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Protein

ATP-binding cassette sub-family F member 1

Gene

Abcf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi328 – 335ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi650 – 657ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 1
Gene namesi
Name:Abcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1351658. Abcf1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleoplasm By similarity
  • Nucleus envelope By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933191 – 837ATP-binding cassette sub-family F member 1Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei90PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei107Phosphoserine; by CK2Combined sources1
Modified residuei138Phosphoserine; by CK2Combined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-107 and Ser-138 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P542.
MaxQBiQ6P542.
PaxDbiQ6P542.
PeptideAtlasiQ6P542.
PRIDEiQ6P542.

PTM databases

iPTMnetiQ6P542.
PhosphoSitePlusiQ6P542.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038762.
ExpressionAtlasiQ6P542. baseline and differential.
GenevisibleiQ6P542. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).By similarity

Protein-protein interaction databases

BioGridi230310. 1 interactor.
IntActiQ6P542. 53 interactors.
MINTiMINT-1859549.
STRINGi10090.ENSMUSP00000036881.

Structurei

3D structure databases

ProteinModelPortaliQ6P542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 540ABC transporter 1PROSITE-ProRule annotationAdd BLAST245
Domaini617 – 832ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 233Glu-richAdd BLAST95

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0066. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ6P542.
KOiK06184.
OMAiQEYERQM.
OrthoDBiEOG091G031N.
PhylomeDBiQ6P542.
TreeFamiTF105207.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK
60 70 80 90 100
QAGEEEKLQK EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDS DERVLMERLK
110 120 130 140 150
QLSVPASDEE DEVPAPIPRG RKKAKGGNVF EALIQDDSEE EEEEEENRVL
160 170 180 190 200
KPAKPEKNRI NKAVAEEPPG LRSKKGKEEK SKGKAKSKPA AADSEGEEEE
210 220 230 240 250
EDTAKEKEPP QQGKDRDKKE AEQGSGEEKE EKEGDLKAND PYANLSKKEK
260 270 280 290 300
KKLKKQMDYE RQVESLKAAN AAENDFSVSQ AEVSSRQAML ENASDIKLEK
310 320 330 340 350
FSISAHGKEL FVNADLYIVA GRRYGLVGPN GKGKTTLLKH IANRALSIPP
360 370 380 390 400
NIDVLLCEQE VVADETPAVQ AVLRADTKRL RLLEEERRLQ GQLEQGDDTA
410 420 430 440 450
AEKLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM
460 470 480 490 500
RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ
510 520 530 540 550
GFLDDVCTDI IHLDTQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL
560 570 580 590 600
KELKAGGKST KQAEKQTKEV LTRKQQKCRR KNQDEESQEP PELLKRPKEY
610 620 630 640 650
TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK PLFKNLDFGI DMDSRICIVG
660 670 680 690 700
PNGVGKSTLL LLLTGKLTPT NGEMRKNHRL KIGFFNQQYA EQLHMEETPT
710 720 730 740 750
EYLQRSFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC
760 770 780 790 800
REPDVLILDE PTNNLDIESI DALGEAINDY KGAVIVVSHD ARLITETNCQ
810 820 830
LWVVEEQGVS QIDGDFDDYK REVLEALGEV MVNRPRD
Length:837
Mass (Da):94,945
Last modified:July 5, 2004 - v1
Checksum:i9CCD1753D5357944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063094 mRNA. Translation: AAH63094.1.
BC068282 mRNA. Translation: AAH68282.1.
CCDSiCCDS28713.1.
RefSeqiNP_038882.1. NM_013854.1.
UniGeneiMm.329022.

Genome annotation databases

EnsembliENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762.
GeneIDi224742.
KEGGimmu:224742.
UCSCiuc008cjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063094 mRNA. Translation: AAH63094.1.
BC068282 mRNA. Translation: AAH68282.1.
CCDSiCCDS28713.1.
RefSeqiNP_038882.1. NM_013854.1.
UniGeneiMm.329022.

3D structure databases

ProteinModelPortaliQ6P542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230310. 1 interactor.
IntActiQ6P542. 53 interactors.
MINTiMINT-1859549.
STRINGi10090.ENSMUSP00000036881.

PTM databases

iPTMnetiQ6P542.
PhosphoSitePlusiQ6P542.

Proteomic databases

EPDiQ6P542.
MaxQBiQ6P542.
PaxDbiQ6P542.
PeptideAtlasiQ6P542.
PRIDEiQ6P542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762.
GeneIDi224742.
KEGGimmu:224742.
UCSCiuc008cjk.1. mouse.

Organism-specific databases

CTDi23.
MGIiMGI:1351658. Abcf1.

Phylogenomic databases

eggNOGiKOG0066. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ6P542.
KOiK06184.
OMAiQEYERQM.
OrthoDBiEOG091G031N.
PhylomeDBiQ6P542.
TreeFamiTF105207.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ6P542.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038762.
ExpressionAtlasiQ6P542. baseline and differential.
GenevisibleiQ6P542. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCF1_MOUSE
AccessioniPrimary (citable) accession number: Q6P542
Secondary accession number(s): Q6NV71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.