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Q6P5E4 (UGGG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose:glycoprotein glucosyltransferase 1

Short name=UGT1
EC=2.4.1.-
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1
Gene names
Name:Uggt1
Synonyms:Gt, Ugcgl1, Uggt, Ugt1, Ugtr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1551 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.

Cofactor

Calcium By similarity.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Monomer as well as in a tight complex with SEP15. Interacts with METTL23 By similarity. Ref.3

Subcellular location

Endoplasmic reticulum lumen By similarity. Endoplasmic reticulum-Golgi intermediate compartment By similarity UniProtKB Q9NYU2.

Domain

The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects By similarity.

Sequence similarities

Belongs to the glycosyltransferase 8 family. UniProtKB Q9JLA3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 By similarity
Chain43 – 15511509UDP-glucose:glycoprotein glucosyltransferase 1
PRO_0000012272

Regions

Region1244 – 1551308Glucosyltransferase By similarity
Motif1548 – 15514Prevents secretion from ER Potential

Amino acid modifications

Modified residue12771Phosphoserine By similarity
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation5361N-linked (GlcNAc...) Potential
Glycosylation12281N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3191K → E in AAH68283. Ref.1
Sequence conflict4451S → F in AAH68283. Ref.1
Sequence conflict8241S → N in AAH68283. Ref.1
Sequence conflict9351Q → R in AAH68283. Ref.1
Sequence conflict10151N → T in AAH68283. Ref.1
Sequence conflict10581I → T in AAH68283. Ref.1
Sequence conflict10831E → Q in AAH62936. Ref.2
Sequence conflict12121K → R in AAH68283. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P5E4 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: 1036D2CCA2DC4A19

FASTA1,551176,434
        10         20         30         40         50         60 
MCSRGDANTA DAAAARRVTG LRYNMRLLIA LALPCLFSLA EANSKAITTS LTTKWFSAPL 

        70         80         90        100        110        120 
LLEASEFLAE DSQEKFWSFV EATQNIGSSD HHDTDHSYYD AVLEAAFRFL SPLQQNLLKF 

       130        140        150        160        170        180 
CLSLRSYSAS IQAFQQIAVD EPPPEGCKSF LSVHGKQTCD LDTLESLLLT AADRPKPLLF 

       190        200        210        220        230        240 
KGDHRYPSSN PESPVVILYS EIGHEEFSNI HHQLISKSNE GKINYVFRHY ISNPSKEPVY 

       250        260        270        280        290        300 
LSGYGVELAI KSTEYKAKDD TQVKGTEVNA TVIGESDPID EVQGFLFGKL RELYPALEGQ 

       310        320        330        340        350        360 
LKEFRKHLVE STNEMAPLKV WQLQDLSFQT AARILAASGA LSLVVMKDIS QNFPTKARAI 

       370        380        390        400        410        420 
TKTAVSAQLR AEVEENQKYF KGTIGLQPGD SALFINGLHI DLDTQDIFSL FDTLRNEARV 

       430        440        450        460        470        480 
MEGLHRLGIE GLSLHNILKL NIQPSETDYA VDIRSPAISW VNNLEVDSRY NSWPSSLQEL 

       490        500        510        520        530        540 
LRPTFPGVIR QIRKNLHNMV FIIDPVHETT AELISIAEMF LSNHIPLRIG FIFVVNDSED 

       550        560        570        580        590        600 
VDGMQDAGVA VLRAYNYVAQ EVDGYHAFQT LTQIYNKVRT GETVKVEHVV SVLEKKYPYV 

       610        620        630        640        650        660 
EVNSILGIDS AYDQNRKEAR GYYEQTGVGP LPVVLFNGMP FEKEQLDPDE LETITMHKIL 

       670        680        690        700        710        720 
ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL TAKREYLDLT ASNNFYVDDF 

       730        740        750        760        770        780 
ARFSALDSRG KTAAIANSMN YLTKKGMSSK EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD 

       790        800        810        820        830        840 
AIKHQKTSNN VRISMINNPS QEISDSSTPI FRAIWAALQT QASSSAKNFI TKMAKEETAE 

       850        860        870        880        890        900 
ALAAGVDIAE FSVGGMDVSL FKEVFESSRM DFILSHALYC RDVLKLKKGQ RVVISNGRII 

       910        920        930        940        950        960 
GPLEDNELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV DALLSAQPKG 

       970        980        990       1000       1010       1020 
EARIEYQFFE DKHSAIKLKP KEGETYYDVV AVVDPVTREA QRLAPLLLVL TQLINMNLRV 

      1030       1040       1050       1060       1070       1080 
FMNCQSKLSD MPLKSFYRYV LEPEISFTAD SSFAKGPIAK FLDMPQSPLF TLNLNTPESW 

      1090       1100       1110       1120       1130       1140 
MVESVRTPYD LDNIYLEEVD SIVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP 

      1150       1160       1170       1180       1190       1200 
TIVDTIVMAN LGYFQLKANP GAWILRLRKG RSDDIYRIYS HDGTDSPPDA NDVVVILNNF 

      1210       1220       1230       1240       1250       1260 
KSKIIKVKVQ KKADMANEDL LSDGTNENES GFWDSFKWGF SGQKAEEVKQ DKDDIINIFS 

      1270       1280       1290       1300       1310       1320 
VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK EFIPYMAKKY NFQYELVQYK 

      1330       1340       1350       1360       1370       1380 
WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY 

      1390       1400       1410       1420       1430       1440 
GYTPFCDSRR EMDGYRFWKS GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG 

      1450       1460       1470       1480       1490       1500 
LSQDPNSLSN LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE 

      1510       1520       1530       1540       1550 
PKLEAAVRIV PEWQDYDQEI KQLQTLFQEE KELGTLHTEE TQEGSQKHEE L 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and ICR.
Tissue: Brain and Trophoblast stem cell.
[3]"Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells."
Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N.
J. Biol. Chem. 276:15330-15336(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SEP15.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC133102 Genomic DNA. No translation available.
BC062936 mRNA. Translation: AAH62936.1.
BC068283 mRNA. Translation: AAH68283.1.
RefSeqNP_942602.2. NM_198899.2.
UniGeneMm.261022.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid235693. 1 interaction.
MINTMINT-1863721.

Protein family/group databases

CAZyGT24. Glycosyltransferase Family 24.

PTM databases

PhosphoSiteQ6P5E4.

Proteomic databases

PaxDbQ6P5E4.
PRIDEQ6P5E4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046875; ENSMUSP00000037930; ENSMUSG00000037470.
GeneID320011.
KEGGmmu:320011.
UCSCuc007app.2. mouse.

Organism-specific databases

CTD56886.
MGIMGI:2443162. Uggt1.

Phylogenomic databases

eggNOGNOG320899.
GeneTreeENSGT00390000004600.
HOGENOMHOG000184622.
HOVERGENHBG079469.
InParanoidQ6P5E4.
KOK11718.
OMAPAISWVN.
OrthoDBEOG75J0M7.
TreeFamTF300320.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

ArrayExpressQ6P5E4.
BgeeQ6P5E4.
CleanExMM_UGCGL1.
GenevestigatorQ6P5E4.

Family and domain databases

InterProIPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERPTHR11226. PTHR11226. 1 hit.
PfamPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUGGT1. mouse.
NextBio395857.
PROQ6P5E4.
SOURCESearch...

Entry information

Entry nameUGGG1_MOUSE
AccessionPrimary (citable) accession number: Q6P5E4
Secondary accession number(s): E9QQ49, Q6NV70
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot