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Q6P5F6

- S39AA_MOUSE

UniProt

Q6P5F6 - S39AA_MOUSE

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Protein
Zinc transporter ZIP10
Gene
Slc39a10, Kiaa1265, Zip10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter By similarity.

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:Slc39a10
Synonyms:Kiaa1265, Zip10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914515. Slc39a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei413 – 43321Helical; Reviewed prediction
Add
BLAST
Transmembranei440 – 46021Helical; Reviewed prediction
Add
BLAST
Transmembranei497 – 51721Helical; Reviewed prediction
Add
BLAST
Transmembranei689 – 70921Helical; Reviewed prediction
Add
BLAST
Transmembranei734 – 75421Helical; Reviewed prediction
Add
BLAST
Transmembranei761 – 78121Helical; Reviewed prediction
Add
BLAST
Transmembranei803 – 82321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 833808Zinc transporter ZIP10
PRO_0000297633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications
Glycosylationi218 – 2181N-linked (GlcNAc...)2 Publications
Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
Modified residuei538 – 5381Phosphothreonine By similarity
Modified residuei555 – 5551Phosphothreonine By similarity
Modified residuei593 – 5931Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P5F6.
PaxDbiQ6P5F6.
PRIDEiQ6P5F6.

PTM databases

PhosphoSiteiQ6P5F6.

Expressioni

Gene expression databases

BgeeiQ6P5F6.
GenevestigatoriQ6P5F6.

Structurei

3D structure databases

ProteinModelPortaliQ6P5F6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 4015His-rich
Add
BLAST
Compositional biasi101 – 294194His-rich
Add
BLAST
Compositional biasi460 – 48526His-rich
Add
BLAST
Compositional biasi609 – 65850His-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00750000117560.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ6P5F6.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG7H791W.
PhylomeDBiQ6P5F6.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5F6-1 [UniParc]FASTAAdd to Basket

« Hide

MKVHIHTKFC LICLLTFIFH HCNHCHEDHD HGPEELHRHH RGMTESESSK    50
FSVQDAENEK KYYIEKLFDR YGENGRLSFF GLEKLLTNLG LGEIKVVEIN 100
HEDLGHDHVS HLDILAVQEG KHFHSHTHQH FHNHLNAENH TTTSVTSKRN 150
HKCDPEKEAA ELPIKADDKH LHDRNHRFHH RHRLHHHLDH NTTRHVHNDS 200
VAHSEHGEPG HSPSPETNKT QEQSEVKSVK VRRKEKGKRK KENSEVNTPG 250
FLPNHDHSEQ YEHNRVHKLD RVHSPGHPHA HLPEHSGHEL GHGHQELDPD 300
NEGELRHTRK REAPHVRKSA IYSTPSHKDQ SEDDRQHECL NVTQLLKHFG 350
LGPNSPISPD LFTYLCPALL YQIDSRLCIE HFDKLLVEDL NKDKTLVPED 400
KTNIGASAWI CGIISITVIS LLSLLGVILV PIINQGCFKF LLTFLVALAV 450
GTMSGDALLH LLPHSQGGHD HSHQHTHGHG HSHGHESKEF LEEYDAVLKG 500
LVALGGIYLL FIIEHCIRMF KHYKQQRGKQ KWFMKQSTEE STIGRKLSDH 550
KLNSTPDADW LQLKPLAGTD DSVVSEDRLN ETELTDLEAQ QESPPKNYLG 600
VEEEKIMDHS HSDGLHTIHE HEVHVTSHNH HDEDKAVLRK HSHQWHHRHA 650
HHSHGPCHSG SDLKETGIAN IAWMVIMGDG IHNFSDGLAI GAAFSAGLTG 700
GISTSIAVFC HELPHELGDF AVLLKAGMTV KQAIVYNLLS AMMAYIGMLI 750
GTAVGQYANN ITLWIFAITA GMFLYVALVD MLPEMLHGDG DHEEHGFCPV 800
GQFILQNLGL LFGFAIMLVI ALYEDKIVFD IQF 833
Length:833
Mass (Da):94,394
Last modified:July 5, 2004 - v1
Checksum:iBA51B66A2296AFC2
GO

Sequence cautioni

The sequence AAH59214.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC33542.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461L → S in BAC65765. 1 Publication
Sequence conflicti676 – 6761I → F in BAC27077. 1 Publication
Sequence conflicti829 – 8291F → Y in BAC65765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052880 mRNA. Translation: AAH52880.1.
BC059214 mRNA. Translation: AAH59214.1. Different initiation.
BC062918 mRNA. Translation: AAH62918.1.
AK122483 mRNA. Translation: BAC65765.1.
AK030685 mRNA. Translation: BAC27077.1.
AK049099 mRNA. Translation: BAC33542.1. Different initiation.
CCDSiCCDS14936.1.
RefSeqiNP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.1.
XP_006495997.1. XM_006495934.1.
XP_006495998.1. XM_006495935.1.
UniGeneiMm.233889.
Mm.475398.

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986.
GeneIDi227059.
KEGGimmu:227059.
UCSCiuc007axc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052880 mRNA. Translation: AAH52880.1 .
BC059214 mRNA. Translation: AAH59214.1 . Different initiation.
BC062918 mRNA. Translation: AAH62918.1 .
AK122483 mRNA. Translation: BAC65765.1 .
AK030685 mRNA. Translation: BAC27077.1 .
AK049099 mRNA. Translation: BAC33542.1 . Different initiation.
CCDSi CCDS14936.1.
RefSeqi NP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.1.
XP_006495997.1. XM_006495934.1.
XP_006495998.1. XM_006495935.1.
UniGenei Mm.233889.
Mm.475398.

3D structure databases

ProteinModelPortali Q6P5F6.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P5F6.

Proteomic databases

MaxQBi Q6P5F6.
PaxDbi Q6P5F6.
PRIDEi Q6P5F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027131 ; ENSMUSP00000027131 ; ENSMUSG00000025986 .
GeneIDi 227059.
KEGGi mmu:227059.
UCSCi uc007axc.1. mouse.

Organism-specific databases

CTDi 57181.
MGIi MGI:1914515. Slc39a10.
Rougei Search...

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00750000117560.
HOGENOMi HOG000013093.
HOVERGENi HBG055748.
InParanoidi Q6P5F6.
KOi K14716.
OMAi DPGHGHQ.
OrthoDBi EOG7H791W.
PhylomeDBi Q6P5F6.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A10. mouse.
NextBioi 378450.
PROi Q6P5F6.
SOURCEi Search...

Gene expression databases

Bgeei Q6P5F6.
Genevestigatori Q6P5F6.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Egg.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-833.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 403-833.
    Strain: C57BL/6J.
    Tissue: Cerebellum and Head.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198 AND ASN-218.
    Tissue: Myoblast.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198; ASN-218 AND ASN-341.

Entry informationi

Entry nameiS39AA_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F6
Secondary accession number(s): Q80TG2, Q8BX42, Q8C0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi