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Q6P5P0

- Q6P5P0_MOUSE

UniProt

Q6P5P0 - Q6P5P0_MOUSE

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Protein
Submitted name: P2X purinoceptor 7
Gene
P2rx7
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. channel activity Source: MGI
  3. extracellular ATP-gated cation channel activity Source: MGI
  4. lipopolysaccharide binding Source: MGI
  5. protein binding Source: MGI
  6. purinergic nucleotide receptor activity Source: RefGenome
  7. receptor activity Source: MGI

GO - Biological processi

  1. NAD transport Source: MGI
  2. T cell homeostasis Source: MGI
  3. T cell proliferation Source: MGI
  4. activation of MAPK activity Source: MGI
  5. bleb assembly Source: MGI
  6. calcium ion transport Source: MGI
  7. cation transport Source: MGI
  8. cell morphogenesis Source: MGI
  9. cell volume homeostasis Source: MGI
  10. cellular response to extracellular stimulus Source: MGI
  11. ceramide biosynthetic process Source: MGI
  12. collagen metabolic process Source: MGI
  13. cytolysis Source: MGI
  14. defense response to Gram-positive bacterium Source: MGI
  15. extrinsic apoptotic signaling pathway Source: MGI
  16. gene expression Source: MGI
  17. homeostasis of number of cells within a tissue Source: MGI
  18. inflammatory response Source: MGI
  19. membrane budding Source: MGI
  20. membrane protein ectodomain proteolysis Source: MGI
  21. mitochondrion organization Source: MGI
  22. multicellular organismal protein catabolic process Source: MGI
  23. negative regulation of MAPK cascade Source: MGI
  24. negative regulation of bone resorption Source: MGI
  25. phagolysosome assembly Source: MGI
  26. phospholipid transfer to membrane Source: MGI
  27. phospholipid translocation Source: MGI
  28. plasma membrane organization Source: MGI
  29. pore complex assembly Source: MGI
  30. positive regulation of MAPK cascade Source: MGI
  31. positive regulation of T cell mediated cytotoxicity Source: MGI
  32. positive regulation of apoptotic process Source: MGI
  33. positive regulation of bone mineralization Source: MGI
  34. positive regulation of catalytic activity Source: MGI
  35. positive regulation of cytokine secretion Source: MGI
  36. positive regulation of gamma-aminobutyric acid secretion Source: MGI
  37. positive regulation of glutamate secretion Source: MGI
  38. positive regulation of interleukin-1 alpha secretion Source: MGI
  39. positive regulation of interleukin-1 beta production Source: MGI
  40. positive regulation of interleukin-1 beta secretion Source: MGI
  41. positive regulation of interleukin-6 production Source: MGI
  42. positive regulation of lymphocyte apoptotic process Source: MGI
  43. positive regulation of mitochondrial depolarization Source: MGI
  44. positive regulation of ossification Source: MGI
  45. positive regulation of prostaglandin secretion Source: MGI
  46. positive regulation of protein phosphorylation Source: MGI
  47. positive regulation of protein secretion Source: MGI
  48. programmed cell death Source: MGI
  49. protein oligomerization Source: MGI
  50. protein phosphorylation Source: MGI
  51. protein processing Source: MGI
  52. purinergic nucleotide receptor signaling pathway Source: GOC
  53. reactive oxygen species metabolic process Source: MGI
  54. release of sequestered calcium ion into cytosol Source: MGI
  55. response to ATP Source: MGI
  56. response to bacterium Source: MGI
  57. response to calcium ion Source: MGI
  58. response to drug Source: MGI
  59. response to electrical stimulus Source: MGI
  60. response to fluid shear stress Source: MGI
  61. response to lipopolysaccharide Source: MGI
  62. response to mechanical stimulus Source: MGI
  63. response to organic cyclic compound Source: MGI
  64. response to organic substance Source: MGI
  65. response to zinc ion Source: MGI
  66. skeletal system morphogenesis Source: MGI
  67. synaptic vesicle exocytosis Source: MGI
  68. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
P2X purinoceptor 7Imported
Submitted name:
Purinergic receptor P2X, ligand-gated ion channel, 7Imported
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of nuclear inner membrane Source: RefGenome
  4. integral component of plasma membrane Source: MGI
  5. membrane Source: MGI
  6. neuromuscular junction Source: MGI
  7. neuronal cell body Source: MGI
  8. plasma membrane Source: MGI
  9. synapse Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6P5P0.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000016028.
HOGENOMiHOG000199495.
HOVERGENiHBG062516.
KOiK05220.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.

Sequencei

Sequence statusi: Complete.

Q6P5P0-1 [UniParc]FASTAAdd to Basket

« Hide

MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL    50
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN 100
SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL 150
ELA 153
Length:153
Mass (Da):17,199
Last modified:July 5, 2004 - v1
Checksum:i05917407370B40CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114632 Genomic DNA. No translation available.
BC062808 mRNA. Translation: AAH62808.1.
RefSeqiNP_001033976.1. NM_001038887.1.
UniGeneiMm.42026.

Genome annotation databases

EnsembliENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468.
GeneIDi18439.
KEGGimmu:18439.
UCSCiuc008zlo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114632 Genomic DNA. No translation available.
BC062808 mRNA. Translation: AAH62808.1 .
RefSeqi NP_001033976.1. NM_001038887.1.
UniGenei Mm.42026.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086247 ; ENSMUSP00000083425 ; ENSMUSG00000029468 .
GeneIDi 18439.
KEGGi mmu:18439.
UCSCi uc008zlo.1. mouse.

Organism-specific databases

CTDi 5027.
MGIi MGI:1339957. P2rx7.

Phylogenomic databases

GeneTreei ENSGT00390000016028.
HOGENOMi HOG000199495.
HOVERGENi HBG062516.
KOi K05220.

Miscellaneous databases

NextBioi 294114.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6P5P0.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01314. P2X7RECEPTOR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary glandImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6P5P0_MOUSE
AccessioniPrimary (citable) accession number: Q6P5P0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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