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Protein

Leiomodin-2

Gene

LMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).By similarity4 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • tropomyosin binding Source: InterPro

GO - Biological processi

  • actin filament polymerization Source: Ensembl
  • actin nucleation Source: UniProtKB
  • pointed-end actin filament capping Source: InterPro
  • positive regulation of actin filament polymerization Source: UniProtKB
  • sarcomere organization Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Leiomodin1 Publication
Gene namesi
Name:LMOD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6648. LMOD2.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • M band Source: UniProtKB-SubCell
  • myofibril Source: UniProtKB
  • sarcomere Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64F → D: Mildly impaired activity in promoting actin polymerization; when associated with D-69. 1 Publication1
Mutagenesisi69L → D: Mildly impaired activity in promoting actin polymerization; when associated with D-64. 1 Publication1
Mutagenesisi72 – 73YW → DD: Mildly impaired activity in promoting actin polymerization. 1 Publication2
Mutagenesisi284G → R: Strongly impaired activity in promoting actin polymerization. 1 Publication1
Mutagenesisi304H → G: Strongly impaired activity in promoting actin polymerization; when associated with G-334 and A-356. 1 Publication1
Mutagenesisi334H → G: Strongly impaired activity in promoting actin polymerization; when associated with G-304 and A-356. 1 Publication1
Mutagenesisi356R → A: Strongly impaired activity in promoting actin polymerization; when associated with G-304 and G-334. 1 Publication1
Mutagenesisi525 – 529LMEAI → AAEAA: Strongly impaired activity in promoting actin polymerization. 1 Publication5
Mutagenesisi537 – 540LKRV → AEEA: Strongly impaired activity in promoting actin polymerization. 1 Publication4

Organism-specific databases

OpenTargetsiENSG00000170807.
PharmGKBiPA30414.

Polymorphism and mutation databases

BioMutaiLMOD2.
DMDMi160395556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113401 – 547Leiomodin-2Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P5Q4.
PaxDbiQ6P5Q4.
PeptideAtlasiQ6P5Q4.
PRIDEiQ6P5Q4.

PTM databases

iPTMnetiQ6P5Q4.
PhosphoSitePlusiQ6P5Q4.

Expressioni

Tissue specificityi

Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues.2 Publications

Gene expression databases

BgeeiENSG00000170807.
CleanExiHS_LMOD2.
ExpressionAtlasiQ6P5Q4. baseline and differential.
GenevisibleiQ6P5Q4. HS.

Organism-specific databases

HPAiHPA051039.

Interactioni

Subunit structurei

Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation (PubMed:18403713, PubMed:26417072). Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus) (PubMed:25250574, PubMed:26873245). May also interact with TPM2 (via N-terminus) (PubMed:25250574).4 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • tropomyosin binding Source: InterPro

Protein-protein interaction databases

STRINGi9606.ENSP00000411932.

Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi199 – 208Combined sources10
Beta strandi215 – 217Combined sources3
Helixi226 – 235Combined sources10
Turni236 – 238Combined sources3
Beta strandi243 – 250Combined sources8
Helixi254 – 264Combined sources11
Beta strandi272 – 278Combined sources7
Helixi282 – 291Combined sources10
Helixi292 – 294Combined sources3
Beta strandi300 – 302Combined sources3
Helixi313 – 321Combined sources9
Helixi322 – 324Combined sources3
Beta strandi330 – 332Combined sources3
Helixi338 – 362Combined sources25
Helixi460 – 468Combined sources9
Helixi490 – 493Combined sources4
Helixi495 – 497Combined sources3
Beta strandi502 – 504Combined sources3
Helixi520 – 530Combined sources11
Helixi534 – 536Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RWTX-ray2.98C/D1-547[»]
ProteinModelPortaliQ6P5Q4.
SMRiQ6P5Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini521 – 540WH2PROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 161Interaction with actin 11 PublicationAdd BLAST161
Regioni1 – 47Interaction with tropomyosin alpha1 PublicationAdd BLAST47
Regioni162 – 497Interaction with actin 21 PublicationAdd BLAST336
Regioni521 – 540Interaction with actin 31 PublicationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 41Sequence analysisAdd BLAST26
Coiled coili113 – 148Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 142Glu-richAdd BLAST129
Compositional biasi385 – 450Pro-richAdd BLAST66
Compositional biasi478 – 487Poly-Lys10

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ6P5Q4.
OMAiKVNQHIT.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ6P5Q4.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
IPR003124. WH2_dom.
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF27. PTHR10901:SF27. 1 hit.
PfamiView protein in Pfam
PF03250. Tropomodulin. 1 hit.
PROSITEiView protein in PROSITE
PS51082. WH2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTFGYRRGL SKYESIDEDE LLASLSAEEL KELERELEDI EPDRNLPVGL
60 70 80 90 100
RQKSLTEKTP TGTFSREALM AYWEKESQKL LEKERLGECG KVAEDKEESE
110 120 130 140 150
EELIFTESNS EVSEEVYTEE EEEESQEEEE EEDSDEEERT IETAKGINGT
160 170 180 190 200
VNYDSVNSDN SKPKIFKSQI ENINLTNGSN GRNTESPAAI HPCGNPTVIE
210 220 230 240 250
DALDKIKSND PDTTEVNLNN IENITTQTLT RFAEALKDNT VVKTFSLANT
260 270 280 290 300
HADDSAAMAI AEMLKVNEHI TNVNVESNFI TGKGILAIMR ALQHNTVLTE
310 320 330 340 350
LRFHNQRHIM GSQVEMEIVK LLKENTTLLR LGYHFELPGP RMSMTSILTR
360 370 380 390 400
NMDKQRQKRL QEQKQQEGYD GGPNLRTKVW QRGTPSSSPY VSPRHSPWSS
410 420 430 440 450
PKLPKKVQTV RSRPLSPVAT PPPPPPPPPP PPPSSQRLPP PPPPPPPPLP
460 470 480 490 500
EKKLITRNIA EVIKQQESAQ RALQNGQKKK KGKKVKKQPN SILKEIKNSL
510 520 530 540
RSVQEKKMED SSRPSTPQRS AHENLMEAIR GSSIKQLKRV EVPEALR
Length:547
Mass (Da):61,675
Last modified:November 13, 2007 - v2
Checksum:i299A4C8F473E8A34
GO
Isoform 2 (identifier: Q6P5Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-138: SEVSEEVYTEEEEEESQEEEEEEDSDEEE → RRSPRRKRRKKTVTKRKEQLKLQKGLMEL
     139-547: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):16,239
Checksum:i41A59C70E0D97495
GO
Isoform 3 (identifier: Q6P5Q4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-129: QKLLEKERLG...EEEEESQEEE → LLLLPLLHSQ...KRSRNSQTVF
     130-547: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,999
Checksum:i7657BE6C1608E942
GO

Sequence cautioni

The sequence AAH17911 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH62765 differs from that shown. Reason: Frameshift at position 99.Curated
The sequence AAH62765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL24334 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL24335 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02952578 – 129QKLLE…SQEEE → LLLLPLLHSQRKSSLPETLQ KSSNNRRVPNGHYKMDKKRK KGKRSRNSQTVF in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_029526110 – 138SEVSE…SDEEE → RRSPRRKRRKKTVTKRKEQL KLQKGLMEL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_029527130 – 547Missing in isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_029528139 – 547Missing in isoform 2. 1 PublicationAdd BLAST409

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24334.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24335.1. Sequence problems.
BC017911 mRNA. Translation: AAH17911.1. Different initiation.
BC062765 mRNA. Translation: AAH62765.1. Sequence problems.
CCDSiCCDS47693.1. [Q6P5Q4-1]
RefSeqiNP_997046.1. NM_207163.2. [Q6P5Q4-1]
UniGeneiHs.592260.

Genome annotation databases

EnsembliENST00000458573; ENSP00000411932; ENSG00000170807. [Q6P5Q4-1]
GeneIDi442721.
KEGGihsa:442721.
UCSCiuc003vky.3. human. [Q6P5Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24334.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24335.1. Sequence problems.
BC017911 mRNA. Translation: AAH17911.1. Different initiation.
BC062765 mRNA. Translation: AAH62765.1. Sequence problems.
CCDSiCCDS47693.1. [Q6P5Q4-1]
RefSeqiNP_997046.1. NM_207163.2. [Q6P5Q4-1]
UniGeneiHs.592260.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RWTX-ray2.98C/D1-547[»]
ProteinModelPortaliQ6P5Q4.
SMRiQ6P5Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000411932.

PTM databases

iPTMnetiQ6P5Q4.
PhosphoSitePlusiQ6P5Q4.

Polymorphism and mutation databases

BioMutaiLMOD2.
DMDMi160395556.

Proteomic databases

EPDiQ6P5Q4.
PaxDbiQ6P5Q4.
PeptideAtlasiQ6P5Q4.
PRIDEiQ6P5Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458573; ENSP00000411932; ENSG00000170807. [Q6P5Q4-1]
GeneIDi442721.
KEGGihsa:442721.
UCSCiuc003vky.3. human. [Q6P5Q4-1]

Organism-specific databases

CTDi442721.
GeneCardsiLMOD2.
HGNCiHGNC:6648. LMOD2.
HPAiHPA051039.
MIMi608006. gene.
neXtProtiNX_Q6P5Q4.
OpenTargetsiENSG00000170807.
PharmGKBiPA30414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ6P5Q4.
OMAiKVNQHIT.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ6P5Q4.
TreeFamiTF315841.

Miscellaneous databases

GenomeRNAii442721.
PROiPR:Q6P5Q4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170807.
CleanExiHS_LMOD2.
ExpressionAtlasiQ6P5Q4. baseline and differential.
GenevisibleiQ6P5Q4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
IPR003124. WH2_dom.
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF27. PTHR10901:SF27. 1 hit.
PfamiView protein in Pfam
PF03250. Tropomodulin. 1 hit.
PROSITEiView protein in PROSITE
PS51082. WH2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLMOD2_HUMAN
AccessioniPrimary (citable) accession number: Q6P5Q4
Secondary accession number(s): A4D0W9, A4D0Y2, Q8WVJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 10, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.