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Protein

Osteoclast-stimulating factor 1

Gene

Ostf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Gene namesi
Name:Ostf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628849. Ostf1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002389562 – 214Osteoclast-stimulating factor 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei200PhosphothreonineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P686.
PRIDEiQ6P686.

PTM databases

iPTMnetiQ6P686.
PhosphoSitePlusiQ6P686.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012156.
GenevisibleiQ6P686. RN.

Interactioni

Subunit structurei

Interacts with SRC and SMN1. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016871.

Structurei

3D structure databases

ProteinModelPortaliQ6P686.
SMRiQ6P686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3PROSITE-ProRule annotationAdd BLAST60
Repeati72 – 101ANK 1Add BLAST30
Repeati105 – 135ANK 2Add BLAST31
Repeati139 – 168ANK 3Add BLAST30

Domaini

The SH3 domain mediates interaction with SMN1.By similarity

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ. Eukaryota.
ENOG410XR45. LUCA.
GeneTreeiENSGT00890000139446.
HOGENOMiHOG000286040.
HOVERGENiHBG053379.
InParanoidiQ6P686.
OMAiKGTCRGR.
OrthoDBiEOG091G0HJ5.
PhylomeDBiQ6P686.
TreeFamiTF314534.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR01415. ANKYRIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00248. ANK. 3 hits.
SM00326. SH3. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW
60 70 80 90 100
KGTCKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEVLFTQPN VELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN NEKKLALDMA TNAACASLLK KKQATDGART
210
LSNAEDYLDD EDSD
Length:214
Mass (Da):23,669
Last modified:July 5, 2004 - v1
Checksum:i2F849A11D40C692F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124V → D in AAM82159 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523266 mRNA. Translation: AAM82159.1.
BC062400 mRNA. Translation: AAH62400.1.
RefSeqiNP_683690.2. NM_148892.3.
XP_008758509.1. XM_008760287.2.
UniGeneiRn.108470.

Genome annotation databases

EnsembliENSRNOT00000016871; ENSRNOP00000016871; ENSRNOG00000012156.
GeneIDi259275.
KEGGirno:259275.
UCSCiRGD:628849. rat.

Similar proteinsi

Entry informationi

Entry nameiOSTF1_RAT
AccessioniPrimary (citable) accession number: Q6P686
Secondary accession number(s): Q8K3X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome