Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6P5D3 (DHX57_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ATP-dependent RNA helicase DHX57

EC=3.6.4.13
Alternative name(s):
DEAH box protein 57
Gene names
Name:Dhx57
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable ATP-binding RNA helicase.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the DEAD box helicase family. DEAH subfamily.

Contains 1 C3H1-type zinc finger.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 UBA domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P5D3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P5D3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     77-129: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6P5D3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1008-1025: IKILEMFSTHNLQSVFSR → LCPSGPPSACLGPAPPPI
     1026-1388: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6P5D3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1000: Missing.
     1001-1006: LEQLCL → MILFFF
Note: No experimental confirmation available.
Isoform 5 (identifier: Q6P5D3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1160: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13881388Putative ATP-dependent RNA helicase DHX57
PRO_0000233152

Regions

Domain175 – 22046UBA
Domain555 – 722168Helicase ATP-binding
Domain832 – 1012181Helicase C-terminal
Zinc finger299 – 32628C3H1-type
Nucleotide binding568 – 5758ATP By similarity
Motif669 – 6724DEVH box
Compositional bias9 – 5042Gly-rich

Amino acid modifications

Modified residue1281Phosphoserine By similarity
Modified residue4751Phosphoserine By similarity

Natural variations

Alternative sequence1 – 11601160Missing in isoform 5.
VSP_018061
Alternative sequence1 – 10001000Missing in isoform 4.
VSP_018062
Alternative sequence77 – 12953Missing in isoform 2.
VSP_018063
Alternative sequence1001 – 10066LEQLCL → MILFFF in isoform 4.
VSP_018064
Alternative sequence1008 – 102518IKILE…SVFSR → LCPSGPPSACLGPAPPPI in isoform 3.
VSP_018065
Alternative sequence1026 – 1388363Missing in isoform 3.
VSP_018066

Experimental info

Sequence conflict4881A → T in AAH66091. Ref.2
Sequence conflict5141S → P in AAH62952. Ref.2
Sequence conflict7251A → T in AAH66091. Ref.2
Sequence conflict11371T → A in BAC29042. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: D3E57C648E53A805

FASTA1,388155,762
        10         20         30         40         50         60 
MSSSVRRKGK PGKGDGKGSS RGGRGGKGHM NKSHGGGGGG GGSCGGGGGG SRKASNRIWD 

        70         80         90        100        110        120 
DGDDFCVFTE PKRPSRPCDS NKSKGETRPK WKPKAKVPLQ TLHMTSENQE KVKALLRDLQ 

       130        140        150        160        170        180 
EQGADAGSER GTSGEEEDSE PQCGEEQGWP AGQEPIFLPD CSPWEYIGPE EVEPPVPECA 

       190        200        210        220        230        240 
VSPLAVQKLS RYGFHTEHCQ LALRICDGDL GAALEHLLRQ CFSETFGERM ALSEAAVYVS 

       250        260        270        280        290        300 
LNECVEQRQE ETLALKSICG EKFIERIQNR VWTIGLELDY LTNKFCKSKQ KESSKNVRDT 

       310        320        330        340        350        360 
SPETCKFYLK GNCKFGSKCK FKHEVPPHQM IGRAERNVND PHLDADDDTT FMYELQIRFS 

       370        380        390        400        410        420 
KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYGKALEF AKTSEPVVYS LITLLEEESE 

       430        440        450        460        470        480 
IVKLLTHTQH KYSVPPVNVP PVPSETRISK PAYRKPVVPS NTFLSNQMLE GERLSELEED 

       490        500        510        520        530        540 
ADEDEGPASI IVENESYVNL KKRSYKRYDR PAKSLFAENS KICRQFQMKQ ASRQFHAILQ 

       550        560        570        580        590        600 
ERQLLPAWEE RETILKLLSK HQVVVISGMT GCGKTTQIPQ FILDNSLNGP PERVANIICT 

       610        620        630        640        650        660 
QPRRISAISV AERVAKERAE RVGLTVGYQI RLESVKSSAT RLLYCTTGVL LRRLEGDATL 

       670        680        690        700        710        720 
QGVTHIIVDE VHERTEESDF LLLVLKDIVM QRATLQVILM SATLDAGLFS KYFSYCPVIT 

       730        740        750        760        770        780 
IPGRAFPVDQ FFLEDALAVT RYVLQDGSPY MRSMKQIAKE KLKARHNRTA QEEVEEDLRL 

       790        800        810        820        830        840 
SLHLQDEEES VKDTIPDQQL DFKQLLIRYK GVSKSVIKTM SVMDFEKVNL ELIEALLEWI 

       850        860        870        880        890        900 
VDGKHAYPPG AVLVFLPGLA EIKMLYEQLQ SNSLFNNRRS HRCVIHPLHS SLSSEEQQAV 

       910        920        930        940        950        960 
FVKPPMGVTK IIISTNIAET SITIDDVVYV IDSGKMKEKR YDAGKGMESL EDTFVSQANA 

       970        980        990       1000       1010       1020 
LQRKGRAGRV ASGVCFHLFT SHHYNHQLLK QQLPEIQRVP LEQLCLRIKI LEMFSTHNLQ 

      1030       1040       1050       1060       1070       1080 
SVFSRLIEPP HIDSLRASKV RLRDLGALTP DEKLTPLGYH LASLPVDVRI GKLMLLGSIF 

      1090       1100       1110       1120       1130       1140 
RCLDPALTIA ASLAFKSPFV SPWDKKEEAN QKKLEFAFAN SDYLALLCAY KGWQLSTKES 

      1150       1160       1170       1180       1190       1200 
ARASYNYCRQ NFLSGRTLQE MASLKRQFTE LLSDIGFVKE GLRAKEIEKR AQGGDGVLDA 

      1210       1220       1230       1240       1250       1260 
TGEEANTNAE NPKLISAVLC AALYPNVVQV KTPEGKFQKT SSGVVRLQPK SAELKFVTKN 

      1270       1280       1290       1300       1310       1320 
DGYVHIHPSS VNYQVRHFDS PYLLYHEKIK TSRVFIRDCS MVSVYPLVLF GGGQVNVQLQ 

      1330       1340       1350       1360       1370       1380 
RGAFVVSLDD GWIRFVAASH QVAELVKELR CELDQLLQDK IKNPSMDLCS CPRGSRIISM 


IVKLITTQ 

« Hide

Isoform 2 [UniParc].

Checksum: F8A8ADE8A236D3DC
Show »

FASTA1,335149,876
Isoform 3 [UniParc].

Checksum: 958E2BC419635835
Show »

FASTA1,025114,839
Isoform 4 [UniParc].

Checksum: 913BF94B09941970
Show »

FASTA38843,553
Isoform 5 [UniParc].

Checksum: B55D98A26BF57252
Show »

FASTA22825,352

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
Strain: C57BL/6J.
Tissue: Eye and Urinary bladder.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK035344 mRNA. Translation: BAC29042.1.
AK053628 mRNA. Translation: BAC35451.1.
AK162192 mRNA. Translation: BAE36782.1.
BC026474 mRNA. Translation: AAH26474.1.
BC062952 mRNA. Translation: AAH62952.1.
BC065169 mRNA. Translation: AAH65169.1.
BC066091 mRNA. Translation: AAH66091.1.
CCDSCCDS28990.1. [Q6P5D3-2]
CCDS50188.1. [Q6P5D3-1]
RefSeqNP_001157231.1. NM_001163759.1. [Q6P5D3-1]
NP_945180.2. NM_198942.2. [Q6P5D3-2]
XP_006523510.1. XM_006523447.1. [Q6P5D3-1]
XP_006523511.1. XM_006523448.1. [Q6P5D3-2]
UniGeneMm.12412.

3D structure databases

ProteinModelPortalQ6P5D3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6P5D3.

Proteomic databases

PaxDbQ6P5D3.
PRIDEQ6P5D3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051. [Q6P5D3-2]
ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051. [Q6P5D3-1]
GeneID106794.
KEGGmmu:106794.
UCSCuc008dqx.2. mouse. [Q6P5D3-5]
uc008dqy.2. mouse. [Q6P5D3-4]
uc008dqz.2. mouse. [Q6P5D3-2]
uc008dra.2. mouse. [Q6P5D3-1]
uc008drb.1. mouse. [Q6P5D3-3]

Organism-specific databases

CTD90957.
MGIMGI:2147067. Dhx57.

Phylogenomic databases

eggNOGCOG1643.
GeneTreeENSGT00740000115350.
HOVERGENHBG080658.
InParanoidQ6P5D3.
KOK13026.
OMATQCFSET.
OrthoDBEOG7SV0TS.
PhylomeDBQ6P5D3.
TreeFamTF324744.

Gene expression databases

BgeeQ6P5D3.
CleanExMM_DHX57.
GenevestigatorQ6P5D3.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00165. UBA. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio358388.
PROQ6P5D3.
SOURCESearch...

Entry information

Entry nameDHX57_MOUSE
AccessionPrimary (citable) accession number: Q6P5D3
Secondary accession number(s): Q3TS93 expand/collapse secondary AC list , Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot