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Q6P4M0 (DHCR7_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-dehydrocholesterol reductase

Short name=7-DHC reductase
EC=1.3.1.21
Alternative name(s):
Sterol Delta(7)-reductase
Gene names
Name:dhcr7
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activity

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ERG4/ERG24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4734737-dehydrocholesterol reductase
PRO_0000207507

Regions

Transmembrane36 – 5621Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane329 – 34921Helical; Potential
Transmembrane419 – 43921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6P4M0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B8D50355E87A2FFD

FASTA47354,785
        10         20         30         40         50         60 
MGERRRANAS RGDKKVANGE KPHVGQWGRA WEVDYFSLAA VLFLLAFAPL IVYYFVMSCD 

        70         80         90        100        110        120 
QYQCALTAPV LDLYWGKAQL SDIWDKTPAL TWGAAKIYIV WVSFQVFLYM LVPDILHKFV 

       130        140        150        160        170        180 
PGYEGGVQEG ARTPAGLINK YQVNGLQAWT ITHLLWFANA YHFHWFSPTI IIDNWVPLLW 

       190        200        210        220        230        240 
CANLLGYSVA TFALLKAYFF PTNAHDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR 

       250        260        270        280        290        300 
PGIVAWTLIN LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 

       310        320        330        340        350        360 
GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STATAVGVLL LGLIGYYIFR MTNHQKDLFR 

       370        380        390        400        410        420 
RTNGNCKIWG KKPKSIECSY TSADGKRHYS KLMISGFWGV ARHLNYTGDL MGSLAYCLAC 

       430        440        450        460        470 
GFDHLLPYFY FTYMTILLVH RCIRDEHRCS SKYGKDWKLY TDAVPYRLLP GLF 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC063347 mRNA. Translation: AAH63347.1.
RefSeqNP_989235.1. NM_203904.1.
UniGeneStr.43032.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000019594.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394844.
KEGGxtr:394844.

Organism-specific databases

CTD1717.
XenbaseXB-GENE-920362. dhcr7.

Phylogenomic databases

eggNOGNOG72042.
HOGENOMHOG000193296.
HOVERGENHBG007825.
InParanoidQ6P4M0.
KOK00213.

Enzyme and pathway databases

UniPathwayUPA00063.

Family and domain databases

InterProIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHCR7_XENTR
AccessionPrimary (citable) accession number: Q6P4M0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways