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Protein

Autophagy-related protein 2 homolog A

Gene

Atg2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (By similarity). Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog A
Gene namesi
Name:Atg2a
Synonyms:Kiaa0404
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1916291. Atg2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19141914Autophagy-related protein 2 homolog APRO_0000315235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei764 – 7641PhosphoserineBy similarity
Modified residuei869 – 8691PhosphoserineCombined sources
Modified residuei875 – 8751PhosphoserineCombined sources
Modified residuei877 – 8771PhosphoserineCombined sources
Modified residuei1246 – 12461PhosphoserineCombined sources
Modified residuei1282 – 12821PhosphoserineBy similarity
Modified residuei1290 – 12901PhosphoserineBy similarity
Modified residuei1381 – 13811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P4T0.
MaxQBiQ6P4T0.
PaxDbiQ6P4T0.
PRIDEiQ6P4T0.

PTM databases

iPTMnetiQ6P4T0.
PhosphoSiteiQ6P4T0.

Expressioni

Gene expression databases

BgeeiQ6P4T0.
ExpressionAtlasiQ6P4T0. baseline and differential.
GenevisibleiQ6P4T0. MM.

Interactioni

Protein-protein interaction databases

BioGridi236694. 3 interactions.
IntActiQ6P4T0. 2 interactions.
STRINGi10090.ENSMUSP00000046412.

Structurei

3D structure databases

ProteinModelPortaliQ6P4T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ6P4T0.
KOiK17906.
OMAiLVKMTLG.
OrthoDBiEOG7S4X51.
PhylomeDBiQ6P4T0.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P4T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRWLWPWSN CVKERVCRYL LQHYLGHFFQ EHLSLDQLSL DLYKGSVALR
60 70 80 90 100
DIHLETWSVN EFLRSMESPL ELVEGFVSSI EVAVPWAALL TDHCTVCVSG
110 120 130 140 150
LQLTLQPRQG SGPGAADSQS WASCMTTSLQ LAQECLREGL PEPSEPPQPL
160 170 180 190 200
EGLEMFAQTI ETVLRRIKVT FLNTVVRVEH SLGDEDRSVA VEVRVQRLEY
210 220 230 240 250
CDEAVRDPSQ APPVDVHQPP AFLHKLLQLS GVCLYFEELP SQADPPQPPL
260 270 280 290 300
QIGSCTGYVE LMVRLKQNEA FPGPKLEVSG QLGSLHLLLT PRQLQQLQRL
310 320 330 340 350
LSAVNLADPA GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAESLSLY
360 370 380 390 400
PITNPLNLDS TDLFFSMAGL TSSVTSAVSE LSVYSVDLGS SVHSNMAFHR
410 420 430 440 450
PSTPPHSGGK MAPTPLLDTT RPDSLVKMTL GGVSLTLLQT ASPSSGPSDL
460 470 480 490 500
PTHFFAEFDA AKDGPFGSRD FSHLRPRFQR ACPCSHVRLT GTAVQLSWEL
510 520 530 540 550
RTGSHSRRTS STEVHFGQLE VLECLWPRAA TEPEYTEILS FPSHSGSEAS
560 570 580 590 600
ARPCAHLRHT QTIRRVLKSR SRRSTACHCH SELSLDLADF QSDVELGSLD
610 620 630 640 650
RLAALFRQVT TPSEPPAGLL TEPPQATELQ TVFRLSAPRA TLRLRFPIPD
660 670 680 690 700
LRPDRDPWAG QAVRAEQLRL ELSEPQFRSE LNSGPGPPAP TRLELTCSDL
710 720 730 740 750
QGIYEDGEKP PVPCLRVSKA LNPRSTEAKY FLPQVVVTLN PQSSGTQWET
760 770 780 790 800
AYEKGRDLEL STESPCELQQ PEPSPFSSKR TMYETEEMVI PGDPEEMRTF
810 820 830 840 850
QSRTLALSRC TLDVIMPSAH IFLPSKEVYE SIYNRINNDL LMWEPADLLP
860 870 880 890 900
TSSAAARPPG SSGFKMCKSA FKLDSDSDEE DAQFFSMASG VPQTPAPEPS
910 920 930 940 950
RRQSQSTFST LVTVLKGRIT ALCEAKDETG KRLDVTHGEL VLDVEQGTIF
960 970 980 990 1000
SVAQYRGQPG LGYFCLEAEK AKLYHRAAIE DYLLPTHLEV PSFAPPAQLA
1010 1020 1030 1040 1050
PTIYPSEEGV TERGTLGRKG QGPPMLSAAV RIHLDPHKNV KEFLVTVRLH
1060 1070 1080 1090 1100
KATLRHYMAP PEQSWHSQLL DFLDVLDDPV LGYLPPTVIT VLHTHLFSCA
1110 1120 1130 1140 1150
VDYRPLYLPV RVLVTAETFT LSSNIVMDTS TFLLRFILDD SALYLSDKCE
1160 1170 1180 1190 1200
VESLDLRRDY VCVLDIDLLE LVIKTWKGST EGRLSQPLFE LRCSNNVVHV
1210 1220 1230 1240 1250
HSCADSCALL VNLLQYLTSS GDLHPPPRPP SPTEIAGQKL SESPASLPSC
1260 1270 1280 1290 1300
LPVETALINQ RDLTDALLDT ERRGLQELAQ SSGGPLPQAS PVSVYLFPGE
1310 1320 1330 1340 1350
RSGAQAPLPP PGASSHTLGS KAKEHENEEE GDGDTLDSDE FCILDAPGLG
1360 1370 1380 1390 1400
IAPRDGEPIV TQLHPGPIIV HDGHFSQPLG STDLLRAPAH FPVPSSRVVL
1410 1420 1430 1440 1450
REVSFIWHLY GGRDFGLHPT YRARVGLTGP RVSPSRSSGP NRPQNSWRTQ
1460 1470 1480 1490 1500
GGIGRQHQVL MEIQLSKVSF QHEVYPEESA IAGGLGQELD ERPLSRQVLI
1510 1520 1530 1540 1550
VQELEIRDRL ATSKINKFLH LHTSERLPRR THSNMLTIKA LHVAPTSSVG
1560 1570 1580 1590 1600
GPECCLRVSM MPLRLNVDQD ALFFLKDFFT SLAASINPMV PGDTSEAPRE
1610 1620 1630 1640 1650
THSRPGSPQE GQSEDTETAS NPPEAPGSSH SSSDQQPIYF REFRFTSEVP
1660 1670 1680 1690 1700
ICLDYHGKHV TVDQVGTFMG LLIGLAQLNC SELKLKRLCC RHGLLGVDKV
1710 1720 1730 1740 1750
LCYALNEWLQ DIRKNQLPGL LGGVGPMHSV VQLFQGFRDL LWLPIEQYRK
1760 1770 1780 1790 1800
DGRLIRGLQR GAASFGSSTA SAALELSNRL VQAIQATAET VYDILSPASP
1810 1820 1830 1840 1850
VSRSLQDKRS SRKLRRGQQP ADLREGMAKA YDAVREGILD TAQTICDVAS
1860 1870 1880 1890 1900
RGHEQKGLTG AVGGVIRQLP PTVVKPIIVA TEATSNVLGG MRNQILPDAH
1910
KDHALKWRLE EAQD
Length:1,914
Mass (Da):210,939
Last modified:September 19, 2006 - v2
Checksum:i16742111A5534572
GO

Sequence cautioni

The sequence BAC97942.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE30685.1 differs from that shown. Reason: Frameshift at position 1765. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851L → M in BAC97942 (PubMed:14621295).Curated
Sequence conflicti1738 – 17381R → G in BAE30685 (PubMed:16141072).Curated
Sequence conflicti1865 – 18651V → M in BAE30685 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129132 mRNA. Translation: BAC97942.1. Different initiation.
BC022657 mRNA. Translation: AAH22657.1.
BC056482 mRNA. Translation: AAH56482.2.
BC063264 mRNA. Translation: AAH63264.2.
AK151782 mRNA. Translation: BAE30685.1. Frameshift.
CCDSiCCDS29500.1.
RefSeqiNP_919329.2. NM_194348.3.
UniGeneiMm.277384.

Genome annotation databases

EnsembliENSMUST00000045351; ENSMUSP00000046412; ENSMUSG00000024773.
ENSMUST00000201269; ENSMUSP00000144551; ENSMUSG00000106907.
GeneIDi329015.
KEGGimmu:329015.
UCSCiuc008ghu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129132 mRNA. Translation: BAC97942.1. Different initiation.
BC022657 mRNA. Translation: AAH22657.1.
BC056482 mRNA. Translation: AAH56482.2.
BC063264 mRNA. Translation: AAH63264.2.
AK151782 mRNA. Translation: BAE30685.1. Frameshift.
CCDSiCCDS29500.1.
RefSeqiNP_919329.2. NM_194348.3.
UniGeneiMm.277384.

3D structure databases

ProteinModelPortaliQ6P4T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236694. 3 interactions.
IntActiQ6P4T0. 2 interactions.
STRINGi10090.ENSMUSP00000046412.

PTM databases

iPTMnetiQ6P4T0.
PhosphoSiteiQ6P4T0.

Proteomic databases

EPDiQ6P4T0.
MaxQBiQ6P4T0.
PaxDbiQ6P4T0.
PRIDEiQ6P4T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045351; ENSMUSP00000046412; ENSMUSG00000024773.
ENSMUST00000201269; ENSMUSP00000144551; ENSMUSG00000106907.
GeneIDi329015.
KEGGimmu:329015.
UCSCiuc008ghu.1. mouse.

Organism-specific databases

CTDi23130.
MGIiMGI:1916291. Atg2a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ6P4T0.
KOiK17906.
OMAiLVKMTLG.
OrthoDBiEOG7S4X51.
PhylomeDBiQ6P4T0.
TreeFamiTF313482.

Miscellaneous databases

ChiTaRSiAtg2a. mouse.
PROiQ6P4T0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P4T0.
ExpressionAtlasiQ6P4T0. baseline and differential.
GenevisibleiQ6P4T0. MM.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1696-1914.
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-875 AND SER-877, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-869; SER-875; SER-877 AND SER-1246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans."
    Qin Q.M., Luo J., Lin X., Pei J., Li L., Ficht T.A., de Figueiredo P.
    PLoS Pathog. 7:E1002078-E1002078(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CRYPTOCOCCUS NEOFORMANS INFECTION.

Entry informationi

Entry nameiATG2A_MOUSE
AccessioniPrimary (citable) accession number: Q6P4T0
Secondary accession number(s): Q3U9I1
, Q6PHN0, Q6ZQC4, Q8R213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 19, 2006
Last modified: July 6, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.