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Protein

T-complex protein 1 subunit gamma

Gene

Cct3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Plays a role in the assembly of the von Hippel-Lindau ubiquitination complex (By similarity). Interacts with DYX1C1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit gamma
Short name:
TCP-1-gamma
Alternative name(s):
CCT-gamma
Gene namesi
Name:Cct3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi735038. Cct3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002707621 – 545T-complex protein 1 subunit gammaAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei247PhosphotyrosineBy similarity1
Modified residuei252PhosphoserineCombined sources1
Disulfide bondi366 ↔ 372By similarity
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei430PhosphothreonineBy similarity1
Modified residuei459PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6P502.
PRIDEiQ6P502.

PTM databases

iPTMnetiQ6P502.
PhosphoSitePlusiQ6P502.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019090.
GenevisibleiQ6P502. RN.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi254921. 5 interactors.
IntActiQ6P502. 2 interactors.
MINTiMINT-4575838.
STRINGi10116.ENSRNOP00000025824.

Structurei

3D structure databases

ProteinModelPortaliQ6P502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0364. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00570000079224.
HOGENOMiHOG000226732.
HOVERGENiHBG104982.
InParanoidiQ6P502.
KOiK09495.
OMAiKVISRWS.
OrthoDBiEOG091G0677.
PhylomeDBiQ6P502.
TreeFamiTF105649.

Family and domain databases

CDDicd03337. TCP1_gamma. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012719. Chap_CCT_gamma.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF63. PTHR11353:SF63. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02344. chap_CCT_gamma. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGHRPVLVL SQNTKRESGR KVQSGNINAA KTIADIIRTC LGPKSMMKML
60 70 80 90 100
LDPMGGIVMT NDGNAILREI QVQHPAAKSM IEISRTQDEE VGDGTTSVII
110 120 130 140 150
LAGEMLSVAE HFLEQQMHPT VVISAYRMAL DDMVSTLKKI STPVDVNNRD
160 170 180 190 200
MMLNIINSSI TTKVISRWSS LACNIALDAV KTVQFEENGR KEIDIKKYAR
210 220 230 240 250
VEKIPGGIIE DSCVLRGVMI NKDVTHPRMR RYIKNPRIVL LDSSLEYKKG
260 270 280 290 300
ESQTDIEITR EEDFTRILQM EEEYIQQLCE DIIQLKPDVV ITEKGISDLA
310 320 330 340 350
QHYLMRANVT AIRRVRKTDN NRIARACGAR IVSRPEELRE DDVGTGAGLL
360 370 380 390 400
EIKKIGDEYF TFITDCKDPK ACTILLRGAS KEILSEVERN LQDAMQVCRN
410 420 430 440 450
VLLDPQLVPG GGASEMAVAH ALTEKSKAMT GVEQWPYRAV AQALEVIPRT
460 470 480 490 500
LIQNCGASTI RLLTSLRAKH TQENCETWGV NGETGTLVDM KELGIWEPLA
510 520 530 540
VKLQTYKTAV ETAVLLLRID DIVSGHKKKG DDQNRQTGAP DAGQE
Length:545
Mass (Da):60,647
Last modified:July 5, 2004 - v1
Checksum:i76C2B128DA799809
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063178 mRNA. Translation: AAH63178.1.
RefSeqiNP_954522.1. NM_199091.2.
UniGeneiRn.203147.

Genome annotation databases

EnsembliENSRNOT00000025824; ENSRNOP00000025824; ENSRNOG00000019090.
GeneIDi295230.
KEGGirno:295230.
UCSCiRGD:735038. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063178 mRNA. Translation: AAH63178.1.
RefSeqiNP_954522.1. NM_199091.2.
UniGeneiRn.203147.

3D structure databases

ProteinModelPortaliQ6P502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254921. 5 interactors.
IntActiQ6P502. 2 interactors.
MINTiMINT-4575838.
STRINGi10116.ENSRNOP00000025824.

PTM databases

iPTMnetiQ6P502.
PhosphoSitePlusiQ6P502.

Proteomic databases

PaxDbiQ6P502.
PRIDEiQ6P502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025824; ENSRNOP00000025824; ENSRNOG00000019090.
GeneIDi295230.
KEGGirno:295230.
UCSCiRGD:735038. rat.

Organism-specific databases

CTDi7203.
RGDi735038. Cct3.

Phylogenomic databases

eggNOGiKOG0364. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00570000079224.
HOGENOMiHOG000226732.
HOVERGENiHBG104982.
InParanoidiQ6P502.
KOiK09495.
OMAiKVISRWS.
OrthoDBiEOG091G0677.
PhylomeDBiQ6P502.
TreeFamiTF105649.

Enzyme and pathway databases

ReactomeiR-RNO-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiQ6P502.

Gene expression databases

BgeeiENSRNOG00000019090.
GenevisibleiQ6P502. RN.

Family and domain databases

CDDicd03337. TCP1_gamma. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012719. Chap_CCT_gamma.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF63. PTHR11353:SF63. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02344. chap_CCT_gamma. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPG_RAT
AccessioniPrimary (citable) accession number: Q6P502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.