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Protein
Submitted name:

Mtmr2 protein

Gene

Mtmr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dephosphorylation Source: MGI
  • inositol phosphate dephosphorylation Source: MGI
  • myelin assembly Source: MGI
  • negative regulation of myelination Source: MGI
  • neuron development Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
  • protein tetramerization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mtmr2 proteinImported
Submitted name:
Myotubularin-related protein 2Imported
Gene namesi
Name:Mtmr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924366. Mtmr2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • nucleus Source: MGI
  • vacuolar membrane Source: MGI
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034396.

Family & Domainsi

Sequence similaritiesi

Contains myotubularin phosphatase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOVERGENiHBG000220.
KOiK18081.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH-like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPALLPGE NIKDMAKDVT YICPFTGAVR GTLTVTSYRL YFKSMERDPP
60 70 80 90 100
FVLDASLGVI SRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR
110 120 130 140 150
RSIFENLMKY AFPVSNGLPL FAFEYKEVFP ENGWKLYDPL LEYRRQGIPN
160 170 180 190 200
ESWRITKINE RYELCDTYPA LLVVPANIPD EELKRVASFR SRGRIPVLSW
210 220 230 240 250
IHPESQATVT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR
260 270 280 290 300
PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP
310 320 330 340 350
TIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD
360 370 380 390 400
RTAQLTSLAM LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA
410 420 430 440 450
DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC
460 470 480 490 500
NSEQQRGKEN LPKKTVSLWS YINSQLEDFT NPLYGSYSNH VLYPVASMRH
510 520 530 540 550
LELWVGYYIR WNPRMKPQEP IHSRYKELLA KRAELQRKVE ELQREISNRS
560 570
TSSSERASSP AQCVTPVQTV V
Length:571
Mass (Da):65,768
Last modified:July 5, 2004 - v1
Checksum:i3A0872B069D5927A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.
BC063050 mRNA. Translation: AAH63050.1.
RefSeqiNP_076347.3. NM_023858.3.
XP_006510746.1. XM_006510683.1.
UniGeneiMm.210405.

Genome annotation databases

EnsembliENSMUST00000155679; ENSMUSP00000115906; ENSMUSG00000031918.
GeneIDi77116.
KEGGimmu:77116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.
BC063050 mRNA. Translation: AAH63050.1.
RefSeqiNP_076347.3. NM_023858.3.
XP_006510746.1. XM_006510683.1.
UniGeneiMm.210405.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155679; ENSMUSP00000115906; ENSMUSG00000031918.
GeneIDi77116.
KEGGimmu:77116.

Organism-specific databases

CTDi8898.
MGIiMGI:1924366. Mtmr2.

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOVERGENiHBG000220.
KOiK18081.

Miscellaneous databases

NextBioi346504.
SOURCEiSearch...

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH-like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: MouseImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6P572_MOUSE
AccessioniPrimary (citable) accession number: Q6P572
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.