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Q6P5D3

- DHX57_MOUSE

UniProt

Q6P5D3 - DHX57_MOUSE

Protein

Putative ATP-dependent RNA helicase DHX57

Gene

Dhx57

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Probable ATP-binding RNA helicase.

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi568 – 5758ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
    Alternative name(s):
    DEAH box protein 57
    Gene namesi
    Name:Dhx57
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2147067. Dhx57.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13881388Putative ATP-dependent RNA helicase DHX57PRO_0000233152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281PhosphoserineBy similarity
    Modified residuei475 – 4751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6P5D3.
    PRIDEiQ6P5D3.

    PTM databases

    PhosphoSiteiQ6P5D3.

    Expressioni

    Gene expression databases

    BgeeiQ6P5D3.
    CleanExiMM_DHX57.
    GenevestigatoriQ6P5D3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P5D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 22046UBAPROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 722168Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini832 – 1012181Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi669 – 6724DEVH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 5042Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1643.
    GeneTreeiENSGT00740000115350.
    HOVERGENiHBG080658.
    InParanoidiQ6P5D3.
    KOiK13026.
    OMAiTQCFSET.
    OrthoDBiEOG7SV0TS.
    PhylomeDBiQ6P5D3.
    TreeFamiTF324744.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00165. UBA. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50030. UBA. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P5D3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSVRRKGK PGKGDGKGSS RGGRGGKGHM NKSHGGGGGG GGSCGGGGGG     50
    SRKASNRIWD DGDDFCVFTE PKRPSRPCDS NKSKGETRPK WKPKAKVPLQ 100
    TLHMTSENQE KVKALLRDLQ EQGADAGSER GTSGEEEDSE PQCGEEQGWP 150
    AGQEPIFLPD CSPWEYIGPE EVEPPVPECA VSPLAVQKLS RYGFHTEHCQ 200
    LALRICDGDL GAALEHLLRQ CFSETFGERM ALSEAAVYVS LNECVEQRQE 250
    ETLALKSICG EKFIERIQNR VWTIGLELDY LTNKFCKSKQ KESSKNVRDT 300
    SPETCKFYLK GNCKFGSKCK FKHEVPPHQM IGRAERNVND PHLDADDDTT 350
    FMYELQIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYGKALEF 400
    AKTSEPVVYS LITLLEEESE IVKLLTHTQH KYSVPPVNVP PVPSETRISK 450
    PAYRKPVVPS NTFLSNQMLE GERLSELEED ADEDEGPASI IVENESYVNL 500
    KKRSYKRYDR PAKSLFAENS KICRQFQMKQ ASRQFHAILQ ERQLLPAWEE 550
    RETILKLLSK HQVVVISGMT GCGKTTQIPQ FILDNSLNGP PERVANIICT 600
    QPRRISAISV AERVAKERAE RVGLTVGYQI RLESVKSSAT RLLYCTTGVL 650
    LRRLEGDATL QGVTHIIVDE VHERTEESDF LLLVLKDIVM QRATLQVILM 700
    SATLDAGLFS KYFSYCPVIT IPGRAFPVDQ FFLEDALAVT RYVLQDGSPY 750
    MRSMKQIAKE KLKARHNRTA QEEVEEDLRL SLHLQDEEES VKDTIPDQQL 800
    DFKQLLIRYK GVSKSVIKTM SVMDFEKVNL ELIEALLEWI VDGKHAYPPG 850
    AVLVFLPGLA EIKMLYEQLQ SNSLFNNRRS HRCVIHPLHS SLSSEEQQAV 900
    FVKPPMGVTK IIISTNIAET SITIDDVVYV IDSGKMKEKR YDAGKGMESL 950
    EDTFVSQANA LQRKGRAGRV ASGVCFHLFT SHHYNHQLLK QQLPEIQRVP 1000
    LEQLCLRIKI LEMFSTHNLQ SVFSRLIEPP HIDSLRASKV RLRDLGALTP 1050
    DEKLTPLGYH LASLPVDVRI GKLMLLGSIF RCLDPALTIA ASLAFKSPFV 1100
    SPWDKKEEAN QKKLEFAFAN SDYLALLCAY KGWQLSTKES ARASYNYCRQ 1150
    NFLSGRTLQE MASLKRQFTE LLSDIGFVKE GLRAKEIEKR AQGGDGVLDA 1200
    TGEEANTNAE NPKLISAVLC AALYPNVVQV KTPEGKFQKT SSGVVRLQPK 1250
    SAELKFVTKN DGYVHIHPSS VNYQVRHFDS PYLLYHEKIK TSRVFIRDCS 1300
    MVSVYPLVLF GGGQVNVQLQ RGAFVVSLDD GWIRFVAASH QVAELVKELR 1350
    CELDQLLQDK IKNPSMDLCS CPRGSRIISM IVKLITTQ 1388
    Length:1,388
    Mass (Da):155,762
    Last modified:May 2, 2006 - v2
    Checksum:iD3E57C648E53A805
    GO
    Isoform 2 (identifier: Q6P5D3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-129: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,335
    Mass (Da):149,876
    Checksum:iF8A8ADE8A236D3DC
    GO
    Isoform 3 (identifier: Q6P5D3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1008-1025: IKILEMFSTHNLQSVFSR → LCPSGPPSACLGPAPPPI
         1026-1388: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,025
    Mass (Da):114,839
    Checksum:i958E2BC419635835
    GO
    Isoform 4 (identifier: Q6P5D3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1000: Missing.
         1001-1006: LEQLCL → MILFFF

    Note: No experimental confirmation available.

    Show »
    Length:388
    Mass (Da):43,553
    Checksum:i913BF94B09941970
    GO
    Isoform 5 (identifier: Q6P5D3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1160: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):25,352
    Checksum:iB55D98A26BF57252
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti488 – 4881A → T in AAH66091. (PubMed:15489334)Curated
    Sequence conflicti514 – 5141S → P in AAH62952. (PubMed:15489334)Curated
    Sequence conflicti725 – 7251A → T in AAH66091. (PubMed:15489334)Curated
    Sequence conflicti1137 – 11371T → A in BAC29042. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11601160Missing in isoform 5. 1 PublicationVSP_018061Add
    BLAST
    Alternative sequencei1 – 10001000Missing in isoform 4. 1 PublicationVSP_018062Add
    BLAST
    Alternative sequencei77 – 12953Missing in isoform 2. 1 PublicationVSP_018063Add
    BLAST
    Alternative sequencei1001 – 10066LEQLCL → MILFFF in isoform 4. 1 PublicationVSP_018064
    Alternative sequencei1008 – 102518IKILE…SVFSR → LCPSGPPSACLGPAPPPI in isoform 3. 1 PublicationVSP_018065Add
    BLAST
    Alternative sequencei1026 – 1388363Missing in isoform 3. 1 PublicationVSP_018066Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035344 mRNA. Translation: BAC29042.1.
    AK053628 mRNA. Translation: BAC35451.1.
    AK162192 mRNA. Translation: BAE36782.1.
    BC026474 mRNA. Translation: AAH26474.1.
    BC062952 mRNA. Translation: AAH62952.1.
    BC065169 mRNA. Translation: AAH65169.1.
    BC066091 mRNA. Translation: AAH66091.1.
    CCDSiCCDS28990.1. [Q6P5D3-2]
    CCDS50188.1. [Q6P5D3-1]
    RefSeqiNP_001157231.1. NM_001163759.1. [Q6P5D3-1]
    NP_945180.2. NM_198942.2. [Q6P5D3-2]
    XP_006523510.1. XM_006523447.1. [Q6P5D3-1]
    XP_006523511.1. XM_006523448.1. [Q6P5D3-2]
    UniGeneiMm.12412.

    Genome annotation databases

    EnsembliENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051. [Q6P5D3-2]
    ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051. [Q6P5D3-1]
    GeneIDi106794.
    KEGGimmu:106794.
    UCSCiuc008dqx.2. mouse. [Q6P5D3-5]
    uc008dqy.2. mouse. [Q6P5D3-4]
    uc008dqz.2. mouse. [Q6P5D3-2]
    uc008dra.2. mouse. [Q6P5D3-1]
    uc008drb.1. mouse. [Q6P5D3-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035344 mRNA. Translation: BAC29042.1 .
    AK053628 mRNA. Translation: BAC35451.1 .
    AK162192 mRNA. Translation: BAE36782.1 .
    BC026474 mRNA. Translation: AAH26474.1 .
    BC062952 mRNA. Translation: AAH62952.1 .
    BC065169 mRNA. Translation: AAH65169.1 .
    BC066091 mRNA. Translation: AAH66091.1 .
    CCDSi CCDS28990.1. [Q6P5D3-2 ]
    CCDS50188.1. [Q6P5D3-1 ]
    RefSeqi NP_001157231.1. NM_001163759.1. [Q6P5D3-1 ]
    NP_945180.2. NM_198942.2. [Q6P5D3-2 ]
    XP_006523510.1. XM_006523447.1. [Q6P5D3-1 ]
    XP_006523511.1. XM_006523448.1. [Q6P5D3-2 ]
    UniGenei Mm.12412.

    3D structure databases

    ProteinModelPortali Q6P5D3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P5D3.

    Proteomic databases

    PaxDbi Q6P5D3.
    PRIDEi Q6P5D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038166 ; ENSMUSP00000041069 ; ENSMUSG00000035051 . [Q6P5D3-2 ]
    ENSMUST00000086555 ; ENSMUSP00000083742 ; ENSMUSG00000035051 . [Q6P5D3-1 ]
    GeneIDi 106794.
    KEGGi mmu:106794.
    UCSCi uc008dqx.2. mouse. [Q6P5D3-5 ]
    uc008dqy.2. mouse. [Q6P5D3-4 ]
    uc008dqz.2. mouse. [Q6P5D3-2 ]
    uc008dra.2. mouse. [Q6P5D3-1 ]
    uc008drb.1. mouse. [Q6P5D3-3 ]

    Organism-specific databases

    CTDi 90957.
    MGIi MGI:2147067. Dhx57.

    Phylogenomic databases

    eggNOGi COG1643.
    GeneTreei ENSGT00740000115350.
    HOVERGENi HBG080658.
    InParanoidi Q6P5D3.
    KOi K13026.
    OMAi TQCFSET.
    OrthoDBi EOG7SV0TS.
    PhylomeDBi Q6P5D3.
    TreeFami TF324744.

    Miscellaneous databases

    NextBioi 358388.
    PROi Q6P5D3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P5D3.
    CleanExi MM_DHX57.
    Genevestigatori Q6P5D3.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00165. UBA. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50030. UBA. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
      Strain: C57BL/6J.
      Tissue: Eye and Urinary bladder.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiDHX57_MOUSE
    AccessioniPrimary (citable) accession number: Q6P5D3
    Secondary accession number(s): Q3TS93
    , Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3