ID   LAP4A_RAT               Reviewed;         233 AA.
AC   Q6P501;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=Lysosomal-associated transmembrane protein 4A;
GN   Name=Laptm4a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary anterior lobe;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function in the transport of nucleosides and/or
CC       nucleoside derivatives between the cytosol and the lumen of an
CC       intracellular membrane-bound compartment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC       membrane-bound compartment. {ECO:0000305}.
CC   -!- DOMAIN: The C-terminal domain is necessary for retention within
CC       intracellular membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC063179; AAH63179.1; -; mRNA.
DR   RefSeq; NP_955416.1; NM_199384.2.
DR   AlphaFoldDB; Q6P501; -.
DR   SMR; Q6P501; -.
DR   BioGRID; 256045; 1.
DR   STRING; 10116.ENSRNOP00000009665; -.
DR   iPTMnet; Q6P501; -.
DR   PhosphoSitePlus; Q6P501; -.
DR   PaxDb; 10116-ENSRNOP00000009665; -.
DR   Ensembl; ENSRNOT00000009665.7; ENSRNOP00000009665.5; ENSRNOG00000006865.7.
DR   GeneID; 298875; -.
DR   KEGG; rno:298875; -.
DR   AGR; RGD:735179; -.
DR   CTD; 9741; -.
DR   RGD; 735179; Laptm4a.
DR   eggNOG; ENOG502QSAX; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   HOGENOM; CLU_059239_2_0_1; -.
DR   InParanoid; Q6P501; -.
DR   OMA; NCYKYII; -.
DR   OrthoDB; 2902684at2759; -.
DR   PhylomeDB; Q6P501; -.
DR   PRO; PR:Q6P501; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000006865; Expressed in ovary and 20 other cell types or tissues.
DR   ExpressionAtlas; Q6P501; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   NCBIfam; TIGR00799; mtp; 1.
DR   PANTHER; PTHR12479; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR12479:SF5; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 4A; 1.
DR   Pfam; PF03821; Mtp; 2.
DR   Genevisible; Q6P501; RN.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..233
FT                   /note="Lysosomal-associated transmembrane protein 4A"
FT                   /id="PRO_0000249717"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15012"
SQ   SEQUENCE   233 AA;  26784 MW;  BF60C9667BD8FBDB CRC64;
     MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
     NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
     VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI
     NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK IPEKEPPPPY LPA
//