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Protein

Glutathione hydrolase 6

Gene

GGT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-174403. Glutathione synthesis and recycling.
R-HSA-5423646. Aflatoxin activation and detoxification.
UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 6 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Gamma-glutamyltranspeptidase 6
Cleaved into the following 2 chains:
Gene namesi
Name:GGT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167741.10.
HGNCiHGNC:26891. GGT6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 75Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini76 – 493ExtracellularSequence analysisAdd BLAST418

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167741.
PharmGKBiPA142671739.

Polymorphism and mutation databases

BioMutaiGGT6.
DMDMi166221586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314955? – 493Glutathione hydrolase 6 light chain
ChainiPRO_00003149541 – ?Glutathione hydrolase 6 heavy chain

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6P531.
PeptideAtlasiQ6P531.
PRIDEiQ6P531.

PTM databases

iPTMnetiQ6P531.
PhosphoSitePlusiQ6P531.

Expressioni

Gene expression databases

BgeeiENSG00000167741.
CleanExiHS_GGT6.
ExpressionAtlasiQ6P531. baseline and differential.
GenevisibleiQ6P531. HS.

Organism-specific databases

HPAiHPA023362.
HPA027213.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

BioGridi125906. 1 interactor.
IntActiQ6P531. 10 interactors.
STRINGi9606.ENSP00000458307.

Structurei

3D structure databases

ProteinModelPortaliQ6P531.
SMRiQ6P531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 30Poly-Glu10

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6P531.
KOiK00681.
PhylomeDBiQ6P531.
TreeFamiTF338758.

Family and domain databases

InterProiView protein in InterPro
IPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiView protein in Pfam
PF01019. G_glu_transpept. 3 hits.
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P531-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA
60 70 80 90 100
GGLPGTWARV VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH
110 120 130 140 150
GPGVYHHGAI ISPAGRELLV AGGNVVDAGV GAALCLAVVH PHATGLGAMF
160 170 180 190 200
WGLFHDSSSG NSTALTSGPA QTLAPGLGLP AALPTLHLLH ARFGRLPWPR
210 220 230 240 250
LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG TPLGAGARAT
260 270 280 290 300
NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ
310 320 330 340 350
LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES
360 370 380 390 400
SALAAVDSSG SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC
410 420 430 440 450
PLILRGSLDD TEADVLGLVA SGTPDVARAM THTLLRHLAA RPPTQAQHQH
460 470 480 490
QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV SSVPHACCPF QGF
Length:493
Mass (Da):50,509
Last modified:January 15, 2008 - v2
Checksum:iBBC8ECC544C0D1A2
GO
Isoform 2 (identifier: Q6P531-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-147: Missing.

Show »
Length:461
Mass (Da):47,490
Checksum:i6979651CA49D8C5E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03813840R → W1 PublicationCorresponds to variant dbSNP:rs7216284Ensembl.1
Natural variantiVAR_03813958A → V3 PublicationsCorresponds to variant dbSNP:rs11657054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030451116 – 147Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074646 mRNA. Translation: BAC11110.1.
AK300648 mRNA. Translation: BAG62336.1.
CH471108 Genomic DNA. Translation: EAW90433.1.
BC063111 mRNA. Translation: AAH63111.1.
CCDSiCCDS11047.1. [Q6P531-2]
CCDS45582.1. [Q6P531-1]
RefSeqiNP_001116362.1. NM_001122890.2. [Q6P531-1]
NP_001275631.1. NM_001288702.1.
NP_001275632.1. NM_001288703.1.
NP_001275633.1. NM_001288704.1.
NP_699169.2. NM_153338.3. [Q6P531-2]
UniGeneiHs.130749.

Genome annotation databases

EnsembliENST00000301395; ENSP00000301395; ENSG00000167741. [Q6P531-2]
ENST00000574154; ENSP00000458307; ENSG00000167741. [Q6P531-1]
GeneIDi124975.
KEGGihsa:124975.
UCSCiuc002fyc.6. human. [Q6P531-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGGT6_HUMAN
AccessioniPrimary (citable) accession number: Q6P531
Secondary accession number(s): B4DUH4, Q8NCM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 27, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families