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Q6P4Z2 (CO2A1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(II) chain
Alternative name(s):
Alpha-1 type II collagen
Gene names
Name:col2a1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length1492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces By similarity.

Subunit structure

Homotrimers of alpha 1(II) chains By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.

Sequence similarities

Belongs to the fibrillar collagen family.

Contains 1 fibrillar collagen NC1 domain.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 186160N-terminal propeptide By similarity
PRO_0000286181
Chain187 – 12461060Collagen alpha-1(II) chain
PRO_0000286182
Propeptide1247 – 1492246C-terminal propeptide By similarity
PRO_0000286183

Regions

Domain36 – 9459VWFC
Domain1258 – 1492235Fibrillar collagen NC1
Region206 – 12191014Triple-helical region
Region1220 – 124627Nonhelical region (C-terminal)

Sites

Metal binding13061Calcium By similarity
Metal binding13081Calcium By similarity
Metal binding13091Calcium; via carbonyl oxygen By similarity
Metal binding13111Calcium; via carbonyl oxygen By similarity
Metal binding13141Calcium By similarity
Site186 – 1872Cleavage; by procollagen N-endopeptidase By similarity
Site1246 – 12472Cleavage; by procollagen C-endopeptidase By similarity

Amino acid modifications

Glycosylation13931N-linked (GlcNAc...) Potential
Disulfide bond1288 ↔ 1320 By similarity
Disulfide bond1294Interchain (with C-1311) By similarity
Disulfide bond1311Interchain (with C-1294) By similarity
Disulfide bond1328 ↔ 1490 By similarity
Disulfide bond1398 ↔ 1443 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P4Z2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DB7AF42B94210EB7

FASTA1,492142,696
        10         20         30         40         50         60 
MFSFVDSRTL VLFAATQVIL LAVVRCQDEE DVLATGSCVQ HGQRYSDKDV WKPEPCQICV 

        70         80         90        100        110        120 
CDTGNVLCDE IICEDPKDCP NAEIPFGECC PICPTEQSST SSGQGVLKGQ KGEPGDIKDV 

       130        140        150        160        170        180 
VGPKGPPGPQ GPSGEQGPRG DRGDKGEKGA PGPRGRDGEP GTPGNPGPVG PPGPPGPPGL 

       190        200        210        220        230        240 
GGNFAAQMTG GFDEKAGGAQ MGVMQGPMGP MGPRGPPGPT GAPGPQGFQG NPGEPGEPGA 

       250        260        270        280        290        300 
GGPMGPRGPP GPAGKPGDDG EAGKPGKSGE RGPPGPQGAR GFPGTPGLPG VKGHRGYPGL 

       310        320        330        340        350        360 
DGSKGEAGAA GAKGEGGATG EAGSPGPMGP RGLPGERGRP GASGAAGARG NDGLPGPAGP 

       370        380        390        400        410        420 
PGPVGPAGAP GFPGAPGSKG EAGPTGARGP EGAQGPRGES GTPGSPGPAG ASGNPGTDGI 

       430        440        450        460        470        480 
PGAKGSSGAP GIAGAPGFPG PRGPPGPQGA TGPLGPKGQT GDPGVAGFKG EHGPKGEIGS 

       490        500        510        520        530        540 
AGPQGAPGPA GEEGKRGARG EPGAAGPLGP PGERGAPGNR GFPGQDGLAG PKGAPGERGV 

       550        560        570        580        590        600 
PGLGGPKGAN GDPGRPGEPG LPGARGLTGR PGDAGPQGKV GPSGASGEDG RPGPPGPQGA 

       610        620        630        640        650        660 
RGQPGVMGFP GPKGANGEPG KAGEKGLLGA PGLRGLPGKD GETGAQGPNG PAGPAGERGE 

       670        680        690        700        710        720 
QGPPGPSGFQ GLPGPPGSPG EGGKPGDQGV PGEAGAPGLV GPRGERGFPG ERGSSGPQGL 

       730        740        750        760        770        780 
QGPRGLPGTP GTDGPKGATG PSGPNGAQGP PGLQGMPGER GAAGISGPKG DRGDTGEKGP 

       790        800        810        820        830        840 
EGAPGKDGSR GLTGPIGPPG PSGPNGEKGE SGPSGPAGIV GARGAPGDRG ETGPPGPAGF 

       850        860        870        880        890        900 
AGPPGADGQA GLKGDQGESG QKGDAGAPGP QGPSGAPGPQ GPTGVNGPKG ARGAQGPPGA 

       910        920        930        940        950        960 
TGFPGAAGRV GPPGPNGNPG PSGAPGSAGK EGPKGARGDA GPTGRAGDPG LQGPAGVPGE 

       970        980        990       1000       1010       1020 
KGESGEDGPS GPDGPPGPQG LSGQRGIVGL PGQRGERGFP GLPGPSGEPG KQGGPGSAGD 

      1030       1040       1050       1060       1070       1080 
RGPPGPVGPP GLTGPAGEPG REGNAGSDGP PGRDGATGIK GDRGETGPLG APGAPGAPGA 

      1090       1100       1110       1120       1130       1140 
PGPVGPTGKQ GDRGESGPQG PLGPSGPAGA RGLPGPQGPR GDKGEAGEAG ERGQKGHRGF 

      1150       1160       1170       1180       1190       1200 
TGLQGLPGPP GTAGDQGASG PAGPGGPRGP PGPVGPSGKD GSNGLPGPIG PPGPRGRGGE 

      1210       1220       1230       1240       1250       1260 
TGPAGPPGQP GPPGPPGPPG PGIDMSAFAG LSQPEKGPDP MRYMRADQAS SSVPQRDVDV 

      1270       1280       1290       1300       1310       1320 
EATLKSLNNQ IESIRSPDGT KKNPARTCRD LKLCHPEWKS GDYWIDPNQG CTVDAIKVFC 

      1330       1340       1350       1360       1370       1380 
NMETGETCVY PNPSKIPKKN WWSAKGKEKK HIWFGETING GFQFSYGDDS SAPNTANIQM 

      1390       1400       1410       1420       1430       1440 
TFLRLLSTDA TQNITYHCKN SIAFMDEASG NLKKAVLLQG SNDVEIRAEG NSRFTYNALE 

      1450       1460       1470       1480       1490 
DGCKKHTGKW SKTVIEYRTQ KTSRLPIVDI APMDIGGADQ EFGVDIGPVC FL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC063191 mRNA. Translation: AAH63191.1.
RefSeqNP_989220.1. NM_203889.1.
UniGeneStr.54515.

3D structure databases

ProteinModelPortalQ6P4Z2.
SMRQ6P4Z2. Positions 36-101.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000023334.

Proteomic databases

PaxDbQ6P4Z2.
PRIDEQ6P4Z2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394828.
KEGGxtr:394828.

Organism-specific databases

CTD1280.
XenbaseXB-GENE-6258353. col2a1.

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG004933.
KOK06236.

Family and domain databases

InterProIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamPF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCO2A1_XENTR
AccessionPrimary (citable) accession number: Q6P4Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families