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Q6P4Q7

- CNNM4_HUMAN

UniProt

Q6P4Q7 - CNNM4_HUMAN

Protein

Metal transporter CNNM4

Gene

CNNM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions By similarity. May play a role in biomineralization and retinal function.By similarity2 Publications

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. ion transport Source: UniProtKB-KW
    3. response to stimulus Source: UniProtKB-KW
    4. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Biomineralization, Ion transport, Sensory transduction, Transport, Vision

    Protein family/group databases

    TCDBi9.A.40.3.4. the hlyc/corc (hcc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metal transporter CNNM4
    Alternative name(s):
    Ancient conserved domain-containing protein 4
    Cyclin-M4
    Gene namesi
    Name:CNNM4
    Synonyms:ACDP4, KIAA1592
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:105. CNNM4.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Jalili syndrome (JALIS) [MIM:217080]: A syndrome characterized by the association of cone-rod dystrophy and amelogenesis imperfecta.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti196 – 1961S → P in JALIS. 1 Publication
    VAR_058319
    Natural varianti200 – 2001S → Y in JALIS. 1 Publication
    VAR_058320
    Natural varianti236 – 2361R → Q in JALIS. 1 Publication
    VAR_058321
    Natural varianti324 – 3241L → P in JALIS. 2 Publications
    VAR_058322

    Keywords - Diseasei

    Amelogenesis imperfecta, Cone-rod dystrophy, Disease mutation

    Organism-specific databases

    MIMi217080. phenotype.
    Orphaneti1873. Jalili syndrome.
    PharmGKBiPA26671.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 775775Metal transporter CNNM4PRO_0000295765Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Modified residuei664 – 6641PhosphoserineBy similarity
    Modified residuei770 – 7701PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P4Q7.
    PaxDbiQ6P4Q7.
    PRIDEiQ6P4Q7.

    PTM databases

    PhosphoSiteiQ6P4Q7.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in heart.1 Publication

    Gene expression databases

    ArrayExpressiQ6P4Q7.
    BgeeiQ6P4Q7.
    CleanExiHS_CNNM4.
    GenevestigatoriQ6P4Q7.

    Organism-specific databases

    HPAiHPA017732.

    Interactioni

    Subunit structurei

    Interacts with COX11.1 Publication

    Protein-protein interaction databases

    BioGridi117711. 3 interactions.
    STRINGi9606.ENSP00000366275.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IY3X-ray3.60A/B/C/D359-511[»]
    ProteinModelPortaliQ6P4Q7.
    SMRiQ6P4Q7. Positions 360-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 178178ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 24041CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 2643CytoplasmicSequence Analysis
    Topological domaini286 – 2938ExtracellularSequence Analysis
    Topological domaini317 – 775459CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini185 – 358174DUF21Add
    BLAST
    Domaini377 – 43862CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 51167CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ACDP family.Curated
    Contains 2 CBS domains.PROSITE-ProRule annotation
    Contains 1 DUF21 domain.Curated

