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Q6P5H2

- NEST_MOUSE

UniProt

Q6P5H2 - NEST_MOUSE

Protein

Nestin

Gene

Nes

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division By similarity. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.By similarity1 Publication

    GO - Molecular functioni

    1. intermediate filament binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. cell projection morphogenesis Source: MGI
    3. embryonic camera-type eye development Source: UniProtKB
    4. G2/M transition of mitotic cell cycle Source: Ensembl
    5. negative regulation of catalytic activity Source: Ensembl
    6. negative regulation of neuron apoptotic process Source: MGI
    7. negative regulation of protein binding Source: Ensembl
    8. nervous system development Source: MGI
    9. positive regulation of intermediate filament depolymerization Source: UniProtKB
    10. positive regulation of neural precursor cell proliferation Source: UniProtKB
    11. stem cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nestin
    Gene namesi
    Name:Nes
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:101784. Nes.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. intermediate filament Source: MGI
    3. intracellular Source: MGI

    Keywords - Cellular componenti

    Intermediate filament

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethality with the neuroepithelium of developing neural tube exhibiting low numbers of neural stem cells and high levels of apoptosis. No effect on cytoskeletal integrity.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18641864NestinPRO_0000285856Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei312 – 3121PhosphoserineBy similarity
    Modified residuei316 – 3161PhosphothreonineBy similarity
    Modified residuei356 – 3561PhosphoserineBy similarity
    Modified residuei359 – 3591PhosphoserineBy similarity
    Modified residuei389 – 3891PhosphothreonineBy similarity
    Modified residuei565 – 5651PhosphoserineBy similarity
    Modified residuei575 – 5751PhosphoserineBy similarity
    Modified residuei688 – 6881PhosphoserineBy similarity
    Modified residuei841 – 8411PhosphoserineBy similarity
    Modified residuei1106 – 11061PhosphoserineBy similarity
    Modified residuei1177 – 11771PhosphoserineBy similarity
    Modified residuei1188 – 11881PhosphoserineBy similarity
    Modified residuei1195 – 11951PhosphoserineBy similarity
    Modified residuei1216 – 12161PhosphoserineBy similarity
    Modified residuei1541 – 15411Phosphoserine1 Publication
    Modified residuei1656 – 16561PhosphoserineBy similarity
    Modified residuei1665 – 16651PhosphoserineBy similarity
    Modified residuei1745 – 17451PhosphoserineBy similarity
    Modified residuei1747 – 17471PhosphoserineBy similarity
    Modified residuei1837 – 18371Phosphoserine1 Publication
    Modified residuei1860 – 18601PhosphoserineBy similarity
    Modified residuei1861 – 18611PhosphoserineBy similarity

    Post-translational modificationi

    Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P5H2.
    PaxDbiQ6P5H2.
    PRIDEiQ6P5H2.

    PTM databases

    PhosphoSiteiQ6P5H2.

    Expressioni

    Gene expression databases

    BgeeiQ6P5H2.
    CleanExiMM_NES.
    GenevestigatoriQ6P5H2.

