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Q6P4Q7

- CNNM4_HUMAN

UniProt

Q6P4Q7 - CNNM4_HUMAN

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Protein
Metal transporter CNNM4
Gene
CNNM4, ACDP4, KIAA1592
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions By similarity. May play a role in biomineralization and retinal function.2 Publications

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
  3. response to stimulus Source: UniProtKB-KW
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biomineralization, Ion transport, Sensory transduction, Transport, Vision

Protein family/group databases

TCDBi9.A.40.3.4. the hlyc/corc (hcc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metal transporter CNNM4
Alternative name(s):
Ancient conserved domain-containing protein 4
Cyclin-M4
Gene namesi
Name:CNNM4
Synonyms:ACDP4, KIAA1592
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:105. CNNM4.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 178178Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 24041Cytoplasmic Reviewed prediction
Add
BLAST
Intramembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Topological domaini262 – 2643Cytoplasmic Reviewed prediction
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Topological domaini286 – 2938Extracellular Reviewed prediction
Transmembranei294 – 31623Helical; Reviewed prediction
Add
BLAST
Topological domaini317 – 775459Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Jalili syndrome (JALIS) [MIM:217080]: A syndrome characterized by the association of cone-rod dystrophy and amelogenesis imperfecta.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti196 – 1961S → P in JALIS. 1 Publication
VAR_058319
Natural varianti200 – 2001S → Y in JALIS. 1 Publication
VAR_058320
Natural varianti236 – 2361R → Q in JALIS. 1 Publication
VAR_058321
Natural varianti324 – 3241L → P in JALIS. 2 Publications
VAR_058322

Keywords - Diseasei

Amelogenesis imperfecta, Cone-rod dystrophy, Disease mutation

Organism-specific databases

MIMi217080. phenotype.
Orphaneti1873. Jalili syndrome.
PharmGKBiPA26671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Metal transporter CNNM4
PRO_0000295765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Modified residuei664 – 6641Phosphoserine By similarity
Modified residuei770 – 7701Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P4Q7.
PaxDbiQ6P4Q7.
PRIDEiQ6P4Q7.

PTM databases

PhosphoSiteiQ6P4Q7.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart.1 Publication

Gene expression databases

ArrayExpressiQ6P4Q7.
BgeeiQ6P4Q7.
CleanExiHS_CNNM4.
GenevestigatoriQ6P4Q7.

Organism-specific databases

HPAiHPA017732.

Interactioni

Subunit structurei

Interacts with COX11.1 Publication

Protein-protein interaction databases

BioGridi117711. 3 interactions.
STRINGi9606.ENSP00000366275.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IY3X-ray3.60A/B/C/D359-511[»]
ProteinModelPortaliQ6P4Q7.
SMRiQ6P4Q7. Positions 360-508.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 358174DUF21
Add
BLAST
Domaini377 – 43862CBS 1
Add
BLAST
Domaini445 – 51167CBS 2
Add
BLAST

Sequence similaritiesi

Belongs to the ACDP family.
Contains 2 CBS domains.
Contains 1 DUF21 domain.

