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Q6P5E4

- UGGG1_MOUSE

UniProt

Q6P5E4 - UGGG1_MOUSE

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Protein

UDP-glucose:glycoprotein glucosyltransferase 1

Gene

Uggt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).By similarity

Cofactori

Ca2+By similarity

Pathwayi

GO - Molecular functioni

  1. UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
  2. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198606. ER Quality Control Compartment (ERQC).
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 1 (EC:2.4.1.-)
Short name:
UGT1
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:Uggt1
Synonyms:Gt, Ugcgl1, Uggt, Ugt1, Ugtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2443162. Uggt1.

Subcellular locationi

Endoplasmic reticulum lumen By similarityPROSITE-ProRule annotation. Endoplasmic reticulum-Golgi intermediate compartment PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  2. endoplasmic reticulum lumen Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242By similarityAdd
BLAST
Chaini43 – 15511509UDP-glucose:glycoprotein glucosyltransferase 1PRO_0000012272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1228 – 12281N-linked (GlcNAc...)Sequence Analysis
Modified residuei1277 – 12771PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P5E4.
PaxDbiQ6P5E4.
PRIDEiQ6P5E4.

PTM databases

PhosphoSiteiQ6P5E4.

Expressioni

Gene expression databases

BgeeiQ6P5E4.
CleanExiMM_UGCGL1.
ExpressionAtlasiQ6P5E4. baseline and differential.
GenevestigatoriQ6P5E4.

Interactioni

Subunit structurei

Monomer as well as in a tight complex with SEP15. Interacts with METTL23 (By similarity).By similarity

Protein-protein interaction databases

BioGridi235693. 2 interactions.
MINTiMINT-1863721.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1244 – 1551308GlucosyltransferaseBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1548 – 15514Prevents secretion from ERPROSITE-ProRule annotation

Domaini

The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.By similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000184622.
HOVERGENiHBG079469.
InParanoidiQ6P5E4.
KOiK11718.
OMAiRDYLDLT.
OrthoDBiEOG75J0M7.
TreeFamiTF300320.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5E4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSRGDANTA DAAAARRVTG LRYNMRLLIA LALPCLFSLA EANSKAITTS
60 70 80 90 100
LTTKWFSAPL LLEASEFLAE DSQEKFWSFV EATQNIGSSD HHDTDHSYYD
110 120 130 140 150
AVLEAAFRFL SPLQQNLLKF CLSLRSYSAS IQAFQQIAVD EPPPEGCKSF
160 170 180 190 200
LSVHGKQTCD LDTLESLLLT AADRPKPLLF KGDHRYPSSN PESPVVILYS
210 220 230 240 250
EIGHEEFSNI HHQLISKSNE GKINYVFRHY ISNPSKEPVY LSGYGVELAI
260 270 280 290 300
KSTEYKAKDD TQVKGTEVNA TVIGESDPID EVQGFLFGKL RELYPALEGQ
310 320 330 340 350
LKEFRKHLVE STNEMAPLKV WQLQDLSFQT AARILAASGA LSLVVMKDIS
360 370 380 390 400
QNFPTKARAI TKTAVSAQLR AEVEENQKYF KGTIGLQPGD SALFINGLHI
410 420 430 440 450
DLDTQDIFSL FDTLRNEARV MEGLHRLGIE GLSLHNILKL NIQPSETDYA
460 470 480 490 500
VDIRSPAISW VNNLEVDSRY NSWPSSLQEL LRPTFPGVIR QIRKNLHNMV
510 520 530 540 550
FIIDPVHETT AELISIAEMF LSNHIPLRIG FIFVVNDSED VDGMQDAGVA
560 570 580 590 600
VLRAYNYVAQ EVDGYHAFQT LTQIYNKVRT GETVKVEHVV SVLEKKYPYV
610 620 630 640 650
EVNSILGIDS AYDQNRKEAR GYYEQTGVGP LPVVLFNGMP FEKEQLDPDE
660 670 680 690 700
LETITMHKIL ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL
710 720 730 740 750
TAKREYLDLT ASNNFYVDDF ARFSALDSRG KTAAIANSMN YLTKKGMSSK
760 770 780 790 800
EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD AIKHQKTSNN VRISMINNPS
810 820 830 840 850
QEISDSSTPI FRAIWAALQT QASSSAKNFI TKMAKEETAE ALAAGVDIAE
860 870 880 890 900
FSVGGMDVSL FKEVFESSRM DFILSHALYC RDVLKLKKGQ RVVISNGRII
910 920 930 940 950
GPLEDNELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV
960 970 980 990 1000
DALLSAQPKG EARIEYQFFE DKHSAIKLKP KEGETYYDVV AVVDPVTREA
1010 1020 1030 1040 1050
QRLAPLLLVL TQLINMNLRV FMNCQSKLSD MPLKSFYRYV LEPEISFTAD
1060 1070 1080 1090 1100
SSFAKGPIAK FLDMPQSPLF TLNLNTPESW MVESVRTPYD LDNIYLEEVD
1110 1120 1130 1140 1150
SIVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP TIVDTIVMAN
1160 1170 1180 1190 1200
LGYFQLKANP GAWILRLRKG RSDDIYRIYS HDGTDSPPDA NDVVVILNNF
1210 1220 1230 1240 1250
KSKIIKVKVQ KKADMANEDL LSDGTNENES GFWDSFKWGF SGQKAEEVKQ
1260 1270 1280 1290 1300
DKDDIINIFS VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK
1310 1320 1330 1340 1350
EFIPYMAKKY NFQYELVQYK WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV
1360 1370 1380 1390 1400
VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY GYTPFCDSRR EMDGYRFWKS
1410 1420 1430 1440 1450
GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG LSQDPNSLSN
1460 1470 1480 1490 1500
LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE
1510 1520 1530 1540 1550
PKLEAAVRIV PEWQDYDQEI KQLQTLFQEE KELGTLHTEE TQEGSQKHEE

L
Length:1,551
Mass (Da):176,434
Last modified:July 27, 2011 - v4
Checksum:i1036D2CCA2DC4A19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191K → E in AAH68283. (PubMed:19468303)Curated
Sequence conflicti445 – 4451S → F in AAH68283. (PubMed:19468303)Curated
Sequence conflicti824 – 8241S → N in AAH68283. (PubMed:19468303)Curated
Sequence conflicti935 – 9351Q → R in AAH68283. (PubMed:19468303)Curated
Sequence conflicti1015 – 10151N → T in AAH68283. (PubMed:19468303)Curated
Sequence conflicti1058 – 10581I → T in AAH68283. (PubMed:19468303)Curated
Sequence conflicti1083 – 10831E → Q in AAH62936. (PubMed:15489334)Curated
Sequence conflicti1212 – 12121K → R in AAH68283. (PubMed:19468303)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133102 Genomic DNA. No translation available.
BC062936 mRNA. Translation: AAH62936.1.
BC068283 mRNA. Translation: AAH68283.1.
CCDSiCCDS48238.1.
RefSeqiNP_942602.2. NM_198899.2.
UniGeneiMm.261022.

Genome annotation databases

EnsembliENSMUST00000046875; ENSMUSP00000037930; ENSMUSG00000037470.
GeneIDi320011.
KEGGimmu:320011.
UCSCiuc007app.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133102 Genomic DNA. No translation available.
BC062936 mRNA. Translation: AAH62936.1 .
BC068283 mRNA. Translation: AAH68283.1 .
CCDSi CCDS48238.1.
RefSeqi NP_942602.2. NM_198899.2.
UniGenei Mm.261022.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 235693. 2 interactions.
MINTi MINT-1863721.

Protein family/group databases

CAZyi GT24. Glycosyltransferase Family 24.

PTM databases

PhosphoSitei Q6P5E4.

Proteomic databases

MaxQBi Q6P5E4.
PaxDbi Q6P5E4.
PRIDEi Q6P5E4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046875 ; ENSMUSP00000037930 ; ENSMUSG00000037470 .
GeneIDi 320011.
KEGGi mmu:320011.
UCSCi uc007app.2. mouse.

Organism-specific databases

CTDi 56886.
MGIi MGI:2443162. Uggt1.

Phylogenomic databases

eggNOGi NOG320899.
GeneTreei ENSGT00390000004600.
HOGENOMi HOG000184622.
HOVERGENi HBG079469.
InParanoidi Q6P5E4.
KOi K11718.
OMAi RDYLDLT.
OrthoDBi EOG75J0M7.
TreeFami TF300320.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_198606. ER Quality Control Compartment (ERQC).

Miscellaneous databases

ChiTaRSi Uggt1. mouse.
NextBioi 395857.
PROi Q6P5E4.
SOURCEi Search...

Gene expression databases

Bgeei Q6P5E4.
CleanExi MM_UGCGL1.
ExpressionAtlasi Q6P5E4. baseline and differential.
Genevestigatori Q6P5E4.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view ]
PANTHERi PTHR11226. PTHR11226. 1 hit.
Pfami PF06427. UDP-g_GGTase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported and ICRImported.
    Tissue: BrainImported and Trophoblast stem cell.
  3. "Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells."
    Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N.
    J. Biol. Chem. 276:15330-15336(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEP15.

Entry informationi

Entry nameiUGGG1_MOUSE
AccessioniPrimary (citable) accession number: Q6P5E4
Secondary accession number(s): E9QQ49, Q6NV70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3