    Interactioni

    Subunit structurei

    Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ6P5H2. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P5H2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 77Head
    Regioni8 – 314307RodAdd
    BLAST
    Regioni8 – 4336Coil 1AAdd
    BLAST
    Regioni44 – 5512Linker 1Add
    BLAST
    Regioni56 – 15196Coil 1BAdd
    BLAST
    Regioni152 – 17423Linker 12Add
    BLAST
    Regioni175 – 19319Coil 2AAdd
    BLAST
    Regioni194 – 1963Linker 2
    Regioni197 – 314118Coil 2BAdd
    BLAST
    Regioni315 – 18641550TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000110953.
    HOGENOMiHOG000113766.
    HOVERGENiHBG006463.
    InParanoidiQ6P5H2.
    KOiK07609.
    OMAiDHASLAP.
    OrthoDBiEOG773XKP.
    PhylomeDBiQ6P5H2.
    TreeFamiTF336633.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P5H2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGCVGEESF QMWELNRRLE AYLTRVKTLE EQNQLLSAEL GGLRAQSGDA     50
    SWRARADDEL AALRVLVDQR WREKHEAEVQ RDNLAEELES VAGRCQQVRL 100
    ARERTIEEAA CSRRALEAEK NARGWLSTQA AELERELEAL RASHEEERAH 150
    LNAQAACTPR RPPAPAHASP IRAPEVEELA RRLGEVWRGA VRDYQERVAH 200
    MESSLGQARE RLGQAVRGAR ESRLEVQQLQ ADRDSLQERR EALEQRLEGR 250
    WQDRLQATEK FQLAVEALEQ EKQGLQSQIA QILEGGQQLA HLKMSLSLEV 300
    ATYRTLLEAE NSRLQTPGRS SQASLGFPDP KLKLHFLGIP EDQHLGSVLP 350
    VLSPTSFSSP LPNTLETPVT AFLKTQEFLK ARTPTLASTP IPPMSEAPYP 400
    KNAEVRAQDV PHSLLQGGRQ QAPEPLWAEA TVPSSTGVLP ELEEPGGEQP 450
    DHFPDDPTSL APPLNPHHSI LEAKDRESSE SRVSSIFQEE EGQIWELVKK 500
    EAATEVKVEN SLAQEIQESG LDTEEIQDSQ GPLQMETLEA LGDEPLMSLK 550
    TQNHETPGKE NCNSSIEENS GTVKSPEKEK QTPLKSLEEK NVEAEKTLEN 600
    GVLELSKPLG EEEPRMEDQE LMSPEHTLET VSFLGKENQE VVRSSEEQNL 650
    ESLITFKEES QYPLGGPEAE DQMLERLVEK EDQRFPRSPE EDQQAFRPLE 700
    KENQEPLRFE EAEDQVLERL IEKERQESLK SPEEEDQQAF RLLEKENQEP 750
    LRFEDAEDQV LERLIEKERQ ESLKSPEEED QQAFRLLEKE NQEPLRFEEA 800
    EDQVLERLVE KESQESLKSP EEEDQRTGKP LEKENQESLR SLDENQETIV 850
    LLESKNQRPL RSLEVEEEEQ RIVKPLEKVS QVSLESLEKE NVQSPRYLEE 900
    DDHMIKSLLE DKTHEILGSL EDRNGENFIP PENETQGSLR PPEEEDQRIV 950
    NHLEKESQEF LRSPEAEEEE EQVMVRSLEG ENHDPLSSVV KEEQMAESKL 1000
    ENESQDSRKS LEDESQETFG SLEKENLESL RSLAGQDQEE QKLEQETQQP 1050
    LRAVEDEQMT VNPPEKVDPE LPKPLRNDQE VVRSLDKENQ ESLVSLNEGG 1100
    METVKSSETE NIESLETVGE CLGRRKSVDT QEPLWSTEVT SETIEPLEDE 1150
    TQEPLGCVDE NQEVLTPLER ESQELRSLGK WNPETVESPG GVEDSQQCLE 1200
    VEEGPEREQH QESLRSLGEV EWELPGSGSQ QRWEDVVEDG EGQEASLGAT 1250
    GVETEDKAEL HLRGQGGEEK AVEEGELLQD AVGEAWSLGS SEPKEQRVPA 1300
    EPLDDLEGQP EQTGTLEVPV AQGMPEATEQ DEDRAQAGEQ DSVEVTLGLE 1350
    AARAGLELEQ EVVGLEDPRH FAREEAIHPS LGEESVKAKI DQGLEEPGKE 1400
    PKEAGALDSG IPELPKTSSE TLECKGWEES GEGWGEEEAS LETSDHEGSH 1450
    APQPRPPKTE EDEGLQAALT VPGPKLLEPC SPIPILTDAH ELQPQAEGIQ 1500
    EAGWQPEAGT EALGRVEDEP EFGRGEIPEG LQDWEEGRED SEADELGETL 1550
    PDSTPLGLYL KSPASPKWEQ AGEQRLFPQG EARKEGWSPA ALAAQGLSDP 1600
    PEEEQQGHDS DLSSEEFEDL GTEASLLPGV PKEVSDHLGQ EPPVLQPACW 1650
    DQGGESDGFA DEEESGEEGE EEDADEEEGA ESGTQWWGPG PSGGGVKVQD 1700
    VTQRGDLEHE SVGDSGLWDD GLSGAAANVL VTALETVSQD SAEPSGSEGS 1750
    ESASLEGEEG QAIDHLDAPQ EVTSVVPGAG DTFDISGQGP NLESEQVNGR 1800
    MENGLEQAEG QVVLHGDEDQ GIPLQEQGTL KAPLVGSPVH LGPSQPLKFT 1850
    LSGVDGDSWS SGED 1864
    Length:1,864
    Mass (Da):207,124
    Last modified:July 5, 2004 - v1
    Checksum:iB9DF21005D977983
    GO
    Isoform 2 (identifier: Q6P5H2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         750-793: Missing.

