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Protein

Gamma-glutamyltransferase 6

Gene

GGT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

  • gamma-glutamyltransferase activity Source: UniProtKB
  • glutathione hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  • glutathione biosynthetic process Source: UniProtKB-KW
  • glutathione metabolic process Source: UniProtKB
  • leukotriene biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-174403. Glutathione synthesis and recycling.
R-HSA-5423646. Aflatoxin activation and detoxification.
UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Alternative name(s):
Gamma-glutamyltranspeptidase 6
Glutathione hydrolase 6 (EC:3.4.19.13)
Cleaved into the following 2 chains:
Gene namesi
Name:GGT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26891. GGT6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454CytoplasmicSequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini76 – 493418ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671739.

Polymorphism and mutation databases

BioMutaiGGT6.
DMDMi166221586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 493Gamma-glutamyltransferase 6 light chainPRO_0000314955
Chaini1 – ?Gamma-glutamyltransferase 6 heavy chainPRO_0000314954

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6P531.
PeptideAtlasiQ6P531.
PRIDEiQ6P531.

PTM databases

iPTMnetiQ6P531.
PhosphoSiteiQ6P531.

Expressioni

Gene expression databases

BgeeiQ6P531.
CleanExiHS_GGT6.
ExpressionAtlasiQ6P531. baseline and differential.
GenevisibleiQ6P531. HS.

Organism-specific databases

HPAiHPA023362.
HPA027213.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

BioGridi125906. 1 interaction.
IntActiQ6P531. 1 interaction.
STRINGi9606.ENSP00000458307.

Structurei

3D structure databases

ProteinModelPortaliQ6P531.
SMRiQ6P531. Positions 109-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 3010Poly-Glu

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6P531.
KOiK00681.
OrthoDBiEOG789CBS.
PhylomeDBiQ6P531.
TreeFamiTF338758.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 3 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P531-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA
60 70 80 90 100
GGLPGTWARV VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH
110 120 130 140 150
GPGVYHHGAI ISPAGRELLV AGGNVVDAGV GAALCLAVVH PHATGLGAMF
160 170 180 190 200
WGLFHDSSSG NSTALTSGPA QTLAPGLGLP AALPTLHLLH ARFGRLPWPR
210 220 230 240 250
LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG TPLGAGARAT
260 270 280 290 300
NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ
310 320 330 340 350
LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES
360 370 380 390 400
SALAAVDSSG SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC
410 420 430 440 450
PLILRGSLDD TEADVLGLVA SGTPDVARAM THTLLRHLAA RPPTQAQHQH
460 470 480 490
QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV SSVPHACCPF QGF
Length:493
Mass (Da):50,509
Last modified:January 15, 2008 - v2
Checksum:iBBC8ECC544C0D1A2
GO
Isoform 2 (identifier: Q6P531-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-147: Missing.

Show »
Length:461
Mass (Da):47,490
Checksum:i6979651CA49D8C5E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401R → W.1 Publication
Corresponds to variant rs7216284 [ dbSNP | Ensembl ].
VAR_038138
Natural varianti58 – 581A → V.3 Publications
Corresponds to variant rs11657054 [ dbSNP | Ensembl ].
VAR_038139

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei116 – 14732Missing in isoform 2. 1 PublicationVSP_030451Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074646 mRNA. Translation: BAC11110.1.
AK300648 mRNA. Translation: BAG62336.1.
CH471108 Genomic DNA. Translation: EAW90433.1.
BC063111 mRNA. Translation: AAH63111.1.
CCDSiCCDS11047.1. [Q6P531-2]
CCDS45582.1. [Q6P531-1]
RefSeqiNP_001116362.1. NM_001122890.2. [Q6P531-1]
NP_001275631.1. NM_001288702.1.
NP_001275632.1. NM_001288703.1.
NP_001275633.1. NM_001288704.1.
NP_699169.2. NM_153338.3. [Q6P531-2]
UniGeneiHs.130749.

Genome annotation databases

EnsembliENST00000301395; ENSP00000301395; ENSG00000167741. [Q6P531-2]
ENST00000574154; ENSP00000458307; ENSG00000167741. [Q6P531-1]
GeneIDi124975.
KEGGihsa:124975.
UCSCiuc002fyc.6. human. [Q6P531-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074646 mRNA. Translation: BAC11110.1.
AK300648 mRNA. Translation: BAG62336.1.
CH471108 Genomic DNA. Translation: EAW90433.1.
BC063111 mRNA. Translation: AAH63111.1.
CCDSiCCDS11047.1. [Q6P531-2]
CCDS45582.1. [Q6P531-1]
RefSeqiNP_001116362.1. NM_001122890.2. [Q6P531-1]
NP_001275631.1. NM_001288702.1.
NP_001275632.1. NM_001288703.1.
NP_001275633.1. NM_001288704.1.
NP_699169.2. NM_153338.3. [Q6P531-2]
UniGeneiHs.130749.

3D structure databases

ProteinModelPortaliQ6P531.
SMRiQ6P531. Positions 109-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125906. 1 interaction.
IntActiQ6P531. 1 interaction.
STRINGi9606.ENSP00000458307.

Protein family/group databases

MEROPSiT03.024.

PTM databases

iPTMnetiQ6P531.
PhosphoSiteiQ6P531.

Polymorphism and mutation databases

BioMutaiGGT6.
DMDMi166221586.

Proteomic databases

PaxDbiQ6P531.
PeptideAtlasiQ6P531.
PRIDEiQ6P531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301395; ENSP00000301395; ENSG00000167741. [Q6P531-2]
ENST00000574154; ENSP00000458307; ENSG00000167741. [Q6P531-1]
GeneIDi124975.
KEGGihsa:124975.
UCSCiuc002fyc.6. human. [Q6P531-1]

Organism-specific databases

CTDi124975.
GeneCardsiGGT6.
H-InvDBHIX0027144.
HGNCiHGNC:26891. GGT6.
HPAiHPA023362.
HPA027213.
MIMi612341. gene.
neXtProtiNX_Q6P531.
PharmGKBiPA142671739.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6P531.
KOiK00681.
OrthoDBiEOG789CBS.
PhylomeDBiQ6P531.
TreeFamiTF338758.

Enzyme and pathway databases

UniPathwayiUPA00204.
ReactomeiR-HSA-174403. Glutathione synthesis and recycling.
R-HSA-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

GenomeRNAii124975.
PROiQ6P531.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P531.
CleanExiHS_GGT6.
ExpressionAtlasiQ6P531. baseline and differential.
GenevisibleiQ6P531. HS.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 3 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TRP-40 AND VAL-58.
    Tissue: Mammary gland and Rectum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-58.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-58.
    Tissue: Kidney.
  4. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiGGT6_HUMAN
AccessioniPrimary (citable) accession number: Q6P531
Secondary accession number(s): B4DUH4, Q8NCM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.