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Protein

Putative ATP-dependent RNA helicase DHX57

Gene

Dhx57

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi568 – 5758ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent RNA helicase activity Source: GO_Central
  3. metal ion binding Source: UniProtKB-KW
  4. poly(A) RNA binding Source: MGI

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. RNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 57
Gene namesi
Name:Dhx57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2147067. Dhx57.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Putative ATP-dependent RNA helicase DHX57PRO_0000233152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281PhosphoserineBy similarity
Modified residuei475 – 4751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P5D3.
PaxDbiQ6P5D3.
PRIDEiQ6P5D3.

PTM databases

PhosphoSiteiQ6P5D3.

Expressioni

Gene expression databases

BgeeiQ6P5D3.
CleanExiMM_DHX57.
GenevestigatoriQ6P5D3.

Structurei

3D structure databases

ProteinModelPortaliQ6P5D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 22046UBAPROSITE-ProRule annotationAdd
BLAST
Domaini555 – 722168Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini832 – 1012181Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724DEVH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 5042Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00760000119189.
HOVERGENiHBG080658.
InParanoidiQ6P5D3.
KOiK13026.
OMAiTQCFSET.
OrthoDBiEOG7SV0TS.
PhylomeDBiQ6P5D3.
TreeFamiTF324744.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00165. UBA. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P5D3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSVRRKGK PGKGDGKGSS RGGRGGKGHM NKSHGGGGGG GGSCGGGGGG
60 70 80 90 100
SRKASNRIWD DGDDFCVFTE PKRPSRPCDS NKSKGETRPK WKPKAKVPLQ
110 120 130 140 150
TLHMTSENQE KVKALLRDLQ EQGADAGSER GTSGEEEDSE PQCGEEQGWP
160 170 180 190 200
AGQEPIFLPD CSPWEYIGPE EVEPPVPECA VSPLAVQKLS RYGFHTEHCQ
210 220 230 240 250
LALRICDGDL GAALEHLLRQ CFSETFGERM ALSEAAVYVS LNECVEQRQE
260 270 280 290 300
ETLALKSICG EKFIERIQNR VWTIGLELDY LTNKFCKSKQ KESSKNVRDT
310 320 330 340 350
SPETCKFYLK GNCKFGSKCK FKHEVPPHQM IGRAERNVND PHLDADDDTT
360 370 380 390 400
FMYELQIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYGKALEF
410 420 430 440 450
AKTSEPVVYS LITLLEEESE IVKLLTHTQH KYSVPPVNVP PVPSETRISK
460 470 480 490 500
PAYRKPVVPS NTFLSNQMLE GERLSELEED ADEDEGPASI IVENESYVNL
510 520 530 540 550
KKRSYKRYDR PAKSLFAENS KICRQFQMKQ ASRQFHAILQ ERQLLPAWEE
560 570 580 590 600
RETILKLLSK HQVVVISGMT GCGKTTQIPQ FILDNSLNGP PERVANIICT
610 620 630 640 650
QPRRISAISV AERVAKERAE RVGLTVGYQI RLESVKSSAT RLLYCTTGVL
660 670 680 690 700
LRRLEGDATL QGVTHIIVDE VHERTEESDF LLLVLKDIVM QRATLQVILM
710 720 730 740 750
SATLDAGLFS KYFSYCPVIT IPGRAFPVDQ FFLEDALAVT RYVLQDGSPY
760 770 780 790 800
MRSMKQIAKE KLKARHNRTA QEEVEEDLRL SLHLQDEEES VKDTIPDQQL
810 820 830 840 850
DFKQLLIRYK GVSKSVIKTM SVMDFEKVNL ELIEALLEWI VDGKHAYPPG
860 870 880 890 900
AVLVFLPGLA EIKMLYEQLQ SNSLFNNRRS HRCVIHPLHS SLSSEEQQAV
910 920 930 940 950
FVKPPMGVTK IIISTNIAET SITIDDVVYV IDSGKMKEKR YDAGKGMESL
960 970 980 990 1000
EDTFVSQANA LQRKGRAGRV ASGVCFHLFT SHHYNHQLLK QQLPEIQRVP
1010 1020 1030 1040 1050
LEQLCLRIKI LEMFSTHNLQ SVFSRLIEPP HIDSLRASKV RLRDLGALTP
1060 1070 1080 1090 1100
DEKLTPLGYH LASLPVDVRI GKLMLLGSIF RCLDPALTIA ASLAFKSPFV
1110 1120 1130 1140 1150
SPWDKKEEAN QKKLEFAFAN SDYLALLCAY KGWQLSTKES ARASYNYCRQ
1160 1170 1180 1190 1200
NFLSGRTLQE MASLKRQFTE LLSDIGFVKE GLRAKEIEKR AQGGDGVLDA
1210 1220 1230 1240 1250
TGEEANTNAE NPKLISAVLC AALYPNVVQV KTPEGKFQKT SSGVVRLQPK
1260 1270 1280 1290 1300
SAELKFVTKN DGYVHIHPSS VNYQVRHFDS PYLLYHEKIK TSRVFIRDCS
1310 1320 1330 1340 1350
MVSVYPLVLF GGGQVNVQLQ RGAFVVSLDD GWIRFVAASH QVAELVKELR
1360 1370 1380
CELDQLLQDK IKNPSMDLCS CPRGSRIISM IVKLITTQ
Length:1,388
Mass (Da):155,762
Last modified:May 2, 2006 - v2
Checksum:iD3E57C648E53A805
GO
Isoform 2 (identifier: Q6P5D3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-129: Missing.

Note: No experimental confirmation available.

