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Protein

Zinc transporter ZIP10

Gene

Slc39a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular zinc ion homeostasis Source: MGI
  • negative regulation of B cell apoptotic process Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of B cell receptor signaling pathway Source: MGI
  • positive regulation of protein tyrosine phosphatase activity Source: MGI
  • zinc II ion transmembrane import Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:Slc39a10
Synonyms:Kiaa1265, Zip10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914515. Slc39a10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Transmembranei734 – 754HelicalSequence analysisAdd BLAST21
Transmembranei761 – 781HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029763326 – 833Zinc transporter ZIP10Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)2 Publications1
Glycosylationi218N-linked (GlcNAc...)2 Publications1
Glycosylationi341N-linked (GlcNAc...)1 Publication1
Modified residuei538PhosphothreonineBy similarity1
Modified residuei555PhosphothreonineBy similarity1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6P5F6.
MaxQBiQ6P5F6.
PaxDbiQ6P5F6.
PeptideAtlasiQ6P5F6.
PRIDEiQ6P5F6.

PTM databases

iPTMnetiQ6P5F6.
PhosphoSitePlusiQ6P5F6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025986.
ExpressionAtlasiQ6P5F6. baseline and differential.
GenevisibleiQ6P5F6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027131.

Structurei

3D structure databases

ProteinModelPortaliQ6P5F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 40His-richAdd BLAST15
Compositional biasi101 – 294His-richAdd BLAST194
Compositional biasi460 – 485His-richAdd BLAST26
Compositional biasi609 – 658His-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ6P5F6.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG091G02WM.
PhylomeDBiQ6P5F6.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVHIHTKFC LICLLTFIFH HCNHCHEDHD HGPEELHRHH RGMTESESSK
60 70 80 90 100
FSVQDAENEK KYYIEKLFDR YGENGRLSFF GLEKLLTNLG LGEIKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHTHQH FHNHLNAENH TTTSVTSKRN
160 170 180 190 200
HKCDPEKEAA ELPIKADDKH LHDRNHRFHH RHRLHHHLDH NTTRHVHNDS
210 220 230 240 250
VAHSEHGEPG HSPSPETNKT QEQSEVKSVK VRRKEKGKRK KENSEVNTPG
260 270 280 290 300
FLPNHDHSEQ YEHNRVHKLD RVHSPGHPHA HLPEHSGHEL GHGHQELDPD
310 320 330 340 350
NEGELRHTRK REAPHVRKSA IYSTPSHKDQ SEDDRQHECL NVTQLLKHFG
360 370 380 390 400
LGPNSPISPD LFTYLCPALL YQIDSRLCIE HFDKLLVEDL NKDKTLVPED
410 420 430 440 450
KTNIGASAWI CGIISITVIS LLSLLGVILV PIINQGCFKF LLTFLVALAV
460 470 480 490 500
GTMSGDALLH LLPHSQGGHD HSHQHTHGHG HSHGHESKEF LEEYDAVLKG
510 520 530 540 550
LVALGGIYLL FIIEHCIRMF KHYKQQRGKQ KWFMKQSTEE STIGRKLSDH
560 570 580 590 600
KLNSTPDADW LQLKPLAGTD DSVVSEDRLN ETELTDLEAQ QESPPKNYLG
610 620 630 640 650
VEEEKIMDHS HSDGLHTIHE HEVHVTSHNH HDEDKAVLRK HSHQWHHRHA
660 670 680 690 700
HHSHGPCHSG SDLKETGIAN IAWMVIMGDG IHNFSDGLAI GAAFSAGLTG
710 720 730 740 750
GISTSIAVFC HELPHELGDF AVLLKAGMTV KQAIVYNLLS AMMAYIGMLI
760 770 780 790 800
GTAVGQYANN ITLWIFAITA GMFLYVALVD MLPEMLHGDG DHEEHGFCPV
810 820 830
GQFILQNLGL LFGFAIMLVI ALYEDKIVFD IQF
Length:833
Mass (Da):94,394
Last modified:July 5, 2004 - v1
Checksum:iBA51B66A2296AFC2
GO

Sequence cautioni

The sequence AAH59214 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33542 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346L → S in BAC65765 (PubMed:12693553).Curated1
Sequence conflicti676I → F in BAC27077 (PubMed:16141072).Curated1
Sequence conflicti829F → Y in BAC65765 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052880 mRNA. Translation: AAH52880.1.
BC059214 mRNA. Translation: AAH59214.1. Different initiation.
BC062918 mRNA. Translation: AAH62918.1.
AK122483 mRNA. Translation: BAC65765.1.
AK030685 mRNA. Translation: BAC27077.1.
AK049099 mRNA. Translation: BAC33542.1. Different initiation.
CCDSiCCDS14936.1.
RefSeqiNP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.3.
XP_006495997.1. XM_006495934.3.
XP_006495998.1. XM_006495935.2.
UniGeneiMm.233889.
Mm.475398.

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986.
GeneIDi227059.
KEGGimmu:227059.
UCSCiuc007axc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052880 mRNA. Translation: AAH52880.1.
BC059214 mRNA. Translation: AAH59214.1. Different initiation.
BC062918 mRNA. Translation: AAH62918.1.
AK122483 mRNA. Translation: BAC65765.1.
AK030685 mRNA. Translation: BAC27077.1.
AK049099 mRNA. Translation: BAC33542.1. Different initiation.
CCDSiCCDS14936.1.
RefSeqiNP_766241.2. NM_172653.2.
XP_006495996.1. XM_006495933.3.
XP_006495997.1. XM_006495934.3.
XP_006495998.1. XM_006495935.2.
UniGeneiMm.233889.
Mm.475398.

3D structure databases

ProteinModelPortaliQ6P5F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027131.

PTM databases

iPTMnetiQ6P5F6.
PhosphoSitePlusiQ6P5F6.

Proteomic databases

EPDiQ6P5F6.
MaxQBiQ6P5F6.
PaxDbiQ6P5F6.
PeptideAtlasiQ6P5F6.
PRIDEiQ6P5F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986.
GeneIDi227059.
KEGGimmu:227059.
UCSCiuc007axc.1. mouse.

Organism-specific databases

CTDi57181.
MGIiMGI:1914515. Slc39a10.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ6P5F6.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG091G02WM.
PhylomeDBiQ6P5F6.
TreeFamiTF318470.

Miscellaneous databases

ChiTaRSiSlc39a10. mouse.
PROiQ6P5F6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025986.
ExpressionAtlasiQ6P5F6. baseline and differential.
GenevisibleiQ6P5F6. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39AA_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F6
Secondary accession number(s): Q80TG2, Q8BX42, Q8C0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.