Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P5E4

- UGGG1_MOUSE

UniProt

Q6P5E4 - UGGG1_MOUSE

Protein

UDP-glucose:glycoprotein glucosyltransferase 1

Gene

Uggt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.By similarity

    Cofactori

    Calcium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
    3. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198606. ER Quality Control Compartment (ERQC).
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT24. Glycosyltransferase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose:glycoprotein glucosyltransferase 1 (EC:2.4.1.-)
    Short name:
    UGT1
    Alternative name(s):
    UDP--Glc:glycoprotein glucosyltransferase
    UDP-glucose ceramide glucosyltransferase-like 1
    Gene namesi
    Name:Uggt1
    Synonyms:Gt, Ugcgl1, Uggt, Ugt1, Ugtr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2443162. Uggt1.

    Subcellular locationi

    Endoplasmic reticulum lumen By similarityPROSITE-ProRule annotation. Endoplasmic reticulum-Golgi intermediate compartment PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4242By similarityAdd
    BLAST
    Chaini43 – 15511509UDP-glucose:glycoprotein glucosyltransferase 1PRO_0000012272Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1228 – 12281N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1277 – 12771PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P5E4.
    PaxDbiQ6P5E4.
    PRIDEiQ6P5E4.

    PTM databases

    PhosphoSiteiQ6P5E4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P5E4.
    BgeeiQ6P5E4.
    CleanExiMM_UGCGL1.
    GenevestigatoriQ6P5E4.

    Interactioni

    Subunit structurei

    Monomer as well as in a tight complex with SEP15. Interacts with METTL23 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi235693. 2 interactions.
    MINTiMINT-1863721.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1244 – 1551308GlucosyltransferaseBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1548 – 15514Prevents secretion from ERPROSITE-ProRule annotation

    Domaini

    The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.By similarity

    Sequence similaritiesi

    Belongs to the glycosyltransferase 8 family.By similarity

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320899.
    GeneTreeiENSGT00390000004600.
    HOGENOMiHOG000184622.
    HOVERGENiHBG079469.
    InParanoidiQ6P5E4.
    KOiK11718.
    OMAiRDYLDLT.
    OrthoDBiEOG75J0M7.
    TreeFamiTF300320.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR009448. UDP-g_GGtrans.
    [Graphical view]
    PANTHERiPTHR11226. PTHR11226. 1 hit.
    PfamiPF06427. UDP-g_GGTase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P5E4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSRGDANTA DAAAARRVTG LRYNMRLLIA LALPCLFSLA EANSKAITTS     50
    LTTKWFSAPL LLEASEFLAE DSQEKFWSFV EATQNIGSSD HHDTDHSYYD 100
    AVLEAAFRFL SPLQQNLLKF CLSLRSYSAS IQAFQQIAVD EPPPEGCKSF 150
    LSVHGKQTCD LDTLESLLLT AADRPKPLLF KGDHRYPSSN PESPVVILYS 200
    EIGHEEFSNI HHQLISKSNE GKINYVFRHY ISNPSKEPVY LSGYGVELAI 250
    KSTEYKAKDD TQVKGTEVNA TVIGESDPID EVQGFLFGKL RELYPALEGQ 300
    LKEFRKHLVE STNEMAPLKV WQLQDLSFQT AARILAASGA LSLVVMKDIS 350
    QNFPTKARAI TKTAVSAQLR AEVEENQKYF KGTIGLQPGD SALFINGLHI 400
    DLDTQDIFSL FDTLRNEARV MEGLHRLGIE GLSLHNILKL NIQPSETDYA 450
    VDIRSPAISW VNNLEVDSRY NSWPSSLQEL LRPTFPGVIR QIRKNLHNMV 500
    FIIDPVHETT AELISIAEMF LSNHIPLRIG FIFVVNDSED VDGMQDAGVA 550
    VLRAYNYVAQ EVDGYHAFQT LTQIYNKVRT GETVKVEHVV SVLEKKYPYV 600
    EVNSILGIDS AYDQNRKEAR GYYEQTGVGP LPVVLFNGMP FEKEQLDPDE 650
    LETITMHKIL ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL 700
    TAKREYLDLT ASNNFYVDDF ARFSALDSRG KTAAIANSMN YLTKKGMSSK 750
    EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD AIKHQKTSNN VRISMINNPS 800
    QEISDSSTPI FRAIWAALQT QASSSAKNFI TKMAKEETAE ALAAGVDIAE 850
    FSVGGMDVSL FKEVFESSRM DFILSHALYC RDVLKLKKGQ RVVISNGRII 900
    GPLEDNELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV 950
    DALLSAQPKG EARIEYQFFE DKHSAIKLKP KEGETYYDVV AVVDPVTREA 1000
    QRLAPLLLVL TQLINMNLRV FMNCQSKLSD MPLKSFYRYV LEPEISFTAD 1050
    SSFAKGPIAK FLDMPQSPLF TLNLNTPESW MVESVRTPYD LDNIYLEEVD 1100
    SIVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP TIVDTIVMAN 1150
    LGYFQLKANP GAWILRLRKG RSDDIYRIYS HDGTDSPPDA NDVVVILNNF 1200
    KSKIIKVKVQ KKADMANEDL LSDGTNENES GFWDSFKWGF SGQKAEEVKQ 1250
    DKDDIINIFS VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK 1300
    EFIPYMAKKY NFQYELVQYK WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV 1350
    VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY GYTPFCDSRR EMDGYRFWKS 1400
    GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG LSQDPNSLSN 1450
    LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE 1500
    PKLEAAVRIV PEWQDYDQEI KQLQTLFQEE KELGTLHTEE TQEGSQKHEE 1550
    L 1551
    Length:1,551
    Mass (Da):176,434
    Last modified:July 27, 2011 - v4
    Checksum:i1036D2CCA2DC4A19
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191K → E in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti445 – 4451S → F in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti824 – 8241S → N in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti935 – 9351Q → R in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti1015 – 10151N → T in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti1058 – 10581I → T in AAH68283. (PubMed:19468303)Curated
    Sequence conflicti1083 – 10831E → Q in AAH62936. (PubMed:15489334)Curated
    Sequence conflicti1212 – 12121K → R in AAH68283. (PubMed:19468303)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133102 Genomic DNA. No translation available.
    BC062936 mRNA. Translation: AAH62936.1.
    BC068283 mRNA. Translation: AAH68283.1.
    CCDSiCCDS48238.1.
    RefSeqiNP_942602.2. NM_198899.2.
    UniGeneiMm.261022.

    Genome annotation databases

    EnsembliENSMUST00000046875; ENSMUSP00000037930; ENSMUSG00000037470.
    GeneIDi320011.
    KEGGimmu:320011.
    UCSCiuc007app.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133102 Genomic DNA. No translation available.
    BC062936 mRNA. Translation: AAH62936.1 .
    BC068283 mRNA. Translation: AAH68283.1 .
    CCDSi CCDS48238.1.
    RefSeqi NP_942602.2. NM_198899.2.
    UniGenei Mm.261022.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 235693. 2 interactions.
    MINTi MINT-1863721.

    Protein family/group databases

    CAZyi GT24. Glycosyltransferase Family 24.

    PTM databases

    PhosphoSitei Q6P5E4.

    Proteomic databases

    MaxQBi Q6P5E4.
    PaxDbi Q6P5E4.
    PRIDEi Q6P5E4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046875 ; ENSMUSP00000037930 ; ENSMUSG00000037470 .
    GeneIDi 320011.
    KEGGi mmu:320011.
    UCSCi uc007app.2. mouse.

    Organism-specific databases

    CTDi 56886.
    MGIi MGI:2443162. Uggt1.

    Phylogenomic databases

    eggNOGi NOG320899.
    GeneTreei ENSGT00390000004600.
    HOGENOMi HOG000184622.
    HOVERGENi HBG079469.
    InParanoidi Q6P5E4.
    KOi K11718.
    OMAi RDYLDLT.
    OrthoDBi EOG75J0M7.
    TreeFami TF300320.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_198606. ER Quality Control Compartment (ERQC).

    Miscellaneous databases

    ChiTaRSi UGGT1. mouse.
    NextBioi 395857.
    PROi Q6P5E4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P5E4.
    Bgeei Q6P5E4.
    CleanExi MM_UGCGL1.
    Genevestigatori Q6P5E4.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR009448. UDP-g_GGtrans.
    [Graphical view ]
    PANTHERi PTHR11226. PTHR11226. 1 hit.
    Pfami PF06427. UDP-g_GGTase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported and ICRImported.
      Tissue: BrainImported and Trophoblast stem cell.
    3. "Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells."
      Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N.
      J. Biol. Chem. 276:15330-15336(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEP15.

    Entry informationi

    Entry nameiUGGG1_MOUSE
    AccessioniPrimary (citable) accession number: Q6P5E4
    Secondary accession number(s): E9QQ49, Q6NV70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3