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Protein

FERM domain-containing protein 5

Gene

Frmd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:Frmd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442557. Frmd5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474471 – 517FERM domain-containing protein 5Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P5H6.
PeptideAtlasiQ6P5H6.
PRIDEiQ6P5H6.

PTM databases

iPTMnetiQ6P5H6.
PhosphoSitePlusiQ6P5H6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027238.
CleanExiMM_FRMD5.
ExpressionAtlasiQ6P5H6. baseline and differential.
GenevisibleiQ6P5H6. MM.

Interactioni

Subunit structurei

Interacts with CTNND1, ITGB5 (via cytoplasmic domain) and ROCK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115136.

Structurei

3D structure databases

ProteinModelPortaliQ6P5H6.
SMRiQ6P5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 298FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 353Interaction with ROCK1By similarityAdd BLAST46

Phylogenomic databases

eggNOGiKOG3530. Eukaryota.
ENOG410XSWH. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ6P5H6.
PhylomeDBiQ6P5H6.
TreeFamiTF343477.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_sf.
IPR035963. FERM_2.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH-like_dom_sf.
IPR029071. Ubiquitin-like_domsf.
PfamiView protein in Pfam
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL
60 70 80 90 100
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD
110 120 130 140 150
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDP
160 170 180 190 200
GKHPEGYSSK FQFFPKHSEK LEKKIAEIHK TELSGQTPAT SELNFLRKAQ
210 220 230 240 250
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK
260 270 280 290 300
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR
360 370 380 390 400
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSSSHGDT
410 420 430 440 450
FLPHVRSSRA DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN
460 470 480 490 500
GATCSIEEEK ESEASTPTAT EAEALGGELR ALCQGHGGSE QEQRVHLKGP
510
QLQQQQWKGW GKSVPLD
Length:517
Mass (Da):58,583
Last modified:July 5, 2004 - v1
Checksum:i064722C4016B4BD5
GO
Isoform 2 (identifier: Q6P5H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → VNKFVLSVLR...RSVVSLLIDT

Show »
Length:481
Mass (Da):54,348
Checksum:iD8DAD64FD0AED216
GO
Isoform 3 (identifier: Q6P5H6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → MQERDRSEEGIEKEQRPWKGPGSTKQDL

Show »
Length:432
Mass (Da):48,513
Checksum:i91418B158E65C848
GO
Isoform 4 (identifier: Q6P5H6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     494-517: RVHLKGPQLQQQQWKGWGKSVPLD → AMVCLQNPLSGEPAN

Show »
Length:419
Mass (Da):46,741
Checksum:i67D194BB8FB371F4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199831 – 89Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST89
Alternative sequenceiVSP_019984494 – 517RVHLK…SVPLD → VNKFVLSVLRLLLVTMGLLF VLLLLLIILTESDLDVAFFR DIRQTPEFEQFHYQYFCPLR RWFACKIRSVVSLLIDT in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_019985494 – 517RVHLK…SVPLD → MQERDRSEEGIEKEQRPWKG PGSTKQDL in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_019986494 – 517RVHLK…SVPLD → AMVCLQNPLSGEPAN in isoform 4. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030883 mRNA. Translation: BAC27170.1.
AL928678 Genomic DNA. Translation: CAQ12956.1.
BC057549 mRNA. Translation: AAH57549.1.
BC062889 mRNA. Translation: AAH62889.1.
CCDSiCCDS16649.1. [Q6P5H6-1]
RefSeqiNP_766261.2. NM_172673.3. [Q6P5H6-1]
UniGeneiMm.121514.
Mm.428057.

Genome annotation databases

EnsembliENSMUST00000121219; ENSMUSP00000113568; ENSMUSG00000027238. [Q6P5H6-2]
ENSMUST00000138157; ENSMUSP00000115136; ENSMUSG00000027238. [Q6P5H6-1]
GeneIDi228564.
KEGGimmu:228564.
UCSCiuc008lzk.1. mouse. [Q6P5H6-1]
uc008lzm.1. mouse. [Q6P5H6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFRMD5_MOUSE
AccessioniPrimary (citable) accession number: Q6P5H6
Secondary accession number(s): B0R0I9, Q6PFH6, Q8C0K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot