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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

Adh5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.UniRule annotation

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenaseUniRule annotation (EC:1.1.1.284UniRule annotation)
Gene namesi
Name:Adh5Imported
ORF Names:mCG_21036Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87929. Adh5.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

MaxQBiQ6P5I3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028138.
ExpressionAtlasiQ6P5I3. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6P5I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 153ADH_NInterPro annotationAdd BLAST121
Domaini202 – 327ADH_zinc_NInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOVERGENiHBG000195.
KOiK00121.
OMAiCIGNVNT.
OrthoDBiEOG091G08N3.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P5I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQVIRCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKIL ATAVCHTDAY
60 70 80 90 100
TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC
110 120 130 140 150
KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKSVFHF MGTSTFSEYT
160 170 180 190 200
VVADISVAKI DPSAPLDKVC LLGCGISTGY GAAVNTAKVE PGSTCAVFGL
210 220 230 240 250
GGVGLAVIMG CKVAGASRII GIDINKDKFA KAKEFGASEC ISPQDFSKSI
260 270 280 290 300
QEVLVEMTDG GVDYSFECIG NVKVMRSALE AAHKGWGVSV VVGVAASGEE
310 320 330 340 350
ISTRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTGNL
360 370
SFDQINQAFD LMHSGDSIRT VLKM
Length:374
Mass (Da):39,548
Last modified:April 3, 2007 - v2
Checksum:i32A3727B5DAB0919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062879 mRNA. Translation: AAH62879.2.
CH466532 Genomic DNA. Translation: EDL12095.1.
RefSeqiNP_031436.2. NM_007410.3.
UniGeneiMm.3874.

Genome annotation databases

GeneIDi11532.
KEGGimmu:11532.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6P5I3_MOUSE
AccessioniPrimary (citable) accession number: Q6P5I3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: April 3, 2007
Last modified: July 5, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)