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1253.
HOGENOMiHOG000231947.
HOVERGENiHBG074775.
InParanoidiQ6P4Q7.
KOiK16302.
OMAiRREILIP.
OrthoDBiEOG72ZCD7.
PhylomeDBiQ6P4Q7.
TreeFamiTF101012.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002550. DUF21.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS51371. CBS. 2 hits.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P4Q7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPVGGGGRP VGGPARGRLL LAAPVLLVLL WALGARGQGS PQQGTIVGMR    50
LASCNKSCGT NPDGIIFVSE GSTVNLRLYG YSLGNISSNL ISFTEVDDAE 100
TLHKSTSCLE LTKDLVVQQL VNVSRGNTSG VLVVLTKFLR RSESMKLYAL 150
CTRAQPDGPW LKWTDKDSLL FMVEEPGRFL PLWLHILLIT VLLVLSGIFS 200
GLNLGLMALD PMELRIVQNC GTEKERRYAR KIEPIRRKGN YLLCSLLLGN 250
VLVNTSLTIL LDNLIGSGLM AVASSTIGIV IFGEILPQAL CSRHGLAVGA 300
NTILLTKFFM LLTFPLSFPI SKLLDFFLGQ EIRTVYNREK LMEMLKVTEP 350
YNDLVKEELN MIQGALELRT KTVEDIMTQL QDCFMIRSDA ILDFNTMSEI 400
MESGYTRIPV FEDEQSNIVD ILYVKDLAFV DPDDCTPLKT ITRFYNHPVH 450
FVFHDTKLDA MLEEFKKGKS HLAIVQKVNN EGEGDPFYEV LGLVTLEDVI 500
EEIIKSEILD ESDMYTDNRS RKRVSEKNKR DFSAFKDADN ELKVKISPQL 550
LLAAHRFLAT EVSQFSPSLI SEKILLRLLK YPDVIQELKF DEHNKYYARH 600
YLYTRNKPAD YFILILQGKV EVEAGKENMK FETGAFSYYG TMALTSVPSD 650
RSPAHPTPLS RSASLSYPDR TDVSTAATLA GSSNQFGSSV LGQYISDFSV 700
RALVDLQYIK ITRQQYQNGL LASRMENSPQ FPIDGCTTHM ENLAEKSELP 750
VVDETTTLLN ERNSLLHKAS HENAI 775
Length:775
Mass (Da):86,607
Last modified:March 3, 2009 - v3
Checksum:iD159303834A9416C
GO
Isoform 2 (identifier: Q6P4Q7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.
     711-775: ITRQQYQNGL...LHKASHENAI → PQSWPCFSRP...HPHGELGREV

Note: No experimental confirmation available.

Show »
Length:263
Mass (Da):29,485
Checksum:i8AB7D712AD2BCC84
GO

Sequence cautioni

The sequence AAF86370.1 differs from that shown. Reason: Frameshift at positions 108 and 120.
The sequence AAY14963.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14266.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261G → R.1 Publication
Corresponds to variant rs17855817 [ dbSNP | Ensembl ].
VAR_033365
Natural varianti134 – 1341V → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035946
Natural varianti196 – 1961S → P in JALIS. 1 Publication
VAR_058319
Natural varianti200 – 2001S → Y in JALIS. 1 Publication
VAR_058320
Natural varianti236 – 2361R → Q in JALIS. 1 Publication
VAR_058321
Natural varianti324 – 3241L → P in JALIS. 2 Publications
VAR_058322

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 513513Missing in isoform 2.
VSP_054271Add
BLAST
Alternative sequencei711 – 77565ITRQQ…HENAI → PQSWPCFSRPGDRVCLPAPP SMNSSLPHADHSAAVPERAA GFSHGEQPSVSHRRVHHPHG ELGREV in isoform 2.
VSP_054272Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021T → I in AAF86370. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022833 mRNA. Translation: BAB14266.1. Different initiation.
AK293915 mRNA. Translation: BAH11626.1.
AC092636 Genomic DNA. Translation: AAY14963.1. Different initiation.
BC063295 mRNA. Translation: AAH63295.2.
FJ619522 Genomic DNA. Translation: ACV32670.1.
FJ619523 Genomic DNA. Translation: ACV32671.1.
FJ619524 Genomic DNA. Translation: ACV32672.1.
AF202777 mRNA. Translation: AAF86370.1. Frameshift.
AB046812 mRNA. Translation: BAB13418.1.
CCDSiCCDS2024.2. [Q6P4Q7-1]
RefSeqiNP_064569.3. NM_020184.3. [Q6P4Q7-1]
UniGeneiHs.175043.

