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Protein

COP9 signalosome complex subunit 8

Gene

Cops8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene namesi
Name:Cops8
Synonyms:Csn8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1311404. Cops8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 209208COP9 signalosome complex subunit 8PRO_0000121010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P4Z9.
PRIDEiQ6P4Z9.

PTM databases

iPTMnetiQ6P4Z9.
PhosphoSiteiQ6P4Z9.

Expressioni

Gene expression databases

GenevisibleiQ6P4Z9. RN.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6P4Z9. 1 interaction.
STRINGi10116.ENSRNOP00000026581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 15184PCIAdd
BLAST

Sequence similaritiesi

Belongs to the CSN8 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG4414. Eukaryota.
ENOG410XW9N. LUCA.
GeneTreeiENSGT00390000000977.
HOGENOMiHOG000253954.
HOVERGENiHBG051139.
InParanoidiQ6P4Z9.
KOiK12181.
OMAiIKYEWSE.
OrthoDBiEOG76DTV5.
PhylomeDBiQ6P4Z9.

Family and domain databases

InterProiIPR033205. COP9_CSN8.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR13339. PTHR13339. 1 hit.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P4Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM
60 70 80 90 100
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE
110 120 130 140 150
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE
160 170 180 190 200
QGWQADSTTR MVLPRKPAPG ALDVSLNRFI PLSEPAPVPP IPNEQQLARL

TDYVAFLEN
Length:209
Mass (Da):23,236
Last modified:July 5, 2004 - v1
Checksum:iDB80E9C47BFAD5B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063182 mRNA. Translation: AAH63182.1.
RefSeqiNP_001013245.1. NM_001013227.2.
UniGeneiRn.99919.

Genome annotation databases

EnsembliENSRNOT00000026581; ENSRNOP00000026581; ENSRNOG00000019635.
GeneIDi363283.
KEGGirno:363283.
UCSCiRGD:1311404. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063182 mRNA. Translation: AAH63182.1.
RefSeqiNP_001013245.1. NM_001013227.2.
UniGeneiRn.99919.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P4Z9. 1 interaction.
STRINGi10116.ENSRNOP00000026581.

PTM databases

iPTMnetiQ6P4Z9.
PhosphoSiteiQ6P4Z9.

Proteomic databases

PaxDbiQ6P4Z9.
PRIDEiQ6P4Z9.

Protocols and materials databases

DNASUi363283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026581; ENSRNOP00000026581; ENSRNOG00000019635.
GeneIDi363283.
KEGGirno:363283.
UCSCiRGD:1311404. rat.

Organism-specific databases

CTDi10920.
RGDi1311404. Cops8.

Phylogenomic databases

eggNOGiKOG4414. Eukaryota.
ENOG410XW9N. LUCA.
GeneTreeiENSGT00390000000977.
HOGENOMiHOG000253954.
HOVERGENiHBG051139.
InParanoidiQ6P4Z9.
KOiK12181.
OMAiIKYEWSE.
OrthoDBiEOG76DTV5.
PhylomeDBiQ6P4Z9.

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

PROiQ6P4Z9.

Gene expression databases

GenevisibleiQ6P4Z9. RN.

Family and domain databases

InterProiIPR033205. COP9_CSN8.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR13339. PTHR13339. 1 hit.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiCSN8_RAT
AccessioniPrimary (citable) accession number: Q6P4Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.