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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 2

Gene

TNFAIP8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 2
Short name:
TIPE2
Short name:
TNF alpha-induced protein 8-like protein 2
Short name:
TNFAIP8-like protein 2
Alternative name(s):
Inflammation factor protein 20
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26277. TNFAIP8L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670723.

Polymorphism and mutation databases

BioMutaiTNFAIP8L2.
DMDMi74749120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Tumor necrosis factor alpha-induced protein 8-like protein 2PRO_0000285771Add
BLAST

Proteomic databases

EPDiQ6P589.
MaxQBiQ6P589.
PaxDbiQ6P589.
PRIDEiQ6P589.

PTM databases

iPTMnetiQ6P589.
PhosphoSiteiQ6P589.

Expressioni

Gene expression databases

BgeeiQ6P589.
CleanExiHS_TNFAIP8L2.
GenevisibleiQ6P589. HS.

Interactioni

Subunit structurei

May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.

Binary interactionsi

WithEntry#Exp.IntActNotes
RAC1P630002EBI-9073209,EBI-413628

Protein-protein interaction databases

BioGridi122756. 3 interactions.
DIPiDIP-60326N.
IntActiQ6P589. 1 interaction.
STRINGi9606.ENSP00000357906.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 5018Combined sources
Helixi53 – 7523Combined sources
Helixi81 – 10424Combined sources
Helixi113 – 13119Combined sources
Turni132 – 1343Combined sources
Helixi137 – 15014Combined sources
Helixi153 – 1597Combined sources
Helixi162 – 1643Combined sources
Helixi165 – 18016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F4MX-ray1.70A24-184[»]
ProteinModelPortaliQ6P589.
SMRiQ6P589. Positions 31-184.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P589.

Family & Domainsi

Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.

Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IGTQ. Eukaryota.
ENOG4111INB. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ6P589.
OMAiRSGCFGP.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ6P589.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT
60 70 80 90 100
HSRPQAQRVI KDLIKVAIKV AVLHRNGSFG PSELALATRF RQKLRQGAMT
110 120 130 140 150
ALSFGEVDFT FEAAVLAGLL TECRDVLLEL VEHHLTPKSH GRIRHVFDHF
160 170 180
SDPGLLTALY GPDFTQHLGK ICDGLRKLLD EGKL
Length:184
Mass (Da):20,556
Last modified:July 5, 2004 - v1
Checksum:iD76EAEF5E24D3895
GO

Sequence cautioni

The sequence AAG44785.1 differs from that shown. Reason: Frameshift at position 117. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481E → G in CAG33656 (Ref. 4) Curated
Sequence conflicti103 – 1031S → T in BAB15664 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548003 mRNA. Translation: AAQ12262.1.
AF271774 mRNA. Translation: AAG44785.1. Frameshift.
AK027120 mRNA. Translation: BAB15664.1.
CR457375 mRNA. Translation: CAG33656.1.
AL833373 mRNA. Translation: CAI46145.1.
AL592424 Genomic DNA. Translation: CAI16379.1.
BC063014 mRNA. Translation: AAH63014.1.
CCDSiCCDS985.1.
RefSeqiNP_078851.2. NM_024575.4.
UniGeneiHs.432360.
Hs.744751.

Genome annotation databases

EnsembliENST00000368910; ENSP00000357906; ENSG00000163154.
GeneIDi79626.
KEGGihsa:79626.
UCSCiuc001ewx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548003 mRNA. Translation: AAQ12262.1.
AF271774 mRNA. Translation: AAG44785.1. Frameshift.
AK027120 mRNA. Translation: BAB15664.1.
CR457375 mRNA. Translation: CAG33656.1.
AL833373 mRNA. Translation: CAI46145.1.
AL592424 Genomic DNA. Translation: CAI16379.1.
BC063014 mRNA. Translation: AAH63014.1.
CCDSiCCDS985.1.
RefSeqiNP_078851.2. NM_024575.4.
UniGeneiHs.432360.
Hs.744751.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F4MX-ray1.70A24-184[»]
ProteinModelPortaliQ6P589.
SMRiQ6P589. Positions 31-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122756. 3 interactions.
DIPiDIP-60326N.
IntActiQ6P589. 1 interaction.
STRINGi9606.ENSP00000357906.

PTM databases

iPTMnetiQ6P589.
PhosphoSiteiQ6P589.

Polymorphism and mutation databases

BioMutaiTNFAIP8L2.
DMDMi74749120.

Proteomic databases

EPDiQ6P589.
MaxQBiQ6P589.
PaxDbiQ6P589.
PRIDEiQ6P589.

Protocols and materials databases

DNASUi79626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368910; ENSP00000357906; ENSG00000163154.
GeneIDi79626.
KEGGihsa:79626.
UCSCiuc001ewx.2. human.

Organism-specific databases

CTDi79626.
GeneCardsiTNFAIP8L2.
HGNCiHGNC:26277. TNFAIP8L2.
MIMi612112. gene.
neXtProtiNX_Q6P589.
PharmGKBiPA142670723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGTQ. Eukaryota.
ENOG4111INB. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ6P589.
OMAiRSGCFGP.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ6P589.
TreeFamiTF323415.

Miscellaneous databases

EvolutionaryTraceiQ6P589.
GenomeRNAii79626.
PROiQ6P589.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P589.
CleanExiHS_TNFAIP8L2.
GenevisibleiQ6P589. HS.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis."
    Sun H., Gong S., Carmody R.J., Hilliard A., Li L., Sun J., Kong L., Xu L., Hilliard B., Hu S., Shen H., Yang X., Chen Y.H.
    Cell 133:415-426(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  8. "Crystal structure of TIPE2 provides insights into immune homeostasis."
    Zhang X., Wang J., Fan C., Li H., Sun H., Gong S., Chen Y.H., Shi Y.
    Nat. Struct. Mol. Biol. 16:89-90(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), LACK OF INTERACTION WITH CASP8.

Entry informationi

Entry nameiTP8L2_HUMAN
AccessioniPrimary (citable) accession number: Q6P589
Secondary accession number(s): Q6I9Y0, Q9H2H7, Q9H5G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.