Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P597

- KLC3_HUMAN

UniProt

Q6P597 - KLC3_HUMAN

Protein

Kinesin light chain 3

Gene

KLC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

    GO - Molecular functioni

    1. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. axon cargo transport Source: Ensembl

    Keywords - Molecular functioni

    Motor protein

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin light chain 3
    Alternative name(s):
    KLC2-like
    kinesin light chain 2
    Gene namesi
    Name:KLC3
    Synonyms:KLC2, KLC2L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20717. KLC3.

    Subcellular locationi

    Cytoplasmcytoskeleton Curated
    Note: Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria.By similarity

    GO - Cellular componenti

    1. ciliary rootlet Source: Ensembl
    2. cytoplasm Source: UniProtKB-KW
    3. kinesin complex Source: InterPro
    4. microtubule Source: UniProtKB-KW
    5. motile cilium Source: Ensembl
    6. neuron projection Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Kinesin light chain 3PRO_0000230785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei466 – 4661Phosphoserine3 Publications
    Modified residuei498 – 4981Phosphothreonine1 Publication
    Modified residuei502 – 5021Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6P597.
    PaxDbiQ6P597.
    PRIDEiQ6P597.

    PTM databases

    PhosphoSiteiQ6P597.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P597.
    BgeeiQ6P597.
    CleanExiHS_KLC2.
    HS_KLC3.
    GenevestigatoriQ6P597.

    Organism-specific databases

    HPAiHPA052797.

    Interactioni

    Subunit structurei

    Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi127078. 5 interactions.
    IntActiQ6P597. 2 interactions.
    MINTiMINT-3318740.
    STRINGi9606.ENSP00000375810.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P597.
    SMRiQ6P597. Positions 197-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati207 – 24034TPR 1Add
    BLAST
    Repeati249 – 28234TPR 2Add
    BLAST
    Repeati291 – 32434TPR 3Add
    BLAST
    Repeati333 – 36634TPR 4Add
    BLAST
    Repeati375 – 40834TPR 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili90 – 15061Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 1844Poly-Glu
    Compositional biasi190 – 1967Poly-Ala

    Domaini

    The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding By similarity.By similarity

    Sequence similaritiesi

    Belongs to the kinesin light chain family.Curated
    Contains 5 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000261663.
    HOVERGENiHBG006217.
    InParanoidiQ6P597.
    KOiK10407.
    OMAiYGKRGRY.
    PhylomeDBiQ6P597.
    TreeFamiTF314010.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR002151. Kinesin_light.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view]
    PRINTSiPR00381. KINESINLIGHT.
    SMARTiSM00028. TPR. 4 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P597-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE    50
    ALAGQGPAAG LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA 100
    EKQRLRSQAR RLAQENVWLR EELEETQRRL RASEESVAQL EEEKRHLEFL 150
    GQLRQYDPPA ESQQSESPPR RDSLASLFPS EEEERKGPEA AGAAAAQQGG 200
    YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT 250
    MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL 300
    YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE 350
    DVERHYARAL SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE 400
    ILHKEDLPAP LGAPNTGTAG DAEQALRRSS SLSKIRESIR RGSEKLVSRL 450
    RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT QFPSWHLDKA PRTLSASTQD 500
    LSPH 504
    Length:504
    Mass (Da):55,364
    Last modified:April 4, 2006 - v2
    Checksum:i3767D66C79EA3D49
    GO
    Isoform 2 (identifier: Q6P597-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         163-163: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:503
    Mass (Da):55,236
    Checksum:iD8F19BD4CAE6E3AB
    GO
    Isoform 3 (identifier: Q6P597-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MIPQTPHHCSPGAAM

    Show »
    Length:518
    Mass (Da):56,793
    Checksum:iC49FD1AE860CB810
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti352 – 3521V → A in BAC03901. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MIPQTPHHCSPGAAM in isoform 3. 1 PublicationVSP_017831
    Alternative sequencei163 – 1631Missing in isoform 2. 1 PublicationVSP_017832

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47234 Genomic DNA. Translation: AAL48324.1.
    AK092481 mRNA. Translation: BAC03901.1.
    BC062998 mRNA. Translation: AAH62998.2.
    BC073841 mRNA. Translation: AAH73841.1.
    BC126418 mRNA. Translation: AAI26419.1.
    BC133037 mRNA. Translation: AAI33038.1.
    CCDSiCCDS12660.2. [Q6P597-1]
    RefSeqiNP_803136.2. NM_177417.2. [Q6P597-1]
    UniGeneiHs.298079.

    Genome annotation databases

    EnsembliENST00000391946; ENSP00000375810; ENSG00000104892. [Q6P597-1]
    ENST00000470402; ENSP00000436019; ENSG00000104892. [Q6P597-3]
    ENST00000585434; ENSP00000466067; ENSG00000104892. [Q6P597-2]
    GeneIDi147700.
    KEGGihsa:147700.
    UCSCiuc002pbf.1. human. [Q6P597-1]
    uc002pbg.1. human. [Q6P597-3]
    uc010ejy.1. human. [Q6P597-2]

    Polymorphism databases

    DMDMi91207086.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47234 Genomic DNA. Translation: AAL48324.1 .
    AK092481 mRNA. Translation: BAC03901.1 .
    BC062998 mRNA. Translation: AAH62998.2 .
    BC073841 mRNA. Translation: AAH73841.1 .
    BC126418 mRNA. Translation: AAI26419.1 .
    BC133037 mRNA. Translation: AAI33038.1 .
    CCDSi CCDS12660.2. [Q6P597-1 ]
    RefSeqi NP_803136.2. NM_177417.2. [Q6P597-1 ]
    UniGenei Hs.298079.

    3D structure databases

    ProteinModelPortali Q6P597.
    SMRi Q6P597. Positions 197-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127078. 5 interactions.
    IntActi Q6P597. 2 interactions.
    MINTi MINT-3318740.
    STRINGi 9606.ENSP00000375810.

    PTM databases

    PhosphoSitei Q6P597.

    Polymorphism databases

    DMDMi 91207086.

    Proteomic databases

    MaxQBi Q6P597.
    PaxDbi Q6P597.
    PRIDEi Q6P597.

    Protocols and materials databases

    DNASUi 147700.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391946 ; ENSP00000375810 ; ENSG00000104892 . [Q6P597-1 ]
    ENST00000470402 ; ENSP00000436019 ; ENSG00000104892 . [Q6P597-3 ]
    ENST00000585434 ; ENSP00000466067 ; ENSG00000104892 . [Q6P597-2 ]
    GeneIDi 147700.
    KEGGi hsa:147700.
    UCSCi uc002pbf.1. human. [Q6P597-1 ]
    uc002pbg.1. human. [Q6P597-3 ]
    uc010ejy.1. human. [Q6P597-2 ]

    Organism-specific databases

    CTDi 147700.
    GeneCardsi GC19P045851.
    HGNCi HGNC:20717. KLC3.
    HPAi HPA052797.
    MIMi 601334. gene.
    neXtProti NX_Q6P597.
    PharmGKBi PA142671588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000261663.
    HOVERGENi HBG006217.
    InParanoidi Q6P597.
    KOi K10407.
    OMAi YGKRGRY.
    PhylomeDBi Q6P597.
    TreeFami TF314010.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Miscellaneous databases

    GeneWikii KLC3.
    GenomeRNAii 147700.
    NextBioi 85698.
    PROi Q6P597.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P597.
    Bgeei Q6P597.
    CleanExi HS_KLC2.
    HS_KLC3.
    Genevestigatori Q6P597.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR002151. Kinesin_light.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00381. KINESINLIGHT.
    SMARTi SM00028. TPR. 4 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes."
      Lamerdin J.E., Stilwagen S.A., Ramirez M.H., Stubbs L., Carrano A.V.
      Genomics 34:399-409(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fibroblast.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Colon.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; THR-498 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKLC3_HUMAN
    AccessioniPrimary (citable) accession number: Q6P597
    Secondary accession number(s): A0AVM3
    , A2RUT6, Q6GMU2, Q8NAL1, Q8WWJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3