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Q6P597 (KLC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin light chain 3
Alternative name(s):
KLC2-like
kinesin light chain 2
Gene names
Name:KLC3
Synonyms:KLC2, KLC2L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Subunit structure

Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 By similarity.

Subcellular location

Cytoplasmcytoskeleton Probable. Note: Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria By similarity.

Domain

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding By similarity.

Sequence similarities

Belongs to the kinesin light chain family.

Contains 5 TPR repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6P597-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPQTPHHCSPGAAM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Kinesin light chain 3
PRO_0000230785

Regions

Repeat207 – 24034TPR 1
Repeat249 – 28234TPR 2
Repeat291 – 32434TPR 3
Repeat333 – 36634TPR 4
Repeat375 – 40834TPR 5
Coiled coil90 – 15061 Potential
Compositional bias181 – 1844Poly-Glu
Compositional bias190 – 1967Poly-Ala

Amino acid modifications

Modified residue4661Phosphoserine Ref.4 Ref.6 Ref.7
Modified residue4981Phosphothreonine Ref.7
Modified residue5021Phosphoserine Ref.4 Ref.7

Natural variations

Alternative sequence11M → MIPQTPHHCSPGAAM in isoform 3.
VSP_017831
Alternative sequence1631Missing in isoform 2.
VSP_017832

Experimental info

Sequence conflict3521V → A in BAC03901. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 3767D66C79EA3D49

FASTA50455,364
        10         20         30         40         50         60 
MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE ALAGQGPAAG 

        70         80         90        100        110        120 
LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA EKQRLRSQAR RLAQENVWLR 

       130        140        150        160        170        180 
EELEETQRRL RASEESVAQL EEEKRHLEFL GQLRQYDPPA ESQQSESPPR RDSLASLFPS 

       190        200        210        220        230        240 
EEEERKGPEA AGAAAAQQGG YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS 

       250        260        270        280        290        300 
SGHCHPDVAT MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL 

       310        320        330        340        350        360 
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE DVERHYARAL 

       370        380        390        400        410        420 
SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE ILHKEDLPAP LGAPNTGTAG 

       430        440        450        460        470        480 
DAEQALRRSS SLSKIRESIR RGSEKLVSRL RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT 

       490        500 
QFPSWHLDKA PRTLSASTQD LSPH 

« Hide

Isoform 2 [UniParc].

Checksum: D8F19BD4CAE6E3AB
Show »

FASTA50355,236
Isoform 3 [UniParc].

Checksum: C49FD1AE860CB810
Show »

FASTA51856,793

References

« Hide 'large scale' references
[1]"Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes."
Lamerdin J.E., Stilwagen S.A., Ramirez M.H., Stubbs L., Carrano A.V.
Genomics 34:399-409(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Fibroblast.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Colon.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; THR-498 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47234 Genomic DNA. Translation: AAL48324.1.
AK092481 mRNA. Translation: BAC03901.1.
BC062998 mRNA. Translation: AAH62998.2.
BC073841 mRNA. Translation: AAH73841.1.
BC126418 mRNA. Translation: AAI26419.1.
BC133037 mRNA. Translation: AAI33038.1.
CCDSCCDS12660.2. [Q6P597-1]
RefSeqNP_803136.2. NM_177417.2. [Q6P597-1]
UniGeneHs.298079.

3D structure databases

ProteinModelPortalQ6P597.
SMRQ6P597. Positions 197-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127078. 5 interactions.
IntActQ6P597. 2 interactions.
MINTMINT-3318740.
STRING9606.ENSP00000375810.

PTM databases

PhosphoSiteQ6P597.

Polymorphism databases

DMDM91207086.

Proteomic databases

MaxQBQ6P597.
PaxDbQ6P597.
PRIDEQ6P597.

Protocols and materials databases

DNASU147700.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391946; ENSP00000375810; ENSG00000104892. [Q6P597-1]
ENST00000470402; ENSP00000436019; ENSG00000104892. [Q6P597-3]
ENST00000585434; ENSP00000466067; ENSG00000104892. [Q6P597-2]
GeneID147700.
KEGGhsa:147700.
UCSCuc002pbf.1. human. [Q6P597-1]
uc002pbg.1. human. [Q6P597-3]
uc010ejy.1. human. [Q6P597-2]

Organism-specific databases

CTD147700.
GeneCardsGC19P045851.
HGNCHGNC:20717. KLC3.
HPAHPA052797.
MIM601334. gene.
neXtProtNX_Q6P597.
PharmGKBPA142671588.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0457.
HOGENOMHOG000261663.
HOVERGENHBG006217.
InParanoidQ6P597.
KOK10407.
OMAYGKRGRY.
PhylomeDBQ6P597.
TreeFamTF314010.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressQ6P597.
BgeeQ6P597.
CleanExHS_KLC2.
HS_KLC3.
GenevestigatorQ6P597.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR002151. Kinesin_light.
IPR015390. Rabaptin_Rab5-bd_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF09311. Rab5-bind. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
PRINTSPR00381. KINESINLIGHT.
SMARTSM00028. TPR. 4 hits.
[Graphical view]
PROSITEPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKLC3.
GenomeRNAi147700.
NextBio85698.
PROQ6P597.
SOURCESearch...

Entry information

Entry nameKLC3_HUMAN
AccessionPrimary (citable) accession number: Q6P597
Secondary accession number(s): A0AVM3 expand/collapse secondary AC list , A2RUT6, Q6GMU2, Q8NAL1, Q8WWJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM