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Protein

Autophagy-related protein 2 homolog A

Gene

Atg2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (By similarity). Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog A
Gene namesi
Name:Atg2a
Synonyms:Kiaa0404
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1916291. Atg2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152351 – 1914Autophagy-related protein 2 homolog AAdd BLAST1914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei764PhosphoserineBy similarity1
Modified residuei869PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei877PhosphoserineCombined sources1
Modified residuei1246PhosphoserineCombined sources1
Modified residuei1282PhosphoserineBy similarity1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1381PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P4T0.
MaxQBiQ6P4T0.
PaxDbiQ6P4T0.
PRIDEiQ6P4T0.

PTM databases

iPTMnetiQ6P4T0.
PhosphoSitePlusiQ6P4T0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024773.
ExpressionAtlasiQ6P4T0. baseline and differential.
GenevisibleiQ6P4T0. MM.

Interactioni

Protein-protein interaction databases

BioGridi236694. 3 interactors.
IntActiQ6P4T0. 2 interactors.
STRINGi10090.ENSMUSP00000046412.

Structurei

3D structure databases

ProteinModelPortaliQ6P4T0.
SMRiQ6P4T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ6P4T0.
KOiK17906.
OMAiLVKMTLG.
OrthoDBiEOG091G0W87.
PhylomeDBiQ6P4T0.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P4T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRWLWPWSN CVKERVCRYL LQHYLGHFFQ EHLSLDQLSL DLYKGSVALR
60 70 80 90 100
DIHLETWSVN EFLRSMESPL ELVEGFVSSI EVAVPWAALL TDHCTVCVSG
110 120 130 140 150
LQLTLQPRQG SGPGAADSQS WASCMTTSLQ LAQECLREGL PEPSEPPQPL
160 170 180 190 200
EGLEMFAQTI ETVLRRIKVT FLNTVVRVEH SLGDEDRSVA VEVRVQRLEY
210 220 230 240 250
CDEAVRDPSQ APPVDVHQPP AFLHKLLQLS GVCLYFEELP SQADPPQPPL
260 270 280 290 300
QIGSCTGYVE LMVRLKQNEA FPGPKLEVSG QLGSLHLLLT PRQLQQLQRL
310 320 330 340 350
LSAVNLADPA GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAESLSLY
360 370 380 390 400
PITNPLNLDS TDLFFSMAGL TSSVTSAVSE LSVYSVDLGS SVHSNMAFHR
410 420 430 440 450
PSTPPHSGGK MAPTPLLDTT RPDSLVKMTL GGVSLTLLQT ASPSSGPSDL
460 470 480 490 500
PTHFFAEFDA AKDGPFGSRD FSHLRPRFQR ACPCSHVRLT GTAVQLSWEL
510 520 530 540 550
RTGSHSRRTS STEVHFGQLE VLECLWPRAA TEPEYTEILS FPSHSGSEAS
560 570 580 590 600
ARPCAHLRHT QTIRRVLKSR SRRSTACHCH SELSLDLADF QSDVELGSLD
610 620 630 640 650
RLAALFRQVT TPSEPPAGLL TEPPQATELQ TVFRLSAPRA TLRLRFPIPD
660 670 680 690 700
LRPDRDPWAG QAVRAEQLRL ELSEPQFRSE LNSGPGPPAP TRLELTCSDL
710 720 730 740 750
QGIYEDGEKP PVPCLRVSKA LNPRSTEAKY FLPQVVVTLN PQSSGTQWET
760 770 780 790 800
AYEKGRDLEL STESPCELQQ PEPSPFSSKR TMYETEEMVI PGDPEEMRTF
810 820 830 840 850
QSRTLALSRC TLDVIMPSAH IFLPSKEVYE SIYNRINNDL LMWEPADLLP
860 870 880 890 900
TSSAAARPPG SSGFKMCKSA FKLDSDSDEE DAQFFSMASG VPQTPAPEPS
910 920 930 940 950
RRQSQSTFST LVTVLKGRIT ALCEAKDETG KRLDVTHGEL VLDVEQGTIF
960 970 980 990 1000
SVAQYRGQPG LGYFCLEAEK AKLYHRAAIE DYLLPTHLEV PSFAPPAQLA
1010 1020 1030 1040 1050
PTIYPSEEGV TERGTLGRKG QGPPMLSAAV RIHLDPHKNV KEFLVTVRLH
1060 1070 1080 1090 1100
KATLRHYMAP PEQSWHSQLL DFLDVLDDPV LGYLPPTVIT VLHTHLFSCA
1110 1120 1130 1140 1150
VDYRPLYLPV RVLVTAETFT LSSNIVMDTS TFLLRFILDD SALYLSDKCE
1160 1170 1180 1190 1200
VESLDLRRDY VCVLDIDLLE LVIKTWKGST EGRLSQPLFE LRCSNNVVHV
1210 1220 1230 1240 1250
HSCADSCALL VNLLQYLTSS GDLHPPPRPP SPTEIAGQKL SESPASLPSC
1260 1270 1280 1290 1300
LPVETALINQ RDLTDALLDT ERRGLQELAQ SSGGPLPQAS PVSVYLFPGE
1310 1320 1330 1340 1350
RSGAQAPLPP PGASSHTLGS KAKEHENEEE GDGDTLDSDE FCILDAPGLG
1360 1370 1380 1390 1400
IAPRDGEPIV TQLHPGPIIV HDGHFSQPLG STDLLRAPAH FPVPSSRVVL
1410 1420 1430 1440 1450
REVSFIWHLY GGRDFGLHPT YRARVGLTGP RVSPSRSSGP NRPQNSWRTQ
1460 1470 1480 1490 1500
GGIGRQHQVL MEIQLSKVSF QHEVYPEESA IAGGLGQELD ERPLSRQVLI
1510 1520 1530 1540 1550
VQELEIRDRL ATSKINKFLH LHTSERLPRR THSNMLTIKA LHVAPTSSVG
1560 1570 1580 1590 1600
GPECCLRVSM MPLRLNVDQD ALFFLKDFFT SLAASINPMV PGDTSEAPRE
1610 1620 1630 1640 1650
THSRPGSPQE GQSEDTETAS NPPEAPGSSH SSSDQQPIYF REFRFTSEVP
1660 1670 1680 1690 1700
ICLDYHGKHV TVDQVGTFMG LLIGLAQLNC SELKLKRLCC RHGLLGVDKV
1710 1720 1730 1740 1750
LCYALNEWLQ DIRKNQLPGL LGGVGPMHSV VQLFQGFRDL LWLPIEQYRK
1760 1770 1780 1790 1800
DGRLIRGLQR GAASFGSSTA SAALELSNRL VQAIQATAET VYDILSPASP
1810 1820 1830 1840 1850
VSRSLQDKRS SRKLRRGQQP ADLREGMAKA YDAVREGILD TAQTICDVAS
1860 1870 1880 1890 1900
RGHEQKGLTG AVGGVIRQLP PTVVKPIIVA TEATSNVLGG MRNQILPDAH
1910
KDHALKWRLE EAQD
Length:1,914
Mass (Da):210,939
Last modified:September 19, 2006 - v2
Checksum:i16742111A5534572
GO

Sequence cautioni

The sequence BAC97942 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE30685 differs from that shown. Reason: Frameshift at position 1765.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285L → M in BAC97942 (PubMed:14621295).Curated1
Sequence conflicti1738R → G in BAE30685 (PubMed:16141072).Curated1
Sequence conflicti1865V → M in BAE30685 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129132 mRNA. Translation: BAC97942.1. Different initiation.
BC022657 mRNA. Translation: AAH22657.1.
BC056482 mRNA. Translation: AAH56482.2.
BC063264 mRNA. Translation: AAH63264.2.
AK151782 mRNA. Translation: BAE30685.1. Frameshift.
CCDSiCCDS29500.1.
RefSeqiNP_919329.2. NM_194348.3.
UniGeneiMm.277384.

Genome annotation databases

EnsembliENSMUST00000045351; ENSMUSP00000046412; ENSMUSG00000024773.
ENSMUST00000201269; ENSMUSP00000144551; ENSMUSG00000106907.
GeneIDi329015.
KEGGimmu:329015.
UCSCiuc008ghu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129132 mRNA. Translation: BAC97942.1. Different initiation.
BC022657 mRNA. Translation: AAH22657.1.
BC056482 mRNA. Translation: AAH56482.2.
BC063264 mRNA. Translation: AAH63264.2.
AK151782 mRNA. Translation: BAE30685.1. Frameshift.
CCDSiCCDS29500.1.
RefSeqiNP_919329.2. NM_194348.3.
UniGeneiMm.277384.

3D structure databases

ProteinModelPortaliQ6P4T0.
SMRiQ6P4T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236694. 3 interactors.
IntActiQ6P4T0. 2 interactors.
STRINGi10090.ENSMUSP00000046412.

PTM databases

iPTMnetiQ6P4T0.
PhosphoSitePlusiQ6P4T0.

Proteomic databases

EPDiQ6P4T0.
MaxQBiQ6P4T0.
PaxDbiQ6P4T0.
PRIDEiQ6P4T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045351; ENSMUSP00000046412; ENSMUSG00000024773.
ENSMUST00000201269; ENSMUSP00000144551; ENSMUSG00000106907.
GeneIDi329015.
KEGGimmu:329015.
UCSCiuc008ghu.1. mouse.

Organism-specific databases

CTDi23130.
MGIiMGI:1916291. Atg2a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ6P4T0.
KOiK17906.
OMAiLVKMTLG.
OrthoDBiEOG091G0W87.
PhylomeDBiQ6P4T0.
TreeFamiTF313482.

Miscellaneous databases

ChiTaRSiAtg2a. mouse.
PROiQ6P4T0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024773.
ExpressionAtlasiQ6P4T0. baseline and differential.
GenevisibleiQ6P4T0. MM.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG2A_MOUSE
AccessioniPrimary (citable) accession number: Q6P4T0
Secondary accession number(s): Q3U9I1
, Q6PHN0, Q6ZQC4, Q8R213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 19, 2006
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.