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Protein

Osteoclast-stimulating factor 1

Gene

Ostf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Gene namesi
Name:Ostf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628849. Ostf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 214213Osteoclast-stimulating factor 1PRO_0000238956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei200 – 2001PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei213 – 2131PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P686.
PRIDEiQ6P686.

PTM databases

iPTMnetiQ6P686.
PhosphoSiteiQ6P686.

Expressioni

Gene expression databases

ExpressionAtlasiQ6P686. baseline.
GenevisibleiQ6P686. RN.

Interactioni

Subunit structurei

Interacts with SRC and SMN1. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016871.

Structurei

3D structure databases

ProteinModelPortaliQ6P686.
SMRiQ6P686. Positions 12-69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7160SH3PROSITE-ProRule annotationAdd
BLAST
Repeati72 – 10130ANK 1Add
BLAST
Repeati105 – 13531ANK 2Add
BLAST
Repeati139 – 16830ANK 3Add
BLAST

Domaini

The SH3 domain mediates interaction with SMN1.By similarity

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ. Eukaryota.
ENOG410XR45. LUCA.
HOGENOMiHOG000286040.
HOVERGENiHBG053379.
InParanoidiQ6P686.
OrthoDBiEOG7N0C61.
PhylomeDBiQ6P686.
TreeFamiTF314534.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW
60 70 80 90 100
KGTCKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEVLFTQPN VELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN NEKKLALDMA TNAACASLLK KKQATDGART
210
LSNAEDYLDD EDSD
Length:214
Mass (Da):23,669
Last modified:July 5, 2004 - v1
Checksum:i2F849A11D40C692F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241V → D in AAM82159 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523266 mRNA. Translation: AAM82159.1.
BC062400 mRNA. Translation: AAH62400.1.
RefSeqiNP_683690.2. NM_148892.3.
XP_008758509.1. XM_008760287.1.
UniGeneiRn.108470.

Genome annotation databases

EnsembliENSRNOT00000016871; ENSRNOP00000016871; ENSRNOG00000012156.
GeneIDi259275.
KEGGirno:259275.
UCSCiRGD:628849. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523266 mRNA. Translation: AAM82159.1.
BC062400 mRNA. Translation: AAH62400.1.
RefSeqiNP_683690.2. NM_148892.3.
XP_008758509.1. XM_008760287.1.
UniGeneiRn.108470.

3D structure databases

ProteinModelPortaliQ6P686.
SMRiQ6P686. Positions 12-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016871.

PTM databases

iPTMnetiQ6P686.
PhosphoSiteiQ6P686.

Proteomic databases

PaxDbiQ6P686.
PRIDEiQ6P686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016871; ENSRNOP00000016871; ENSRNOG00000012156.
GeneIDi259275.
KEGGirno:259275.
UCSCiRGD:628849. rat.

Organism-specific databases

CTDi26578.
RGDi628849. Ostf1.

Phylogenomic databases

eggNOGiENOG410IIWQ. Eukaryota.
ENOG410XR45. LUCA.
HOGENOMiHOG000286040.
HOVERGENiHBG053379.
InParanoidiQ6P686.
OrthoDBiEOG7N0C61.
PhylomeDBiQ6P686.
TreeFamiTF314534.

Miscellaneous databases

PROiQ6P686.

Gene expression databases

ExpressionAtlasiQ6P686. baseline.
GenevisibleiQ6P686. RN.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSTF1_RAT
AccessioniPrimary (citable) accession number: Q6P686
Secondary accession number(s): Q8K3X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.