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Q6P5F9

- XPO1_MOUSE

UniProt

Q6P5F9 - XPO1_MOUSE

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Protein

Exportin-1

Gene

Xpo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).By similarity

GO - Molecular functioni

  1. nucleocytoplasmic transporter activity Source: Ensembl
  2. protein transporter activity Source: MGI
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. protein export from nucleus Source: MGI
  4. protein localization to nucleus Source: MGI
  5. regulation of centrosome duplication Source: MGI
  6. regulation of protein catabolic process Source: MGI
  7. regulation of protein export from nucleus Source: MGI
  8. response to drug Source: Ensembl
  9. ribosomal large subunit export from nucleus Source: Ensembl
  10. ribosomal small subunit export from nucleus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198691. HuR stabilizes mRNA.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_215733. Downregulation of TGF-beta receptor signaling.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Short name:
Exp1
Alternative name(s):
Chromosome region maintenance 1 protein homolog
Gene namesi
Name:Xpo1
Synonyms:Crm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2144013. Xpo1.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleoplasm By similarity. NucleusCajal body By similarity. Nucleusnucleolus By similarity
Note: Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm (By similarity).By similarity

GO - Cellular componenti

  1. annulate lamellae Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
  3. kinetochore Source: UniProtKB
  4. nuclear membrane Source: Ensembl
  5. nucleus Source: MGI
  6. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10711071Exportin-1PRO_0000204706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei446 – 4461N6-acetyllysine1 Publication
Modified residuei448 – 4481PhosphothreonineBy similarity
Modified residuei450 – 4501PhosphoserineBy similarity
Modified residuei454 – 4541PhosphotyrosineBy similarity
Modified residuei693 – 6931N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6P5F9.
PaxDbiQ6P5F9.
PRIDEiQ6P5F9.

PTM databases

PhosphoSiteiQ6P5F9.

Expressioni

Gene expression databases

BgeeiQ6P5F9.
CleanExiMM_XPO1.
ExpressionAtlasiQ6P5F9. baseline and differential.
GenevestigatoriQ6P5F9.

Interactioni

Subunit structurei

Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1 (By similarity). Interacts with DCAF8.By similarity

Protein-protein interaction databases

BioGridi222117. 10 interactions.
DIPiDIP-48612N.
IntActiQ6P5F9. 4 interactions.
STRINGi10090.ENSMUSP00000099934.

Structurei

Secondary structure

1
1071
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 203Combined sources
Helixi25 – 339Combined sources
Turni34 – 363Combined sources
Helixi40 – 5112Combined sources
Turni52 – 543Combined sources
Beta strandi55 – 573Combined sources
Helixi59 – 635Combined sources
Helixi73 – 8917Combined sources
Helixi91 – 933Combined sources
Helixi96 – 11419Combined sources
Helixi117 – 1204Combined sources
Helixi124 – 14118Combined sources
Turni142 – 1454Combined sources
Helixi149 – 15911Combined sources
Helixi161 – 17818Combined sources
Helixi182 – 1854Combined sources
Helixi188 – 20013Combined sources
Helixi203 – 21513Combined sources
Helixi219 – 23214Combined sources
Turni233 – 2353Combined sources
Helixi239 – 2424Combined sources
Beta strandi243 – 2453Combined sources
Helixi246 – 2538Combined sources
Beta strandi255 – 2573Combined sources
Helixi258 – 27316Combined sources
Helixi277 – 2793Combined sources
Helixi280 – 29718Combined sources
Beta strandi300 – 3023Combined sources
Helixi304 – 3096Combined sources
Helixi315 – 33925Combined sources
Helixi341 – 3433Combined sources
Helixi344 – 35714Combined sources
Helixi363 – 38321Combined sources
Helixi404 – 4074Combined sources
Helixi410 – 42213Combined sources
Beta strandi430 – 4345Combined sources
Beta strandi436 – 4383Combined sources
Beta strandi440 – 4445Combined sources
Helixi449 – 46719Combined sources
Helixi469 – 48416Combined sources
Helixi491 – 50313Combined sources
Turni504 – 5063Combined sources
Helixi510 – 53021Combined sources
Helixi534 – 55017Combined sources
Helixi552 – 5576Combined sources
Helixi559 – 57214Combined sources
Helixi580 – 59415Combined sources
Helixi596 – 5994Combined sources
Helixi610 – 6156Combined sources
Helixi618 – 6225Combined sources
Helixi627 – 64115Combined sources
Helixi647 – 65711Combined sources
Helixi659 – 67416Combined sources
Helixi676 – 6805Combined sources
Helixi682 – 70221Combined sources
Helixi704 – 7063Combined sources
Helixi707 – 73529Combined sources
Helixi737 – 7404Combined sources
Helixi743 – 76321Combined sources
Helixi769 – 7757Combined sources
Helixi778 – 7836Combined sources
Helixi785 – 7906Combined sources
Helixi793 – 7953Combined sources
Helixi799 – 81113Combined sources
Helixi812 – 8143Combined sources
Helixi816 – 8183Combined sources
Helixi819 – 83416Combined sources
Beta strandi838 – 8403Combined sources
Helixi842 – 85817Combined sources
Helixi860 – 8623Combined sources
Turni863 – 8653Combined sources
Helixi868 – 88215Combined sources
Helixi887 – 90418Combined sources
Helixi908 – 93023Combined sources
Helixi936 – 9383Combined sources
Helixi939 – 95315Combined sources
Turni954 – 9563Combined sources
Beta strandi961 – 9633Combined sources
Turni965 – 9684Combined sources
Helixi970 – 98516Combined sources
Beta strandi987 – 9893Combined sources
Helixi991 – 100313Combined sources
Turni1004 – 10063Combined sources
Helixi1008 – 102215Combined sources
Turni1027 – 10293Combined sources
Helixi1037 – 105216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GJXX-ray2.50A/D1-1071[»]
3NBYX-ray3.42A/D1-1071[»]
3NBZX-ray2.80A/D1-1071[»]
3NC0X-ray2.90A/D1-1071[»]
3NC1X-ray3.35A1-1071[»]
ProteinModelPortaliQ6P5F9.
SMRiQ6P5F9. Positions 53-1061.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P5F9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 11267Importin N-terminalPROSITE-ProRule annotationAdd
BLAST
Repeati217 – 24024HEAT 1Add
BLAST
Repeati241 – 27737HEAT 2Add
BLAST
Repeati354 – 472119HEAT 3Add
BLAST
Repeati515 – 55339HEAT 4Add
BLAST
Repeati560 – 59738HEAT 5Add
BLAST
Repeati602 – 63938HEAT 6Add
BLAST
Repeati775 – 81339HEAT 7Add
BLAST
Repeati885 – 91632HEAT 8Add
BLAST
Repeati917 – 95438HEAT 9Add
BLAST
Repeati1002 – 103938HEAT 10Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 450124Necessary for interaction with Ran and nuclear export complex formationBy similarityAdd
BLAST
Regioni411 – 48171Necessary for interaction with RANBP3By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 10 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5101.
GeneTreeiENSGT00390000000572.
HOGENOMiHOG000209012.
HOVERGENiHBG052817.
InParanoidiQ6P5F9.
KOiK14290.
OMAiQTYFTDI.
OrthoDBiEOG7CZK4S.
PhylomeDBiQ6P5F9.
TreeFamiTF105695.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P5F9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL
60 70 80 90 100
THLKEHPDAW TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE
110 120 130 140 150
GIKKYVVGLI IKTSSDPTCV EKEKVYIGKL NMILVQILKQ EWPKHWPTFI
160 170 180 190 200
SDIVGASRTS ESLCQNNMVI LKLLSEEVFD FSSGQITQVK AKHLKDSMCN
210 220 230 240 250
EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY IFETKLISTL
260 270 280 290 300
IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFETLFTLT MMQLKQMLPL
310 320 330 340 350
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHGQLLEKR LNLREALMEA
360 370 380 390 400
LHYMLLVSEV EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF
410 420 430 440 450
DIPPRRQLYL TVLSKVRLLM VSRMAKPEEV LVVENDQGEV VREFMKDTDS
460 470 480 490 500
INLYKNMRET LVYLTHLDYV DTEIIMTKKL QNQVNGTEWS WKNLNTLCWA
510 520 530 540 550
IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII ASNIMYIVGQ
560 570 580 590 600
YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV
610 620 630 640 650
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ
660 670 680 690 700
EHLIEKYMLL PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK
710 720 730 740 750
AVGHPFVIQL GRIYLDMLNV YKCLSENISA AIQANGEMVT KQPLIRSMRT
760 770 780 790 800
VKRETLKLIS GWVSRSNDPQ MVAENFVPPL LDAVLIDYQR NVPAAREPEV
810 820 830 840 850
LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE YPEHRTNFFL
860 870 880 890 900
LLQAVNSHCF PAFLAIPPAQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL
910 920 930 940 950
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF
960 970 980 990 1000
NLVEEGKIST PLNPGNPVNN QMFIQDYVAN LLKSAFPHLQ DAQVKLFVTG
1010 1020 1030 1040 1050
LFSLNQDIPA FKEHLRDFLV QIKEFAGEDT SDLFLEERET ALRQAQEEKH
1060 1070
KLQMSVPGIL NPHEIPEEMC D
Length:1,071
Mass (Da):123,093
Last modified:July 5, 2004 - v1
Checksum:iB451A19780024562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062912 mRNA. Translation: AAH62912.1.
CCDSiCCDS24475.1.
RefSeqiNP_001030303.1. NM_001035226.1.
NP_598775.2. NM_134014.3.
XP_006514493.1. XM_006514430.1.
UniGeneiMm.217547.

Genome annotation databases

EnsembliENSMUST00000020538; ENSMUSP00000020538; ENSMUSG00000020290.
ENSMUST00000102869; ENSMUSP00000099933; ENSMUSG00000020290.
ENSMUST00000102870; ENSMUSP00000099934; ENSMUSG00000020290.
ENSMUST00000109551; ENSMUSP00000105178; ENSMUSG00000020290.
GeneIDi103573.
KEGGimmu:103573.
UCSCiuc007iet.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062912 mRNA. Translation: AAH62912.1 .
CCDSi CCDS24475.1.
RefSeqi NP_001030303.1. NM_001035226.1.
NP_598775.2. NM_134014.3.
XP_006514493.1. XM_006514430.1.
UniGenei Mm.217547.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GJX X-ray 2.50 A/D 1-1071 [» ]
3NBY X-ray 3.42 A/D 1-1071 [» ]
3NBZ X-ray 2.80 A/D 1-1071 [» ]
3NC0 X-ray 2.90 A/D 1-1071 [» ]
3NC1 X-ray 3.35 A 1-1071 [» ]
ProteinModelPortali Q6P5F9.
SMRi Q6P5F9. Positions 53-1061.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222117. 10 interactions.
DIPi DIP-48612N.
IntActi Q6P5F9. 4 interactions.
STRINGi 10090.ENSMUSP00000099934.

PTM databases

PhosphoSitei Q6P5F9.

Proteomic databases

MaxQBi Q6P5F9.
PaxDbi Q6P5F9.
PRIDEi Q6P5F9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020538 ; ENSMUSP00000020538 ; ENSMUSG00000020290 .
ENSMUST00000102869 ; ENSMUSP00000099933 ; ENSMUSG00000020290 .
ENSMUST00000102870 ; ENSMUSP00000099934 ; ENSMUSG00000020290 .
ENSMUST00000109551 ; ENSMUSP00000105178 ; ENSMUSG00000020290 .
GeneIDi 103573.
KEGGi mmu:103573.
UCSCi uc007iet.1. mouse.

Organism-specific databases

CTDi 7514.
MGIi MGI:2144013. Xpo1.

Phylogenomic databases

eggNOGi COG5101.
GeneTreei ENSGT00390000000572.
HOGENOMi HOG000209012.
HOVERGENi HBG052817.
InParanoidi Q6P5F9.
KOi K14290.
OMAi QTYFTDI.
OrthoDBi EOG7CZK4S.
PhylomeDBi Q6P5F9.
TreeFami TF105695.

Enzyme and pathway databases

Reactomei REACT_198691. HuR stabilizes mRNA.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_215733. Downregulation of TGF-beta receptor signaling.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi Xpo1. mouse.
EvolutionaryTracei Q6P5F9.
NextBioi 356011.
PROi Q6P5F9.
SOURCEi Search...

Gene expression databases

Bgeei Q6P5F9.
CleanExi MM_XPO1.
ExpressionAtlasi Q6P5F9. baseline and differential.
Genevestigatori Q6P5F9.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view ]
SMARTi SM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation."
    Ohno M., Segref A., Bachi A., Wilm M., Mattaj I.W.
    Cell 101:187-198(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A U SNRNA EXPORT COMPLEX WITH NCBP1; NCBP2; RAN; RNUXA/PHAX AND M7G-CAPPED RNA.
  3. "Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression."
    Fei E., Ma X., Zhu C., Xue T., Yan J., Xu Y., Zhou J., Wang G.
    J. Biol. Chem. 285:38630-38640(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DTNBP1, FUNCTION.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiXPO1_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3