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Protein

Leucine carboxyl methyltransferase 1

Gene

Lcmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.By similarity

Catalytic activityi

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71S-adenosyl-L-methionineBy similarity1
Binding sitei96S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei120S-adenosyl-L-methionineBy similarity1
Binding sitei196S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine carboxyl methyltransferase 1 (EC:2.1.1.233)
Alternative name(s):
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Gene namesi
Name:Lcmt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735118. Lcmt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002261511 – 332Leucine carboxyl methyltransferase 1Add BLAST332

Proteomic databases

PaxDbiQ6P4Z6.
PRIDEiQ6P4Z6.

PTM databases

PhosphoSitePlusiQ6P4Z6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019640.

Structurei

3D structure databases

ProteinModelPortaliQ6P4Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2918. Eukaryota.
ENOG410YB9K. LUCA.
HOGENOMiHOG000205368.
HOVERGENiHBG052313.
InParanoidiQ6P4Z6.
KOiK18203.
PhylomeDBiQ6P4Z6.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016651. Leu_CO_MeTrfase_LCMT1.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
PIRSFiPIRSF016305. LCM_mtfrase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P4Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGSRESSF SSCASSCDFD DEGVRGTCED ASLCKRFAVS IGHWHDPYIE
60 70 80 90 100
HLVRQSKERK APEINRGYFA RVHGVSQLIK AFLRKTECRC QILNLGAGMD
110 120 130 140 150
TTFWKLKDEG LLPNKYFEVD FPMIVTRKLH TIKNKPLLFR PIMELHPEDT
160 170 180 190 200
LQIDSHMLDS KRYAIIGADL RDLSELEEKL KKCNMNTQLP TLLITECVLV
210 220 230 240 250
YMTPEQSANL LKWAARSFET AMFINYEQVN MDDRFGQIMI ENLRRRQCDL
260 270 280 290 300
AGVETCKSLE SQKERLLLNG WETASAVNMM ELYSGLPRAE VNRIESLEFL
310 320 330
DEMELLEQLM RHYCLCWATR GGQELGLKEI TY
Length:332
Mass (Da):38,330
Last modified:July 5, 2004 - v1
Checksum:i1190662A8B869337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063186 mRNA. Translation: AAH63186.1.
RefSeqiNP_955437.1. NM_199405.2.
UniGeneiRn.162464.

Genome annotation databases

GeneIDi361643.
KEGGirno:361643.
UCSCiRGD:735118. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063186 mRNA. Translation: AAH63186.1.
RefSeqiNP_955437.1. NM_199405.2.
UniGeneiRn.162464.

3D structure databases

ProteinModelPortaliQ6P4Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019640.

PTM databases

PhosphoSitePlusiQ6P4Z6.

Proteomic databases

PaxDbiQ6P4Z6.
PRIDEiQ6P4Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361643.
KEGGirno:361643.
UCSCiRGD:735118. rat.

Organism-specific databases

CTDi51451.
RGDi735118. Lcmt1.

Phylogenomic databases

eggNOGiKOG2918. Eukaryota.
ENOG410YB9K. LUCA.
HOGENOMiHOG000205368.
HOVERGENiHBG052313.
InParanoidiQ6P4Z6.
KOiK18203.
PhylomeDBiQ6P4Z6.

Miscellaneous databases

PROiQ6P4Z6.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016651. Leu_CO_MeTrfase_LCMT1.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
PIRSFiPIRSF016305. LCM_mtfrase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCMT1_RAT
AccessioniPrimary (citable) accession number: Q6P4Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.