Show »
Length:1,335
Mass (Da):149,876
Checksum:iF8A8ADE8A236D3DC
GO
Isoform 3 (identifier: Q6P5D3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1008-1025: IKILEMFSTHNLQSVFSR → LCPSGPPSACLGPAPPPI
     1026-1388: Missing.

Note: No experimental confirmation available.

Show »
Length:1,025
Mass (Da):114,839
Checksum:i958E2BC419635835
GO
Isoform 4 (identifier: Q6P5D3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1000: Missing.
     1001-1006: LEQLCL → MILFFF

Note: No experimental confirmation available.

Show »
Length:388
Mass (Da):43,553
Checksum:i913BF94B09941970
GO
Isoform 5 (identifier: Q6P5D3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1160: Missing.

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):25,352
Checksum:iB55D98A26BF57252
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti488 – 4881A → T in AAH66091. (PubMed:15489334)Curated
Sequence conflicti514 – 5141S → P in AAH62952. (PubMed:15489334)Curated
Sequence conflicti725 – 7251A → T in AAH66091. (PubMed:15489334)Curated
Sequence conflicti1137 – 11371T → A in BAC29042. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11601160Missing in isoform 5. 1 PublicationVSP_018061Add
BLAST
Alternative sequencei1 – 10001000Missing in isoform 4. 1 PublicationVSP_018062Add
BLAST
Alternative sequencei77 – 12953Missing in isoform 2. 1 PublicationVSP_018063Add
BLAST
Alternative sequencei1001 – 10066LEQLCL → MILFFF in isoform 4. 1 PublicationVSP_018064
Alternative sequencei1008 – 102518IKILE…SVFSR → LCPSGPPSACLGPAPPPI in isoform 3. 1 PublicationVSP_018065Add
BLAST
Alternative sequencei1026 – 1388363Missing in isoform 3. 1 PublicationVSP_018066Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035344 mRNA. Translation: BAC29042.1.
AK053628 mRNA. Translation: BAC35451.1.
AK162192 mRNA. Translation: BAE36782.1.
BC026474 mRNA. Translation: AAH26474.1.
BC062952 mRNA. Translation: AAH62952.1.
BC065169 mRNA. Translation: AAH65169.1.
BC066091 mRNA. Translation: AAH66091.1.
CCDSiCCDS28990.1. [Q6P5D3-2]
CCDS50188.1. [Q6P5D3-1]
RefSeqiNP_001157231.1. NM_001163759.1. [Q6P5D3-1]
NP_945180.2. NM_198942.2. [Q6P5D3-2]
XP_006523510.1. XM_006523447.1. [Q6P5D3-1]
XP_006523511.1. XM_006523448.1. [Q6P5D3-2]
UniGeneiMm.12412.

Genome annotation databases

EnsembliENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051. [Q6P5D3-2]
ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051. [Q6P5D3-1]
GeneIDi106794.
KEGGimmu:106794.
UCSCiuc008dqx.2. mouse. [Q6P5D3-5]
uc008dqy.2. mouse. [Q6P5D3-4]
uc008dqz.2. mouse. [Q6P5D3-2]
uc008dra.2. mouse. [Q6P5D3-1]
uc008drb.1. mouse. [Q6P5D3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035344 mRNA. Translation: BAC29042.1.
AK053628 mRNA. Translation: BAC35451.1.
AK162192 mRNA. Translation: BAE36782.1.
BC026474 mRNA. Translation: AAH26474.1.
BC062952 mRNA. Translation: AAH62952.1.
BC065169 mRNA. Translation: AAH65169.1.
BC066091 mRNA. Translation: AAH66091.1.
CCDSiCCDS28990.1. [Q6P5D3-2]
CCDS50188.1. [Q6P5D3-1]
RefSeqiNP_001157231.1. NM_001163759.1. [Q6P5D3-1]
NP_945180.2. NM_198942.2. [Q6P5D3-2]
XP_006523510.1. XM_006523447.1. [Q6P5D3-1]
XP_006523511.1. XM_006523448.1. [Q6P5D3-2]
UniGeneiMm.12412.

3D structure databases

ProteinModelPortaliQ6P5D3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6P5D3.

Proteomic databases

MaxQBiQ6P5D3.
PaxDbiQ6P5D3.
PRIDEiQ6P5D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038166; ENSMUSP00000041069; ENSMUSG00000035051. [Q6P5D3-2]
ENSMUST00000086555; ENSMUSP00000083742; ENSMUSG00000035051. [Q6P5D3-1]
GeneIDi106794.
KEGGimmu:106794.
UCSCiuc008dqx.2. mouse. [Q6P5D3-5]
uc008dqy.2. mouse. [Q6P5D3-4]
uc008dqz.2. mouse. [Q6P5D3-2]
uc008dra.2. mouse. [Q6P5D3-1]
uc008drb.1. mouse. [Q6P5D3-3]

Organism-specific databases

CTDi90957.
MGIiMGI:2147067. Dhx57.

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00760000119189.
HOVERGENiHBG080658.
InParanoidiQ6P5D3.
KOiK13026.
OMAiTQCFSET.
OrthoDBiEOG7SV0TS.
PhylomeDBiQ6P5D3.
TreeFamiTF324744.

Miscellaneous databases

NextBioi358388.
PROiQ6P5D3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P5D3.
CleanExiMM_DHX57.
GenevestigatoriQ6P5D3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00165. UBA. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Eye and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiDHX57_MOUSE
AccessioniPrimary (citable) accession number: Q6P5D3
Secondary accession number(s): Q3TS93
, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: February 4, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.