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Q6P5F6

- S39AA_MOUSE

UniProt

Q6P5F6 - S39AA_MOUSE

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Protein

Zinc transporter ZIP10

Gene

Slc39a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:Slc39a10
Synonyms:Kiaa1265, Zip10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914515. Slc39a10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 833808Zinc transporter ZIP10PRO_0000297633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications
Glycosylationi218 – 2181N-linked (GlcNAc...)2 Publications
Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
Modified residuei538 – 5381PhosphothreonineBy similarity
Modified residuei555 – 5551PhosphothreonineBy similarity
Modified residuei593 – 5931PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P5F6.
PaxDbiQ6P5F6.
PRIDEiQ6P5F6.

PTM databases

PhosphoSiteiQ6P5F6.

Expressioni

Gene expression databases

BgeeiQ6P5F6.
GenevestigatoriQ6P5F6.

Structurei

3D structure databases

ProteinModelPortaliQ6P5F6.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST
Transmembranei689 – 70921HelicalSequence AnalysisAdd
BLAST
Transmembranei734 – 75421HelicalSequence AnalysisAdd
BLAST
Transmembranei761 – 78121HelicalSequence AnalysisAdd
BLAST
Transmembranei803 – 82321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 4015His-richAdd
BLAST
Compositional biasi101 – 294194His-richAdd
BLAST
Compositional biasi460 – 48526His-richAdd
BLAST
Compositional biasi609 – 65850His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ6P5F6.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG7H791W.
PhylomeDBiQ6P5F6.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5F6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVHIHTKFC LICLLTFIFH HCNHCHEDHD HGPEELHRHH RGMTESESSK
60 70 80 90 100
FSVQDAENEK KYYIEKLFDR YGENGRLSFF GLEKLLTNLG LGEIKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHTHQH FHNHLNAENH TTTSVTSKRN
160 170 180 190 200
HKCDPEKEAA ELPIKADDKH LHDRNHRFHH RHRLHHHLDH NTTRHVHNDS
210 220 230 240 250
VAHSEHGEPG HSPSPETNKT QEQSEVKSVK VRRKEKGKRK KENSEVNTPG
260 270 280 290 300
FLPNHDHSEQ YEHNRVHKLD RVHSPGHPHA HLPEHSGHEL GHGHQELDPD
310 320 330 340 350
NEGELRHTRK REAPHVRKSA IYSTPSHKDQ SEDDRQHECL NVTQLLKHFG
360 370 380 390 400
LGPNSPISPD LFTYLCPALL YQIDSRLCIE HFDKLLVEDL NKDKTLVPED
410 420 430 440 450
KTNIGASAWI CGIISITVIS LLSLLGVILV PIINQGCFKF LLTFLVALAV
460 470 480 490 500
GTMSGDALLH LLPHSQGGHD HSHQHTHGHG HSHGHESKEF LEEYDAVLKG
510 520 530 540 550
LVALGGIYLL FIIEHCIRMF KHYKQQRGKQ KWFMKQSTEE STIGRKLSDH
560 570 580 590 600
KLNSTPDADW LQLKPLAGTD DSVVSEDRLN ETELTDLEAQ QESPPKNYLG
610 620 630 640 650
VEEEKIMDHS HSDGLHTIHE HEVHVTSHNH HDEDKAVLRK HSHQWHHRHA
660 670 680 690 700
HHSHGPCHSG SDLKETGIAN IAWMVIMGDG IHNFSDGLAI GAAFSAGLTG
710 720 730 740 750
GISTSIAVFC HELPHELGDF AVLLKAGMTV KQAIVYNLLS AMMAYIGMLI
760 770 780 790 800
GTAVGQYANN ITLWIFAITA GMFLYVALVD MLPEMLHGDG DHEEHGFCPV
810 820 830
GQFILQNLGL LFGFAIMLVI ALYEDKIVFD IQF
Length:833
Mass (Da):94,394
Last modified:July 5, 2004 - v1
Checksum:iBA51B66A2296AFC2
GO

Sequence cautioni

The sequence AAH59214.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC33542.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461L → S in BAC65765. (PubMed:12693553)Curated
Sequence conflicti676 – 6761I → F in BAC27077. (PubMed:16141072)Curated
Sequence conflicti829 – 8291F → Y in BAC65765. (PubMed:12693553)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052880 mRNA. Translation: AAH52880.1.
BC059214 mRNA. Translation: AAH59214.1. Different initiation.
BC062918 mRNA. Translation: AAH62918.1.
AK122483 mRNA. Translation: BAC65765.1.
AK030685 mRNA. Translation: BAC27077.1.
AK049099 mRNA. Translation: BAC33542.1. Different initiation.
CCDSiCCDS14936.1.
RefSeqiNP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.1.
XP_006495997.1. XM_006495934.1.
XP_006495998.1. XM_006495935.1.
UniGeneiMm.233889.
Mm.475398.

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986.
GeneIDi227059.
KEGGimmu:227059.
UCSCiuc007axc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC052880 mRNA. Translation: AAH52880.1 .
BC059214 mRNA. Translation: AAH59214.1 . Different initiation.
BC062918 mRNA. Translation: AAH62918.1 .
AK122483 mRNA. Translation: BAC65765.1 .
AK030685 mRNA. Translation: BAC27077.1 .
AK049099 mRNA. Translation: BAC33542.1 . Different initiation.
CCDSi CCDS14936.1.
RefSeqi NP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.1.
XP_006495997.1. XM_006495934.1.
XP_006495998.1. XM_006495935.1.
UniGenei Mm.233889.
Mm.475398.

3D structure databases

ProteinModelPortali Q6P5F6.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P5F6.

Proteomic databases

MaxQBi Q6P5F6.
PaxDbi Q6P5F6.
PRIDEi Q6P5F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027131 ; ENSMUSP00000027131 ; ENSMUSG00000025986 .
GeneIDi 227059.
KEGGi mmu:227059.
UCSCi uc007axc.1. mouse.

Organism-specific databases

CTDi 57181.
MGIi MGI:1914515. Slc39a10.
Rougei Search...

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00760000119115.
HOGENOMi HOG000013093.
HOVERGENi HBG055748.
InParanoidi Q6P5F6.
KOi K14716.
OMAi DPGHGHQ.
OrthoDBi EOG7H791W.
PhylomeDBi Q6P5F6.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A10. mouse.
NextBioi 378450.
PROi Q6P5F6.
SOURCEi Search...

Gene expression databases

Bgeei Q6P5F6.
Genevestigatori Q6P5F6.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Egg.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-833.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 403-833.
    Strain: C57BL/6J.
    Tissue: Cerebellum and Head.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198 AND ASN-218.
    Tissue: Myoblast.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198; ASN-218 AND ASN-341.

Entry informationi

Entry nameiS39AA_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F6
Secondary accession number(s): Q80TG2, Q8BX42, Q8C0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3