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Q6P5F6

- S39AA_MOUSE

UniProt

Q6P5F6 - S39AA_MOUSE

Protein

Zinc transporter ZIP10

Gene

Slc39a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May act as a zinc-influx transporter.By similarity

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP10
    Alternative name(s):
    Solute carrier family 39 member 10
    Zrt- and Irt-like protein 10
    Short name:
    ZIP-10
    Gene namesi
    Name:Slc39a10
    Synonyms:Kiaa1265, Zip10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914515. Slc39a10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 833808Zinc transporter ZIP10PRO_0000297633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications
    Glycosylationi218 – 2181N-linked (GlcNAc...)2 Publications
    Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
    Modified residuei538 – 5381PhosphothreonineBy similarity
    Modified residuei555 – 5551PhosphothreonineBy similarity
    Modified residuei593 – 5931PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P5F6.
    PaxDbiQ6P5F6.
    PRIDEiQ6P5F6.

    PTM databases

    PhosphoSiteiQ6P5F6.

    Expressioni

    Gene expression databases

    BgeeiQ6P5F6.
    GenevestigatoriQ6P5F6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P5F6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei440 – 46021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei689 – 70921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei734 – 75421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei761 – 78121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi26 – 4015His-richAdd
    BLAST
    Compositional biasi101 – 294194His-richAdd
    BLAST
    Compositional biasi460 – 48526His-richAdd
    BLAST
    Compositional biasi609 – 65850His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    GeneTreeiENSGT00750000117560.
    HOGENOMiHOG000013093.
    HOVERGENiHBG055748.
    InParanoidiQ6P5F6.
    KOiK14716.
    OMAiDPGHGHQ.
    OrthoDBiEOG7H791W.
    PhylomeDBiQ6P5F6.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P5F6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVHIHTKFC LICLLTFIFH HCNHCHEDHD HGPEELHRHH RGMTESESSK    50
    FSVQDAENEK KYYIEKLFDR YGENGRLSFF GLEKLLTNLG LGEIKVVEIN 100
    HEDLGHDHVS HLDILAVQEG KHFHSHTHQH FHNHLNAENH TTTSVTSKRN 150
    HKCDPEKEAA ELPIKADDKH LHDRNHRFHH RHRLHHHLDH NTTRHVHNDS 200
    VAHSEHGEPG HSPSPETNKT QEQSEVKSVK VRRKEKGKRK KENSEVNTPG 250
    FLPNHDHSEQ YEHNRVHKLD RVHSPGHPHA HLPEHSGHEL GHGHQELDPD 300
    NEGELRHTRK REAPHVRKSA IYSTPSHKDQ SEDDRQHECL NVTQLLKHFG 350
    LGPNSPISPD LFTYLCPALL YQIDSRLCIE HFDKLLVEDL NKDKTLVPED 400
    KTNIGASAWI CGIISITVIS LLSLLGVILV PIINQGCFKF LLTFLVALAV 450
    GTMSGDALLH LLPHSQGGHD HSHQHTHGHG HSHGHESKEF LEEYDAVLKG 500
    LVALGGIYLL FIIEHCIRMF KHYKQQRGKQ KWFMKQSTEE STIGRKLSDH 550
    KLNSTPDADW LQLKPLAGTD DSVVSEDRLN ETELTDLEAQ QESPPKNYLG 600
    VEEEKIMDHS HSDGLHTIHE HEVHVTSHNH HDEDKAVLRK HSHQWHHRHA 650
    HHSHGPCHSG SDLKETGIAN IAWMVIMGDG IHNFSDGLAI GAAFSAGLTG 700
    GISTSIAVFC HELPHELGDF AVLLKAGMTV KQAIVYNLLS AMMAYIGMLI 750
    GTAVGQYANN ITLWIFAITA GMFLYVALVD MLPEMLHGDG DHEEHGFCPV 800
    GQFILQNLGL LFGFAIMLVI ALYEDKIVFD IQF 833
    Length:833
    Mass (Da):94,394
    Last modified:July 5, 2004 - v1
    Checksum:iBA51B66A2296AFC2
    GO

    Sequence cautioni

    The sequence AAH59214.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC33542.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti346 – 3461L → S in BAC65765. (PubMed:12693553)Curated
    Sequence conflicti676 – 6761I → F in BAC27077. (PubMed:16141072)Curated
    Sequence conflicti829 – 8291F → Y in BAC65765. (PubMed:12693553)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC052880 mRNA. Translation: AAH52880.1.
    BC059214 mRNA. Translation: AAH59214.1. Different initiation.
    BC062918 mRNA. Translation: AAH62918.1.
    AK122483 mRNA. Translation: BAC65765.1.
    AK030685 mRNA. Translation: BAC27077.1.
    AK049099 mRNA. Translation: BAC33542.1. Different initiation.
    CCDSiCCDS14936.1.
    RefSeqiNP_766241.2. NM_172653.2.
    XP_006495996.1. XM_006495933.1.
    XP_006495997.1. XM_006495934.1.
    XP_006495998.1. XM_006495935.1.
    UniGeneiMm.233889.
    Mm.475398.

    Genome annotation databases

    EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986.
    GeneIDi227059.
    KEGGimmu:227059.
    UCSCiuc007axc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC052880 mRNA. Translation: AAH52880.1 .
    BC059214 mRNA. Translation: AAH59214.1 . Different initiation.
    BC062918 mRNA. Translation: AAH62918.1 .
    AK122483 mRNA. Translation: BAC65765.1 .
    AK030685 mRNA. Translation: BAC27077.1 .
    AK049099 mRNA. Translation: BAC33542.1 . Different initiation.
    CCDSi CCDS14936.1.
    RefSeqi NP_766241.2. NM_172653.2.
    XP_006495996.1. XM_006495933.1.
    XP_006495997.1. XM_006495934.1.
    XP_006495998.1. XM_006495935.1.
    UniGenei Mm.233889.
    Mm.475398.

    3D structure databases

    ProteinModelPortali Q6P5F6.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P5F6.

    Proteomic databases

    MaxQBi Q6P5F6.
    PaxDbi Q6P5F6.
    PRIDEi Q6P5F6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027131 ; ENSMUSP00000027131 ; ENSMUSG00000025986 .
    GeneIDi 227059.
    KEGGi mmu:227059.
    UCSCi uc007axc.1. mouse.

    Organism-specific databases

    CTDi 57181.
    MGIi MGI:1914515. Slc39a10.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0428.
    GeneTreei ENSGT00750000117560.
    HOGENOMi HOG000013093.
    HOVERGENi HBG055748.
    InParanoidi Q6P5F6.
    KOi K14716.
    OMAi DPGHGHQ.
    OrthoDBi EOG7H791W.
    PhylomeDBi Q6P5F6.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A10. mouse.
    NextBioi 378450.
    PROi Q6P5F6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P5F6.
    Genevestigatori Q6P5F6.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Egg.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-833.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 403-833.
      Strain: C57BL/6J.
      Tissue: Cerebellum and Head.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198 AND ASN-218.
      Tissue: Myoblast.
    6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198; ASN-218 AND ASN-341.

    Entry informationi

    Entry nameiS39AA_MOUSE
    AccessioniPrimary (citable) accession number: Q6P5F6
    Secondary accession number(s): Q80TG2, Q8BX42, Q8C0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3