Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6P542

- ABCF1_MOUSE

UniProt

Q6P542 - ABCF1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ATP-binding cassette sub-family F member 1

Gene

Abcf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi328 – 3358ATP 1PROSITE-ProRule annotation
Nucleotide bindingi650 – 6578ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB
  3. poly(A) RNA binding Source: Ensembl
  4. ribosome binding Source: UniProtKB
  5. translation activator activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of translation Source: UniProtKB
  2. translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 1
Gene namesi
Name:Abcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1351658. Abcf1.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleoplasm By similarity. Nucleus envelope By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear envelope Source: UniProtKB
  3. nucleoplasm Source: UniProtKB
  4. polysomal ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837ATP-binding cassette sub-family F member 1PRO_0000093319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei90 – 901Phosphoserine1 Publication
Modified residuei103 – 1031Phosphoserine2 Publications
Modified residuei107 – 1071Phosphoserine; by CK24 Publications
Modified residuei138 – 1381Phosphoserine; by CK23 Publications
Modified residuei194 – 1941Phosphoserine2 Publications
Cross-linki565 – 565Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki574 – 574Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei587 – 5871PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-107 and Ser-138 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6P542.
PaxDbiQ6P542.
PRIDEiQ6P542.

PTM databases

PhosphoSiteiQ6P542.

Expressioni

Gene expression databases

BgeeiQ6P542.
ExpressionAtlasiQ6P542. baseline and differential.
GenevestigatoriQ6P542.

Interactioni

Subunit structurei

Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).By similarity

Protein-protein interaction databases

BioGridi230310. 1 interaction.
MINTiMINT-1859549.

Structurei

3D structure databases

ProteinModelPortaliQ6P542.
SMRiQ6P542. Positions 273-828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 540245ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini617 – 832216ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi139 – 23395Glu-richAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0488.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ6P542.
KOiK06184.
OMAiVPYEEYL.
OrthoDBiEOG7WDN23.
PhylomeDBiQ6P542.
TreeFamiTF105207.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P542 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK
60 70 80 90 100
QAGEEEKLQK EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDS DERVLMERLK
110 120 130 140 150
QLSVPASDEE DEVPAPIPRG RKKAKGGNVF EALIQDDSEE EEEEEENRVL
160 170 180 190 200
KPAKPEKNRI NKAVAEEPPG LRSKKGKEEK SKGKAKSKPA AADSEGEEEE
210 220 230 240 250
EDTAKEKEPP QQGKDRDKKE AEQGSGEEKE EKEGDLKAND PYANLSKKEK
260 270 280 290 300
KKLKKQMDYE RQVESLKAAN AAENDFSVSQ AEVSSRQAML ENASDIKLEK
310 320 330 340 350
FSISAHGKEL FVNADLYIVA GRRYGLVGPN GKGKTTLLKH IANRALSIPP
360 370 380 390 400
NIDVLLCEQE VVADETPAVQ AVLRADTKRL RLLEEERRLQ GQLEQGDDTA
410 420 430 440 450
AEKLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM
460 470 480 490 500
RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ
510 520 530 540 550
GFLDDVCTDI IHLDTQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL
560 570 580 590 600
KELKAGGKST KQAEKQTKEV LTRKQQKCRR KNQDEESQEP PELLKRPKEY
610 620 630 640 650
TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK PLFKNLDFGI DMDSRICIVG
660 670 680 690 700
PNGVGKSTLL LLLTGKLTPT NGEMRKNHRL KIGFFNQQYA EQLHMEETPT
710 720 730 740 750
EYLQRSFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC
760 770 780 790 800
REPDVLILDE PTNNLDIESI DALGEAINDY KGAVIVVSHD ARLITETNCQ
810 820 830
LWVVEEQGVS QIDGDFDDYK REVLEALGEV MVNRPRD
Length:837
Mass (Da):94,945
Last modified:July 5, 2004 - v1
Checksum:i9CCD1753D5357944
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063094 mRNA. Translation: AAH63094.1.
BC068282 mRNA. Translation: AAH68282.1.
CCDSiCCDS28713.1.
RefSeqiNP_038882.1. NM_013854.1.
UniGeneiMm.329022.

Genome annotation databases

EnsembliENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762.
GeneIDi224742.
KEGGimmu:224742.
UCSCiuc008cjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063094 mRNA. Translation: AAH63094.1 .
BC068282 mRNA. Translation: AAH68282.1 .
CCDSi CCDS28713.1.
RefSeqi NP_038882.1. NM_013854.1.
UniGenei Mm.329022.

3D structure databases

ProteinModelPortali Q6P542.
SMRi Q6P542. Positions 273-828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230310. 1 interaction.
MINTi MINT-1859549.

PTM databases

PhosphoSitei Q6P542.

Proteomic databases

MaxQBi Q6P542.
PaxDbi Q6P542.
PRIDEi Q6P542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043757 ; ENSMUSP00000036881 ; ENSMUSG00000038762 .
GeneIDi 224742.
KEGGi mmu:224742.
UCSCi uc008cjk.1. mouse.

Organism-specific databases

CTDi 23.
MGIi MGI:1351658. Abcf1.

Phylogenomic databases

eggNOGi COG0488.
GeneTreei ENSGT00630000089843.
HOGENOMi HOG000271637.
HOVERGENi HBG050440.
InParanoidi Q6P542.
KOi K06184.
OMAi VPYEEYL.
OrthoDBi EOG7WDN23.
PhylomeDBi Q6P542.
TreeFami TF105207.

Miscellaneous databases

NextBioi 377328.
PROi Q6P542.
SOURCEi Search...

Gene expression databases

Bgeei Q6P542.
ExpressionAtlasi Q6P542. baseline and differential.
Genevestigatori Q6P542.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ICR.
    Tissue: Limb and Trophoblast stem cell.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103; SER-107 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-103; SER-107; SER-138 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiABCF1_MOUSE
AccessioniPrimary (citable) accession number: Q6P542
Secondary accession number(s): Q6NV71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3