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Q6P5F9

- XPO1_MOUSE

UniProt

Q6P5F9 - XPO1_MOUSE

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Protein
Exportin-1
Gene
Xpo1, Crm1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap By similarity.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein transporter activity Source: MGI

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. protein export from nucleus Source: MGI
  4. protein localization to nucleus Source: MGI
  5. regulation of centrosome duplication Source: MGI
  6. regulation of protein catabolic process Source: MGI
  7. regulation of protein export from nucleus Source: MGI
  8. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198691. HuR stabilizes mRNA.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_215733. Downregulation of TGF-beta receptor signaling.
REACT_219771. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Short name:
Exp1
Alternative name(s):
Chromosome region maintenance 1 protein homolog
Gene namesi
Name:Xpo1
Synonyms:Crm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2144013. Xpo1.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleoplasm By similarity. NucleusCajal body By similarity. Nucleusnucleolus By similarity
Note: Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm By similarity.

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
  2. annulate lamellae Source: Ensembl
  3. cytoplasm Source: UniProtKB-SubCell
  4. kinetochore Source: UniProtKB
  5. nucleolus Source: UniProtKB-SubCell
  6. nucleus Source: MGI
  7. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10711071Exportin-1
PRO_0000204706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911Phosphoserine By similarity
Modified residuei446 – 4461N6-acetyllysine1 Publication
Modified residuei448 – 4481Phosphothreonine By similarity
Modified residuei450 – 4501Phosphoserine By similarity
Modified residuei454 – 4541Phosphotyrosine By similarity
Modified residuei693 – 6931N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6P5F9.
PaxDbiQ6P5F9.
PRIDEiQ6P5F9.

PTM databases

PhosphoSiteiQ6P5F9.

Expressioni

Gene expression databases

ArrayExpressiQ6P5F9.
BgeeiQ6P5F9.
CleanExiMM_XPO1.
GenevestigatoriQ6P5F9.

Interactioni

Subunit structurei

Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2.2 Publications

Protein-protein interaction databases

BioGridi222117. 10 interactions.
DIPiDIP-48612N.
IntActiQ6P5F9. 4 interactions.
STRINGi10090.ENSMUSP00000099934.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 203
Helixi25 – 339
Turni34 – 363
Helixi40 – 5112
Turni52 – 543
Beta strandi55 – 573
Helixi59 – 635
Helixi73 – 8917
Helixi91 – 933
Helixi96 – 11419
Helixi117 – 1204
Helixi124 – 14118
Turni142 – 1454
Helixi149 – 15911
Helixi161 – 17818
Helixi182 – 1854
Helixi188 – 20013
Helixi203 – 21513
Helixi219 – 23214
Turni233 – 2353
Helixi239 – 2424
Beta strandi243 – 2453
Helixi246 – 2538
Beta strandi255 – 2573
Helixi258 – 27316
Helixi277 – 2793
Helixi280 – 29718
Beta strandi300 – 3023
Helixi304 – 3096
Helixi315 – 33925
Helixi341 – 3433
Helixi344 – 35714
Helixi363 – 38321
Helixi404 – 4074
Helixi410 – 42213
Beta strandi430 – 4345
Beta strandi436 – 4383
Beta strandi440 – 4445
Helixi449 – 46719
Helixi469 – 48416
Helixi491 – 50313
Turni504 – 5063
Helixi510 – 53021
Helixi534 – 55017
Helixi552 – 5576
Helixi559 – 57214
Helixi580 – 59415
Helixi596 – 5994
Helixi610 – 6156
Helixi618 – 6225
Helixi627 – 64115
Helixi647 – 65711
Helixi659 – 67416
Helixi676 – 6805
Helixi682 – 70221
Helixi704 – 7063
Helixi707 – 73529
Helixi737 – 7404
Helixi743 – 76321
Helixi769 – 7757
Helixi778 – 7836
Helixi785 – 7906
Helixi793 – 7953
Helixi799 – 81113
Helixi812 – 8143
Helixi816 – 8183
Helixi819 – 83416
Beta strandi838 – 8403
Helixi842 – 85817
Helixi860 – 8623
Turni863 – 8653
Helixi868 – 88215
Helixi887 – 90418
Helixi908 – 93023
Helixi936 – 9383
Helixi939 – 95315
Turni954 – 9563
Beta strandi961 – 9633
Turni965 – 9684
Helixi970 – 98516
Beta strandi987 – 9893
Helixi991 – 100313
Turni1004 – 10063
Helixi1008 – 102215
Turni1027 – 10293
Helixi1037 – 105216

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GJXX-ray2.50A/D1-1071[»]
3NBYX-ray3.42A/D1-1071[»]
3NBZX-ray2.80A/D1-1071[»]
3NC0X-ray2.90A/D1-1071[»]
3NC1X-ray3.35A1-1071[»]
ProteinModelPortaliQ6P5F9.
SMRiQ6P5F9. Positions 53-1061.

Miscellaneous databases

EvolutionaryTraceiQ6P5F9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 11267Importin N-terminal
Add
BLAST
Repeati217 – 24024HEAT 1
Add
BLAST
Repeati241 – 27737HEAT 2
Add
BLAST
Repeati354 – 472119HEAT 3
Add
BLAST
Repeati515 – 55339HEAT 4
Add
BLAST
Repeati560 – 59738HEAT 5
Add
BLAST
Repeati602 – 63938HEAT 6
Add
BLAST
Repeati775 – 81339HEAT 7
Add
BLAST
Repeati885 – 91632HEAT 8
Add
BLAST
Repeati917 – 95438HEAT 9
Add
BLAST
Repeati1002 – 103938HEAT 10
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 450124Necessary for interaction with Ran and nuclear export complex formation By similarity
Add
BLAST
Regioni411 – 48171Necessary for interaction with RANBP3 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the exportin family.
Contains 10 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5101.
GeneTreeiENSGT00390000000572.
HOGENOMiHOG000209012.
HOVERGENiHBG052817.
InParanoidiQ6P5F9.
KOiK14290.
OMAiQTYFTDI.
OrthoDBiEOG7CZK4S.
PhylomeDBiQ6P5F9.
TreeFamiTF105695.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P5F9-1 [UniParc]FASTAAdd to Basket

« Hide

MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL     50
THLKEHPDAW TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE 100
GIKKYVVGLI IKTSSDPTCV EKEKVYIGKL NMILVQILKQ EWPKHWPTFI 150
SDIVGASRTS ESLCQNNMVI LKLLSEEVFD FSSGQITQVK AKHLKDSMCN 200
EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY IFETKLISTL 250
IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFETLFTLT MMQLKQMLPL 300
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHGQLLEKR LNLREALMEA 350
LHYMLLVSEV EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF 400
DIPPRRQLYL TVLSKVRLLM VSRMAKPEEV LVVENDQGEV VREFMKDTDS 450
INLYKNMRET LVYLTHLDYV DTEIIMTKKL QNQVNGTEWS WKNLNTLCWA 500
IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII ASNIMYIVGQ 550
YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV 600
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ 650
EHLIEKYMLL PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK 700
AVGHPFVIQL GRIYLDMLNV YKCLSENISA AIQANGEMVT KQPLIRSMRT 750
VKRETLKLIS GWVSRSNDPQ MVAENFVPPL LDAVLIDYQR NVPAAREPEV 800
LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE YPEHRTNFFL 850
LLQAVNSHCF PAFLAIPPAQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL 900
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF 950
NLVEEGKIST PLNPGNPVNN QMFIQDYVAN LLKSAFPHLQ DAQVKLFVTG 1000
LFSLNQDIPA FKEHLRDFLV QIKEFAGEDT SDLFLEERET ALRQAQEEKH 1050
KLQMSVPGIL NPHEIPEEMC D 1071
Length:1,071
Mass (Da):123,093
Last modified:July 5, 2004 - v1
Checksum:iB451A19780024562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062912 mRNA. Translation: AAH62912.1.
CCDSiCCDS24475.1.
RefSeqiNP_001030303.1. NM_001035226.1.
NP_598775.2. NM_134014.3.
XP_006514493.1. XM_006514430.1.
UniGeneiMm.217547.

Genome annotation databases

EnsembliENSMUST00000020538; ENSMUSP00000020538; ENSMUSG00000020290.
ENSMUST00000102869; ENSMUSP00000099933; ENSMUSG00000020290.
ENSMUST00000102870; ENSMUSP00000099934; ENSMUSG00000020290.
ENSMUST00000109551; ENSMUSP00000105178; ENSMUSG00000020290.
GeneIDi103573.
KEGGimmu:103573.
UCSCiuc007iet.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062912 mRNA. Translation: AAH62912.1 .
CCDSi CCDS24475.1.
RefSeqi NP_001030303.1. NM_001035226.1.
NP_598775.2. NM_134014.3.
XP_006514493.1. XM_006514430.1.
UniGenei Mm.217547.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GJX X-ray 2.50 A/D 1-1071 [» ]
3NBY X-ray 3.42 A/D 1-1071 [» ]
3NBZ X-ray 2.80 A/D 1-1071 [» ]
3NC0 X-ray 2.90 A/D 1-1071 [» ]
3NC1 X-ray 3.35 A 1-1071 [» ]
ProteinModelPortali Q6P5F9.
SMRi Q6P5F9. Positions 53-1061.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222117. 10 interactions.
DIPi DIP-48612N.
IntActi Q6P5F9. 4 interactions.
STRINGi 10090.ENSMUSP00000099934.

PTM databases

PhosphoSitei Q6P5F9.

Proteomic databases

MaxQBi Q6P5F9.
PaxDbi Q6P5F9.
PRIDEi Q6P5F9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020538 ; ENSMUSP00000020538 ; ENSMUSG00000020290 .
ENSMUST00000102869 ; ENSMUSP00000099933 ; ENSMUSG00000020290 .
ENSMUST00000102870 ; ENSMUSP00000099934 ; ENSMUSG00000020290 .
ENSMUST00000109551 ; ENSMUSP00000105178 ; ENSMUSG00000020290 .
GeneIDi 103573.
KEGGi mmu:103573.
UCSCi uc007iet.1. mouse.

Organism-specific databases

CTDi 7514.
MGIi MGI:2144013. Xpo1.

Phylogenomic databases

eggNOGi COG5101.
GeneTreei ENSGT00390000000572.
HOGENOMi HOG000209012.
HOVERGENi HBG052817.
InParanoidi Q6P5F9.
KOi K14290.
OMAi QTYFTDI.
OrthoDBi EOG7CZK4S.
PhylomeDBi Q6P5F9.
TreeFami TF105695.

Enzyme and pathway databases

Reactomei REACT_198691. HuR stabilizes mRNA.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_207679. Separation of Sister Chromatids.
REACT_215733. Downregulation of TGF-beta receptor signaling.
REACT_219771. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

ChiTaRSi XPO1. mouse.
EvolutionaryTracei Q6P5F9.
NextBioi 356011.
PROi Q6P5F9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P5F9.
Bgeei Q6P5F9.
CleanExi MM_XPO1.
Genevestigatori Q6P5F9.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view ]
SMARTi SM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation."
    Ohno M., Segref A., Bachi A., Wilm M., Mattaj I.W.
    Cell 101:187-198(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A U SNRNA EXPORT COMPLEX WITH NCBP1; NCBP2; RAN; RNUXA/PHAX AND M7G-CAPPED RNA.
  3. "Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression."
    Fei E., Ma X., Zhu C., Xue T., Yan J., Xu Y., Zhou J., Wang G.
    J. Biol. Chem. 285:38630-38640(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DTNBP1, FUNCTION.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiXPO1_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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