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Q6P501

- LAP4A_RAT

UniProt

Q6P501 - LAP4A_RAT

Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.By similarity

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 4A
    Gene namesi
    Name:Laptm4a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi735179. Laptm4a.

    Subcellular locationi

    Endomembrane system Curated; Multi-pass membrane protein Curated
    Note: May reside in an intracellular membrane-bound compartment.Curated

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Lysosomal-associated transmembrane protein 4APRO_0000249717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ6P501.

    PTM databases

    PhosphoSiteiQ6P501.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P501.

    Interactioni

    Protein-protein interaction databases

    BioGridi256045. 1 interaction.
    STRINGi10116.ENSRNOP00000009665.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi226 – 2294Poly-Pro

    Domaini

    The C-terminal domain is necessary for retention within intracellular membranes.By similarity

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260939.
    GeneTreeiENSGT00390000013359.
    HOGENOMiHOG000007698.
    HOVERGENiHBG000908.
    InParanoidiQ6P501.
    KOiK12387.
    OMAiRMSENAC.
    OrthoDBiEOG7QC7X3.
    PhylomeDBiQ6P501.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00799. mtp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6P501-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE    50
    VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG 100
    AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK 150
    DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV 200
    YPAFEAPPQY VLPTYEMAVK IPEKEPPPPY LPA 233
    Length:233
    Mass (Da):26,784
    Last modified:July 5, 2004 - v1
    Checksum:iBF60C9667BD8FBDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063179 mRNA. Translation: AAH63179.1.
    RefSeqiNP_955416.1. NM_199384.2.
    UniGeneiRn.108012.

    Genome annotation databases

    EnsembliENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865.
    GeneIDi298875.
    KEGGirno:298875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063179 mRNA. Translation: AAH63179.1 .
    RefSeqi NP_955416.1. NM_199384.2.
    UniGenei Rn.108012.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 256045. 1 interaction.
    STRINGi 10116.ENSRNOP00000009665.

    PTM databases

    PhosphoSitei Q6P501.

    Proteomic databases

    PRIDEi Q6P501.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009665 ; ENSRNOP00000009665 ; ENSRNOG00000006865 .
    GeneIDi 298875.
    KEGGi rno:298875.

    Organism-specific databases

    CTDi 9741.
    RGDi 735179. Laptm4a.

    Phylogenomic databases

    eggNOGi NOG260939.
    GeneTreei ENSGT00390000013359.
    HOGENOMi HOG000007698.
    HOVERGENi HBG000908.
    InParanoidi Q6P501.
    KOi K12387.
    OMAi RMSENAC.
    OrthoDBi EOG7QC7X3.
    PhylomeDBi Q6P501.

    Miscellaneous databases

    NextBioi 644438.
    PROi Q6P501.

    Gene expression databases

    Genevestigatori Q6P501.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00799. mtp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary anterior lobe.

    Entry informationi

    Entry nameiLAP4A_RAT
    AccessioniPrimary (citable) accession number: Q6P501
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3