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Q6P5P0

- Q6P5P0_MOUSE

UniProt

Q6P5P0 - Q6P5P0_MOUSE

Protein
Submitted name:

P2X purinoceptor 7

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ATP binding Source: MGI
    2. channel activity Source: MGI
    3. extracellular ATP-gated cation channel activity Source: MGI
    4. lipopolysaccharide binding Source: MGI
    5. protein binding Source: MGI
    6. purinergic nucleotide receptor activity Source: RefGenome
    7. receptor activity Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. bleb assembly Source: MGI
    3. calcium ion transport Source: MGI
    4. cation transport Source: MGI
    5. cell morphogenesis Source: MGI
    6. cellular response to extracellular stimulus Source: MGI
    7. cell volume homeostasis Source: MGI
    8. ceramide biosynthetic process Source: MGI
    9. collagen metabolic process Source: MGI
    10. cytolysis Source: MGI
    11. defense response to Gram-positive bacterium Source: MGI
    12. extrinsic apoptotic signaling pathway Source: MGI
    13. gene expression Source: MGI
    14. homeostasis of number of cells within a tissue Source: MGI
    15. inflammatory response Source: MGI
    16. membrane budding Source: MGI
    17. membrane protein ectodomain proteolysis Source: MGI
    18. mitochondrion organization Source: MGI
    19. multicellular organismal protein catabolic process Source: MGI
    20. NAD transport Source: MGI
    21. negative regulation of bone resorption Source: MGI
    22. negative regulation of MAPK cascade Source: MGI
    23. phagolysosome assembly Source: MGI
    24. phospholipid transfer to membrane Source: MGI
    25. phospholipid translocation Source: MGI
    26. plasma membrane organization Source: MGI
    27. pore complex assembly Source: MGI
    28. positive regulation of apoptotic process Source: MGI
    29. positive regulation of bone mineralization Source: MGI
    30. positive regulation of catalytic activity Source: MGI
    31. positive regulation of cytokine secretion Source: MGI
    32. positive regulation of gamma-aminobutyric acid secretion Source: MGI
    33. positive regulation of glutamate secretion Source: MGI
    34. positive regulation of interleukin-1 alpha secretion Source: MGI
    35. positive regulation of interleukin-1 beta production Source: MGI
    36. positive regulation of interleukin-1 beta secretion Source: MGI
    37. positive regulation of interleukin-6 production Source: MGI
    38. positive regulation of lymphocyte apoptotic process Source: MGI
    39. positive regulation of MAPK cascade Source: MGI
    40. positive regulation of mitochondrial depolarization Source: MGI
    41. positive regulation of ossification Source: MGI
    42. positive regulation of prostaglandin secretion Source: MGI
    43. positive regulation of protein phosphorylation Source: MGI
    44. positive regulation of protein secretion Source: MGI
    45. positive regulation of T cell mediated cytotoxicity Source: MGI
    46. programmed cell death Source: MGI
    47. protein oligomerization Source: MGI
    48. protein phosphorylation Source: MGI
    49. protein processing Source: MGI
    50. purinergic nucleotide receptor signaling pathway Source: GOC
    51. reactive oxygen species metabolic process Source: MGI
    52. release of sequestered calcium ion into cytosol Source: MGI
    53. response to ATP Source: MGI
    54. response to bacterium Source: MGI
    55. response to calcium ion Source: MGI
    56. response to drug Source: MGI
    57. response to electrical stimulus Source: MGI
    58. response to fluid shear stress Source: MGI
    59. response to lipopolysaccharide Source: MGI
    60. response to mechanical stimulus Source: MGI
    61. response to organic cyclic compound Source: MGI
    62. response to organic substance Source: MGI
    63. response to zinc ion Source: MGI
    64. skeletal system morphogenesis Source: MGI
    65. synaptic vesicle exocytosis Source: MGI
    66. T cell homeostasis Source: MGI
    67. T cell proliferation Source: MGI
    68. transmembrane transport Source: GOC

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    P2X purinoceptor 7Imported
    Submitted name:
    Purinergic receptor P2X, ligand-gated ion channel, 7Imported
    Gene namesi
    Name:P2rx7Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1339957. P2rx7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of nuclear inner membrane Source: RefGenome
    4. integral component of plasma membrane Source: MGI
    5. membrane Source: MGI
    6. neuromuscular junction Source: MGI
    7. neuronal cell body Source: MGI
    8. plasma membrane Source: MGI
    9. synapse Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P5P0.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000016028.
    HOGENOMiHOG000199495.
    HOVERGENiHBG062516.
    KOiK05220.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01314. P2X7RECEPTOR.

    Sequencei

    Sequence statusi: Complete.

    Q6P5P0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL    50
    YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN 100
    SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL 150
    ELA 153
    Length:153
    Mass (Da):17,199
    Last modified:July 5, 2004 - v1
    Checksum:i05917407370B40CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114632 Genomic DNA. No translation available.
    BC062808 mRNA. Translation: AAH62808.1.
    RefSeqiNP_001033976.1. NM_001038887.1.
    UniGeneiMm.42026.

    Genome annotation databases

    EnsembliENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468.
    GeneIDi18439.
    KEGGimmu:18439.
    UCSCiuc008zlo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114632 Genomic DNA. No translation available.
    BC062808 mRNA. Translation: AAH62808.1 .
    RefSeqi NP_001033976.1. NM_001038887.1.
    UniGenei Mm.42026.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086247 ; ENSMUSP00000083425 ; ENSMUSG00000029468 .
    GeneIDi 18439.
    KEGGi mmu:18439.
    UCSCi uc008zlo.1. mouse.

    Organism-specific databases

    CTDi 5027.
    MGIi MGI:1339957. P2rx7.

    Phylogenomic databases

    GeneTreei ENSGT00390000016028.
    HOGENOMi HOG000199495.
    HOVERGENi HBG062516.
    KOi K05220.

    Miscellaneous databases

    NextBioi 294114.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6P5P0.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01314. P2X7RECEPTOR.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary glandImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6P5P0_MOUSE
    AccessioniPrimary (citable) accession number: Q6P5P0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3