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Protein

COP9 signalosome complex subunit 8

Gene

Cops8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5696394 DNA Damage Recognition in GG-NER
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene namesi
Name:Cops8
Synonyms:Csn8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1311404 Cops8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210101 – 209COP9 signalosome complex subunit 8Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P4Z9
PRIDEiQ6P4Z9

PTM databases

iPTMnetiQ6P4Z9
PhosphoSitePlusiQ6P4Z9

Expressioni

Gene expression databases

BgeeiENSRNOG00000019635
GenevisibleiQ6P4Z9 RN

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B).By similarity

Protein-protein interaction databases

IntActiQ6P4Z9, 1 interactor
STRINGi10116.ENSRNOP00000026581

Structurei

3D structure databases

SMRiQ6P4Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 179PCIPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the CSN8 family.Curated

Phylogenomic databases

eggNOGiKOG4414 Eukaryota
ENOG410XW9N LUCA
GeneTreeiENSGT00390000000977
HOGENOMiHOG000253954
HOVERGENiHBG051139
InParanoidiQ6P4Z9
KOiK12181
OMAiCETQELE
OrthoDBiEOG091G0O7O
PhylomeDBiQ6P4Z9

Family and domain databases

InterProiView protein in InterPro
IPR033205 COP9_CSN8
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR13339 PTHR13339, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P4Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM
60 70 80 90 100
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE
110 120 130 140 150
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE
160 170 180 190 200
QGWQADSTTR MVLPRKPAPG ALDVSLNRFI PLSEPAPVPP IPNEQQLARL

TDYVAFLEN
Length:209
Mass (Da):23,236
Last modified:July 5, 2004 - v1
Checksum:iDB80E9C47BFAD5B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063182 mRNA Translation: AAH63182.1
RefSeqiNP_001013245.1, NM_001013227.2
UniGeneiRn.99919

Genome annotation databases

EnsembliENSRNOT00000026581; ENSRNOP00000026581; ENSRNOG00000019635
GeneIDi363283
KEGGirno:363283
UCSCiRGD:1311404 rat

Similar proteinsi

Entry informationi

Entry nameiCSN8_RAT
AccessioniPrimary (citable) accession number: Q6P4Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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