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Protein

NACHT and WD repeat domain-containing protein 2

Gene

Nwd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT and WD repeat domain-containing protein 2
Alternative name(s):
Leucine-rich repeat and WD repeat-containing protein KIAA1239
Gene namesi
Name:Nwd2
Synonyms:Kiaa1239
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1920464. Nwd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17421742NACHT and WD repeat domain-containing protein 2PRO_0000320921Add
BLAST

Proteomic databases

MaxQBiQ6P5U7.
PaxDbiQ6P5U7.
PRIDEiQ6P5U7.

PTM databases

iPTMnetiQ6P5U7.
PhosphoSiteiQ6P5U7.

Expressioni

Gene expression databases

BgeeiQ6P5U7.
CleanExiMM_3110047P20RIK.
ExpressionAtlasiQ6P5U7. baseline and differential.
GenevisibleiQ6P5U7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6P5U7. 1 interaction.
STRINGi10090.ENSMUSP00000124712.

Structurei

3D structure databases

ProteinModelPortaliQ6P5U7.
SMRiQ6P5U7. Positions 1017-1048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati386 – 41025LRR 1Add
BLAST
Domaini410 – 737328NACHTAdd
BLAST
Repeati677 – 69822LRR 2Add
BLAST
Repeati724 – 74724LRR 3Add
BLAST
Repeati883 – 90624LRR 4Add
BLAST
Repeati925 – 95329LRR 5Add
BLAST
Repeati963 – 100442WD 1Add
BLAST
Repeati1007 – 104640WD 2Add
BLAST
Repeati1140 – 117940WD 3Add
BLAST
Repeati1229 – 127143WD 4Add
BLAST
Repeati1272 – 131140WD 5Add
BLAST
Repeati1314 – 135340WD 6Add
BLAST
Repeati1355 – 139440WD 7Add
BLAST
Repeati1396 – 143439WD 8Add
BLAST
Repeati1476 – 151641WD 9Add
BLAST
Repeati1522 – 156140WD 10Add
BLAST
Repeati1614 – 165340WD 11Add
BLAST

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00530000063450.
HOGENOMiHOG000113161.
HOVERGENiHBG108031.
InParanoidiQ6P5U7.
OMAiQSAILIC.
OrthoDBiEOG7VQJC3.
PhylomeDBiQ6P5U7.
TreeFamiTF332647.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR025139. DUF4062.
IPR027417. P-loop_NTPase.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P5U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPAGAGTKL PCPRDSALRR AAFSGNLTAL PSHLVPAGRS VRVFISANPE
60 70 80 90 100
DTGAERQALR ETVYPKLREF CRENYGLEFQ VIDLYWGIEE DEWDSPELQK
110 120 130 140 150
MRMKLLEECL KTSAGPCFVG LLGEKYGNIR IPGEVEASEF EMILDAAVEA
160 170 180 190 200
KLETKLLEDW YCRDENSVPA AYYLRPRLEV PRSNKNSTQP SASSEQERPW
210 220 230 240 250
QEISDEIKTI FKAAVKLLHE QGKMKQSQAK RYLFSAIEDE FDFALGKQTP
260 270 280 290 300
AFLKKCVCYI RKIANIERFV KIPEMGKYMD ITGTDPRIVR DPEAQEKLIK
310 320 330 340 350
LRDEFIPTIV ASSNLRVYTS VTHCDMKLGY SQEIENHYIE GLGKQFYEDM
360 370 380 390 400
IDIIQATVQQ NFDTETDTLY DEILQHSSLC KTYASFYEYK CESLNILHKY
410 420 430 440 450
ILPSKTGHIN PLVVYGGPCT GKTLLLAEVA KKAYGWLHED TGPDSDPVVI
460 470 480 490 500
VRFLGTTDMS IDLRTLLLSV CEQLAVNYRC LVQSFPKKIH DLRDLFINLL
510 520 530 540 550
NESSLQRPLV IILDALEQLS EADEARKLWW LPAHLPRFVR IILSTLPNKH
560 570 580 590 600
GILQKLRCLI HEEDNYIELI PRDRKMCSQV LKHQLLRVKR KVTSGQQIYV
610 620 630 640 650
NNAFSKCTLP MFVNLTFREV RHWRSHKDVD ESSLCVTVHE SIEQLFWSLE
660 670 680 690 700
KKCGQKLVSR ALGYITMAKM GLSEMELEDV LALDNSVMNE LNENTRPSNP
710 720 730 740 750
LRVPYLYIAR LKEGLNGYLI ERHVKNVTLL VWANRHLQLI AQKLYLQEDS
760 770 780 790 800
NLREMHTILA DYFLGVWSGG RRKAFCLEDP YLNGCLDLEN RSLLEEEKHF
810 820 830 840 850
MEQASFDRQA PDQPWVFQCN PLEPDIFFVN HRKMSELLYH LTRCGKTDDL
860 870 880 890 900
LYGIIMNFSW LYTMIKIGQF DKVLADIELA YNYSQEKELK FLASTLRSIR
910 920 930 940 950
NKVIAFPGSL SAELQQRLLP VVSSLPKLRH LLLECDKDGP KYCSIVPLHS
960 970 980 990 1000
SMDVTYSPER LPLASSHLHV TEILPTCNPS TVLTALENGS ISTWDVETRQ
1010 1020 1030 1040 1050
LLRQITTAQS VILGMKLSSD EKYLVVATTN NTLLIYDNVN SCLLSEVEIK
1060 1070 1080 1090 1100
GTKHGSGSTY INGFTLSVNH ALAWLEASKD VTVIDLLYGW PLYQFHCWYE
1110 1120 1130 1140 1150
VTCVQCSLDG VYAFCGQYLN NTTIFHLGSG EKICTVTSEF SGGFVKFLLI
1160 1170 1180 1190 1200
LDTAQEMVMV DSEGSLSVWN TEDISNPQLT EDFDCRKEDS EVVSIELSED
1210 1220 1230 1240 1250
QSAILICKAL SIELLDTGMW KVAEKFRARH NERFVSAVLS KNGDCIIATM
1260 1270 1280 1290 1300
ENTPAVFFWR RDTGQCLASL QESSGTIVKL VKSSHHNMLL SLSTSGVLSI
1310 1320 1330 1340 1350
WDIDIITAMS NIDKTGKPIQ SLVLPARGEI IYSLDGSDCV HKWNFSSGFI
1360 1370 1380 1390 1400
EAVFKHEGIV EHCVLTSTGD LMVTSDDKSS QYVWHTSSGE NLFRINGQRI
1410 1420 1430 1440 1450
SQLLITHNDQ FVVSLCEENA SRVWRLATGH RVCNILTTLQ NAFITSANTF
1460 1470 1480 1490 1500
VVGMTKSKVL AVSLWTGSIT KKFCCEDGIT IVNFKLIPDC PDVIVFITSA
1510 1520 1530 1540 1550
ETVNLWSLTD EVICRRVQLP SNFLKNLEDF EISPNGKLGI ISRGDENINV
1560 1570 1580 1590 1600
LDLHSGKLRV VHASGVIWRQ RLSRDGRYLV YICFRNGEEE EENDAISSLI
1610 1620 1630 1640 1650
VMRLADGKNI GACSLYKTPT FLALSQRHLN IIVGFDDGSI GIYTVVDRVD
1660 1670 1680 1690 1700
AALKIKIATS NSRQIFNNAT QTSRPKSNSY SFKVSVDCLW RESTEVFARD
1710 1720 1730 1740
SPITVSDSSE SNEATPSKKH NSCYDRVCAA LESRSHSYTP DN
Length:1,742
Mass (Da):197,414
Last modified:February 26, 2008 - v2
Checksum:i630DA9B992EBB2D2
GO

