137614 mRNA. Translation: CAB70843.1.
CCDSiCCDS31136.1. [Q6P6B7-1]
CCDS31137.1. [Q6P6B7-2]
PIRiT46316.
RefSeqiNP_001009941.1. NM_001009941.2. [Q6P6B7-1]
NP_001009943.1. NM_001009943.2. [Q6P6B7-2]
NP_061919.1. NM_019046.2. [Q6P6B7-1]
UniGeneiHs.289828.

Genome annotation databases

EnsembliENST00000191063; ENSP00000352361; ENSG00000134461. [Q6P6B7-2]
ENST00000380092; ENSP00000369434; ENSG00000134461. [Q6P6B7-1]
ENST00000380094; ENSP00000369436; ENSG00000134461. [Q6P6B7-1]
GeneIDi54522.
KEGGihsa:54522.
UCSCiuc001iiq.4. human. [Q6P6B7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137186 Genomic DNA. Translation: CAI41072.1.
AL596094 Genomic DNA. No translation available.
BC062346 mRNA. Translation: AAH62346.1.
AL137614 mRNA. Translation: CAB70843.1.
CCDSiCCDS31136.1. [Q6P6B7-1]
CCDS31137.1. [Q6P6B7-2]
PIRiT46316.
RefSeqiNP_001009941.1. NM_001009941.2. [Q6P6B7-1]
NP_001009943.1. NM_001009943.2. [Q6P6B7-2]
NP_061919.1. NM_019046.2. [Q6P6B7-1]
UniGeneiHs.289828.

3D structure databases

ProteinModelPortaliQ6P6B7.
SMRiQ6P6B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120015. 2 interactors.
IntActiQ6P6B7. 2 interactors.
STRINGi9606.ENSP00000369434.

PTM databases

iPTMnetiQ6P6B7.
PhosphoSitePlusiQ6P6B7.

Polymorphism and mutation databases

BioMutaiANKRD16.
DMDMi74749136.

Proteomic databases

EPDiQ6P6B7.
MaxQBiQ6P6B7.
PaxDbiQ6P6B7.
PeptideAtlasiQ6P6B7.
PRIDEiQ6P6B7.

Protocols and materials databases

DNASUi54522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000191063; ENSP00000352361; ENSG00000134461. [Q6P6B7-2]
ENST00000380092; ENSP00000369434; ENSG00000134461. [Q6P6B7-1]
ENST00000380094; ENSP00000369436; ENSG00000134461. [Q6P6B7-1]
GeneIDi54522.
KEGGihsa:54522.
UCSCiuc001iiq.4. human. [Q6P6B7-1]

Organism-specific databases

CTDi54522.
GeneCardsiANKRD16.
HGNCiHGNC:23471. ANKRD16.
HPAiHPA037920.
HPA037921.
neXtProtiNX_Q6P6B7.
OpenTargetsiENSG00000134461.
PharmGKBiPA134916467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133884.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiQ6P6B7.
OMAiHMACIGQ.
OrthoDBiEOG091G0AGX.
PhylomeDBiQ6P6B7.
TreeFamiTF329520.

Miscellaneous databases

GenomeRNAii54522.
PROiQ6P6B7.

Gene expression databases

BgeeiENSG00000134461.
CleanExiHS_ANKRD16.
GenevisibleiQ6P6B7. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR16_HUMAN
AccessioniPrimary (citable) accession number: Q6P6B7
Secondary accession number(s): A6NEF0, F8WEI4, Q9NT01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.