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Q6P5E4

- UGGG1_MOUSE

UniProt

Q6P5E4 - UGGG1_MOUSE

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Protein
UDP-glucose:glycoprotein glucosyltransferase 1
Gene
Uggt1, Gt, Ugcgl1, Uggt, Ugt1, Ugtr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.

Cofactori

Calcium By similarity.

Pathwayi

GO - Molecular functioni

  1. UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. unfolded protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198606. ER Quality Control Compartment (ERQC).
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 1 (EC:2.4.1.-)
Short name:
UGT1
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:Uggt1
Synonyms:Gt, Ugcgl1, Uggt, Ugt1, Ugtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2443162. Uggt1.

Subcellular locationi

Endoplasmic reticulum lumen By similarity. Endoplasmic reticulum-Golgi intermediate compartment By similarity By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
  2. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242 By similarity
Add
BLAST
Chaini43 – 15511509UDP-glucose:glycoprotein glucosyltransferase 1
PRO_0000012272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi536 – 5361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1228 – 12281N-linked (GlcNAc...) Reviewed prediction
Modified residuei1277 – 12771Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P5E4.
PaxDbiQ6P5E4.
PRIDEiQ6P5E4.

PTM databases

PhosphoSiteiQ6P5E4.

Expressioni

Gene expression databases

ArrayExpressiQ6P5E4.
BgeeiQ6P5E4.
CleanExiMM_UGCGL1.
GenevestigatoriQ6P5E4.

Interactioni

Subunit structurei

Monomer as well as in a tight complex with SEP15. Interacts with METTL23 By similarity.1 Publication

Protein-protein interaction databases

BioGridi235693. 2 interactions.
MINTiMINT-1863721.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1244 – 1551308Glucosyltransferase By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1548 – 15514Prevents secretion from ER Reviewed prediction

Domaini

The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects By similarity.

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000184622.
HOVERGENiHBG079469.
InParanoidiQ6P5E4.
KOiK11718.
OMAiRDYLDLT.
OrthoDBiEOG75J0M7.
TreeFamiTF300320.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5E4-1 [UniParc]FASTAAdd to Basket

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MCSRGDANTA DAAAARRVTG LRYNMRLLIA LALPCLFSLA EANSKAITTS     50
LTTKWFSAPL LLEASEFLAE DSQEKFWSFV EATQNIGSSD HHDTDHSYYD 100
AVLEAAFRFL SPLQQNLLKF CLSLRSYSAS IQAFQQIAVD EPPPEGCKSF 150
LSVHGKQTCD LDTLESLLLT AADRPKPLLF KGDHRYPSSN PESPVVILYS 200
EIGHEEFSNI HHQLISKSNE GKINYVFRHY ISNPSKEPVY LSGYGVELAI 250
KSTEYKAKDD TQVKGTEVNA TVIGESDPID EVQGFLFGKL RELYPALEGQ 300
LKEFRKHLVE STNEMAPLKV WQLQDLSFQT AARILAASGA LSLVVMKDIS 350
QNFPTKARAI TKTAVSAQLR AEVEENQKYF KGTIGLQPGD SALFINGLHI 400
DLDTQDIFSL FDTLRNEARV MEGLHRLGIE GLSLHNILKL NIQPSETDYA 450
VDIRSPAISW VNNLEVDSRY NSWPSSLQEL LRPTFPGVIR QIRKNLHNMV 500
FIIDPVHETT AELISIAEMF LSNHIPLRIG FIFVVNDSED VDGMQDAGVA 550
VLRAYNYVAQ EVDGYHAFQT LTQIYNKVRT GETVKVEHVV SVLEKKYPYV 600
EVNSILGIDS AYDQNRKEAR GYYEQTGVGP LPVVLFNGMP FEKEQLDPDE 650
LETITMHKIL ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL 700
TAKREYLDLT ASNNFYVDDF ARFSALDSRG KTAAIANSMN YLTKKGMSSK 750
EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD AIKHQKTSNN VRISMINNPS 800
QEISDSSTPI FRAIWAALQT QASSSAKNFI TKMAKEETAE ALAAGVDIAE 850
FSVGGMDVSL FKEVFESSRM DFILSHALYC RDVLKLKKGQ RVVISNGRII 900
GPLEDNELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV 950
DALLSAQPKG EARIEYQFFE DKHSAIKLKP KEGETYYDVV AVVDPVTREA 1000
QRLAPLLLVL TQLINMNLRV FMNCQSKLSD MPLKSFYRYV LEPEISFTAD 1050
SSFAKGPIAK FLDMPQSPLF TLNLNTPESW MVESVRTPYD LDNIYLEEVD 1100
SIVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP TIVDTIVMAN 1150
LGYFQLKANP GAWILRLRKG RSDDIYRIYS HDGTDSPPDA NDVVVILNNF 1200
KSKIIKVKVQ KKADMANEDL LSDGTNENES GFWDSFKWGF SGQKAEEVKQ 1250
DKDDIINIFS VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK 1300
EFIPYMAKKY NFQYELVQYK WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV 1350
VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY GYTPFCDSRR EMDGYRFWKS 1400
GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG LSQDPNSLSN 1450
LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE 1500
PKLEAAVRIV PEWQDYDQEI KQLQTLFQEE KELGTLHTEE TQEGSQKHEE 1550
L 1551
Length:1,551
Mass (Da):176,434
Last modified:July 27, 2011 - v4
Checksum:i1036D2CCA2DC4A19
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191K → E in AAH68283. 1 Publication
Sequence conflicti445 – 4451S → F in AAH68283. 1 Publication
Sequence conflicti824 – 8241S → N in AAH68283. 1 Publication
Sequence conflicti935 – 9351Q → R in AAH68283. 1 Publication
Sequence conflicti1015 – 10151N → T in AAH68283. 1 Publication
Sequence conflicti1058 – 10581I → T in AAH68283. 1 Publication
Sequence conflicti1083 – 10831E → Q in AAH62936. 1 Publication
Sequence conflicti1212 – 12121K → R in AAH68283. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133102 Genomic DNA. No translation available.
BC062936 mRNA. Translation: AAH62936.1.
BC068283 mRNA. Translation: AAH68283.1.
CCDSiCCDS48238.1.
RefSeqiNP_942602.2. NM_198899.2.
UniGeneiMm.261022.

