Q6P531 (GGT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyltransferase 6
Short name=GGT 6
EC=2.3.2.2

Alternative name(s):
Gamma-glutamyltranspeptidase 6

Cleaved into the following 2 chains:

1. Gamma-glutamyltransferase 6 heavy chain
2. Gamma-glutamyltransferase 6 light chain

Gene names

Name:

GGT6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cleaves glutathione conjugates By similarity.
Catalytic activity	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid. Glutathione + H2O = L-cysteinylglycine + L-glutamate.
Pathway	Sulfur metabolism; glutathione metabolism.
Subunit structure	Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
Biological process	Glutathione biosynthesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW leukotriene biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	anchored to external side of plasma membrane Traceable author statement Ref.4. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	gamma-glutamyltransferase activity Traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P531-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P531-2)

The sequence of this isoform differs from the canonical sequence as follows:
     116-147: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ?		Gamma-glutamyltransferase 6 heavy chain		PRO_0000314954
	Chain	? – 493		Gamma-glutamyltransferase 6 light chain		PRO_0000314955
Regions
	Topological domain	1 – 54	54	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	76 – 493	418	Extracellular Potential
	Compositional bias	21 – 30	10	Poly-Glu
Amino acid modifications
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	116 – 147	32	Missing in isoform 2.		VSP_030451
	Natural variant	40	1	R → W. Ref.1 Corresponds to variant rs7216284 [ dbSNP | Ensembl ].		VAR_038138
	Natural variant	58	1	A → V. Ref.1 Ref.2 Ref.3 Corresponds to variant rs11657054 [ dbSNP | Ensembl ].		VAR_038139

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: BBC8ECC544C0D1A2	FASTA	493	50,509
	10 20 30 40 50 60 MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA GGLPGTWARV 70 80 90 100 110 120 VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH GPGVYHHGAI ISPAGRELLV 130 140 150 160 170 180 AGGNVVDAGV GAALCLAVVH PHATGLGAMF WGLFHDSSSG NSTALTSGPA QTLAPGLGLP 190 200 210 220 230 240 AALPTLHLLH ARFGRLPWPR LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG 250 260 270 280 290 300 TPLGAGARAT NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ 310 320 330 340 350 360 LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES SALAAVDSSG 370 380 390 400 410 420 SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC PLILRGSLDD TEADVLGLVA 430 440 450 460 470 480 SGTPDVARAM THTLLRHLAA RPPTQAQHQH QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV 490 SSVPHACCPF QGF
	Isoform 2 [UniParc]. Checksum: 6979651CA49D8C5E	FASTA	461	47,490
	10 20 30 40 50 60 MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA GGLPGTWARV 70 80 90 100 110 120 VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH GPGVYHHGAI ISPAGAMFWG 130 140 150 160 170 180 LFHDSSSGNS TALTSGPAQT LAPGLGLPAA LPTLHLLHAR FGRLPWPRLL VGPTTLAQEG 190 200 210 220 230 240 FLVDTPLARA LVARGTEGLC PLLCHADGTP LGAGARATNP QLAAVLRSAA LAPTSDLAGD 250 260 270 280 290 300 ALLSLLAGDL GVEVPSAVPR PTLEPAEQLP VPQGILFTTP SPSAGPELLA LLEAALRSGA 310 320 330 340 350 360 PIPDPCPPFL QTAVSPESSA LAAVDSSGSV LLLTSSLNCS FGSAHLSPST GVLLSNLVAK 370 380 390 400 410 420 STTSAWACPL ILRGSLDDTE ADVLGLVASG TPDVARAMTH TLLRHLAARP PTQAQHQHQG 430 440 450 460 QQEPTEHPST CGQGTLLQVA AHTEHAHVSS VPHACCPFQG F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TRP-40 AND VAL-58. Tissue: Mammary gland and Rectum.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-58.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-58. Tissue: Kidney.
[4]	"The human gamma-glutamyltransferase gene family." Heisterkamp N., Groffen J., Warburton D., Sneddon T.P. Hum. Genet. 123:321-332(2008) [PubMed: 18357469] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074646 mRNA. Translation: BAC11110.1. AK300648 mRNA. Translation: BAG62336.1. CH471108 Genomic DNA. Translation: EAW90433.1. BC063111 mRNA. Translation: AAH63111.1.
IPI	IPI00749196. IPI00940353.
RefSeq	NP_001116362.1. NM_001122890.1. NP_699169.2. NM_153338.2.
UniGene	Hs.130749.
3D structure databases
ProteinModelPortal	Q6P531.
SMR	Q6P531. Positions 99-324.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6P531. 1 interaction.
STRING	Q6P531.
Protein family/group databases
MEROPS	T03.024.
Polymorphism databases
DMDM	166221586.
Proteomic databases
PRIDE	Q6P531.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381550; ENSP00000370962; ENSG00000167741.
GeneID	124975.
KEGG	hsa:124975.
UCSC	uc002fyc.2. human. uc002fyd.2. human.
Organism-specific databases
CTD	124975.
GeneCards	GC17M004460.
H-InvDB	HIX0027144.
HGNC	HGNC:26891. GGT6.
HPA	HPA023362. HPA027213.
MIM	612341. gene.
neXtProt	NX_Q6P531.
PharmGKB	PA142671739.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG055504.
InParanoid	Q6P531.
PhylomeDB	Q6P531.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q6P531.
Bgee	Q6P531.
CleanEx	HS_GGT6.
Genevestigator	Q6P531.
Family and domain databases
InterPro	IPR000101. GGT_peptidase. [Graphical view]
KO	K00681.
PANTHER	PTHR11686. GGT_peptidase. 1 hit.
Pfam	PF01019. G_glu_transpept. 2 hits. [Graphical view]
PRINTS	PR01210. GGTRANSPTASE.
PROSITE	PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	81450.
SOURCE	Search...

Entry information

Entry name

GGT6_HUMAN

Accession

Primary (citable) accession number: Q6P531
Secondary accession number(s): B4DUH4, Q8NCM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.