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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

Adh5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.UniRule annotation

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenaseUniRule annotation (EC:1.1.1.284UniRule annotation)
Gene namesi
Name:Adh5Imported
ORF Names:mCG_21036Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87929 Adh5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ6P5I3
PRIDEiQ6P5I3

Expressioni

Gene expression databases

BgeeiENSMUSG00000028138
ExpressionAtlasiQ6P5I3 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6P5I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 153ADH_NInterPro annotationAdd BLAST121
Domaini202 – 327ADH_zinc_NInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOVERGENiHBG000195
KOiK00121
OMAiCIGNVNT
OrthoDBiEOG091G08N3

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P5I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQVIRCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKIL ATAVCHTDAY
60 70 80 90 100
TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC
110 120 130 140 150
KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKSVFHF MGTSTFSEYT
160 170 180 190 200
VVADISVAKI DPSAPLDKVC LLGCGISTGY GAAVNTAKVE PGSTCAVFGL
210 220 230 240 250
GGVGLAVIMG CKVAGASRII GIDINKDKFA KAKEFGASEC ISPQDFSKSI
260 270 280 290 300
QEVLVEMTDG GVDYSFECIG NVKVMRSALE AAHKGWGVSV VVGVAASGEE
310 320 330 340 350
ISTRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTGNL
360 370
SFDQINQAFD LMHSGDSIRT VLKM
Length:374
Mass (Da):39,548
Last modified:April 3, 2007 - v2
Checksum:i32A3727B5DAB0919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062879 mRNA Translation: AAH62879.2
CH466532 Genomic DNA Translation: EDL12095.1
RefSeqiNP_031436.2, NM_007410.3
UniGeneiMm.3874

Genome annotation databases

GeneIDi11532
KEGGimmu:11532

Similar proteinsi

Entry informationi

Entry nameiQ6P5I3_MOUSE
AccessioniPrimary (citable) accession number: Q6P5I3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health