Genome annotation databases

EnsembliENST00000377075; ENSP00000366275; ENSG00000158158.
ENST00000540067; ENSP00000444806; ENSG00000158158.
GeneIDi26504.
KEGGihsa:26504.
UCSCiuc002swx.3. human. [Q6P4Q7-1]

Polymorphism databases

DMDMi224471892.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022833 mRNA. Translation: BAB14266.1 . Different initiation.
AK293915 mRNA. Translation: BAH11626.1 .
AC092636 Genomic DNA. Translation: AAY14963.1 . Different initiation.
BC063295 mRNA. Translation: AAH63295.2 .
FJ619522 Genomic DNA. Translation: ACV32670.1 .
FJ619523 Genomic DNA. Translation: ACV32671.1 .
FJ619524 Genomic DNA. Translation: ACV32672.1 .
AF202777 mRNA. Translation: AAF86370.1 . Frameshift.
AB046812 mRNA. Translation: BAB13418.1 .
CCDSi CCDS2024.2. [Q6P4Q7-1 ]
RefSeqi NP_064569.3. NM_020184.3. [Q6P4Q7-1 ]
UniGenei Hs.175043.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IY3 X-ray 3.60 A/B/C/D 359-511 [» ]
ProteinModelPortali Q6P4Q7.
SMRi Q6P4Q7. Positions 360-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117711. 3 interactions.
STRINGi 9606.ENSP00000366275.

Protein family/group databases

TCDBi 9.A.40.3.4. the hlyc/corc (hcc) family.

PTM databases

PhosphoSitei Q6P4Q7.

Polymorphism databases

DMDMi 224471892.

Proteomic databases

MaxQBi Q6P4Q7.
PaxDbi Q6P4Q7.
PRIDEi Q6P4Q7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377075 ; ENSP00000366275 ; ENSG00000158158 .
ENST00000540067 ; ENSP00000444806 ; ENSG00000158158 .
GeneIDi 26504.
KEGGi hsa:26504.
UCSCi uc002swx.3. human. [Q6P4Q7-1 ]

Organism-specific databases

CTDi 26504.
GeneCardsi GC02P097426.
H-InvDB HIX0002279.
HIX0161875.
HGNCi HGNC:105. CNNM4.
HPAi HPA017732.
MIMi 217080. phenotype.
607805. gene.
neXtProti NX_Q6P4Q7.
Orphaneti 1873. Jalili syndrome.
PharmGKBi PA26671.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1253.
HOGENOMi HOG000231947.
HOVERGENi HBG074775.
InParanoidi Q6P4Q7.
KOi K16302.
OMAi RREILIP.
OrthoDBi EOG72ZCD7.
PhylomeDBi Q6P4Q7.
TreeFami TF101012.

Miscellaneous databases

ChiTaRSi CNNM4. human.
GenomeRNAii 26504.
NextBioi 35478818.
PROi Q6P4Q7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P4Q7.
Bgeei Q6P4Q7.
CleanExi HS_CNNM4.
Genevestigatori Q6P4Q7.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR000644. CBS_dom.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002550. DUF21.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00571. CBS. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
PROSITEi PS51371. CBS. 2 hits.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-775 (ISOFORM 1).
    Tissue: Cerebellum and Teratocarcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-467, VARIANTS JALIS GLN-236 AND PRO-324, FUNCTION.
  5. "Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)."
    Wang C.-Y., Shi J.-D., Yang P., Kumar P.G., Li Q.-Z., Run Q.-G., Su Y.-C., Scott H.S., Kao K.-J., She J.-X.
    Gene 306:37-44(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-775 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-775 (ISOFORM 1).
  7. "Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis."
    Guo D., Ling J., Wang M.-H., She J.-X., Gu J., Wang C.-Y.
    Mol. Pain 1:15-15(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COX11.
  8. Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-134.
  10. Cited for: VARIANTS JALIS PRO-196; TYR-200 AND PRO-324, FUNCTION.

Entry informationi

Entry nameiCNNM4_HUMAN
AccessioniPrimary (citable) accession number: Q6P4Q7
Secondary accession number(s): B7Z1U0
, C7SQM3, C7SQM4, C7SQM5, Q53RE5, Q9H9G3, Q9HCI0, Q9NRN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no cyclin-like function in vivo.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi