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Protein

Eyes absent homolog

Gene

Eya3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homologUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Eya3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109339. Eya3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000028886.

Interactioni

Protein-protein interaction databases

DIPiDIP-60447N.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. EYA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3107. Eukaryota.
ENOG410XT12. LUCA.
GeneTreeiENSGT00390000008860.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
OMAiSQYQACY.
OrthoDBiEOG091G04YD.
TreeFamiTF319337.

Family and domain databases

CDDicd02601. HAD_Eya. 1 hit.
Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR028479. EYA3.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
IPR023214. HAD-like_dom.
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF19. PTHR10190:SF19. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P4T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEQDLPEQ PVKKAKMQEP REQTLSQVNN PDASDEKPET SSLASNLSMS
60 70 80 90 100
EEIMTCTDYI PRSSNDYTSQ MYSAKPYAHI LSVPVSETTY PGQTQYQTLQ
110 120 130 140 150
QSQPYAVYPQ ATQTYGLPPF ASSTNASLIP TSSAIANIPA AAVASISNQD
160 170 180 190 200
YPTYTILGQN QYQACYPSSS FGVTGQTNSD AETTTLAATT YQTEKPSAMV
210 220 230 240 250
PAPATQRLPS DSSASPPLSQ TTPNKDADDQ ARKNMTVKNR GKRKADASSS
260 270 280 290 300
QDSELERVFL WDLDETIIIF HSLLTGSYAQ KYGKDPTVVI GSGLTMEEMI
310 320 330 340 350
FEVADTHLFF NDLEECDQVH VEDVASDDNG QDLSNYSFST DGFSGSGGSG
360 370 380 390 400
SHGSSVGVQG GVDWMRKLAF RYRKVREIYD KHKSNVGGLL SPQRKEALQR
410 420 430 440 450
LRAEIEVLTD SWLGTALKSL LLIQSRKNCA NVLITTTQLV PALAKVLLYG
460 470 480 490 500
LGEIFPIENI YSATKIGKES CFERIVSRFG KKVTYVVIGD GRDEEIAAKQ
510 520
HNMPFWRITN HGDLVSLHQA LELDFL
Length:526
Mass (Da):57,854
Last modified:July 5, 2004 - v1
Checksum:i7324723EB0D9701A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627130 Genomic DNA. No translation available.
BC063259 mRNA. Translation: AAH63259.1.
RefSeqiNP_997592.1. NM_210071.2.
NP_997596.1. NM_211357.2.
UniGeneiMm.227733.

Genome annotation databases

EnsembliENSMUST00000081726; ENSMUSP00000080425; ENSMUSG00000028886.
GeneIDi14050.
UCSCiuc008vbp.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ6P4T3_MOUSE
AccessioniPrimary (citable) accession number: Q6P4T3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported