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Protein

FERM domain-containing protein 5

Gene

Frmd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:Frmd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442557. Frmd5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517FERM domain-containing protein 5PRO_0000247447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei375 – 3751PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P5H6.
PaxDbiQ6P5H6.
PRIDEiQ6P5H6.

PTM databases

iPTMnetiQ6P5H6.
PhosphoSiteiQ6P5H6.

Expressioni

Gene expression databases

BgeeiQ6P5H6.
CleanExiMM_FRMD5.
ExpressionAtlasiQ6P5H6. baseline and differential.
GenevisibleiQ6P5H6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115136.

Structurei

3D structure databases

ProteinModelPortaliQ6P5H6.
SMRiQ6P5H6. Positions 19-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 298282FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3530. Eukaryota.
ENOG410XSWH. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ6P5H6.
PhylomeDBiQ6P5H6.
TreeFamiTF343477.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL
60 70 80 90 100
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD
110 120 130 140 150
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDP
160 170 180 190 200
GKHPEGYSSK FQFFPKHSEK LEKKIAEIHK TELSGQTPAT SELNFLRKAQ
210 220 230 240 250
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK
260 270 280 290 300
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR
360 370 380 390 400
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSSSHGDT
410 420 430 440 450
FLPHVRSSRA DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN
460 470 480 490 500
GATCSIEEEK ESEASTPTAT EAEALGGELR ALCQGHGGSE QEQRVHLKGP
510
QLQQQQWKGW GKSVPLD
Length:517
Mass (Da):58,583
Last modified:July 5, 2004 - v1
Checksum:i064722C4016B4BD5
GO
Isoform 2 (identifier: Q6P5H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → VNKFVLSVLR...RSVVSLLIDT

Show »
Length:481
Mass (Da):54,348
Checksum:iD8DAD64FD0AED216
GO
Isoform 3 (identifier: Q6P5H6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → MQERDRSEEGIEKEQRPWKGPGSTKQDL

Show »
Length:432
Mass (Da):48,513
Checksum:i91418B158E65C848
GO
Isoform 4 (identifier: Q6P5H6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → AMVCLQNPLSGEPAN

Show »
Length:419
Mass (Da):46,741
Checksum:i67D194BB8FB371F4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_019983Add
BLAST
Alternative sequencei494 – 51724RVHLK…SVPLD → VNKFVLSVLRLLLVTMGLLF VLLLLLIILTESDLDVAFFR DIRQTPEFEQFHYQYFCPLR RWFACKIRSVVSLLIDT in isoform 2. 1 PublicationVSP_019984Add
BLAST
Alternative sequencei494 – 51724RVHLK…SVPLD → MQERDRSEEGIEKEQRPWKG PGSTKQDL in isoform 3. 1 PublicationVSP_019985Add
BLAST
Alternative sequencei494 – 51724RVHLK…SVPLD → AMVCLQNPLSGEPAN in isoform 4. 1 PublicationVSP_019986Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030883 mRNA. Translation: BAC27170.1.
AL928678 Genomic DNA. Translation: CAQ12956.1.
BC057549 mRNA. Translation: AAH57549.1.
BC062889 mRNA. Translation: AAH62889.1.
CCDSiCCDS16649.1. [Q6P5H6-1]
RefSeqiNP_766261.2. NM_172673.3. [Q6P5H6-1]
UniGeneiMm.121514.
Mm.428057.

Genome annotation databases

EnsembliENSMUST00000121219; ENSMUSP00000113568; ENSMUSG00000027238. [Q6P5H6-2]
ENSMUST00000138157; ENSMUSP00000115136; ENSMUSG00000027238. [Q6P5H6-1]
GeneIDi228564.
KEGGimmu:228564.
UCSCiuc008lzk.1. mouse. [Q6P5H6-1]
uc008lzm.1. mouse. [Q6P5H6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030883 mRNA. Translation: BAC27170.1.
AL928678 Genomic DNA. Translation: CAQ12956.1.
BC057549 mRNA. Translation: AAH57549.1.
BC062889 mRNA. Translation: AAH62889.1.
CCDSiCCDS16649.1. [Q6P5H6-1]
RefSeqiNP_766261.2. NM_172673.3. [Q6P5H6-1]
UniGeneiMm.121514.
Mm.428057.

3D structure databases

ProteinModelPortaliQ6P5H6.
SMRiQ6P5H6. Positions 19-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115136.

PTM databases

iPTMnetiQ6P5H6.
PhosphoSiteiQ6P5H6.

Proteomic databases

MaxQBiQ6P5H6.
PaxDbiQ6P5H6.
PRIDEiQ6P5H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000121219; ENSMUSP00000113568; ENSMUSG00000027238. [Q6P5H6-2]
ENSMUST00000138157; ENSMUSP00000115136; ENSMUSG00000027238. [Q6P5H6-1]
GeneIDi228564.
KEGGimmu:228564.
UCSCiuc008lzk.1. mouse. [Q6P5H6-1]
uc008lzm.1. mouse. [Q6P5H6-2]

Organism-specific databases

CTDi84978.
MGIiMGI:2442557. Frmd5.

Phylogenomic databases

eggNOGiKOG3530. Eukaryota.
ENOG410XSWH. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ6P5H6.
PhylomeDBiQ6P5H6.
TreeFamiTF343477.

Miscellaneous databases

PROiQ6P5H6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P5H6.
CleanExiMM_FRMD5.
ExpressionAtlasiQ6P5H6. baseline and differential.
GenevisibleiQ6P5H6. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiFRMD5_MOUSE
AccessioniPrimary (citable) accession number: Q6P5H6
Secondary accession number(s): B0R0I9, Q6PFH6, Q8C0K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.