Q6P4Z2 (CO2A1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(II) chain

Alternative name(s):
Alpha-1 type II collagen

Gene names

Name:

col2a1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	1492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces By similarity.
Subunit structure	Homotrimers of alpha 1(II) chains By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Propeptide	27 – 186	160	N-terminal propeptide By similarity		PRO_0000286181
	Chain	187 – 1246	1060	Collagen alpha-1(II) chain		PRO_0000286182
	Propeptide	1247 – 1492	246	C-terminal propeptide By similarity		PRO_0000286183
Regions
	Domain	36 – 94	59	VWFC
	Domain	1258 – 1492	235	Fibrillar collagen NC1
	Region	206 – 1219	1014	Triple-helical region
	Region	1220 – 1246	27	Nonhelical region (C-terminal)
Sites
	Metal binding	1306	1	Calcium By similarity
	Metal binding	1308	1	Calcium By similarity
	Metal binding	1309	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1311	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1314	1	Calcium By similarity
	Site	186 – 187	2	Cleavage; by procollagen N-endopeptidase By similarity
	Site	1246 – 1247	2	Cleavage; by procollagen C-endopeptidase By similarity
Amino acid modifications
	Glycosylation	1393	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1288 ↔ 1320		By similarity
	Disulfide bond	1294		Interchain (with C-1311) By similarity
	Disulfide bond	1311		Interchain (with C-1294) By similarity
	Disulfide bond	1328 ↔ 1490		By similarity
	Disulfide bond	1398 ↔ 1443		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P4Z2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DB7AF42B94210EB7	FASTA	1,492	142,696
	10 20 30 40 50 60 MFSFVDSRTL VLFAATQVIL LAVVRCQDEE DVLATGSCVQ HGQRYSDKDV WKPEPCQICV 70 80 90 100 110 120 CDTGNVLCDE IICEDPKDCP NAEIPFGECC PICPTEQSST SSGQGVLKGQ KGEPGDIKDV 130 140 150 160 170 180 VGPKGPPGPQ GPSGEQGPRG DRGDKGEKGA PGPRGRDGEP GTPGNPGPVG PPGPPGPPGL 190 200 210 220 230 240 GGNFAAQMTG GFDEKAGGAQ MGVMQGPMGP MGPRGPPGPT GAPGPQGFQG NPGEPGEPGA 250 260 270 280 290 300 GGPMGPRGPP GPAGKPGDDG EAGKPGKSGE RGPPGPQGAR GFPGTPGLPG VKGHRGYPGL 310 320 330 340 350 360 DGSKGEAGAA GAKGEGGATG EAGSPGPMGP RGLPGERGRP GASGAAGARG NDGLPGPAGP 370 380 390 400 410 420 PGPVGPAGAP GFPGAPGSKG EAGPTGARGP EGAQGPRGES GTPGSPGPAG ASGNPGTDGI 430 440 450 460 470 480 PGAKGSSGAP GIAGAPGFPG PRGPPGPQGA TGPLGPKGQT GDPGVAGFKG EHGPKGEIGS 490 500 510 520 530 540 AGPQGAPGPA GEEGKRGARG EPGAAGPLGP PGERGAPGNR GFPGQDGLAG PKGAPGERGV 550 560 570 580 590 600 PGLGGPKGAN GDPGRPGEPG LPGARGLTGR PGDAGPQGKV GPSGASGEDG RPGPPGPQGA 610 620 630 640 650 660 RGQPGVMGFP GPKGANGEPG KAGEKGLLGA PGLRGLPGKD GETGAQGPNG PAGPAGERGE 670 680 690 700 710 720 QGPPGPSGFQ GLPGPPGSPG EGGKPGDQGV PGEAGAPGLV GPRGERGFPG ERGSSGPQGL 730 740 750 760 770 780 QGPRGLPGTP GTDGPKGATG PSGPNGAQGP PGLQGMPGER GAAGISGPKG DRGDTGEKGP 790 800 810 820 830 840 EGAPGKDGSR GLTGPIGPPG PSGPNGEKGE SGPSGPAGIV GARGAPGDRG ETGPPGPAGF 850 860 870 880 890 900 AGPPGADGQA GLKGDQGESG QKGDAGAPGP QGPSGAPGPQ GPTGVNGPKG ARGAQGPPGA 910 920 930 940 950 960 TGFPGAAGRV GPPGPNGNPG PSGAPGSAGK EGPKGARGDA GPTGRAGDPG LQGPAGVPGE 970 980 990 1000 1010 1020 KGESGEDGPS GPDGPPGPQG LSGQRGIVGL PGQRGERGFP GLPGPSGEPG KQGGPGSAGD 1030 1040 1050 1060 1070 1080 RGPPGPVGPP GLTGPAGEPG REGNAGSDGP PGRDGATGIK GDRGETGPLG APGAPGAPGA 1090 1100 1110 1120 1130 1140 PGPVGPTGKQ GDRGESGPQG PLGPSGPAGA RGLPGPQGPR GDKGEAGEAG ERGQKGHRGF 1150 1160 1170 1180 1190 1200 TGLQGLPGPP GTAGDQGASG PAGPGGPRGP PGPVGPSGKD GSNGLPGPIG PPGPRGRGGE 1210 1220 1230 1240 1250 1260 TGPAGPPGQP GPPGPPGPPG PGIDMSAFAG LSQPEKGPDP MRYMRADQAS SSVPQRDVDV 1270 1280 1290 1300 1310 1320 EATLKSLNNQ IESIRSPDGT KKNPARTCRD LKLCHPEWKS GDYWIDPNQG CTVDAIKVFC 1330 1340 1350 1360 1370 1380 NMETGETCVY PNPSKIPKKN WWSAKGKEKK HIWFGETING GFQFSYGDDS SAPNTANIQM 1390 1400 1410 1420 1430 1440 TFLRLLSTDA TQNITYHCKN SIAFMDEASG NLKKAVLLQG SNDVEIRAEG NSRFTYNALE 1450 1460 1470 1480 1490 DGCKKHTGKW SKTVIEYRTQ KTSRLPIVDI APMDIGGADQ EFGVDIGPVC FL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC063191 mRNA. Translation: AAH63191.1.
RefSeq	NP_989220.1. NM_203889.1.
UniGene	Str.68458.
3D structure databases
HSSP	HSSP built from PDB template 1Q7D based on UniProtKB Q15201.
ProteinModelPortal	Q6P4Z2.
SMR	Q6P4Z2. Positions 36-101.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000023334.
Proteomic databases
PaxDb	Q6P4Z2.
PRIDE	Q6P4Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	394828.
KEGG	xtr:394828.
Organism-specific databases
CTD	1280.
Xenbase	XB-GENE-6258353. col2a1.
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG004933.
KO	K06236.
Family and domain databases
InterPro	IPR008160. Collagen. IPR000885. Fib_collagen_C. IPR001007. VWF_C. [Graphical view]
Pfam	PF01410. COLFI. 1 hit. PF01391. Collagen. 7 hits. PF00093. VWC. 1 hit. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS51461. NC1_FIB. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CO2A1_XENTR

Accession

Primary (citable) accession number: Q6P4Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program