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Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.By similarity

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Gene namesi
Name:Laptm4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi735179. Laptm4a.

Subcellular locationi

Endomembrane system Curated; Multi-pass membrane protein Curated
Note: May reside in an intracellular membrane-bound compartment.Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Lysosomal-associated transmembrane protein 4APRO_0000249717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ6P501.

PTM databases

PhosphoSiteiQ6P501.

Expressioni

Gene expression databases

GenevestigatoriQ6P501.

Interactioni

Protein-protein interaction databases

BioGridi256045. 1 interaction.
STRINGi10116.ENSRNOP00000009665.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 2294Poly-Pro

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.By similarity

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260939.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ6P501.
KOiK12387.
OMAiDLQYEVI.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ6P501.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P501-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFEAPPQY VLPTYEMAVK IPEKEPPPPY LPA
Length:233
Mass (Da):26,784
Last modified:July 5, 2004 - v1
Checksum:iBF60C9667BD8FBDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063179 mRNA. Translation: AAH63179.1.
RefSeqiNP_955416.1. NM_199384.2.
UniGeneiRn.108012.

Genome annotation databases

EnsembliENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865.
GeneIDi298875.
KEGGirno:298875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063179 mRNA. Translation: AAH63179.1.
RefSeqiNP_955416.1. NM_199384.2.
UniGeneiRn.108012.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256045. 1 interaction.
STRINGi10116.ENSRNOP00000009665.

PTM databases

PhosphoSiteiQ6P501.

Proteomic databases

PRIDEiQ6P501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865.
GeneIDi298875.
KEGGirno:298875.

Organism-specific databases

CTDi9741.
RGDi735179. Laptm4a.

Phylogenomic databases

eggNOGiNOG260939.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ6P501.
KOiK12387.
OMAiDLQYEVI.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ6P501.

Miscellaneous databases

NextBioi644438.
PROiQ6P501.

Gene expression databases

GenevestigatoriQ6P501.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary anterior lobe.

Entry informationi

Entry nameiLAP4A_RAT
AccessioniPrimary (citable) accession number: Q6P501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.