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Protein

Leucine carboxyl methyltransferase 1

Gene

Lcmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.By similarity

Catalytic activityi

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711S-adenosyl-L-methionineBy similarity
Binding sitei96 – 961S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
Binding sitei120 – 1201S-adenosyl-L-methionineBy similarity
Binding sitei196 – 1961S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine carboxyl methyltransferase 1 (EC:2.1.1.233)
Alternative name(s):
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Gene namesi
Name:Lcmt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735118. Lcmt1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Leucine carboxyl methyltransferase 1PRO_0000226151Add
BLAST

Proteomic databases

PaxDbiQ6P4Z6.
PRIDEiQ6P4Z6.

PTM databases

PhosphoSiteiQ6P4Z6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019640.

Structurei

3D structure databases

ProteinModelPortaliQ6P4Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1702S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2918. Eukaryota.
ENOG410YB9K. LUCA.
HOGENOMiHOG000205368.
HOVERGENiHBG052313.
InParanoidiQ6P4Z6.
KOiK18203.
PhylomeDBiQ6P4Z6.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016651. Leu_CO_MeTrfase_LCMT1.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
PIRSFiPIRSF016305. LCM_mtfrase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P4Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGSRESSF SSCASSCDFD DEGVRGTCED ASLCKRFAVS IGHWHDPYIE
60 70 80 90 100
HLVRQSKERK APEINRGYFA RVHGVSQLIK AFLRKTECRC QILNLGAGMD
110 120 130 140 150
TTFWKLKDEG LLPNKYFEVD FPMIVTRKLH TIKNKPLLFR PIMELHPEDT
160 170 180 190 200
LQIDSHMLDS KRYAIIGADL RDLSELEEKL KKCNMNTQLP TLLITECVLV
210 220 230 240 250
YMTPEQSANL LKWAARSFET AMFINYEQVN MDDRFGQIMI ENLRRRQCDL
260 270 280 290 300
AGVETCKSLE SQKERLLLNG WETASAVNMM ELYSGLPRAE VNRIESLEFL
310 320 330
DEMELLEQLM RHYCLCWATR GGQELGLKEI TY
Length:332
Mass (Da):38,330
Last modified:July 5, 2004 - v1
Checksum:i1190662A8B869337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063186 mRNA. Translation: AAH63186.1.
RefSeqiNP_955437.1. NM_199405.2.
UniGeneiRn.162464.

Genome annotation databases

GeneIDi361643.
KEGGirno:361643.
UCSCiRGD:735118. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063186 mRNA. Translation: AAH63186.1.
RefSeqiNP_955437.1. NM_199405.2.
UniGeneiRn.162464.

3D structure databases

ProteinModelPortaliQ6P4Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019640.

PTM databases

PhosphoSiteiQ6P4Z6.

Proteomic databases

PaxDbiQ6P4Z6.
PRIDEiQ6P4Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361643.
KEGGirno:361643.
UCSCiRGD:735118. rat.

Organism-specific databases

CTDi51451.
RGDi735118. Lcmt1.

Phylogenomic databases

eggNOGiKOG2918. Eukaryota.
ENOG410YB9K. LUCA.
HOGENOMiHOG000205368.
HOVERGENiHBG052313.
InParanoidiQ6P4Z6.
KOiK18203.
PhylomeDBiQ6P4Z6.

Miscellaneous databases

PROiQ6P4Z6.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016651. Leu_CO_MeTrfase_LCMT1.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
PIRSFiPIRSF016305. LCM_mtfrase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiLCMT1_RAT
AccessioniPrimary (citable) accession number: Q6P4Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.