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Protein

60S ribosomal protein L22-like 1

Gene

RPL22L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

SIGNORiQ6P5R6.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22-like 1
Gene namesi
Name:RPL22L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27610. RPL22L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671026.

Polymorphism and mutation databases

BioMutaiRPL22L1.
DMDMi109893176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12212260S ribosomal protein L22-like 1PRO_0000240632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121PhosphoserineCombined sources
Modified residuei118 – 1181PhosphoserineCombined sources
Modified residuei120 – 1201PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P5R6.
MaxQBiQ6P5R6.
PaxDbiQ6P5R6.
PeptideAtlasiQ6P5R6.
PRIDEiQ6P5R6.

PTM databases

iPTMnetiQ6P5R6.
PhosphoSiteiQ6P5R6.

Expressioni

Gene expression databases

BgeeiENSG00000163584.
CleanExiHS_RPL22L1.
ExpressionAtlasiQ6P5R6. baseline and differential.
GenevisibleiQ6P5R6. HS.

Organism-specific databases

HPAiHPA056207.

Interactioni

Protein-protein interaction databases

BioGridi128356. 15 interactions.
IntActiQ6P5R6. 3 interactions.
STRINGi9606.ENSP00000346080.

Structurei

3D structure databases

ProteinModelPortaliQ6P5R6.
SMRiQ6P5R6. Positions 15-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L22e family.Curated

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiQ6P5R6.
KOiK02891.
PhylomeDBiQ6P5R6.
TreeFamiTF313018.

Family and domain databases

InterProiIPR002671. Ribosomal_L22e.
IPR028370. RPL22L1.
[Graphical view]
PANTHERiPTHR10064. PTHR10064. 1 hit.
PTHR10064:SF1. PTHR10064:SF1. 1 hit.
PfamiPF01776. Ribosomal_L22e. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P5R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQKDRKPK RSTWRFNLDL THPVEDGIFD SGNFEQFLRE KVKVNGKTGN
60 70 80 90 100
LGNVVHIERF KNKITVVSEK QFSKRYLKYL TKKYLKKNNL RDWLRVVASD
110 120
KETYELRYFQ ISQDEDESES ED
Length:122
Mass (Da):14,607
Last modified:June 27, 2006 - v2
Checksum:i6C480CDD9FFAE761
GO

Sequence cautioni

The sequence AAH62731 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971V → F.
Corresponds to variant rs13462 [ dbSNP | Ensembl ].
VAR_061771

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062731 mRNA. Translation: AAH62731.1. Different initiation.
BC107708 mRNA. Translation: AAI07709.1.
CCDSiCCDS46955.1.
RefSeqiNP_001093115.1. NM_001099645.1.
UniGeneiHs.380933.

Genome annotation databases

EnsembliENST00000295830; ENSP00000346080; ENSG00000163584.
GeneIDi200916.
KEGGihsa:200916.
UCSCiuc003fhc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062731 mRNA. Translation: AAH62731.1. Different initiation.
BC107708 mRNA. Translation: AAI07709.1.
CCDSiCCDS46955.1.
RefSeqiNP_001093115.1. NM_001099645.1.
UniGeneiHs.380933.

3D structure databases

ProteinModelPortaliQ6P5R6.
SMRiQ6P5R6. Positions 15-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128356. 15 interactions.
IntActiQ6P5R6. 3 interactions.
STRINGi9606.ENSP00000346080.

PTM databases

iPTMnetiQ6P5R6.
PhosphoSiteiQ6P5R6.

Polymorphism and mutation databases

BioMutaiRPL22L1.
DMDMi109893176.

Proteomic databases

EPDiQ6P5R6.
MaxQBiQ6P5R6.
PaxDbiQ6P5R6.
PeptideAtlasiQ6P5R6.
PRIDEiQ6P5R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295830; ENSP00000346080; ENSG00000163584.
GeneIDi200916.
KEGGihsa:200916.
UCSCiuc003fhc.5. human.

Organism-specific databases

CTDi200916.
GeneCardsiRPL22L1.
HGNCiHGNC:27610. RPL22L1.
HPAiHPA056207.
neXtProtiNX_Q6P5R6.
PharmGKBiPA142671026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiQ6P5R6.
KOiK02891.
PhylomeDBiQ6P5R6.
TreeFamiTF313018.

Enzyme and pathway databases

SIGNORiQ6P5R6.

Miscellaneous databases

ChiTaRSiRPL22L1. human.
GenomeRNAii200916.
PROiQ6P5R6.

Gene expression databases

BgeeiENSG00000163584.
CleanExiHS_RPL22L1.
ExpressionAtlasiQ6P5R6. baseline and differential.
GenevisibleiQ6P5R6. HS.

Family and domain databases

InterProiIPR002671. Ribosomal_L22e.
IPR028370. RPL22L1.
[Graphical view]
PANTHERiPTHR10064. PTHR10064. 1 hit.
PTHR10064:SF1. PTHR10064:SF1. 1 hit.
PfamiPF01776. Ribosomal_L22e. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL22L_HUMAN
AccessioniPrimary (citable) accession number: Q6P5R6
Secondary accession number(s): Q32Q77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.