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Protein

Kinesin light chain 3

Gene

KLC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-5625970. RHO GTPases activate KTN1.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 3
Alternative name(s):
KLC2-like
kinesin light chain 2
Gene namesi
Name:KLC3
Synonyms:KLC2, KLC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20717. KLC3.

Subcellular locationi

  • Cytoplasmcytoskeleton Curated

  • Note: Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi147700.
OpenTargetsiENSG00000104892.
PharmGKBiPA142671588.

Polymorphism and mutation databases

BioMutaiKLC3.
DMDMi91207086.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307851 – 504Kinesin light chain 3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei498PhosphothreonineCombined sources1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P597.
MaxQBiQ6P597.
PaxDbiQ6P597.
PeptideAtlasiQ6P597.
PRIDEiQ6P597.
TopDownProteomicsiQ6P597-1. [Q6P597-1]
Q6P597-2. [Q6P597-2]

PTM databases

iPTMnetiQ6P597.
PhosphoSitePlusiQ6P597.

Expressioni

Gene expression databases

BgeeiENSG00000104892.
CleanExiHS_KLC2.
HS_KLC3.
ExpressionAtlasiQ6P597. baseline and differential.
GenevisibleiQ6P597. HS.

Organism-specific databases

HPAiHPA052797.
HPA056508.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127078. 73 interactors.
IntActiQ6P597. 72 interactors.
MINTiMINT-3318740.
STRINGi9606.ENSP00000375810.

Structurei

3D structure databases

ProteinModelPortaliQ6P597.
SMRiQ6P597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 240TPR 1Add BLAST34
Repeati249 – 282TPR 2Add BLAST34
Repeati291 – 324TPR 3Add BLAST34
Repeati333 – 366TPR 4Add BLAST34
Repeati375 – 408TPR 5Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 150Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 184Poly-Glu4
Compositional biasi190 – 196Poly-Ala7

Domaini

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ6P597.
KOiK10407.
OMAiCHPDVAT.
OrthoDBiEOG091G05DM.
PhylomeDBiQ6P597.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.10.10.10. 3 hits.
InterProiView protein in InterPro
IPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
PRINTSiPR00381. KINESINLIGHT.
SMARTiView protein in SMART
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE
60 70 80 90 100
ALAGQGPAAG LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA
110 120 130 140 150
EKQRLRSQAR RLAQENVWLR EELEETQRRL RASEESVAQL EEEKRHLEFL
160 170 180 190 200
GQLRQYDPPA ESQQSESPPR RDSLASLFPS EEEERKGPEA AGAAAAQQGG
210 220 230 240 250
YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT
260 270 280 290 300
MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL
310 320 330 340 350
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE
360 370 380 390 400
DVERHYARAL SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE
410 420 430 440 450
ILHKEDLPAP LGAPNTGTAG DAEQALRRSS SLSKIRESIR RGSEKLVSRL
460 470 480 490 500
RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT QFPSWHLDKA PRTLSASTQD

LSPH
Length:504
Mass (Da):55,364
Last modified:April 4, 2006 - v2
Checksum:i3767D66C79EA3D49
GO
Isoform 2 (identifier: Q6P597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: Missing.

Note: No experimental confirmation available.
Show »
Length:503
Mass (Da):55,236
Checksum:iD8F19BD4CAE6E3AB
GO
Isoform 3 (identifier: Q6P597-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPQTPHHCSPGAAM

Show »
Length:518
Mass (Da):56,793
Checksum:iC49FD1AE860CB810
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352V → A in BAC03901 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178311M → MIPQTPHHCSPGAAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_017832163Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA. Translation: AAL48324.1.
AK092481 mRNA. Translation: BAC03901.1.
BC062998 mRNA. Translation: AAH62998.2.
BC073841 mRNA. Translation: AAH73841.1.
BC126418 mRNA. Translation: AAI26419.1.
BC133037 mRNA. Translation: AAI33038.1.
CCDSiCCDS12660.2. [Q6P597-1]
RefSeqiNP_803136.2. NM_177417.2. [Q6P597-1]
UniGeneiHs.298079.

Genome annotation databases

EnsembliENST00000391946; ENSP00000375810; ENSG00000104892. [Q6P597-1]
ENST00000470402; ENSP00000436019; ENSG00000104892. [Q6P597-3]
ENST00000585434; ENSP00000466067; ENSG00000104892. [Q6P597-2]
GeneIDi147700.
KEGGihsa:147700.
UCSCiuc002pbf.2. human. [Q6P597-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKLC3_HUMAN
AccessioniPrimary (citable) accession number: Q6P597
Secondary accession number(s): A0AVM3
, A2RUT6, Q6GMU2, Q8NAL1, Q8WWJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: May 10, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families