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Q6P572

- Q6P572_MOUSE

UniProt

Q6P572 - Q6P572_MOUSE

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Protein
Submitted name:

Mtmr2 protein

Gene

Mtmr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phosphatidylinositol phosphate phosphatase activity Source: MGI
  2. protein homodimerization activity Source: MGI
  3. protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  1. dendritic spine maintenance Source: Ensembl
  2. dephosphorylation Source: MGI
  3. inositol phosphate dephosphorylation Source: MGI
  4. myelin assembly Source: MGI
  5. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
  6. negative regulation of myelination Source: MGI
  7. negative regulation of receptor catabolic process Source: Ensembl
  8. negative regulation of receptor internalization Source: Ensembl
  9. neuron development Source: MGI
  10. phosphatidylinositol dephosphorylation Source: MGI
  11. phosphatidylinositol metabolic process Source: MGI
  12. positive regulation of early endosome to late endosome transport Source: Ensembl
  13. protein tetramerization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mtmr2 proteinImported
Submitted name:
Myotubularin-related protein 2Imported
Gene namesi
Name:Mtmr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924366. Mtmr2.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytosol Source: Ensembl
  4. dendritic spine Source: Ensembl
  5. neuronal postsynaptic density Source: Ensembl
  6. nucleus Source: Ensembl
  7. synaptic membrane Source: Ensembl
  8. synaptic vesicle Source: Ensembl
  9. vacuolar membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6P572.

Family & Domainsi

Sequence similaritiesi

Contains myotubularin phosphatase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOVERGENiHBG000220.
KOiK18081.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P572-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEPALLPGE NIKDMAKDVT YICPFTGAVR GTLTVTSYRL YFKSMERDPP
60 70 80 90 100
FVLDASLGVI SRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR
110 120 130 140 150
RSIFENLMKY AFPVSNGLPL FAFEYKEVFP ENGWKLYDPL LEYRRQGIPN
160 170 180 190 200
ESWRITKINE RYELCDTYPA LLVVPANIPD EELKRVASFR SRGRIPVLSW
210 220 230 240 250
IHPESQATVT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR
260 270 280 290 300
PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP
310 320 330 340 350
TIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD
360 370 380 390 400
RTAQLTSLAM LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA
410 420 430 440 450
DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC
460 470 480 490 500
NSEQQRGKEN LPKKTVSLWS YINSQLEDFT NPLYGSYSNH VLYPVASMRH
510 520 530 540 550
LELWVGYYIR WNPRMKPQEP IHSRYKELLA KRAELQRKVE ELQREISNRS
560 570
TSSSERASSP AQCVTPVQTV V
Length:571
Mass (Da):65,768
Last modified:July 5, 2004 - v1
Checksum:i3A0872B069D5927A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.
BC063050 mRNA. Translation: AAH63050.1.
RefSeqiNP_076347.3. NM_023858.3.
XP_006510746.1. XM_006510683.1.
UniGeneiMm.210405.

Genome annotation databases

EnsembliENSMUST00000155679; ENSMUSP00000115906; ENSMUSG00000031918.
GeneIDi77116.
KEGGimmu:77116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010488 Genomic DNA. No translation available.
BC063050 mRNA. Translation: AAH63050.1 .
RefSeqi NP_076347.3. NM_023858.3.
XP_006510746.1. XM_006510683.1.
UniGenei Mm.210405.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000155679 ; ENSMUSP00000115906 ; ENSMUSG00000031918 .
GeneIDi 77116.
KEGGi mmu:77116.

Organism-specific databases

CTDi 8898.
MGIi MGI:1924366. Mtmr2.

Phylogenomic databases

GeneTreei ENSGT00760000118832.
HOVERGENi HBG000220.
KOi K18081.

Miscellaneous databases

NextBioi 346504.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6P572.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00568. GRAM. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: MouseImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6P572_MOUSE
AccessioniPrimary (citable) accession number: Q6P572
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3