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Protein

Osteoclast-stimulating factor 1

Gene

Ostf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Gene namesi
Name:Ostf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628849 Ostf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002389562 – 214Osteoclast-stimulating factor 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei200PhosphothreonineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P686
PRIDEiQ6P686

PTM databases

iPTMnetiQ6P686
PhosphoSitePlusiQ6P686

Expressioni

Gene expression databases

BgeeiENSRNOG00000012156
GenevisibleiQ6P686 RN

Interactioni

Subunit structurei

Interacts with SRC and SMN1. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016871

Structurei

3D structure databases

ProteinModelPortaliQ6P686
SMRiQ6P686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3PROSITE-ProRule annotationAdd BLAST60
Repeati72 – 101ANK 1Add BLAST30
Repeati105 – 135ANK 2Add BLAST31
Repeati139 – 168ANK 3Add BLAST30

Domaini

The SH3 domain mediates interaction with SMN1.By similarity

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ Eukaryota
ENOG410XR45 LUCA
GeneTreeiENSGT00910000144158
HOGENOMiHOG000286040
HOVERGENiHBG053379
InParanoidiQ6P686
OMAiALYWGCH
OrthoDBiEOG091G0HJ5
PhylomeDBiQ6P686
TreeFamiTF314534

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.201 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR01415 ANKYRIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW
60 70 80 90 100
KGTCKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEVLFTQPN VELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN NEKKLALDMA TNAACASLLK KKQATDGART
210
LSNAEDYLDD EDSD
Length:214
Mass (Da):23,669
Last modified:July 5, 2004 - v1
Checksum:i2F849A11D40C692F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124V → D in AAM82159 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523266 mRNA Translation: AAM82159.1
BC062400 mRNA Translation: AAH62400.1
RefSeqiNP_683690.2, NM_148892.3
XP_008758509.1, XM_008760287.2
UniGeneiRn.108470

Genome annotation databases

EnsembliENSRNOT00000016871; ENSRNOP00000016871; ENSRNOG00000012156
GeneIDi259275
KEGGirno:259275
UCSCiRGD:628849 rat

Similar proteinsi

Entry informationi

Entry nameiOSTF1_RAT
AccessioniPrimary (citable) accession number: Q6P686
Secondary accession number(s): Q8K3X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome