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Protein

Eyes absent homolog

Gene

Eya3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homologUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Eya3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109339. Eya3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-60447N.
STRINGi10090.ENSMUSP00000080425.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. EYA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3107. Eukaryota.
ENOG410XT12. LUCA.
GeneTreeiENSGT00390000008860.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
OMAiSQYQACY.
TreeFamiTF319337.

Family and domain databases

InterProiIPR028479. EYA3.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF5. PTHR10190:SF5. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P4T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEQDLPEQ PVKKAKMQEP REQTLSQVNN PDASDEKPET SSLASNLSMS
60 70 80 90 100
EEIMTCTDYI PRSSNDYTSQ MYSAKPYAHI LSVPVSETTY PGQTQYQTLQ
110 120 130 140 150
QSQPYAVYPQ ATQTYGLPPF ASSTNASLIP TSSAIANIPA AAVASISNQD
160 170 180 190 200
YPTYTILGQN QYQACYPSSS FGVTGQTNSD AETTTLAATT YQTEKPSAMV
210 220 230 240 250
PAPATQRLPS DSSASPPLSQ TTPNKDADDQ ARKNMTVKNR GKRKADASSS
260 270 280 290 300
QDSELERVFL WDLDETIIIF HSLLTGSYAQ KYGKDPTVVI GSGLTMEEMI
310 320 330 340 350
FEVADTHLFF NDLEECDQVH VEDVASDDNG QDLSNYSFST DGFSGSGGSG
360 370 380 390 400
SHGSSVGVQG GVDWMRKLAF RYRKVREIYD KHKSNVGGLL SPQRKEALQR
410 420 430 440 450
LRAEIEVLTD SWLGTALKSL LLIQSRKNCA NVLITTTQLV PALAKVLLYG
460 470 480 490 500
LGEIFPIENI YSATKIGKES CFERIVSRFG KKVTYVVIGD GRDEEIAAKQ
510 520
HNMPFWRITN HGDLVSLHQA LELDFL
Length:526
Mass (Da):57,854
Last modified:July 5, 2004 - v1
Checksum:i7324723EB0D9701A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627130 Genomic DNA. No translation available.
BC063259 mRNA. Translation: AAH63259.1.
RefSeqiNP_997592.1. NM_210071.2.
NP_997596.1. NM_211357.2.
UniGeneiMm.227733.

Genome annotation databases

EnsembliENSMUST00000081726; ENSMUSP00000080425; ENSMUSG00000028886.
GeneIDi14050.
UCSCiuc008vbp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627130 Genomic DNA. No translation available.
BC063259 mRNA. Translation: AAH63259.1.
RefSeqiNP_997592.1. NM_210071.2.
NP_997596.1. NM_211357.2.
UniGeneiMm.227733.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60447N.
STRINGi10090.ENSMUSP00000080425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081726; ENSMUSP00000080425; ENSMUSG00000028886.
GeneIDi14050.
UCSCiuc008vbp.2. mouse.

Organism-specific databases

CTDi2140.
MGIiMGI:109339. Eya3.

Phylogenomic databases

eggNOGiKOG3107. Eukaryota.
ENOG410XT12. LUCA.
GeneTreeiENSGT00390000008860.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
OMAiSQYQACY.
TreeFamiTF319337.

Miscellaneous databases

ChiTaRSiEya3. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR028479. EYA3.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF5. PTHR10190:SF5. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6P4T3_MOUSE
AccessioniPrimary (citable) accession number: Q6P4T3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.