    Keywords - Domaini

    CBS domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1253.
    HOGENOMiHOG000231947.
    HOVERGENiHBG074775.
    InParanoidiQ6P4Q7.
    KOiK16302.
    OMAiRREILIP.
    OrthoDBiEOG72ZCD7.
    PhylomeDBiQ6P4Q7.
    TreeFamiTF101012.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR000644. CBS_dom.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002550. DUF21.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00571. CBS. 1 hit.
    PF01595. DUF21. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    PROSITEiPS51371. CBS. 2 hits.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P4Q7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPVGGGGRP VGGPARGRLL LAAPVLLVLL WALGARGQGS PQQGTIVGMR    50
    LASCNKSCGT NPDGIIFVSE GSTVNLRLYG YSLGNISSNL ISFTEVDDAE 100
    TLHKSTSCLE LTKDLVVQQL VNVSRGNTSG VLVVLTKFLR RSESMKLYAL 150
    CTRAQPDGPW LKWTDKDSLL FMVEEPGRFL PLWLHILLIT VLLVLSGIFS 200
    GLNLGLMALD PMELRIVQNC GTEKERRYAR KIEPIRRKGN YLLCSLLLGN 250
    VLVNTSLTIL LDNLIGSGLM AVASSTIGIV IFGEILPQAL CSRHGLAVGA 300
    NTILLTKFFM LLTFPLSFPI SKLLDFFLGQ EIRTVYNREK LMEMLKVTEP 350
    YNDLVKEELN MIQGALELRT KTVEDIMTQL QDCFMIRSDA ILDFNTMSEI 400
    MESGYTRIPV FEDEQSNIVD ILYVKDLAFV DPDDCTPLKT ITRFYNHPVH 450
    FVFHDTKLDA MLEEFKKGKS HLAIVQKVNN EGEGDPFYEV LGLVTLEDVI 500
    EEIIKSEILD ESDMYTDNRS RKRVSEKNKR DFSAFKDADN ELKVKISPQL 550
    LLAAHRFLAT EVSQFSPSLI SEKILLRLLK YPDVIQELKF DEHNKYYARH 600
    YLYTRNKPAD YFILILQGKV EVEAGKENMK FETGAFSYYG TMALTSVPSD 650
    RSPAHPTPLS RSASLSYPDR TDVSTAATLA GSSNQFGSSV LGQYISDFSV 700
    RALVDLQYIK ITRQQYQNGL LASRMENSPQ FPIDGCTTHM ENLAEKSELP 750
    VVDETTTLLN ERNSLLHKAS HENAI 775
    Length:775
    Mass (Da):86,607
    Last modified:March 3, 2009 - v3
    Checksum:iD159303834A9416C
    GO
    Isoform 2 (identifier: Q6P4Q7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-513: Missing.
         711-775: ITRQQYQNGL...LHKASHENAI → PQSWPCFSRP...HPHGELGREV

    Note: No experimental confirmation available.

    Show »
    Length:263
    Mass (Da):29,485
    Checksum:i8AB7D712AD2BCC84
    GO

    Sequence cautioni

    The sequence AAF86370.1 differs from that shown. Reason: Frameshift at positions 108 and 120.
    The sequence AAY14963.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14266.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti302 – 3021T → I in AAF86370. (PubMed:12657465)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261G → R.1 Publication
    Corresponds to variant rs17855817 [ dbSNP | Ensembl ].
    VAR_033365
    Natural varianti134 – 1341V → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035946
    Natural varianti196 – 1961S → P in JALIS. 1 Publication
    VAR_058319
    Natural varianti200 – 2001S → Y in JALIS. 1 Publication
    VAR_058320
    Natural varianti236 – 2361R → Q in JALIS. 1 Publication
    VAR_058321
    Natural varianti324 – 3241L → P in JALIS. 2 Publications
    VAR_058322

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 513513Missing in isoform 2. 1 PublicationVSP_054271Add
    BLAST
    Alternative sequencei711 – 77565ITRQQ…HENAI → PQSWPCFSRPGDRVCLPAPP SMNSSLPHADHSAAVPERAA GFSHGEQPSVSHRRVHHPHG ELGREV in isoform 2. 1 PublicationVSP_054272Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022833 mRNA. Translation: BAB14266.1. Different initiation.
    AK293915 mRNA. Translation: BAH11626.1.
    AC092636 Genomic DNA. Translation: AAY14963.1. Different initiation.
    BC063295 mRNA. Translation: AAH63295.2.
    FJ619522 Genomic DNA. Translation: ACV32670.1.
    FJ619523 Genomic DNA. Translation: ACV32671.1.
    FJ619524 Genomic DNA. Translation: ACV32672.1.
    AF202777 mRNA. Translation: AAF86370.1. Frameshift.
    AB046812 mRNA. Translation: BAB13418.1.
    CCDSiCCDS2024.2. [Q6P4Q7-1]
    RefSeqiNP_064569.3. NM_020184.3. [Q6P4Q7-1]
    UniGeneiHs.175043.

    Genome annotation databases

    EnsembliENST00000377075; ENSP00000366275; ENSG00000158158. [Q6P4Q7-1]
    GeneIDi26504.
    KEGGihsa:26504.
    UCSCiuc002swx.3. human. [Q6P4Q7-1]

    Polymorphism databases

    DMDMi224471892.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022833 mRNA. Translation: BAB14266.1 . Different initiation.
    AK293915 mRNA. Translation: BAH11626.1 .
    AC092636 Genomic DNA. Translation: AAY14963.1 . Different initiation.
    BC063295 mRNA. Translation: AAH63295.2 .
    FJ619522 Genomic DNA. Translation: ACV32670.1 .
    FJ619523 Genomic DNA. Translation: ACV32671.1 .
    FJ619524 Genomic DNA. Translation: ACV32672.1 .
    AF202777 mRNA. Translation: AAF86370.1 . Frameshift.
    AB046812 mRNA. Translation: BAB13418.1 .
    CCDSi CCDS2024.2. [Q6P4Q7-1 ]
    RefSeqi NP_064569.3. NM_020184.3. [Q6P4Q7-1 ]
    UniGenei Hs.175043.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IY3 X-ray 3.60 A/B/C/D 359-511 [» ]
    ProteinModelPortali Q6P4Q7.
    SMRi Q6P4Q7. Positions 360-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117711. 3 interactions.
    STRINGi 9606.ENSP00000366275.

    Protein family/group databases

    TCDBi 9.A.40.3.4. the hlyc/corc (hcc) family.

    PTM databases

    PhosphoSitei Q6P4Q7.

    Polymorphism databases

    DMDMi 224471892.

    Proteomic databases

    MaxQBi Q6P4Q7.
    PaxDbi Q6P4Q7.
    PRIDEi Q6P4Q7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377075 ; ENSP00000366275 ; ENSG00000158158 . [Q6P4Q7-1 ]
    GeneIDi 26504.
    KEGGi hsa:26504.
    UCSCi uc002swx.3. human. [Q6P4Q7-1 ]

    Organism-specific databases

    CTDi 26504.
    GeneCardsi GC02P097426.
    H-InvDB HIX0002279.
    HIX0161875.
    HGNCi HGNC:105. CNNM4.
    HPAi HPA017732.
    MIMi 217080. phenotype.
    607805. gene.
    neXtProti NX_Q6P4Q7.
    Orphaneti 1873. Jalili syndrome.
    PharmGKBi PA26671.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1253.
    HOGENOMi HOG000231947.
    HOVERGENi HBG074775.
    InParanoidi Q6P4Q7.
    KOi K16302.
    OMAi RREILIP.
    OrthoDBi EOG72ZCD7.
    PhylomeDBi Q6P4Q7.
    TreeFami TF101012.

    Miscellaneous databases

    ChiTaRSi CNNM4. human.
    GenomeRNAii 26504.
    NextBioi 35478818.
    PROi Q6P4Q7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P4Q7.
    Bgeei Q6P4Q7.
    CleanExi HS_CNNM4.
    Genevestigatori Q6P4Q7.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR000644. CBS_dom.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002550. DUF21.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00571. CBS. 1 hit.
    PF01595. DUF21. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    PROSITEi PS51371. CBS. 2 hits.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-775 (ISOFORM 1).
      Tissue: Cerebellum and Teratocarcinoma.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126.
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-467, VARIANTS JALIS GLN-236 AND PRO-324, FUNCTION.
    5. "Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)."
      Wang C.-Y., Shi J.-D., Yang P., Kumar P.G., Li Q.-Z., Run Q.-G., Su Y.-C., Scott H.S., Kao K.-J., She J.-X.
      Gene 306:37-44(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-775 (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-775 (ISOFORM 1).
    7. "Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis."
      Guo D., Ling J., Wang M.-H., She J.-X., Gu J., Wang C.-Y.
      Mol. Pain 1:15-15(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH COX11.
    8. Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-134.
    10. Cited for: VARIANTS JALIS PRO-196; TYR-200 AND PRO-324, FUNCTION.

    Entry informationi

    Entry nameiCNNM4_HUMAN
    AccessioniPrimary (citable) accession number: Q6P4Q7
    Secondary accession number(s): B7Z1U0
    , C7SQM3, C7SQM4, C7SQM5, Q53RE5, Q9H9G3, Q9HCI0, Q9NRN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no cyclin-like function in vivo.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3