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Q6P4Z2

- CO2A1_XENTR

UniProt

Q6P4Z2 - CO2A1_XENTR

Protein

Collagen alpha-1(II) chain

Gene

col2a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei186 – 1872Cleavage; by procollagen N-endopeptidaseBy similarity
    Sitei1246 – 12472Cleavage; by procollagen C-endopeptidaseBy similarity
    Metal bindingi1306 – 13061CalciumBy similarity
    Metal bindingi1308 – 13081CalciumBy similarity
    Metal bindingi1309 – 13091Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1311 – 13111Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1314 – 13141CalciumBy similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(II) chain
    Alternative name(s):
    Alpha-1 type II collagen
    Gene namesi
    Name:col2a1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-6258353. col2a1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 186160N-terminal propeptideBy similarityPRO_0000286181Add
    BLAST
    Chaini187 – 12461060Collagen alpha-1(II) chainPRO_0000286182Add
    BLAST
    Propeptidei1247 – 1492246C-terminal propeptideBy similarityPRO_0000286183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1288 ↔ 1320PROSITE-ProRule annotation
    Disulfide bondi1294 – 1294Interchain (with C-1311)PROSITE-ProRule annotation
    Disulfide bondi1311 – 1311Interchain (with C-1294)PROSITE-ProRule annotation
    Disulfide bondi1328 ↔ 1490PROSITE-ProRule annotation
    Glycosylationi1393 – 13931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1398 ↔ 1443PROSITE-ProRule annotation

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiQ6P4Z2.
    PRIDEiQ6P4Z2.

    Interactioni

    Subunit structurei

    Homotrimers of alpha 1(II) chains.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000023334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P4Z2.
    SMRiQ6P4Z2. Positions 36-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 9459VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini1258 – 1492235Fibrillar collagen NC1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni206 – 12191014Triple-helical regionAdd
    BLAST
    Regioni1220 – 124627Nonhelical region (C-terminal)Add
    BLAST

    Domaini

    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
    Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG004933.
    KOiK06236.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01410. COLFI. 1 hit.
    PF01391. Collagen. 7 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    ProDomiPD002078. Fib_collagen_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00038. COLFI. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS51461. NC1_FIB. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P4Z2-1 [UniParc]FASTAAdd to Basket

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    MFSFVDSRTL VLFAATQVIL LAVVRCQDEE DVLATGSCVQ HGQRYSDKDV     50
    WKPEPCQICV CDTGNVLCDE IICEDPKDCP NAEIPFGECC PICPTEQSST 100
    SSGQGVLKGQ KGEPGDIKDV VGPKGPPGPQ GPSGEQGPRG DRGDKGEKGA 150
    PGPRGRDGEP GTPGNPGPVG PPGPPGPPGL GGNFAAQMTG GFDEKAGGAQ 200
    MGVMQGPMGP MGPRGPPGPT GAPGPQGFQG NPGEPGEPGA GGPMGPRGPP 250
    GPAGKPGDDG EAGKPGKSGE RGPPGPQGAR GFPGTPGLPG VKGHRGYPGL 300
    DGSKGEAGAA GAKGEGGATG EAGSPGPMGP RGLPGERGRP GASGAAGARG 350
    NDGLPGPAGP PGPVGPAGAP GFPGAPGSKG EAGPTGARGP EGAQGPRGES 400
    GTPGSPGPAG ASGNPGTDGI PGAKGSSGAP GIAGAPGFPG PRGPPGPQGA 450
    TGPLGPKGQT GDPGVAGFKG EHGPKGEIGS AGPQGAPGPA GEEGKRGARG 500
    EPGAAGPLGP PGERGAPGNR GFPGQDGLAG PKGAPGERGV PGLGGPKGAN 550
    GDPGRPGEPG LPGARGLTGR PGDAGPQGKV GPSGASGEDG RPGPPGPQGA 600
    RGQPGVMGFP GPKGANGEPG KAGEKGLLGA PGLRGLPGKD GETGAQGPNG 650
    PAGPAGERGE QGPPGPSGFQ GLPGPPGSPG EGGKPGDQGV PGEAGAPGLV 700
    GPRGERGFPG ERGSSGPQGL QGPRGLPGTP GTDGPKGATG PSGPNGAQGP 750
    PGLQGMPGER GAAGISGPKG DRGDTGEKGP EGAPGKDGSR GLTGPIGPPG 800
    PSGPNGEKGE SGPSGPAGIV GARGAPGDRG ETGPPGPAGF AGPPGADGQA 850
    GLKGDQGESG QKGDAGAPGP QGPSGAPGPQ GPTGVNGPKG ARGAQGPPGA 900
    TGFPGAAGRV GPPGPNGNPG PSGAPGSAGK EGPKGARGDA GPTGRAGDPG 950
    LQGPAGVPGE KGESGEDGPS GPDGPPGPQG LSGQRGIVGL PGQRGERGFP 1000
    GLPGPSGEPG KQGGPGSAGD RGPPGPVGPP GLTGPAGEPG REGNAGSDGP 1050
    PGRDGATGIK GDRGETGPLG APGAPGAPGA PGPVGPTGKQ GDRGESGPQG 1100
    PLGPSGPAGA RGLPGPQGPR GDKGEAGEAG ERGQKGHRGF TGLQGLPGPP 1150
    GTAGDQGASG PAGPGGPRGP PGPVGPSGKD GSNGLPGPIG PPGPRGRGGE 1200
    TGPAGPPGQP GPPGPPGPPG PGIDMSAFAG LSQPEKGPDP MRYMRADQAS 1250
    SSVPQRDVDV EATLKSLNNQ IESIRSPDGT KKNPARTCRD LKLCHPEWKS 1300
    GDYWIDPNQG CTVDAIKVFC NMETGETCVY PNPSKIPKKN WWSAKGKEKK 1350
    HIWFGETING GFQFSYGDDS SAPNTANIQM TFLRLLSTDA TQNITYHCKN 1400
    SIAFMDEASG NLKKAVLLQG SNDVEIRAEG NSRFTYNALE DGCKKHTGKW 1450
    SKTVIEYRTQ KTSRLPIVDI APMDIGGADQ EFGVDIGPVC FL 1492
    Length:1,492
    Mass (Da):142,696
    Last modified:July 5, 2004 - v1
    Checksum:iDB7AF42B94210EB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063191 mRNA. Translation: AAH63191.1.
    RefSeqiNP_989220.1. NM_203889.1.
    UniGeneiStr.54515.

    Genome annotation databases

    GeneIDi394828.
    KEGGixtr:394828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063191 mRNA. Translation: AAH63191.1 .
    RefSeqi NP_989220.1. NM_203889.1.
    UniGenei Str.54515.

    3D structure databases

    ProteinModelPortali Q6P4Z2.
    SMRi Q6P4Z2. Positions 36-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000023334.

    Proteomic databases

    PaxDbi Q6P4Z2.
    PRIDEi Q6P4Z2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394828.
    KEGGi xtr:394828.

    Organism-specific databases

    CTDi 1280.
    Xenbasei XB-GENE-6258353. col2a1.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG004933.
    KOi K06236.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01410. COLFI. 1 hit.
    PF01391. Collagen. 7 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    ProDomi PD002078. Fib_collagen_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00038. COLFI. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS51461. NC1_FIB. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCO2A1_XENTR
    AccessioniPrimary (citable) accession number: Q6P4Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3