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Protein

Leiomodin-2

Gene

LMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Increases the rate of actin polymerization (PubMed:25250574).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Gene namesi
Name:LMOD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6648. LMOD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30414.

Polymorphism and mutation databases

BioMutaiLMOD2.
DMDMi160395556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Leiomodin-2PRO_0000311340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P5Q4.
PRIDEiQ6P5Q4.

PTM databases

iPTMnetiQ6P5Q4.
PhosphoSiteiQ6P5Q4.

Expressioni

Tissue specificityi

Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues.2 Publications

Gene expression databases

BgeeiQ6P5Q4.
CleanExiHS_LMOD2.
ExpressionAtlasiQ6P5Q4. baseline and differential.
GenevisibleiQ6P5Q4. HS.

Organism-specific databases

HPAiHPA051039.

Interactioni

Subunit structurei

May interact with tropomyosin alpha (TPM1/2) N-terminus.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000411932.

Structurei

Secondary structure

1
547
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi199 – 20810Combined sources
Beta strandi215 – 2173Combined sources
Helixi226 – 23510Combined sources
Turni236 – 2383Combined sources
Beta strandi243 – 2508Combined sources
Helixi254 – 26411Combined sources
Beta strandi272 – 2787Combined sources
Helixi282 – 29110Combined sources
Helixi292 – 2943Combined sources
Beta strandi300 – 3023Combined sources
Helixi313 – 3219Combined sources
Helixi322 – 3243Combined sources
Beta strandi330 – 3323Combined sources
Helixi338 – 36225Combined sources
Helixi460 – 4689Combined sources
Helixi490 – 4934Combined sources
Helixi495 – 4973Combined sources
Beta strandi502 – 5043Combined sources
Helixi520 – 53011Combined sources
Helixi534 – 5363Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RWTX-ray2.98C/D1-485[»]
C/D487-547[»]
ProteinModelPortaliQ6P5Q4.
SMRiQ6P5Q4. Positions 195-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini521 – 54020WH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4747Interaction with tropomyosin alpha1 PublicationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – 4126Sequence analysisAdd
BLAST
Coiled coili113 – 14836Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 142129Glu-richAdd
BLAST
Compositional biasi385 – 45066Pro-richAdd
BLAST
Compositional biasi478 – 48710Poly-Lys

Sequence similaritiesi

Belongs to the tropomodulin family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ6P5Q4.
OMAiKQRQKRM.
OrthoDBiEOG725DHJ.
PhylomeDBiQ6P5Q4.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF12. PTHR10901:SF12. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTFGYRRGL SKYESIDEDE LLASLSAEEL KELERELEDI EPDRNLPVGL
60 70 80 90 100
RQKSLTEKTP TGTFSREALM AYWEKESQKL LEKERLGECG KVAEDKEESE
110 120 130 140 150
EELIFTESNS EVSEEVYTEE EEEESQEEEE EEDSDEEERT IETAKGINGT
160 170 180 190 200
VNYDSVNSDN SKPKIFKSQI ENINLTNGSN GRNTESPAAI HPCGNPTVIE
210 220 230 240 250
DALDKIKSND PDTTEVNLNN IENITTQTLT RFAEALKDNT VVKTFSLANT
260 270 280 290 300
HADDSAAMAI AEMLKVNEHI TNVNVESNFI TGKGILAIMR ALQHNTVLTE
310 320 330 340 350
LRFHNQRHIM GSQVEMEIVK LLKENTTLLR LGYHFELPGP RMSMTSILTR
360 370 380 390 400
NMDKQRQKRL QEQKQQEGYD GGPNLRTKVW QRGTPSSSPY VSPRHSPWSS
410 420 430 440 450
PKLPKKVQTV RSRPLSPVAT PPPPPPPPPP PPPSSQRLPP PPPPPPPPLP
460 470 480 490 500
EKKLITRNIA EVIKQQESAQ RALQNGQKKK KGKKVKKQPN SILKEIKNSL
510 520 530 540
RSVQEKKMED SSRPSTPQRS AHENLMEAIR GSSIKQLKRV EVPEALR
Length:547
Mass (Da):61,675
Last modified:November 13, 2007 - v2
Checksum:i299A4C8F473E8A34
GO
Isoform 2 (identifier: Q6P5Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-138: SEVSEEVYTEEEEEESQEEEEEEDSDEEE → RRSPRRKRRKKTVTKRKEQLKLQKGLMEL
     139-547: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):16,239
Checksum:i41A59C70E0D97495
GO
Isoform 3 (identifier: Q6P5Q4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-129: QKLLEKERLG...EEEEESQEEE → LLLLPLLHSQ...KRSRNSQTVF
     130-547: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,999
Checksum:i7657BE6C1608E942
GO

