Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P542

- ABCF1_MOUSE

UniProt

Q6P542 - ABCF1_MOUSE

Protein

ATP-binding cassette sub-family F member 1

Gene

Abcf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi328 – 3358ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi650 – 6578ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB
    3. ribosome binding Source: UniProtKB
    4. translation activator activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of translation Source: UniProtKB
    2. translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family F member 1
    Gene namesi
    Name:Abcf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1351658. Abcf1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleoplasm By similarity. Nucleus envelope By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nuclear envelope Source: UniProtKB
    3. nucleoplasm Source: UniProtKB
    4. polysomal ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 837837ATP-binding cassette sub-family F member 1PRO_0000093319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei90 – 901Phosphoserine1 Publication
    Modified residuei103 – 1031Phosphoserine2 Publications
    Modified residuei107 – 1071Phosphoserine; by CK24 Publications
    Modified residuei138 – 1381Phosphoserine; by CK23 Publications
    Modified residuei194 – 1941Phosphoserine2 Publications
    Cross-linki565 – 565Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki574 – 574Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei587 – 5871PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-107 and Ser-138 by CK2; inhibits association of EIF2 with ribosomes By similarity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ6P542.
    PaxDbiQ6P542.
    PRIDEiQ6P542.

    PTM databases

    PhosphoSiteiQ6P542.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P542.
    BgeeiQ6P542.
    GenevestigatoriQ6P542.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230310. 1 interaction.
    MINTiMINT-1859549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P542.
    SMRiQ6P542. Positions 293-828.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini296 – 540245ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini617 – 832216ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi139 – 23395Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0488.
    GeneTreeiENSGT00630000089843.
    HOGENOMiHOG000271637.
    HOVERGENiHBG050440.
    InParanoidiQ6P542.
    KOiK06184.
    OMAiVPYEEYL.
    OrthoDBiEOG7WDN23.
    PhylomeDBiQ6P542.
    TreeFamiTF105207.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK    50
    QAGEEEKLQK EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDS DERVLMERLK 100
    QLSVPASDEE DEVPAPIPRG RKKAKGGNVF EALIQDDSEE EEEEEENRVL 150
    KPAKPEKNRI NKAVAEEPPG LRSKKGKEEK SKGKAKSKPA AADSEGEEEE 200
    EDTAKEKEPP QQGKDRDKKE AEQGSGEEKE EKEGDLKAND PYANLSKKEK 250
    KKLKKQMDYE RQVESLKAAN AAENDFSVSQ AEVSSRQAML ENASDIKLEK 300
    FSISAHGKEL FVNADLYIVA GRRYGLVGPN GKGKTTLLKH IANRALSIPP 350
    NIDVLLCEQE VVADETPAVQ AVLRADTKRL RLLEEERRLQ GQLEQGDDTA 400
    AEKLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM 450
    RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ 500
    GFLDDVCTDI IHLDTQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL 550
    KELKAGGKST KQAEKQTKEV LTRKQQKCRR KNQDEESQEP PELLKRPKEY 600
    TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK PLFKNLDFGI DMDSRICIVG 650
    PNGVGKSTLL LLLTGKLTPT NGEMRKNHRL KIGFFNQQYA EQLHMEETPT 700
    EYLQRSFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC 750
    REPDVLILDE PTNNLDIESI DALGEAINDY KGAVIVVSHD ARLITETNCQ 800
    LWVVEEQGVS QIDGDFDDYK REVLEALGEV MVNRPRD 837
    Length:837
    Mass (Da):94,945
    Last modified:July 5, 2004 - v1
    Checksum:i9CCD1753D5357944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063094 mRNA. Translation: AAH63094.1.
    BC068282 mRNA. Translation: AAH68282.1.
    CCDSiCCDS28713.1.
    RefSeqiNP_038882.1. NM_013854.1.
    UniGeneiMm.329022.

    Genome annotation databases

    EnsembliENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762.
    GeneIDi224742.
    KEGGimmu:224742.
    UCSCiuc008cjk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063094 mRNA. Translation: AAH63094.1 .
    BC068282 mRNA. Translation: AAH68282.1 .
    CCDSi CCDS28713.1.
    RefSeqi NP_038882.1. NM_013854.1.
    UniGenei Mm.329022.

    3D structure databases

    ProteinModelPortali Q6P542.
    SMRi Q6P542. Positions 293-828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230310. 1 interaction.
    MINTi MINT-1859549.

    PTM databases

    PhosphoSitei Q6P542.

    Proteomic databases

    MaxQBi Q6P542.
    PaxDbi Q6P542.
    PRIDEi Q6P542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043757 ; ENSMUSP00000036881 ; ENSMUSG00000038762 .
    GeneIDi 224742.
    KEGGi mmu:224742.
    UCSCi uc008cjk.1. mouse.

    Organism-specific databases

    CTDi 23.
    MGIi MGI:1351658. Abcf1.

    Phylogenomic databases

    eggNOGi COG0488.
    GeneTreei ENSGT00630000089843.
    HOGENOMi HOG000271637.
    HOVERGENi HBG050440.
    InParanoidi Q6P542.
    KOi K06184.
    OMAi VPYEEYL.
    OrthoDBi EOG7WDN23.
    PhylomeDBi Q6P542.
    TreeFami TF105207.

    Miscellaneous databases

    NextBioi 377328.
    PROi Q6P542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P542.
    Bgeei Q6P542.
    Genevestigatori Q6P542.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: ICR.
      Tissue: Limb and Trophoblast stem cell.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103; SER-107 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-103; SER-107; SER-138 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiABCF1_MOUSE
    AccessioniPrimary (citable) accession number: Q6P542
    Secondary accession number(s): Q6NV71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3