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Q6P501 (LAP4A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal-associated transmembrane protein 4A
Gene names
Name:Laptm4a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment By similarity.

Subcellular location

Endomembrane system; Multi-pass membrane protein Potential. Note: May reside in an intracellular membrane-bound compartment Potential.

Domain

The C-terminal domain is necessary for retention within intracellular membranes By similarity.

Sequence similarities

Belongs to the LAPTM4/LAPTM5 transporter family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Lysosomal-associated transmembrane protein 4A
PRO_0000249717

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane160 – 18021Helical; Potential
Compositional bias226 – 2294Poly-Pro

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P501 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BF60C9667BD8FBDB

FASTA23326,784
        10         20         30         40         50         60 
MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV 

        70         80         90        100        110        120 
NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF 

       130        140        150        160        170        180 
VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI 

       190        200        210        220        230 
NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK IPEKEPPPPY LPA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary anterior lobe.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC063179 mRNA. Translation: AAH63179.1.
RefSeqNP_955416.1. NM_199384.2.
UniGeneRn.108012.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid256045. 1 interaction.
STRING10116.ENSRNOP00000009665.

PTM databases

PhosphoSiteQ6P501.

Proteomic databases

PRIDEQ6P501.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865.
GeneID298875.
KEGGrno:298875.

Organism-specific databases

CTD9741.
RGD735179. Laptm4a.

Phylogenomic databases

eggNOGNOG260939.
GeneTreeENSGT00390000013359.
HOGENOMHOG000007698.
HOVERGENHBG000908.
InParanoidQ6P501.
KOK12387.
OMARMSENAC.
OrthoDBEOG7QC7X3.
PhylomeDBQ6P501.

Gene expression databases

GenevestigatorQ6P501.

Family and domain databases

InterProIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERPTHR12479. PTHR12479. 1 hit.
PfamPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsTIGR00799. mtp. 1 hit.
ProtoNetSearch...

Other

NextBio644438.
PROQ6P501.

Entry information

Entry nameLAP4A_RAT
AccessionPrimary (citable) accession number: Q6P501
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families