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Q6P572

- Q6P572_MOUSE

UniProt

Q6P572 - Q6P572_MOUSE

Protein
Submitted name:

Mtmr2 protein

Gene

Mtmr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatidylinositol phosphate phosphatase activity Source: MGI
    2. protein homodimerization activity Source: MGI
    3. protein tyrosine phosphatase activity Source: InterPro

    GO - Biological processi

    1. dendritic spine maintenance Source: Ensembl
    2. dephosphorylation Source: MGI
    3. inositol phosphate dephosphorylation Source: MGI
    4. myelin assembly Source: MGI
    5. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
    6. negative regulation of myelination Source: MGI
    7. negative regulation of receptor catabolic process Source: Ensembl
    8. negative regulation of receptor internalization Source: Ensembl
    9. neuron development Source: MGI
    10. phosphatidylinositol dephosphorylation Source: MGI
    11. phosphatidylinositol metabolic process Source: MGI
    12. positive regulation of early endosome to late endosome transport Source: Ensembl
    13. protein tetramerization Source: MGI

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mtmr2 proteinImported
    Submitted name:
    Myotubularin-related protein 2Imported
    Gene namesi
    Name:Mtmr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1924366. Mtmr2.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: MGI
    3. cytosol Source: Ensembl
    4. dendritic spine Source: Ensembl
    5. neuronal postsynaptic density Source: Ensembl
    6. nucleus Source: Ensembl
    7. synaptic membrane Source: Ensembl
    8. synaptic vesicle Source: Ensembl
    9. vacuolar membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P572.

    Family & Domainsi

    Sequence similaritiesi

    Contains myotubularin phosphatase domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00670000097670.
    HOVERGENiHBG000220.
    InParanoidiQ6P572.
    KOiK18081.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00568. GRAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P572-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEPALLPGE NIKDMAKDVT YICPFTGAVR GTLTVTSYRL YFKSMERDPP    50
    FVLDASLGVI SRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR 100
    RSIFENLMKY AFPVSNGLPL FAFEYKEVFP ENGWKLYDPL LEYRRQGIPN 150
    ESWRITKINE RYELCDTYPA LLVVPANIPD EELKRVASFR SRGRIPVLSW 200
    IHPESQATVT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR 250
    PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP 300
    TIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD 350
    RTAQLTSLAM LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA 400
    DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC 450
    NSEQQRGKEN LPKKTVSLWS YINSQLEDFT NPLYGSYSNH VLYPVASMRH 500
    LELWVGYYIR WNPRMKPQEP IHSRYKELLA KRAELQRKVE ELQREISNRS 550
    TSSSERASSP AQCVTPVQTV V 571
    Length:571
    Mass (Da):65,768
    Last modified:July 5, 2004 - v1
    Checksum:i3A0872B069D5927A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010488 Genomic DNA. No translation available.
    BC063050 mRNA. Translation: AAH63050.1.
    RefSeqiNP_076347.3. NM_023858.3.
    XP_006510746.1. XM_006510683.1.
    UniGeneiMm.210405.

    Genome annotation databases

    EnsembliENSMUST00000155679; ENSMUSP00000115906; ENSMUSG00000031918.
    GeneIDi77116.
    KEGGimmu:77116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010488 Genomic DNA. No translation available.
    BC063050 mRNA. Translation: AAH63050.1 .
    RefSeqi NP_076347.3. NM_023858.3.
    XP_006510746.1. XM_006510683.1.
    UniGenei Mm.210405.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000155679 ; ENSMUSP00000115906 ; ENSMUSG00000031918 .
    GeneIDi 77116.
    KEGGi mmu:77116.

    Organism-specific databases

    CTDi 8898.
    MGIi MGI:1924366. Mtmr2.

    Phylogenomic databases

    GeneTreei ENSGT00670000097670.
    HOVERGENi HBG000220.
    InParanoidi Q6P572.
    KOi K18081.

    Miscellaneous databases

    NextBioi 346504.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6P572.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00568. GRAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: MouseImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6P572_MOUSE
    AccessioniPrimary (citable) accession number: Q6P572
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3