Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitotic-spindle organizing protein 2A

Gene

MZT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic-spindle organizing protein 2A
Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A
Gene namesi
Name:MZT2A
Synonyms:FAM128A, MOZART2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33187. MZT2A.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • gamma-tubulin ring complex Source: UniProtKB
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165696923.

Polymorphism and mutation databases

BioMutaiMZT2A.
DMDMi190359337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Mitotic-spindle organizing protein 2APRO_0000338987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei152 – 1521PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P582.
MaxQBiQ6P582.
PaxDbiQ6P582.
PeptideAtlasiQ6P582.
PRIDEiQ6P582.

PTM databases

iPTMnetiQ6P582.
PhosphoSiteiQ6P582.

Expressioni

Gene expression databases

BgeeiQ6P582.
CleanExiHS_FAM128A.
ExpressionAtlasiQ6P582. baseline and differential.
GenevisibleiQ6P582. HS.

Organism-specific databases

HPAiHPA052623.

Interactioni

Subunit structurei

Part of the gamma-tubulin complex.1 Publication

Protein-protein interaction databases

BioGridi576069. 27 interactions.
IntActiQ6P582. 23 interactions.
STRINGi9606.ENSP00000311500.

Structurei

3D structure databases

ProteinModelPortaliQ6P582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOZART2 family.Curated

Phylogenomic databases

eggNOGiENOG410IZ6M. Eukaryota.
ENOG410Y69K. LUCA.
GeneTreeiENSGT00390000014845.
HOGENOMiHOG000089967.
HOVERGENiHBG107896.
InParanoidiQ6P582.
KOiK16574.
OMAiERSNHEG.
PhylomeDBiQ6P582.
TreeFamiTF333013.

Family and domain databases

InterProiIPR024332. MOZART2.
[Graphical view]
PfamiPF12926. MOZART2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG
60 70 80 90 100
IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS
110 120 130 140 150
SVPETRGRDK GSAALGGVLA LAERSNHEGS SQRMPRQPSA TRLPKGGGPG

KSPTQGST
Length:158
Mass (Da):16,221
Last modified:June 10, 2008 - v2
Checksum:iB0B90630AE086B75
GO

Sequence cautioni

The sequence AAX93252.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 5722EEMEL…PDVFK → LQGGGRAGRRGLTGPASVPA R in AAI04651 (PubMed:15489334).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073869 Genomic DNA. Translation: AAX93252.1. Different initiation.
BC018206 mRNA. Translation: AAH18206.2.
BC063024 mRNA. Translation: AAH63024.1.
BC104650 mRNA. Translation: AAI04651.1.
CCDSiCCDS42758.1.
RefSeqiNP_001078834.1. NM_001085365.1.
UniGeneiHs.655067.

Genome annotation databases

EnsembliENST00000309451; ENSP00000311500; ENSG00000173272.
GeneIDi653784.
KEGGihsa:653784.
UCSCiuc002tsw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073869 Genomic DNA. Translation: AAX93252.1. Different initiation.
BC018206 mRNA. Translation: AAH18206.2.
BC063024 mRNA. Translation: AAH63024.1.
BC104650 mRNA. Translation: AAI04651.1.
CCDSiCCDS42758.1.
RefSeqiNP_001078834.1. NM_001085365.1.
UniGeneiHs.655067.

3D structure databases

ProteinModelPortaliQ6P582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576069. 27 interactions.
IntActiQ6P582. 23 interactions.
STRINGi9606.ENSP00000311500.

PTM databases

iPTMnetiQ6P582.
PhosphoSiteiQ6P582.

Polymorphism and mutation databases

BioMutaiMZT2A.
DMDMi190359337.

Proteomic databases

EPDiQ6P582.
MaxQBiQ6P582.
PaxDbiQ6P582.
PeptideAtlasiQ6P582.
PRIDEiQ6P582.

Protocols and materials databases

DNASUi653784.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309451; ENSP00000311500; ENSG00000173272.
GeneIDi653784.
KEGGihsa:653784.
UCSCiuc002tsw.5. human.

Organism-specific databases

CTDi653784.
GeneCardsiMZT2A.
HGNCiHGNC:33187. MZT2A.
HPAiHPA052623.
MIMi613449. gene.
neXtProtiNX_Q6P582.
PharmGKBiPA165696923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ6M. Eukaryota.
ENOG410Y69K. LUCA.
GeneTreeiENSGT00390000014845.
HOGENOMiHOG000089967.
HOVERGENiHBG107896.
InParanoidiQ6P582.
KOiK16574.
OMAiERSNHEG.
PhylomeDBiQ6P582.
TreeFamiTF333013.

Miscellaneous databases

GenomeRNAii653784.
PROiQ6P582.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P582.
CleanExiHS_FAM128A.
ExpressionAtlasiQ6P582. baseline and differential.
GenevisibleiQ6P582. HS.

Family and domain databases

InterProiIPR024332. MOZART2.
[Graphical view]
PfamiPF12926. MOZART2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Pancreas.
  3. Cited for: IDENTIFICATION IN THE GAMMA-TUBULIN COMPLEX.

Entry informationi

Entry nameiMZT2A_HUMAN
AccessioniPrimary (citable) accession number: Q6P582
Secondary accession number(s): Q3SWV8, Q8WVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.