Sequence cautioni

The sequence BAC41474.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1218 – 12181G → S in BAC41474 (PubMed:12465718).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114408 Genomic DNA. No translation available.
AC122744 Genomic DNA. No translation available.
BC062655 mRNA. Translation: AAH62655.1.
AB093290 mRNA. Translation: BAC41474.1. Different initiation.
AK136869 mRNA. Translation: BAE23152.1.
CCDSiCCDS51508.1.
RefSeqiNP_795980.2. NM_177006.3.
UniGeneiMm.319487.

Genome annotation databases

EnsembliENSMUST00000159584; ENSMUSP00000124712; ENSMUSG00000090061.
GeneIDi319807.
KEGGimmu:319807.
UCSCiuc008xmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114408 Genomic DNA. No translation available.
AC122744 Genomic DNA. No translation available.
BC062655 mRNA. Translation: AAH62655.1.
AB093290 mRNA. Translation: BAC41474.1. Different initiation.
AK136869 mRNA. Translation: BAE23152.1.
CCDSiCCDS51508.1.
RefSeqiNP_795980.2. NM_177006.3.
UniGeneiMm.319487.

3D structure databases

ProteinModelPortaliQ6P5U7.
SMRiQ6P5U7. Positions 1017-1048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P5U7. 1 interaction.
STRINGi10090.ENSMUSP00000124712.

PTM databases

iPTMnetiQ6P5U7.
PhosphoSiteiQ6P5U7.

Proteomic databases

MaxQBiQ6P5U7.
PaxDbiQ6P5U7.
PRIDEiQ6P5U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159584; ENSMUSP00000124712; ENSMUSG00000090061.
GeneIDi319807.
KEGGimmu:319807.
UCSCiuc008xmf.2. mouse.

Organism-specific databases

CTDi57495.
MGIiMGI:1920464. Nwd2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00530000063450.
HOGENOMiHOG000113161.
HOVERGENiHBG108031.
InParanoidiQ6P5U7.
OMAiQSAILIC.
OrthoDBiEOG7VQJC3.
PhylomeDBiQ6P5U7.
TreeFamiTF332647.

Miscellaneous databases

PROiQ6P5U7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P5U7.
CleanExiMM_3110047P20RIK.
ExpressionAtlasiQ6P5U7. baseline and differential.
GenevisibleiQ6P5U7. MM.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR025139. DUF4062.
IPR027417. P-loop_NTPase.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-1742.
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 541-1742.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1046-1742.
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNWD2_MOUSE
AccessioniPrimary (citable) accession number: Q6P5U7
Secondary accession number(s): Q3UVW7, Q8CHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.