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Protein

Putative ATP-dependent RNA helicase DHX57

Gene

Dhx57

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri299 – 326C3H1-typePROSITE-ProRule annotationAdd BLAST28
Nucleotide bindingi568 – 575ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 57
Gene namesi
Name:Dhx57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147067 Dhx57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331521 – 1388Putative ATP-dependent RNA helicase DHX57Add BLAST1388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P5D3
PaxDbiQ6P5D3
PeptideAtlasiQ6P5D3
PRIDEiQ6P5D3

PTM databases

iPTMnetiQ6P5D3
PhosphoSitePlusiQ6P5D3

Expressioni

Gene expression databases

BgeeiENSMUSG00000035051
CleanExiMM_DHX57
GenevisibleiQ6P5D3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083742

Structurei

3D structure databases

ProteinModelPortaliQ6P5D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 220UBAPROSITE-ProRule annotationAdd BLAST46
Domaini555 – 722Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini832 – 1012Helicase C-terminalPROSITE-ProRule annotationAdd BLAST181

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi669 – 672DEVH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 50Gly-richAdd BLAST42

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri299 – 326C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
HOVERGENiHBG080658
InParanoidiQ6P5D3
KOiK13026
OMAiVEIICTQ
OrthoDBiEOG091G01I0
PhylomeDBiQ6P5D3
TreeFamiTF324744

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR006575 RWD-domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF05773 RWD, 1 hit
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00165 UBA, 1 hit
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52540 SSF52540, 2 hits
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50030 UBA, 1 hit
PS50103 ZF_C3H1, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P5D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSVRRKGK PGKGDGKGSS RGGRGGKGHM NKSHGGGGGG GGSCGGGGGG
60 70 80 90 100
SRKASNRIWD DGDDFCVFTE PKRPSRPCDS NKSKGETRPK WKPKAKVPLQ
110 120 130 140 150
TLHMTSENQE KVKALLRDLQ EQGADAGSER GTSGEEEDSE PQCGEEQGWP
160 170 180 190 200
AGQEPIFLPD CSPWEYIGPE EVEPPVPECA VSPLAVQKLS RYGFHTEHCQ
210 220 230 240 250
LALRICDGDL GAALEHLLRQ CFSETFGERM ALSEAAVYVS LNECVEQRQE
260 270 280 290 300
ETLALKSICG EKFIERIQNR VWTIGLELDY LTNKFCKSKQ KESSKNVRDT
310 320 330 340 350
SPETCKFYLK GNCKFGSKCK FKHEVPPHQM IGRAERNVND PHLDADDDTT
360 370 380 390 400
FMYELQIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYGKALEF
410 420 430 440 450
AKTSEPVVYS LITLLEEESE IVKLLTHTQH KYSVPPVNVP PVPSETRISK
460 470 480 490 500
PAYRKPVVPS NTFLSNQMLE GERLSELEED ADEDEGPASI IVENESYVNL
510 520 530 540 550
KKRSYKRYDR PAKSLFAENS KICRQFQMKQ ASRQFHAILQ ERQLLPAWEE
560 570 580 590 600
RETILKLLSK HQVVVISGMT GCGKTTQIPQ FILDNSLNGP PERVANIICT
610 620 630 640 650
QPRRISAISV AERVAKERAE RVGLTVGYQI RLESVKSSAT RLLYCTTGVL
660 670 680 690 700
LRRLEGDATL QGVTHIIVDE VHERTEESDF LLLVLKDIVM QRATLQVILM
710 720 730 740 750
SATLDAGLFS KYFSYCPVIT IPGRAFPVDQ FFLEDALAVT RYVLQDGSPY
760 770 780 790 800
MRSMKQIAKE KLKARHNRTA QEEVEEDLRL SLHLQDEEES VKDTIPDQQL
810 820 830 840 850
DFKQLLIRYK GVSKSVIKTM SVMDFEKVNL ELIEALLEWI VDGKHAYPPG
860 870 880 890 900
AVLVFLPGLA EIKMLYEQLQ SNSLFNNRRS HRCVIHPLHS SLSSEEQQAV
910 920 930 940 950
FVKPPMGVTK IIISTNIAET SITIDDVVYV IDSGKMKEKR YDAGKGMESL
960 970 980 990 1000
EDTFVSQANA LQRKGRAGRV ASGVCFHLFT SHHYNHQLLK QQLPEIQRVP
1010 1020 1030 1040 1050
LEQLCLRIKI LEMFSTHNLQ SVFSRLIEPP HIDSLRASKV RLRDLGALTP
1060 1070 1080 1090 1100
DEKLTPLGYH LASLPVDVRI GKLMLLGSIF RCLDPALTIA ASLAFKSPFV
1110 1120 1130 1140 1150
SPWDKKEEAN QKKLEFAFAN SDYLALLCAY KGWQLSTKES ARASYNYCRQ
1160 1170 1180 1190 1200
NFLSGRTLQE MASLKRQFTE LLSDIGFVKE GLRAKEIEKR AQGGDGVLDA
1210 1220 1230 1240 1250
TGEEANTNAE NPKLISAVLC AALYPNVVQV KTPEGKFQKT SSGVVRLQPK
1260 1270 1280 1290 1300
SAELKFVTKN DGYVHIHPSS VNYQVRHFDS PYLLYHEKIK TSRVFIRDCS
1310 1320 1330 1340 1350
MVSVYPLVLF GGGQVNVQLQ RGAFVVSLDD GWIRFVAASH QVAELVKELR
1360 1370 1380
CELDQLLQDK IKNPSMDLCS CPRGSRIISM IVKLITTQ
Length:1,388
Mass (Da):155,762
Last modified:May 2, 2006 - v2
Checksum:iD3E57C648E53A805
GO
Isoform 2 (identifier: Q6P5D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-129: Missing.

Note: No experimental confirmation available.
Show »
Length:1,335
Mass (Da):149,876
Checksum:iF8A8ADE8A236D3DC
GO
Isoform 3 (identifier: Q6P5D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1008-1025: IKILEMFSTHNLQSVFSR → LCPSGPPSACLGPAPPPI
     1026-1388: Missing.

Note: No experimental confirmation available.
Show »
Length:1,025
Mass (Da):114,839
Checksum:i958E2BC419635835
GO
Isoform 4 (identifier: Q6P5D3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1000: Missing.
     1001-1006: LEQLCL → MILFFF

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):43,553
Checksum:i913BF94B09941970
GO
Isoform 5 (identifier: Q6P5D3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1160: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,352
Checksum:iB55D98A26BF57252
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti488A → T in AAH66091 (PubMed:15489334).Curated1
Sequence conflicti514S → P in AAH62952 (PubMed:15489334).Curated1
Sequence conflicti725A → T in AAH66091 (PubMed:15489334).Curated1
Sequence conflicti1137T → A in BAC29042 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0180611 – 1160Missing in isoform 5. 1 PublicationAdd BLAST1160
Alternative sequenceiVSP_0180621 – 1000Missing in isoform 4. 1 PublicationAdd BLAST1000
Alternative sequenceiVSP_01806377 – 129Missing in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0180641001 – 1006LEQLCL → MILFFF in isoform 4. 1 Publication6
Alternative sequenceiVSP_0180651008 – 1025IKILE…SVFSR → LCPSGPPSACLGPAPPPI in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0180661026 – 1388Missing in isoform 3. 1 PublicationAdd BLAST363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035344 mRNA Translation: BAC29042.1
AK053628 mRNA Translation: BAC35451.1
AK162192 mRNA Translation: BAE36782.1
BC026474 mRNA Translation: AAH26474.1
BC062952 mRNA Translation: AAH62952.1
BC065169 mRNA Translation: AAH65169.1
BC066091 mRNA Translation: AAH66091.1
CCDSiCCDS28990.1 [Q6P5D3-2]
CCDS50188.1 [Q6P5D3-1]
RefSeqiNP_001157231.1, NM_001163759.1 [Q6P5D3-1]
NP_945180.2, NM_198942.2 [Q6P5D3-2]
XP_006523510.1, XM_006523447.1 [Q6P5D3-1]
XP_006523511.1, XM_006523448.1 [Q6P5D3-2]
XP_017172691.1, XM_017317202.1 [Q6P5D3-3]
UniGeneiMm.12412

Genome annotation databases

EnsembliENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051 [Q6P5D3-2]
ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051 [Q6P5D3-1]
GeneIDi106794
KEGGimmu:106794
UCSCiuc008dqx.2 mouse [Q6P5D3-5]
uc008dqy.2 mouse [Q6P5D3-4]
uc008dqz.2 mouse [Q6P5D3-2]
uc008dra.2 mouse [Q6P5D3-1]
uc008drb.1 mouse [Q6P5D3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHX57_MOUSE
AccessioniPrimary (citable) accession number: Q6P5D3
Secondary accession number(s): Q3TS93
, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health