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Protein

Ribonuclease kappa

Gene

RNASEK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.1 Publication

GO - Molecular functioni

  • endoribonuclease activity Source: UniProtKB

GO - Biological processi

  • rRNA transcription Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease kappa (EC:3.1.-.-)
Short name:
RNase K
Short name:
RNase kappa
Gene namesi
Name:RNASEK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33911. RNASEK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi440400.
OpenTargetsiENSG00000219200.
PharmGKBiPA162401458.

Polymorphism and mutation databases

BioMutaiRNASEK.
DMDMi485956029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442211 – 137Ribonuclease kappaAdd BLAST137

Proteomic databases

PaxDbiQ6P5S7.
PeptideAtlasiQ6P5S7.
PRIDEiQ6P5S7.

PTM databases

iPTMnetiQ6P5S7.
PhosphoSitePlusiQ6P5S7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000219200.
CleanExiHS_RNASEK.
ExpressionAtlasiQ6P5S7. baseline and differential.
GenevisibleiQ6P5S7. HS.

Organism-specific databases

HPAiHPA044708.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000449500.

Structurei

3D structure databases

ProteinModelPortaliQ6P5S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITXX. Eukaryota.
ENOG411200W. LUCA.
GeneTreeiENSGT00390000009664.
HOGENOMiHOG000006603.
HOVERGENiHBG054314.
InParanoidiQ6P5S7.
KOiK19770.
OMAiWAFSHRF.
OrthoDBiEOG091G0YDZ.
TreeFamiTF300182.

Family and domain databases

InterProiIPR026770. RNase_K.
[Graphical view]
PANTHERiPTHR31733. PTHR31733. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5S7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWLRPGPRP LCPPARASWA FSHRFPSPLA PRRSPTPFFM ASLLCCGPKL
60 70 80 90 100
AACGIVLSAW GVIMLIMLGI FFNVHSAVLI EDVPFTEKDF ENGPQNIYNL
110 120 130
YEQVSYNCFI AAGLYLLLGG FSFCQVRLNK RKEYMVR
Length:137
Mass (Da):15,420
Last modified:May 1, 2013 - v2
Checksum:i1E8DD4A350DCCC4F
GO
Isoform 2 (identifier: Q6P5S7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MGWLRPGPRP...VLSAWGVIML → MVEAGATPPL...HRPQRLGSDH

Show »
Length:134
Mass (Da):14,900
Checksum:iE07681CBD5CE783E
GO

Sequence cautioni

The sequence AAH51802 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH62705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF82619 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAN89245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 27PS → GG in AAH62705 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0464961 – 65MGWLR…GVIML → MVEAGATPPLPPCEGILGFL PPLSEPACTSAIPDSLLYGV APVLWAEAGRLRHRPQRLGS DH in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC040977 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90275.1.
AK289930 mRNA. Translation: BAF82619.1. Different initiation.
BC051802 mRNA. Translation: AAH51802.1. Different initiation.
BC062705 mRNA. Translation: AAH62705.1. Different initiation.
BC095436 mRNA. Translation: AAH95436.1.
AM746459 mRNA. Translation: CAN89245.1. Different initiation.
CCDSiCCDS45594.2. [Q6P5S7-1]
RefSeqiNP_001004333.2. NM_001004333.4. [Q6P5S7-1]
UniGeneiHs.632232.

Genome annotation databases

EnsembliENST00000548577; ENSP00000449500; ENSG00000219200. [Q6P5S7-1]
GeneIDi440400.
KEGGihsa:440400.
UCSCiuc002gea.5. human. [Q6P5S7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC040977 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90275.1.
AK289930 mRNA. Translation: BAF82619.1. Different initiation.
BC051802 mRNA. Translation: AAH51802.1. Different initiation.
BC062705 mRNA. Translation: AAH62705.1. Different initiation.
BC095436 mRNA. Translation: AAH95436.1.
AM746459 mRNA. Translation: CAN89245.1. Different initiation.
CCDSiCCDS45594.2. [Q6P5S7-1]
RefSeqiNP_001004333.2. NM_001004333.4. [Q6P5S7-1]
UniGeneiHs.632232.

3D structure databases

ProteinModelPortaliQ6P5S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000449500.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiQ6P5S7.
PhosphoSitePlusiQ6P5S7.

Polymorphism and mutation databases

BioMutaiRNASEK.
DMDMi485956029.

Proteomic databases

PaxDbiQ6P5S7.
PeptideAtlasiQ6P5S7.
PRIDEiQ6P5S7.

Protocols and materials databases

DNASUi440400.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548577; ENSP00000449500; ENSG00000219200. [Q6P5S7-1]
GeneIDi440400.
KEGGihsa:440400.
UCSCiuc002gea.5. human. [Q6P5S7-1]

Organism-specific databases

CTDi440400.
DisGeNETi440400.
GeneCardsiRNASEK.
HGNCiHGNC:33911. RNASEK.
HPAiHPA044708.
neXtProtiNX_Q6P5S7.
OpenTargetsiENSG00000219200.
PharmGKBiPA162401458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITXX. Eukaryota.
ENOG411200W. LUCA.
GeneTreeiENSGT00390000009664.
HOGENOMiHOG000006603.
HOVERGENiHBG054314.
InParanoidiQ6P5S7.
KOiK19770.
OMAiWAFSHRF.
OrthoDBiEOG091G0YDZ.
TreeFamiTF300182.

Miscellaneous databases

GenomeRNAii440400.
PROiQ6P5S7.

Gene expression databases

BgeeiENSG00000219200.
CleanExiHS_RNASEK.
ExpressionAtlasiQ6P5S7. baseline and differential.
GenevisibleiQ6P5S7. HS.

Family and domain databases

InterProiIPR026770. RNase_K.
[Graphical view]
PANTHERiPTHR31733. PTHR31733. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNK_HUMAN
AccessioniPrimary (citable) accession number: Q6P5S7
Secondary accession number(s): G3V1Z9, Q502Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 2013
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-40 is the initiator. Orthologous sequences cannot be extended.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.