    Show »
    Length:1,820
    Mass (Da):201,770
    Checksum:i270C501DACA10100
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841G → C in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti257 – 2571A → P in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti265 – 2651V → L in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti319 – 3191R → G in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti458 – 4581T → S in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti535 – 5351M → K in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti544 – 5441E → K in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti558 – 5581G → R in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti570 – 5701S → L in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti587 – 5871L → S in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti673 – 6731M → I in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti704 – 7041Q → L in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti734 – 7341E → D in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti851 – 8511L → P in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti855 – 8551K → R in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti900 – 9001E → D in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1008 – 10114RKSL → GKFF in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1021 – 10211S → F in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1157 – 11571C → S in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1241 – 12411E → EV in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1382 – 13821G → A in ABK96808. 1 PublicationCurated
    Sequence conflicti1404 – 14041A → T in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1410 – 14101G → S in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1577 – 15771F → S in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1586 – 15916GWSPAA → DWGPAV in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1684 – 16841T → A in AAF04456. (PubMed:10842089)Curated
    Sequence conflicti1821 – 18211G → D in AAF04456. (PubMed:10842089)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei750 – 79344Missing in isoform 2. 1 PublicationVSP_024923Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076623 mRNA. Translation: AAF04456.2.
    BC060693 mRNA. Translation: AAH60693.1.
    BC062893 mRNA. Translation: AAH62893.1.
    AK009706 mRNA. Translation: BAB26451.1.
    AK075690 mRNA. Translation: BAC35892.1.
    S78708 mRNA. Translation: AAP32014.1.
    EF101559 mRNA. Translation: ABK96808.1.
    CCDSiCCDS17461.1. [Q6P5H2-1]
    RefSeqiNP_057910.3. NM_016701.3. [Q6P5H2-1]
    UniGeneiMm.331129.

    Genome annotation databases

    EnsembliENSMUST00000090973; ENSMUSP00000088493; ENSMUSG00000004891. [Q6P5H2-1]
    ENSMUST00000160694; ENSMUSP00000125571; ENSMUSG00000004891. [Q6P5H2-2]
    GeneIDi18008.
    KEGGimmu:18008.
    UCSCiuc008ptm.1. mouse. [Q6P5H2-2]
    uc008ptn.1. mouse. [Q6P5H2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076623 mRNA. Translation: AAF04456.2 .
    BC060693 mRNA. Translation: AAH60693.1 .
    BC062893 mRNA. Translation: AAH62893.1 .
    AK009706 mRNA. Translation: BAB26451.1 .
    AK075690 mRNA. Translation: BAC35892.1 .
    S78708 mRNA. Translation: AAP32014.1 .
    EF101559 mRNA. Translation: ABK96808.1 .
    CCDSi CCDS17461.1. [Q6P5H2-1 ]
    RefSeqi NP_057910.3. NM_016701.3. [Q6P5H2-1 ]
    UniGenei Mm.331129.

    3D structure databases

    ProteinModelPortali Q6P5H2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P5H2. 4 interactions.

    PTM databases

    PhosphoSitei Q6P5H2.

    Proteomic databases

    MaxQBi Q6P5H2.
    PaxDbi Q6P5H2.
    PRIDEi Q6P5H2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090973 ; ENSMUSP00000088493 ; ENSMUSG00000004891 . [Q6P5H2-1 ]
    ENSMUST00000160694 ; ENSMUSP00000125571 ; ENSMUSG00000004891 . [Q6P5H2-2 ]
    GeneIDi 18008.
    KEGGi mmu:18008.
    UCSCi uc008ptm.1. mouse. [Q6P5H2-2 ]
    uc008ptn.1. mouse. [Q6P5H2-1 ]

    Organism-specific databases

    CTDi 10763.
    MGIi MGI:101784. Nes.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000110953.
    HOGENOMi HOG000113766.
    HOVERGENi HBG006463.
    InParanoidi Q6P5H2.
    KOi K07609.
    OMAi DHASLAP.
    OrthoDBi EOG773XKP.
    PhylomeDBi Q6P5H2.
    TreeFami TF336633.

    Miscellaneous databases

    ChiTaRSi NES. mouse.
    NextBioi 293025.
    PROi Q6P5H2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P5H2.
    CleanExi MM_NES.
    Genevestigatori Q6P5H2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nestin expression during mouse eye and lens development."
      Yang J., Bian W., Gao X., Chen L., Jing N.
      Mech. Dev. 94:287-291(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-764 AND 1510-1864.
      Strain: C57BL/6J.
      Tissue: Tongue.
    4. "Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart."
      Kachinsky A.M., Dominov J.A., Miller J.B.
      J. Histochem. Cytochem. 43:843-847(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-57.
      Tissue: Heart.
    5. "Novel metastatic mouse tumor cells express multiple properties of macrophages."
      Huysentruyt L.C., Banerjee D., Seyfried T.N.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1358-1514.
      Strain: VM.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1541, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1837, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "Nestin is required for the proper self-renewal of neural stem cells."
      Park D., Xiang A.P., Mao F.F., Zhang L., Di C.G., Liu X.M., Shao Y., Ma B.F., Lee J.H., Ha K.S., Walton N., Lahn B.T.
      Stem Cells 28:2162-2171(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiNEST_MOUSE
    AccessioniPrimary (citable) accession number: Q6P5H2
    Secondary accession number(s): A1E2I2
    , Q80X00, Q8BPH7, Q9CV43, Q9R0C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3