Sequence cautioni

The sequence AAH17911.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH62765.1 differs from that shown. Reason: Frameshift at position 99. Curated
The sequence AAH62765.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL24334.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAL24335.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 12952QKLLE…SQEEE → LLLLPLLHSQRKSSLPETLQ KSSNNRRVPNGHYKMDKKRK KGKRSRNSQTVF in isoform 3. 1 PublicationVSP_029525Add
BLAST
Alternative sequencei110 – 13829SEVSE…SDEEE → RRSPRRKRRKKTVTKRKEQL KLQKGLMEL in isoform 2. 1 PublicationVSP_029526Add
BLAST
Alternative sequencei130 – 547418Missing in isoform 3. 1 PublicationVSP_029527Add
BLAST
Alternative sequencei139 – 547409Missing in isoform 2. 1 PublicationVSP_029528Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24334.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24335.1. Sequence problems.
BC017911 mRNA. Translation: AAH17911.1. Different initiation.
BC062765 mRNA. Translation: AAH62765.1. Sequence problems.
CCDSiCCDS47693.1. [Q6P5Q4-1]
RefSeqiNP_997046.1. NM_207163.1. [Q6P5Q4-1]
UniGeneiHs.592260.

Genome annotation databases

EnsembliENST00000458573; ENSP00000411932; ENSG00000170807. [Q6P5Q4-1]
GeneIDi442721.
KEGGihsa:442721.
UCSCiuc003vky.3. human. [Q6P5Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24334.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24335.1. Sequence problems.
BC017911 mRNA. Translation: AAH17911.1. Different initiation.
BC062765 mRNA. Translation: AAH62765.1. Sequence problems.
CCDSiCCDS47693.1. [Q6P5Q4-1]
RefSeqiNP_997046.1. NM_207163.1. [Q6P5Q4-1]
UniGeneiHs.592260.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RWTX-ray2.98C/D1-485[»]
C/D487-547[»]
ProteinModelPortaliQ6P5Q4.
SMRiQ6P5Q4. Positions 195-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000411932.

PTM databases

iPTMnetiQ6P5Q4.
PhosphoSiteiQ6P5Q4.

Polymorphism and mutation databases

BioMutaiLMOD2.
DMDMi160395556.

Proteomic databases

PaxDbiQ6P5Q4.
PRIDEiQ6P5Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458573; ENSP00000411932; ENSG00000170807. [Q6P5Q4-1]
GeneIDi442721.
KEGGihsa:442721.
UCSCiuc003vky.3. human. [Q6P5Q4-1]

Organism-specific databases

CTDi442721.
GeneCardsiLMOD2.
HGNCiHGNC:6648. LMOD2.
HPAiHPA051039.
MIMi608006. gene.
neXtProtiNX_Q6P5Q4.
PharmGKBiPA30414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ6P5Q4.
OMAiKQRQKRM.
OrthoDBiEOG725DHJ.
PhylomeDBiQ6P5Q4.
TreeFamiTF315841.

Miscellaneous databases

GenomeRNAii442721.
PROiQ6P5Q4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P5Q4.
CleanExiHS_LMOD2.
ExpressionAtlasiQ6P5Q4. baseline and differential.
GenevisibleiQ6P5Q4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF12. PTHR10901:SF12. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Skeletal muscle.
  3. "Leiomodins: larger members of the tropomodulin (Tmod) gene family."
    Conley C.A., Fritz-Six K.L., Almenar-Queralt A., Fowler V.M.
    Genomics 73:127-139(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy."
    Yuen M., Sandaradura S.A., Dowling J.J., Kostyukova A.S., Moroz N., Quinlan K.G., Lehtokari V.L., Ravenscroft G., Todd E.J., Ceyhan-Birsoy O., Gokhin D.S., Maluenda J., Lek M., Nolent F., Pappas C.T., Novak S.M., D'Amico A., Malfatti E.
    , Thomas B.P., Gabriel S.B., Gupta N., Daly M.J., Ilkovski B., Houweling P.J., Davidson A.E., Swanson L.C., Brownstein C.A., Gupta V.A., Medne L., Shannon P., Martin N., Bick D.P., Flisberg A., Holmberg E., Van den Bergh P., Lapunzina P., Waddell L.B., Sloboda D.D., Bertini E., Chitayat D., Telfer W.R., Laquerriere A., Gregorio C.C., Ottenheijm C.A., Boennemann C.G., Pelin K., Beggs A.H., Hayashi Y.K., Romero N.B., Laing N.G., Nishino I., Wallgren-Pettersson C., Melki J., Fowler V.M., MacArthur D.G., North K.N., Clarke N.F.
    J. Clin. Invest. 124:4693-4708(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TPM1/2, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLMOD2_HUMAN
AccessioniPrimary (citable) accession number: Q6P5Q4
Secondary accession number(s): A4D0W9, A4D0Y2, Q8WVJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.