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Q6P4M0

- DHCR7_XENTR

UniProt

Q6P4M0 - DHCR7_XENTR

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Protein

7-dehydrocholesterol reductase

Gene
dhcr7
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:dhcr7
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-920362. dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Reviewed predictionAdd
BLAST
Transmembranei264 – 28421Helical; Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Transmembranei329 – 34921Helical; Reviewed predictionAdd
BLAST
Transmembranei419 – 43921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4734737-dehydrocholesterol reductasePRO_0000207507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019594.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ6P4M0.
KOiK00213.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P4M0-1 [UniParc]FASTAAdd to Basket

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MGERRRANAS RGDKKVANGE KPHVGQWGRA WEVDYFSLAA VLFLLAFAPL    50
IVYYFVMSCD QYQCALTAPV LDLYWGKAQL SDIWDKTPAL TWGAAKIYIV 100
WVSFQVFLYM LVPDILHKFV PGYEGGVQEG ARTPAGLINK YQVNGLQAWT 150
ITHLLWFANA YHFHWFSPTI IIDNWVPLLW CANLLGYSVA TFALLKAYFF 200
PTNAHDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR PGIVAWTLIN 250
LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 300
GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STATAVGVLL LGLIGYYIFR 350
MTNHQKDLFR RTNGNCKIWG KKPKSIECSY TSADGKRHYS KLMISGFWGV 400
ARHLNYTGDL MGSLAYCLAC GFDHLLPYFY FTYMTILLVH RCIRDEHRCS 450
SKYGKDWKLY TDAVPYRLLP GLF 473
Length:473
Mass (Da):54,785
Last modified:July 5, 2004 - v1
Checksum:iB8D50355E87A2FFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063347 mRNA. Translation: AAH63347.1.
RefSeqiNP_989235.1. NM_203904.1.
UniGeneiStr.43032.

Genome annotation databases

GeneIDi394844.
KEGGixtr:394844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC063347 mRNA. Translation: AAH63347.1 .
RefSeqi NP_989235.1. NM_203904.1.
UniGenei Str.43032.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000019594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 394844.
KEGGi xtr:394844.

Organism-specific databases

CTDi 1717.
Xenbasei XB-GENE-920362. dhcr7.

Phylogenomic databases

eggNOGi NOG72042.
HOGENOMi HOG000193296.
HOVERGENi HBG007825.
InParanoidi Q6P4M0.
KOi K00213.

Enzyme and pathway databases

UniPathwayi UPA00063 .

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDHCR7_XENTR
AccessioniPrimary (citable) accession number: Q6P4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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