Q6P4Z6 (LCMT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine carboxyl methyltransferase 1
EC=2.1.1.233

Alternative name(s):
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene names

Name:

Lcmt1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
Sequence similarities	Belongs to the methyltransferase superfamily. LCMT family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Leucine carboxyl methyltransferase 1		PRO_0000226151
Regions
	Region	169 – 170	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	71	1	S-adenosyl-L-methionine By similarity
	Binding site	96	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	120	1	S-adenosyl-L-methionine By similarity
	Binding site	196	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P4Z6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1190662A8B869337	FASTA	332	38,330
	10 20 30 40 50 60 MATGSRESSF SSCASSCDFD DEGVRGTCED ASLCKRFAVS IGHWHDPYIE HLVRQSKERK 70 80 90 100 110 120 APEINRGYFA RVHGVSQLIK AFLRKTECRC QILNLGAGMD TTFWKLKDEG LLPNKYFEVD 130 140 150 160 170 180 FPMIVTRKLH TIKNKPLLFR PIMELHPEDT LQIDSHMLDS KRYAIIGADL RDLSELEEKL 190 200 210 220 230 240 KKCNMNTQLP TLLITECVLV YMTPEQSANL LKWAARSFET AMFINYEQVN MDDRFGQIMI 250 260 270 280 290 300 ENLRRRQCDL AGVETCKSLE SQKERLLLNG WETASAVNMM ELYSGLPRAE VNRIESLEFL 310 320 330 DEMELLEQLM RHYCLCWATR GGQELGLKEI TY

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC063186 mRNA. Translation: AAH63186.1.
IPI	IPI00400748.
RefSeq	NP_955437.1. NM_199405.2.
UniGene	Rn.162464.
3D structure databases
ProteinModelPortal	Q6P4Z6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000019640.
PTM databases
PhosphoSite	Q6P4Z6.
Proteomic databases
PaxDb	Q6P4Z6.
PRIDE	Q6P4Z6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	361643.
KEGG	rno:361643.
UCSC	RGD:735118. rat.
Organism-specific databases
CTD	51451.
RGD	735118. Lcmt1.
Phylogenomic databases
eggNOG	NOG329644.
HOGENOM	HOG000205368.
HOVERGEN	HBG052313.
InParanoid	Q6P4Z6.
OrthoDB	EOG4TF0KQ.
Gene expression databases
Genevestigator	Q6P4Z6.
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR021121. LCM_MeTrfase_euk. IPR016651. Leu_CO_MeTrfase_LCTM1. [Graphical view]
PANTHER	PTHR13600. PTHR13600. 1 hit.
Pfam	PF04072. LCM. 1 hit. [Graphical view]
PIRSF	PIRSF016305. LCM_mtfrase. 1 hit.
ProtoNet	Search...
Other
NextBio	677065.

Entry information

Entry name

LCMT1_RAT

Accession

Primary (citable) accession number: Q6P4Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program