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Q6P5D3

- DHX57_MOUSE

UniProt

Q6P5D3 - DHX57_MOUSE

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Protein

Putative ATP-dependent RNA helicase DHX57

Gene
Dhx57
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32628C3H1-typeAdd
BLAST
Nucleotide bindingi568 – 5758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 57
Gene namesi
Name:Dhx57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2147067. Dhx57.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Putative ATP-dependent RNA helicase DHX57PRO_0000233152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine By similarity
Modified residuei475 – 4751Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P5D3.
PRIDEiQ6P5D3.

PTM databases

PhosphoSiteiQ6P5D3.

Expressioni

Gene expression databases

BgeeiQ6P5D3.
CleanExiMM_DHX57.
GenevestigatoriQ6P5D3.

Structurei

3D structure databases

ProteinModelPortaliQ6P5D3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 22046UBAAdd
BLAST
Domaini555 – 722168Helicase ATP-bindingAdd
BLAST
Domaini832 – 1012181Helicase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724DEVH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 5042Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 UBA domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32628C3H1-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00740000115350.
HOVERGENiHBG080658.
InParanoidiQ6P5D3.
KOiK13026.
OMAiTQCFSET.
OrthoDBiEOG7SV0TS.
PhylomeDBiQ6P5D3.
TreeFamiTF324744.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00165. UBA. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P5D3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSSVRRKGK PGKGDGKGSS RGGRGGKGHM NKSHGGGGGG GGSCGGGGGG     50
SRKASNRIWD DGDDFCVFTE PKRPSRPCDS NKSKGETRPK WKPKAKVPLQ 100
TLHMTSENQE KVKALLRDLQ EQGADAGSER GTSGEEEDSE PQCGEEQGWP 150
AGQEPIFLPD CSPWEYIGPE EVEPPVPECA VSPLAVQKLS RYGFHTEHCQ 200
LALRICDGDL GAALEHLLRQ CFSETFGERM ALSEAAVYVS LNECVEQRQE 250
ETLALKSICG EKFIERIQNR VWTIGLELDY LTNKFCKSKQ KESSKNVRDT 300
SPETCKFYLK GNCKFGSKCK FKHEVPPHQM IGRAERNVND PHLDADDDTT 350
FMYELQIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYGKALEF 400
AKTSEPVVYS LITLLEEESE IVKLLTHTQH KYSVPPVNVP PVPSETRISK 450
PAYRKPVVPS NTFLSNQMLE GERLSELEED ADEDEGPASI IVENESYVNL 500
KKRSYKRYDR PAKSLFAENS KICRQFQMKQ ASRQFHAILQ ERQLLPAWEE 550
RETILKLLSK HQVVVISGMT GCGKTTQIPQ FILDNSLNGP PERVANIICT 600
QPRRISAISV AERVAKERAE RVGLTVGYQI RLESVKSSAT RLLYCTTGVL 650
LRRLEGDATL QGVTHIIVDE VHERTEESDF LLLVLKDIVM QRATLQVILM 700
SATLDAGLFS KYFSYCPVIT IPGRAFPVDQ FFLEDALAVT RYVLQDGSPY 750
MRSMKQIAKE KLKARHNRTA QEEVEEDLRL SLHLQDEEES VKDTIPDQQL 800
DFKQLLIRYK GVSKSVIKTM SVMDFEKVNL ELIEALLEWI VDGKHAYPPG 850
AVLVFLPGLA EIKMLYEQLQ SNSLFNNRRS HRCVIHPLHS SLSSEEQQAV 900
FVKPPMGVTK IIISTNIAET SITIDDVVYV IDSGKMKEKR YDAGKGMESL 950
EDTFVSQANA LQRKGRAGRV ASGVCFHLFT SHHYNHQLLK QQLPEIQRVP 1000
LEQLCLRIKI LEMFSTHNLQ SVFSRLIEPP HIDSLRASKV RLRDLGALTP 1050
DEKLTPLGYH LASLPVDVRI GKLMLLGSIF RCLDPALTIA ASLAFKSPFV 1100
SPWDKKEEAN QKKLEFAFAN SDYLALLCAY KGWQLSTKES ARASYNYCRQ 1150
NFLSGRTLQE MASLKRQFTE LLSDIGFVKE GLRAKEIEKR AQGGDGVLDA 1200
TGEEANTNAE NPKLISAVLC AALYPNVVQV KTPEGKFQKT SSGVVRLQPK 1250
SAELKFVTKN DGYVHIHPSS VNYQVRHFDS PYLLYHEKIK TSRVFIRDCS 1300
MVSVYPLVLF GGGQVNVQLQ RGAFVVSLDD GWIRFVAASH QVAELVKELR 1350
CELDQLLQDK IKNPSMDLCS CPRGSRIISM IVKLITTQ 1388
Length:1,388
Mass (Da):155,762
Last modified:May 2, 2006 - v2
Checksum:iD3E57C648E53A805
GO
Isoform 2 (identifier: Q6P5D3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-129: Missing.

Note: No experimental confirmation available.

Show »
Length:1,335
Mass (Da):149,876
Checksum:iF8A8ADE8A236D3DC
GO
Isoform 3 (identifier: Q6P5D3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1008-1025: IKILEMFSTHNLQSVFSR → LCPSGPPSACLGPAPPPI
     1026-1388: Missing.