Genome annotation databases

EnsembliENSMUST00000046875; ENSMUSP00000037930; ENSMUSG00000037470.
GeneIDi320011.
KEGGimmu:320011.
UCSCiuc007app.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133102 Genomic DNA. No translation available.
BC062936 mRNA. Translation: AAH62936.1 .
BC068283 mRNA. Translation: AAH68283.1 .
CCDSi CCDS48238.1.
RefSeqi NP_942602.2. NM_198899.2.
UniGenei Mm.261022.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 235693. 2 interactions.
MINTi MINT-1863721.

Protein family/group databases

CAZyi GT24. Glycosyltransferase Family 24.

PTM databases

PhosphoSitei Q6P5E4.

Proteomic databases

MaxQBi Q6P5E4.
PaxDbi Q6P5E4.
PRIDEi Q6P5E4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046875 ; ENSMUSP00000037930 ; ENSMUSG00000037470 .
GeneIDi 320011.
KEGGi mmu:320011.
UCSCi uc007app.2. mouse.

Organism-specific databases

CTDi 56886.
MGIi MGI:2443162. Uggt1.

Phylogenomic databases

eggNOGi NOG320899.
GeneTreei ENSGT00390000004600.
HOGENOMi HOG000184622.
HOVERGENi HBG079469.
InParanoidi Q6P5E4.
KOi K11718.
OMAi RDYLDLT.
OrthoDBi EOG75J0M7.
TreeFami TF300320.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_198606. ER Quality Control Compartment (ERQC).

Miscellaneous databases

ChiTaRSi UGGT1. mouse.
NextBioi 395857.
PROi Q6P5E4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P5E4.
Bgeei Q6P5E4.
CleanExi MM_UGCGL1.
Genevestigatori Q6P5E4.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view ]
PANTHERi PTHR11226. PTHR11226. 1 hit.
Pfami PF06427. UDP-g_GGTase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and ICR.
    Tissue: Brain and Trophoblast stem cell.
  3. "Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells."
    Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N.
    J. Biol. Chem. 276:15330-15336(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEP15.

Entry informationi

Entry nameiUGGG1_MOUSE
AccessioniPrimary (citable) accession number: Q6P5E4
Secondary accession number(s): E9QQ49, Q6NV70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi