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Q6P572 (Q6P572_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Myotubularin-related protein 2 Ensembl ENSMUSP00000115906
Gene names
Name:Mtmr2 Ensembl ENSMUSP00000115906 MGI 1924366
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH63050.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains myotubularin phosphatase domain. SAAS SAAS010569

Ontologies

Keywords
   Molecular functionHydrolase RuleBase RU000691
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdendritic spine maintenance

Inferred from electronic annotation. Source: Ensembl

dephosphorylation

Inferred from direct assay PubMed 16399794. Source: MGI

inositol phosphate dephosphorylation

Inferred from direct assay PubMed 16399794. Source: MGI

myelin assembly

Inferred from mutant phenotype PubMed 22028665. Source: MGI

negative regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

negative regulation of myelination

Inferred from genetic interaction PubMed 22028665. Source: MGI

negative regulation of receptor catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor internalization

Inferred from electronic annotation. Source: Ensembl

neuron development

Inferred from genetic interaction PubMed 22028665. Source: MGI

phosphatidylinositol dephosphorylation

Inferred from direct assay PubMed 16399794. Source: MGI

phosphatidylinositol metabolic process

Inferred from mutant phenotype PubMed 22028665. Source: MGI

positive regulation of early endosome to late endosome transport

Inferred from electronic annotation. Source: Ensembl

protein tetramerization

Inferred from physical interaction PubMed 16399794. Source: MGI

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 12837694PubMed 16399794. Source: MGI

cytosol

Inferred from electronic annotation. Source: Ensembl

neuronal postsynaptic density

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

synaptic membrane

Inferred from electronic annotation. Source: Ensembl

synaptic vesicle

Inferred from electronic annotation. Source: Ensembl

vacuolar membrane

Inferred from direct assay PubMed 16399794. Source: MGI

   Molecular_functionphosphatidylinositol phosphate phosphatase activity

Inferred from mutant phenotype PubMed 22028665. Source: MGI

protein homodimerization activity

Inferred from physical interaction PubMed 16399794. Source: MGI

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6P572 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3A0872B069D5927A

FASTA57165,768
        10         20         30         40         50         60 
MEEPALLPGE NIKDMAKDVT YICPFTGAVR GTLTVTSYRL YFKSMERDPP FVLDASLGVI 

        70         80         90        100        110        120 
SRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR RSIFENLMKY AFPVSNGLPL 

       130        140        150        160        170        180 
FAFEYKEVFP ENGWKLYDPL LEYRRQGIPN ESWRITKINE RYELCDTYPA LLVVPANIPD 

       190        200        210        220        230        240 
EELKRVASFR SRGRIPVLSW IHPESQATVT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ 

       250        260        270        280        290        300 
SHKIFIFDAR PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP 

       310        320        330        340        350        360 
TIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD RTAQLTSLAM 

       370        380        390        400        410        420 
LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA DADRSPVFLQ FIDCVWQMTR 

       430        440        450        460        470        480 
QFPTAFEFNE YFLITILDHL YSCLFGTFLC NSEQQRGKEN LPKKTVSLWS YINSQLEDFT 

       490        500        510        520        530        540 
NPLYGSYSNH VLYPVASMRH LELWVGYYIR WNPRMKPQEP IHSRYKELLA KRAELQRKVE 

       550        560        570 
ELQREISNRS TSSSERASSP AQCVTPVQTV V 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH63050.1.
Tissue: Mouse EMBL AAH63050.1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000115906.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000115906.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT010488 Genomic DNA. No translation available.
BC063050 mRNA. Translation: AAH63050.1.
RefSeqNP_076347.3. NM_023858.3.
XP_006510746.1. XM_006510683.1.
UniGeneMm.210405.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000155679; ENSMUSP00000115906; ENSMUSG00000031918.
GeneID77116.
KEGGmmu:77116.

Organism-specific databases

CTD8898.
MGIMGI:1924366. Mtmr2.

Phylogenomic databases

GeneTreeENSGT00670000097670.
HOVERGENHBG000220.
InParanoidQ6P572.
KOK01112.

Gene expression databases

GenevestigatorQ6P572.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio346504.
SOURCESearch...

Entry information

Entry nameQ6P572_MOUSE
AccessionPrimary (citable) accession number: Q6P572
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)