UDP-glucose:glycoprotein glucosyltransferase 1 precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 1
Short name=UGT1
EC=2.4.1.-

Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1

Gene names

Name:	Uggt1
Synonyms:	Gt, Ugcgl1, Uggt, Ugt1, Ugtr

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.
Cofactor	Calcium By similarity.
Pathway	Protein modification; protein glycosylation.
Subunit structure	Monomer as well as in a tight complex with SEP15. Ref.3
Subcellular location	Endoplasmic reticulum lumen By similarity. Endoplasmic reticulum-Golgi intermediate compartment By similarity UniProtKB Q9NYU2.
Domain	The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects By similarity.
Sequence similarities	Belongs to the glycosyltransferase 8 family. UniProtKB Q9JLA3

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein glycosylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	endoplasmic reticulum lumen Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum-Golgi intermediate compartment Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	UDP-glucose:glycoprotein glucosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB unfolded protein binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 42

42

By similarity

Chain

43 – 1551

1509

UDP-glucose:glycoprotein glucosyltransferase 1

PRO_0000012272

Regions

Region

1244 – 1551

308

Glucosyltransferase By similarity

Motif

1548 – 1551

4

Prevents secretion from ER Potential

Amino acid modifications

Modified residue

1277

1

Phosphoserine By similarity

Glycosylation

269

1

N-linked (GlcNAc...) Potential

Glycosylation

536

1

N-linked (GlcNAc...) Potential

Glycosylation

1228

1

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

319

1

K → E in AAH68283. Ref.1

Sequence conflict

445

1

S → F in AAH68283. Ref.1

Sequence conflict

824

1

S → N in AAH68283. Ref.1

Sequence conflict

935

1

Q → R in AAH68283. Ref.1

Sequence conflict

1015

1

N → T in AAH68283. Ref.1

Sequence conflict

1058

1

I → T in AAH68283. Ref.1

Sequence conflict

1083

1

E → Q in AAH62936. Ref.2

Sequence conflict

1212

1

K → R in AAH68283. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q6P5E4 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: 1036D2CCA2DC4A19
Show »

FASTA

1,551

176,434

        10         20         30         40         50         60 
MCSRGDANTA DAAAARRVTG LRYNMRLLIA LALPCLFSLA EANSKAITTS LTTKWFSAPL 

        70         80         90        100        110        120 
LLEASEFLAE DSQEKFWSFV EATQNIGSSD HHDTDHSYYD AVLEAAFRFL SPLQQNLLKF 

       130        140        150        160        170        180 
CLSLRSYSAS IQAFQQIAVD EPPPEGCKSF LSVHGKQTCD LDTLESLLLT AADRPKPLLF 

       190        200        210        220        230        240 
KGDHRYPSSN PESPVVILYS EIGHEEFSNI HHQLISKSNE GKINYVFRHY ISNPSKEPVY 

       250        260        270        280        290        300 
LSGYGVELAI KSTEYKAKDD TQVKGTEVNA TVIGESDPID EVQGFLFGKL RELYPALEGQ 

       310        320        330        340        350        360 
LKEFRKHLVE STNEMAPLKV WQLQDLSFQT AARILAASGA LSLVVMKDIS QNFPTKARAI 

       370        380        390        400        410        420 
TKTAVSAQLR AEVEENQKYF KGTIGLQPGD SALFINGLHI DLDTQDIFSL FDTLRNEARV 

       430        440        450        460        470        480 
MEGLHRLGIE GLSLHNILKL NIQPSETDYA VDIRSPAISW VNNLEVDSRY NSWPSSLQEL 

       490        500        510        520        530        540 
LRPTFPGVIR QIRKNLHNMV FIIDPVHETT AELISIAEMF LSNHIPLRIG FIFVVNDSED 

       550        560        570        580        590        600 
VDGMQDAGVA VLRAYNYVAQ EVDGYHAFQT LTQIYNKVRT GETVKVEHVV SVLEKKYPYV 

       610        620        630        640        650        660 
EVNSILGIDS AYDQNRKEAR GYYEQTGVGP LPVVLFNGMP FEKEQLDPDE LETITMHKIL 

