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Q6P4Z2

- CO2A1_XENTR

UniProt

Q6P4Z2 - CO2A1_XENTR

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Protein
Collagen alpha-1(II) chain
Gene
col2a1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei186 – 1872Cleavage; by procollagen N-endopeptidase By similarity
Sitei1246 – 12472Cleavage; by procollagen C-endopeptidase By similarity
Metal bindingi1306 – 13061Calcium By similarity
Metal bindingi1308 – 13081Calcium By similarity
Metal bindingi1309 – 13091Calcium; via carbonyl oxygen By similarity
Metal bindingi1311 – 13111Calcium; via carbonyl oxygen By similarity
Metal bindingi1314 – 13141Calcium By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(II) chain
Alternative name(s):
Alpha-1 type II collagen
Gene namesi
Name:col2a1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-6258353. col2a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Propeptidei27 – 186160N-terminal propeptide By similarity
PRO_0000286181Add
BLAST
Chaini187 – 12461060Collagen alpha-1(II) chain
PRO_0000286182Add
BLAST
Propeptidei1247 – 1492246C-terminal propeptide By similarity
PRO_0000286183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1288 ↔ 1320 By similarity
Disulfide bondi1294 – 1294Interchain (with C-1311) By similarity
Disulfide bondi1311 – 1311Interchain (with C-1294) By similarity
Disulfide bondi1328 ↔ 1490 By similarity
Glycosylationi1393 – 13931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1398 ↔ 1443 By similarity

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ6P4Z2.
PRIDEiQ6P4Z2.

Interactioni

Subunit structurei

Homotrimers of alpha 1(II) chains By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000023334.

Structurei

3D structure databases

ProteinModelPortaliQ6P4Z2.
SMRiQ6P4Z2. Positions 36-101.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9459VWFC
Add
BLAST
Domaini1258 – 1492235Fibrillar collagen NC1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 12191014Triple-helical region
Add
BLAST
Regioni1220 – 124627Nonhelical region (C-terminal)
Add
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similaritiesi

Contains 1 VWFC domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG004933.
KOiK06236.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P4Z2-1 [UniParc]FASTAAdd to Basket

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MFSFVDSRTL VLFAATQVIL LAVVRCQDEE DVLATGSCVQ HGQRYSDKDV     50
WKPEPCQICV CDTGNVLCDE IICEDPKDCP NAEIPFGECC PICPTEQSST 100
SSGQGVLKGQ KGEPGDIKDV VGPKGPPGPQ GPSGEQGPRG DRGDKGEKGA 150
PGPRGRDGEP GTPGNPGPVG PPGPPGPPGL GGNFAAQMTG GFDEKAGGAQ 200
MGVMQGPMGP MGPRGPPGPT GAPGPQGFQG NPGEPGEPGA GGPMGPRGPP 250
GPAGKPGDDG EAGKPGKSGE RGPPGPQGAR GFPGTPGLPG VKGHRGYPGL 300
DGSKGEAGAA GAKGEGGATG EAGSPGPMGP RGLPGERGRP GASGAAGARG 350
NDGLPGPAGP PGPVGPAGAP GFPGAPGSKG EAGPTGARGP EGAQGPRGES 400
GTPGSPGPAG ASGNPGTDGI PGAKGSSGAP GIAGAPGFPG PRGPPGPQGA 450
TGPLGPKGQT GDPGVAGFKG EHGPKGEIGS AGPQGAPGPA GEEGKRGARG 500
EPGAAGPLGP PGERGAPGNR GFPGQDGLAG PKGAPGERGV PGLGGPKGAN 550
GDPGRPGEPG LPGARGLTGR PGDAGPQGKV GPSGASGEDG RPGPPGPQGA 600
RGQPGVMGFP GPKGANGEPG KAGEKGLLGA PGLRGLPGKD GETGAQGPNG 650
PAGPAGERGE QGPPGPSGFQ GLPGPPGSPG EGGKPGDQGV PGEAGAPGLV 700
GPRGERGFPG ERGSSGPQGL QGPRGLPGTP GTDGPKGATG PSGPNGAQGP 750
PGLQGMPGER GAAGISGPKG DRGDTGEKGP EGAPGKDGSR GLTGPIGPPG 800
PSGPNGEKGE SGPSGPAGIV GARGAPGDRG ETGPPGPAGF AGPPGADGQA 850
GLKGDQGESG QKGDAGAPGP QGPSGAPGPQ GPTGVNGPKG ARGAQGPPGA 900
TGFPGAAGRV GPPGPNGNPG PSGAPGSAGK EGPKGARGDA GPTGRAGDPG 950
LQGPAGVPGE KGESGEDGPS GPDGPPGPQG LSGQRGIVGL PGQRGERGFP 1000
GLPGPSGEPG KQGGPGSAGD RGPPGPVGPP GLTGPAGEPG REGNAGSDGP 1050
PGRDGATGIK GDRGETGPLG APGAPGAPGA PGPVGPTGKQ GDRGESGPQG 1100
PLGPSGPAGA RGLPGPQGPR GDKGEAGEAG ERGQKGHRGF TGLQGLPGPP 1150
GTAGDQGASG PAGPGGPRGP PGPVGPSGKD GSNGLPGPIG PPGPRGRGGE 1200
TGPAGPPGQP GPPGPPGPPG PGIDMSAFAG LSQPEKGPDP MRYMRADQAS 1250
SSVPQRDVDV EATLKSLNNQ IESIRSPDGT KKNPARTCRD LKLCHPEWKS 1300
GDYWIDPNQG CTVDAIKVFC NMETGETCVY PNPSKIPKKN WWSAKGKEKK 1350
HIWFGETING GFQFSYGDDS SAPNTANIQM TFLRLLSTDA TQNITYHCKN 1400
SIAFMDEASG NLKKAVLLQG SNDVEIRAEG NSRFTYNALE DGCKKHTGKW 1450
SKTVIEYRTQ KTSRLPIVDI APMDIGGADQ EFGVDIGPVC FL 1492
Length:1,492
Mass (Da):142,696
Last modified:July 5, 2004 - v1
Checksum:iDB7AF42B94210EB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063191 mRNA. Translation: AAH63191.1.
RefSeqiNP_989220.1. NM_203889.1.
UniGeneiStr.54515.

Genome annotation databases

GeneIDi394828.
KEGGixtr:394828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063191 mRNA. Translation: AAH63191.1 .
RefSeqi NP_989220.1. NM_203889.1.
UniGenei Str.54515.

3D structure databases

ProteinModelPortali Q6P4Z2.
SMRi Q6P4Z2. Positions 36-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000023334.

Proteomic databases

PaxDbi Q6P4Z2.
PRIDEi Q6P4Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 394828.
KEGGi xtr:394828.

Organism-specific databases

CTDi 1280.
Xenbasei XB-GENE-6258353. col2a1.

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG004933.
KOi K06236.

Family and domain databases

InterProi IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCO2A1_XENTR
AccessioniPrimary (citable) accession number: Q6P4Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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