Note: No experimental confirmation available.

Show »
Length:1,025
Mass (Da):114,839
Checksum:i958E2BC419635835
GO
Isoform 4 (identifier: Q6P5D3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1000: Missing.
     1001-1006: LEQLCL → MILFFF

Note: No experimental confirmation available.

Show »
Length:388
Mass (Da):43,553
Checksum:i913BF94B09941970
GO
Isoform 5 (identifier: Q6P5D3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1160: Missing.

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):25,352
Checksum:iB55D98A26BF57252
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11601160Missing in isoform 5. VSP_018061Add
BLAST
Alternative sequencei1 – 10001000Missing in isoform 4. VSP_018062Add
BLAST
Alternative sequencei77 – 12953Missing in isoform 2. VSP_018063Add
BLAST
Alternative sequencei1001 – 10066LEQLCL → MILFFF in isoform 4. VSP_018064
Alternative sequencei1008 – 102518IKILE…SVFSR → LCPSGPPSACLGPAPPPI in isoform 3. VSP_018065Add
BLAST
Alternative sequencei1026 – 1388363Missing in isoform 3. VSP_018066Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti488 – 4881A → T in AAH66091. 1 Publication
Sequence conflicti514 – 5141S → P in AAH62952. 1 Publication
Sequence conflicti725 – 7251A → T in AAH66091. 1 Publication
Sequence conflicti1137 – 11371T → A in BAC29042. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035344 mRNA. Translation: BAC29042.1.
AK053628 mRNA. Translation: BAC35451.1.
AK162192 mRNA. Translation: BAE36782.1.
BC026474 mRNA. Translation: AAH26474.1.
BC062952 mRNA. Translation: AAH62952.1.
BC065169 mRNA. Translation: AAH65169.1.
BC066091 mRNA. Translation: AAH66091.1.
CCDSiCCDS28990.1. [Q6P5D3-2]
CCDS50188.1. [Q6P5D3-1]
RefSeqiNP_001157231.1. NM_001163759.1. [Q6P5D3-1]
NP_945180.2. NM_198942.2. [Q6P5D3-2]
XP_006523510.1. XM_006523447.1. [Q6P5D3-1]
XP_006523511.1. XM_006523448.1. [Q6P5D3-2]
UniGeneiMm.12412.

Genome annotation databases

EnsembliENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051. [Q6P5D3-2]
ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051. [Q6P5D3-1]
GeneIDi106794.
KEGGimmu:106794.
UCSCiuc008dqx.2. mouse. [Q6P5D3-5]
uc008dqy.2. mouse. [Q6P5D3-4]
uc008dqz.2. mouse. [Q6P5D3-2]
uc008dra.2. mouse. [Q6P5D3-1]
uc008drb.1. mouse. [Q6P5D3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035344 mRNA. Translation: BAC29042.1 .
AK053628 mRNA. Translation: BAC35451.1 .
AK162192 mRNA. Translation: BAE36782.1 .
BC026474 mRNA. Translation: AAH26474.1 .
BC062952 mRNA. Translation: AAH62952.1 .
BC065169 mRNA. Translation: AAH65169.1 .
BC066091 mRNA. Translation: AAH66091.1 .
CCDSi CCDS28990.1. [Q6P5D3-2 ]
CCDS50188.1. [Q6P5D3-1 ]
RefSeqi NP_001157231.1. NM_001163759.1. [Q6P5D3-1 ]
NP_945180.2. NM_198942.2. [Q6P5D3-2 ]
XP_006523510.1. XM_006523447.1. [Q6P5D3-1 ]
XP_006523511.1. XM_006523448.1. [Q6P5D3-2 ]
UniGenei Mm.12412.

3D structure databases

ProteinModelPortali Q6P5D3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P5D3.

Proteomic databases

PaxDbi Q6P5D3.
PRIDEi Q6P5D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038166 ; ENSMUSP00000041069 ; ENSMUSG00000035051 . [Q6P5D3-2 ]
ENSMUST00000086555 ; ENSMUSP00000083742 ; ENSMUSG00000035051 . [Q6P5D3-1 ]
GeneIDi 106794.
KEGGi mmu:106794.
UCSCi uc008dqx.2. mouse. [Q6P5D3-5 ]
uc008dqy.2. mouse. [Q6P5D3-4 ]
uc008dqz.2. mouse. [Q6P5D3-2 ]
uc008dra.2. mouse. [Q6P5D3-1 ]
uc008drb.1. mouse. [Q6P5D3-3 ]

Organism-specific databases

CTDi 90957.
MGIi MGI:2147067. Dhx57.

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00740000115350.
HOVERGENi HBG080658.
InParanoidi Q6P5D3.
KOi K13026.
OMAi TQCFSET.
OrthoDBi EOG7SV0TS.
PhylomeDBi Q6P5D3.
TreeFami TF324744.

Miscellaneous databases

NextBioi 358388.
PROi Q6P5D3.
SOURCEi Search...

Gene expression databases

Bgeei Q6P5D3.
CleanExi MM_DHX57.
Genevestigatori Q6P5D3.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00165. UBA. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Eye and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiDHX57_MOUSE
AccessioniPrimary (citable) accession number: Q6P5D3
Secondary accession number(s): Q3TS93
, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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