       670        680        690        700        710        720 
ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL TAKREYLDLT ASNNFYVDDF 

       730        740        750        760        770        780 
ARFSALDSRG KTAAIANSMN YLTKKGMSSK EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD 

       790        800        810        820        830        840 
AIKHQKTSNN VRISMINNPS QEISDSSTPI FRAIWAALQT QASSSAKNFI TKMAKEETAE 

       850        860        870        880        890        900 
ALAAGVDIAE FSVGGMDVSL FKEVFESSRM DFILSHALYC RDVLKLKKGQ RVVISNGRII 

       910        920        930        940        950        960 
GPLEDNELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV DALLSAQPKG 

       970        980        990       1000       1010       1020 
EARIEYQFFE DKHSAIKLKP KEGETYYDVV AVVDPVTREA QRLAPLLLVL TQLINMNLRV 

      1030       1040       1050       1060       1070       1080 
FMNCQSKLSD MPLKSFYRYV LEPEISFTAD SSFAKGPIAK FLDMPQSPLF TLNLNTPESW 

      1090       1100       1110       1120       1130       1140 
MVESVRTPYD LDNIYLEEVD SIVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP 

      1150       1160       1170       1180       1190       1200 
TIVDTIVMAN LGYFQLKANP GAWILRLRKG RSDDIYRIYS HDGTDSPPDA NDVVVILNNF 

      1210       1220       1230       1240       1250       1260 
KSKIIKVKVQ KKADMANEDL LSDGTNENES GFWDSFKWGF SGQKAEEVKQ DKDDIINIFS 

      1270       1280       1290       1300       1310       1320 
VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK EFIPYMAKKY NFQYELVQYK 

      1330       1340       1350       1360       1370       1380 
WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY 

      1390       1400       1410       1420       1430       1440 
GYTPFCDSRR EMDGYRFWKS GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG 

      1450       1460       1470       1480       1490       1500 
LSQDPNSLSN LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE 

      1510       1520       1530       1540       1550 
PKLEAAVRIV PEWQDYDQEI KQLQTLFQEE KELGTLHTEE TQEGSQKHEE L

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and ICR. Tissue: Brain and Trophoblast stem cell.
[3]	"Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells." Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N. J. Biol. Chem. 276:15330-15336(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SEP15.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC133102 Genomic DNA. No translation available. BC062936 mRNA. Translation: AAH62936.1. BC068283 mRNA. Translation: AAH68283.1.
IPI	IPI00762897.
RefSeq	NP_942602.2. NM_198899.2.
UniGene	Mm.261022.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1863721.
Protein family/group databases
CAZy	GT24. Glycosyltransferase Family 24.
PTM databases
PhosphoSite	Q6P5E4.
Proteomic databases
PaxDb	Q6P5E4.
PRIDE	Q6P5E4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046875; ENSMUSP00000037930; ENSMUSG00000037470.
GeneID	320011.
KEGG	mmu:320011.
UCSC	uc007app.2. mouse.
Organism-specific databases
CTD	56886.
MGI	MGI:2443162. Uggt1.
Phylogenomic databases
eggNOG	NOG320899.
GeneTree	ENSGT00390000004600.
HOGENOM	HOG000184622.
HOVERGEN	HBG079469.
InParanoid	Q6P5E4.
KO	K11718.
OMA	QNIGSSD.
OrthoDB	EOG46WZ7H.
Enzyme and pathway databases
UniPathway	UPA00378.
Gene expression databases
ArrayExpress	Q6P5E4.
Bgee	Q6P5E4.
CleanEx	MM_UGCGL1.
Genevestigator	Q6P5E4.
GermOnline	ENSMUSG00000037470. Mus musculus.
Family and domain databases
InterPro	IPR009448. UDP-g_GGtrans. [Graphical view]
PANTHER	PTHR11226. PTHR11226. 1 hit.
Pfam	PF06427. UDP-g_GGTase. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	UGGT1. mouse.
NextBio	395857.
SOURCE	Search...

Entry information

Entry name

UGGG1_MOUSE

Accession

Primary (citable) accession number: Q6P5E4
Secondary accession number(s): E9QQ49, Q6NV70

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 82 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents