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Protein

Protein tweety homolog 3

Gene

Ttyh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable large-conductance Ca2+-activated chloride channel. May play a role in Ca2+ signal transduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tweety homolog 3
Short name:
mTTY3
Gene namesi
Name:Ttyh3
Synonyms:Kiaa1691
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1925589. Ttyh3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 86CytoplasmicSequence analysisAdd BLAST23
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 211ExtracellularSequence analysisAdd BLAST104
Transmembranei212 – 232Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini233 – 236CytoplasmicSequence analysis4
Transmembranei237 – 257Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini258 – 386ExtracellularSequence analysisAdd BLAST129
Transmembranei387 – 407Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini408 – 524CytoplasmicSequence analysisAdd BLAST117

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122521 – 524Protein tweety homolog 3Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi351N-linked (GlcNAc...)Sequence analysis1
Modified residuei496PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P5F7.
PeptideAtlasiQ6P5F7.
PRIDEiQ6P5F7.

PTM databases

iPTMnetiQ6P5F7.
PhosphoSitePlusiQ6P5F7.
SwissPalmiQ6P5F7.

Expressioni

Tissue specificityi

Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. Also expressed in fat, the pancreas, thymus, and uterus.1 Publication

Gene expression databases

BgeeiENSMUSG00000036565.
CleanExiMM_TTYH3.
ExpressionAtlasiQ6P5F7. baseline and differential.
GenevisibleiQ6P5F7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037447.

Structurei

3D structure databases

ProteinModelPortaliQ6P5F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tweety family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4433. Eukaryota.
ENOG410ZNTN. LUCA.
GeneTreeiENSGT00390000010182.
HOGENOMiHOG000070449.
HOVERGENiHBG108621.
InParanoidiQ6P5F7.
OMAiSVPHTWP.
OrthoDBiEOG091G05MR.
PhylomeDBiQ6P5F7.
TreeFamiTF319025.

Family and domain databases

CDDicd07912. Tweety_N. 1 hit.
InterProiIPR006990. Tweety.
[Graphical view]
PANTHERiPTHR12424. PTHR12424. 1 hit.
PfamiPF04906. Tweety. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSYAAPW WVSLLHRLPH FDLRWEATSS QFRPEDADYQ QALLLLGATA
60 70 80 90 100
LACLALDLLF LLFYSFWLCC RRRKTDEHLD ADCCCTAWCV IITTLVCSAG
110 120 130 140 150
IAVGFYGNGE TSDGIHRATY SLRHANRTVA GVQDRVWDTA AALNRTAEPN
160 170 180 190 200
LQSLERQLAG RQEPLRAVQR LQTLLGTLLG YTAAIPFWRN PGVSLEVLAE
210 220 230 240 250
QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV GVCLLGVLAL
260 270 280 290 300
VISWGALGLE LAVSVGSSDF CVDPDTFVTK MVEEHSVLSG DILQYYLACS
310 320 330 340 350
PRATNPFQQK LSGSHKALVE MQDVVAELLR NVPREHPATK DPLLRVQEVL
360 370 380 390 400
NGTEVNLQHL TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL
410 420 430 440 450
MFSSIVCSIP HTWQQKRGPD DDGEEETAPG PRQAHDSLYR VHMPSLYSCG
460 470 480 490 500
SSYGSEASIP AAAHTVSNAP VTEYMSQNAN FQNPRCENTP LIGRESPPPS
510 520
YTSSMRAKYL ATSQPRPDSS GSGH
Length:524
Mass (Da):57,714
Last modified:July 5, 2004 - v1
Checksum:i95B499209DBC6D51
GO
Isoform 2 (identifier: Q6P5F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-479: MSQNA → ITPPA
     480-524: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):52,760
Checksum:i06B2A40FC02D6283
GO

Sequence cautioni

The sequence AAH59083 differs from that shown. Reason: Erroneous termination at position 294. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60F → L in BAC34944 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029771475 – 479MSQNA → ITPPA in isoform 2. 1 Publication5
Alternative sequenceiVSP_029772480 – 524Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052340 mRNA. Translation: BAC34944.1.
BC059083 mRNA. Translation: AAH59083.1. Sequence problems.
BC062917 mRNA. Translation: AAH62917.1.
AK173233 mRNA. Translation: BAD32511.1.
CCDSiCCDS19822.1. [Q6P5F7-1]
CCDS80450.1. [Q6P5F7-2]
RefSeqiNP_001294969.1. NM_001308040.1. [Q6P5F7-2]
NP_780483.2. NM_175274.5. [Q6P5F7-1]
UniGeneiMm.28947.

Genome annotation databases

EnsembliENSMUST00000042661; ENSMUSP00000037447; ENSMUSG00000036565. [Q6P5F7-1]
ENSMUST00000197452; ENSMUSP00000142655; ENSMUSG00000036565. [Q6P5F7-2]
GeneIDi78339.
KEGGimmu:78339.
UCSCiuc009ahw.2. mouse. [Q6P5F7-1]
uc012egc.1. mouse. [Q6P5F7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052340 mRNA. Translation: BAC34944.1.
BC059083 mRNA. Translation: AAH59083.1. Sequence problems.
BC062917 mRNA. Translation: AAH62917.1.
AK173233 mRNA. Translation: BAD32511.1.
CCDSiCCDS19822.1. [Q6P5F7-1]
CCDS80450.1. [Q6P5F7-2]
RefSeqiNP_001294969.1. NM_001308040.1. [Q6P5F7-2]
NP_780483.2. NM_175274.5. [Q6P5F7-1]
UniGeneiMm.28947.

3D structure databases

ProteinModelPortaliQ6P5F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037447.

PTM databases

iPTMnetiQ6P5F7.
PhosphoSitePlusiQ6P5F7.
SwissPalmiQ6P5F7.

Proteomic databases

PaxDbiQ6P5F7.
PeptideAtlasiQ6P5F7.
PRIDEiQ6P5F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042661; ENSMUSP00000037447; ENSMUSG00000036565. [Q6P5F7-1]
ENSMUST00000197452; ENSMUSP00000142655; ENSMUSG00000036565. [Q6P5F7-2]
GeneIDi78339.
KEGGimmu:78339.
UCSCiuc009ahw.2. mouse. [Q6P5F7-1]
uc012egc.1. mouse. [Q6P5F7-2]

Organism-specific databases

CTDi80727.
MGIiMGI:1925589. Ttyh3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4433. Eukaryota.
ENOG410ZNTN. LUCA.
GeneTreeiENSGT00390000010182.
HOGENOMiHOG000070449.
HOVERGENiHBG108621.
InParanoidiQ6P5F7.
OMAiSVPHTWP.
OrthoDBiEOG091G05MR.
PhylomeDBiQ6P5F7.
TreeFamiTF319025.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSiTtyh3. mouse.
PROiQ6P5F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036565.
CleanExiMM_TTYH3.
ExpressionAtlasiQ6P5F7. baseline and differential.
GenevisibleiQ6P5F7. MM.

Family and domain databases

CDDicd07912. Tweety_N. 1 hit.
InterProiIPR006990. Tweety.
[Graphical view]
PANTHERiPTHR12424. PTHR12424. 1 hit.
PfamiPF04906. Tweety. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTYH3_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F7
Secondary accession number(s): Q69ZD3, Q6PCX0, Q8C789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.