Q6P4M0 (DHCR7_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
7-dehydrocholesterol reductase
Short name=7-DHC reductase
EC=1.3.1.21

Alternative name(s):
Sterol Delta(7)-reductase

Gene names

Name:

dhcr7

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.
Catalytic activity	Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.
Pathway	Steroid biosynthesis; cholesterol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ERG4/ERG24 family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	7-dehydrocholesterol reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	7-dehydrocholesterol reductase		PRO_0000207507
Regions
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	264 – 284	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Transmembrane	329 – 349	21	Helical; Potential
	Transmembrane	419 – 439	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6P4M0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B8D50355E87A2FFD	FASTA	473	54,785
	10 20 30 40 50 60 MGERRRANAS RGDKKVANGE KPHVGQWGRA WEVDYFSLAA VLFLLAFAPL IVYYFVMSCD 70 80 90 100 110 120 QYQCALTAPV LDLYWGKAQL SDIWDKTPAL TWGAAKIYIV WVSFQVFLYM LVPDILHKFV 130 140 150 160 170 180 PGYEGGVQEG ARTPAGLINK YQVNGLQAWT ITHLLWFANA YHFHWFSPTI IIDNWVPLLW 190 200 210 220 230 240 CANLLGYSVA TFALLKAYFF PTNAHDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR 250 260 270 280 290 300 PGIVAWTLIN LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 310 320 330 340 350 360 GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STATAVGVLL LGLIGYYIFR MTNHQKDLFR 370 380 390 400 410 420 RTNGNCKIWG KKPKSIECSY TSADGKRHYS KLMISGFWGV ARHLNYTGDL MGSLAYCLAC 430 440 450 460 470 GFDHLLPYFY FTYMTILLVH RCIRDEHRCS SKYGKDWKLY TDAVPYRLLP GLF

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC063347 mRNA. Translation: AAH63347.1.
RefSeq	NP_989235.1. NM_203904.1.
UniGene	Str.43032.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P4M0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	394844.
KEGG	xtr:394844.
Organism-specific databases
CTD	1717.
Xenbase	XB-GENE-920362. dhcr7.
Phylogenomic databases
eggNOG	veNOG06047.
GeneTree	ENSGT00390000000417.
HOGENOM	HBG592488.
HOVERGEN	HBG007825.
InParanoid	Q6P4M0.
OrthoDB	EOG4GQQ4Q.
Gene expression databases
Bgee	Q6P4M0.
Family and domain databases
InterPro	IPR001171. Ergosterol_biosynth_ERG4_ERG24. IPR018083. Sterol_reductase_CS. [Graphical view]
KO	K00213.
Pfam	PF01222. ERG4_ERG24. 1 hit. [Graphical view]
PROSITE	PS01017. STEROL_REDUCT_1. 1 hit. PS01018. STEROL_REDUCT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHCR7_XENTR

Accession

Primary (citable) accession number: Q6P4M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program